ProBrainBiotics MAX


Seven clinically studied probiotic strains – providing 30 billion CFU per capsule – come together in ProBrainBiotics MAX, making it the best probiotic supplement available.

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Promotes positive mood and emotional balance


Provides antioxidant support and immune system boosters
Brain Health

Brain Health

Supports optimal brain function with key brain-healthy nutrients


Promotes health digestion
Serving Size 1 Capsule
Servings Per Container 30
Amount Per Serving % DV *
Probiotic Strains 30 billion CFU 533 mg
Bifidobacterium lactis HN019™ 17.0 billion CFU  †
Lactobacillus helveticus Rosell®-52 4.5 billion CFU  †
Bifidobacterium bifidum Rosell®-71 3.0 billion CFU  †
Bifidobacterium longum BB536™ 2.0 billion CFU  †
Lactobacillus plantarum KABP™-031 1.5 billion CFU  †
Lactobacillus plantarum KABP™-032 1.5 billion CFU  †
Bifidobacterium longum Rosell®-175 0.5 billion CFU  †
1 CFU  = Colony-Forming Units, number of live bacteria
† Daily Value (DV) not established.

Other Ingredients: Vegetable cellulose (vegetarian capsule), microcrystalline cellulose, acacia gum, magnesium stearate.

Free from gluten, sugar, corn, nuts, egg, yeast, and artificial colorings or flavorings. Contains dairy and soy (traces).

Minimum CFU count 30 billion at time of manufacture.

  • Egg Free
    Egg Free
  • Sugar Free
  • Corn Free
    Corn Free
  • Gluten/Yeast Free
  • Artificial Additive Free

Month 1

Clinically studied nutrients get to work

Month 2-3

Nutritional deficiencies are corrected (varies by person)

Month 4 & Beyond

Amplify the benefits & support long-term health

Good Health Begins With Gut Health

With a premium blend of powerful probiotic strains and a total 30 billion CFU (colony-forming units) per day, ProBrainBiotics MAX is one of the most powerful and effective scientifically-researched probiotics available. These fully-defined probiotic strains benefit the brain (mood, stress, occasional anxious feelings), immunity (help to increase immune cell population), and gut health (bowel regularity and comfort, intestinal probiotic balance).

This broad-spectrum, one-a-day probiotic supplement is a breakthrough for human health.

Mood Problems? Feed Your Friendly Bacteria

In the U.S., at least 1 in 5 people experience