Meet Smart Relief: 4 of the Best Nutrients for Brain & Body Comfort

The best way I know to introduce our exciting new product Smart Relief is to tell you a story about Dr. Daniel Amen.

I’m not telling stories out of school—Dr. Amen told this one himself on one of his terrific PBS specials, so I’m sure he won’t mind my passing it on to you.

Here’s the story.

Apparently, Dr. Amen had a close friend, a cardiologist with a major back problem. In fact, the poor guy had been battling back discomfort for over four years, and had tried just about everything: medication, physical therapy, even injections. When an MRI revealed spinal issues, he scheduled surgery, hoping it would finally bring relief.

Over dinner one night, Dr. Amen asked his friend a simple question that changed everything for him:

“What if the problem isn’t just in your back? What if it’s also stuck in your brain?”

He explained that when discomfort drags on for weeks or months, it doesn’t just live in the body anymore—it rewires your brain. The brain starts to expect pain, to anticipate it, to amplify it. In a sense, the body gets trapped in a loop.

Dr. Amen told his friend something that stunned him: Over 60% of people over 50 who have no pain at all show abnormal MRIs.

By age 70, that number climbs to 80%.

The real issue, said Dr. Amen, isn’t the MRI—it’s the fear it creates. The brain begins spinning a story of worry and limitation, locking you into what he calls the “doom loop.”

But the beautiful truth is that this story can be rewritten.

A few weeks later, the cardiologist called him. His pain was 90% gone. No surgery. No new drugs. Just a new way of finding relief—not starting with his back, but with his brain.

Enter Smart Relief

That same principle—that comfort begins in the brain—is what inspired Smart Relief, BrainMD’s newest innovation for supporting physical comfort, mobility, and ease.*

Because the more we understand the connection between the brain and body, the more we realize that when you support one, the other responds.*

There’s nothing quite like the feeling of ease—your body moves freely, your mind feels lighter, and you can take on the day without those little reminders that something aches, tugs, or tightens.

But let’s be honest—for most of us, that feeling doesn’t come as easily as it used to.

Between long hours at a desk, ambitious workouts, and the sheer stress of everyday life, the body takes a beating. You don’t have to be an athlete to feel the effects. By evening, your back talks to you. Your joints grumble. Even your brain seems to slow down when your body’s uncomfortable.

That’s exactly why BrainMD created Smart Relief—a science-based formula designed to help your body bounce back, move more easily, and feel more comfortable, day after day.*

Why Your Body Deserves Smart Relief

Smart Relief isn’t about masking symptoms. It’s about helping your body restore its natural sense of balance and ease.*

Modern life throws a lot at us—repetitive motion, screen time, stress hormones, even dietary choices—and they all chip away at the body’s comfort zone.* Over time, your internal “inflammation switch” can stay turned on longer than it should, leaving you stiff, sore, or sluggish.*

Smart Relief was created to help your body maintain a healthy inflammatory balance—the kind that naturally settles once the job’s done.* Because when your body feels supported, recovery happens naturally.*

 

The BrainMD Difference: Four Clinically Studied Ingredients, One Powerful Formula

Each capsule of Smart Relief delivers a precise combination of four research-backed nutrients that work together to support comfort, flexibility, and whole-body recovery.*

Here’s what’s inside — and why it matters.

1. Palmitoylethanolamide (PEA): Nature’s Calming Molecule

Palmitoylethanolamide (PEA) is a fatty acid naturally produced by the body to help soothe overstimulated nerves and maintain comfort.* The ultra-micronized form used in Smart Relief dissolves more efficiently, helping your system absorb and utilize it effectively.* Studies show that PEA supports the body’s natural ability to quiet every day physical discomfort and promote a sense of ease and relaxation. In research, palmitoylethanolamide has been studied for its role in supporting the body’s natural inflammatory balance and overall comfort.*

2. Boswellia Serrata: The Ancient Herb for Modern Mobility

Used for centuries in traditional wellness practices, Boswellia is now supported by modern research showing it can help maintain healthy joints and flexibility.* The active compounds, called boswellic acids, support the body’s natural inflammatory balance, helping you move with less stiffness and more flow—whether you’re getting out of bed or back on the tennis court.*

3. Ginger Extract: Powerful Plant Support for Everyday Recovery

Ginger is more than a kitchen spice—it’s one of nature’s most reliable comfort allies.* Concentrated ginger extract helps modulate key pathways in the body that influence how you respond to physical stress.* Clinical studies suggest ginger supports joint health, recovery from exercise, and general well-being—all without drowsiness or dependency.*

4. Calcium Fructoborate: A Unique Nutrient Complex for Joint and Cellular Health

This patented compound combines calcium, fructose, and boron in a natural form the body easily recognizes.* Research shows it can help maintain healthy levels of C-reactive protein (a key marker of inflammation) while supporting joint comfort and flexibility.* Think of it as foundational nutrition for resilient, comfortable movement.*

Why It Works Better—The Magic of Synergy

Each ingredient in Smart Relief is effective on its own.* But when combined, they complement one another beautifully—addressing comfort from multiple angles at once.*

While most supplements focus on just one ingredient, Smart Relief blends four clinically researched compounds into a single, synergistic formula.* It’s designed to support both short-term recovery and long-term mobility, helping you stay active, independent, and engaged in life.*

And because it’s non-drowsy, non-habit-forming, vegan, gluten-free, and free of artificial colors or flavors, it fits seamlessly into your daily routine—whether you take it in the morning before work or after an evening workout.*

Who Can Benefit from Smart Relief

• Active Adults and Athletes – Support faster recovery and ease after intense workouts or long games.*
• Busy Professionals – Help offset the stiffness that builds up from long hours sitting at a desk.*
• Older Adults – Support joint comfort and flexibility to stay mobile and confident.*
• Anyone with an active life – If you move, stretch, lift, or sit all day — your body will thank you.*

Smart Relief is for anyone who wants to stay active, vibrant, and comfortable—no matter what life brings.*

How to Use Smart Relief

Take 2 capsules daily, preferably with food, and use consistently as part of your wellness routine. Like any supplement, consistency is key—Smart Relief works best when you give your body the steady support it needs to stay balanced.*

Smart Relief at a Glance

• Supports a healthy inflammatory response*
• Helps ease occasional everyday discomfort*
• Promotes joint comfort, flexibility, and mobility*
• Encourages faster recovery after physical stress*
• Enhances overall physical comfort and total wellness*

When Your Body Feels Better, Your Brain Does Too

At BrainMD, we’ve always believed that body health and brain health are one and the same. When your body is tense, stiff, or uncomfortable, your brain feels it—and when your body moves freely, your mood, focus, and energy all follow.*

Smart Relief was developed to help bridge that connection: supporting both brain and body comfort, so you can feel clearer, stronger, and more at ease in your own skin.*

Because you deserve more than momentary relief — you deserve lasting comfort that keeps up with your life.*

 

*These statements have not been evaluated by the FDA. This content is for informational purposes only. It is not meant to substitute for medical or healthcare advice from a physician, nor is it intended to diagnose, treat, cure, or prevent any disease. Consult your healthcare provider before beginning a new health regimen.

 

References:

1. Clayton, P., et. al. (2021) Palmitoylethanolamide: A Natural Compound for Health Management https://pubmed.ncbi.nlm.nih.gov/34069940/
2. Rankin, L., Fowler, C.J. (2020) The Basal Pharmacology of Palmitoylenthanolide https://pubmed.ncbi.nlm.nih.gov/33114698/
3. Lang-Illievich, K., et. al. (2023) Palmitoylethanolamide in the Treatment of Chronic Pain: A Systematic Review and Meta-Analysis of Double-Blind Randomized Controlled Trials https://pubmed.ncbi.nlm.nih.gov/36986081/
4. Petrosino, S., Moriello, A.S. (2020) Palmitoylethanolamide: A Nutritional Approach to Keep Neuroinflammation within Physiological Boundaries—A Systematic Review https://pubmed.ncbi.nlm.nih.gov/33333772/
5. Yu, G., et. al. (2020) Effectiveness of Boswellia and Boswellia extract for osteoarthritis patients: a systematic review and meta-analysis https://pubmed.ncbi.nlm.nih.gov/32680575/
6. Siddiqui, M. Z. (2011) Boswellia serrata, a potential anti-inflammatory agent: an overview https://pubmed.ncbi.nlm.nih.gov/22457547/
7. Majeed, M., et. al. (2019) A pilot, randomized, double-blind, placebo-controlled trial to assess the safety and efficacy of a novel Boswellia serrata extract in the management of osteoarthritis of the knee https://pubmed.ncbi.nlm.nih.gov/30838706/
8. Rondanelli, M, et. al. (2020) Clinical trials on pain lowering effect of ginger: A narrative review https://pubmed.ncbi.nlm.nih.gov/32436242/
9. Kim, S., et. al. (2022) The Effect of Ginger and Its Sub-Components on Pain https://pubmed.ncbi.nlm.nih.gov/36079679/
10. Moshfeghinia, R., et. al. (2024) Ginger for Pain Management in Primary Dysmenorrhea: A Systematic Review and Meta-Analysis https://pubmed.ncbi.nlm.nih.gov/38770631/
11. EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA), et. al. (2021) Safety of calcium fructoborate as a novel food pursuant to Regulation (EU) 2015/2283 https://pubmed.ncbi.nlm.nih.gov/34257728/
12. Scorei, R. I., Rotaru, P. (2011) Calcium fructoborate—potential anti-inflammatory agent https://pubmed.ncbi.nlm.nih.gov/21274653/
13. Scorei, I. D., Scorei, R. I. (2013) Calcium fructoborate helps control inflammation associated with diminished bone health https://pubmed.ncbi.nlm.nih.gov/23982445/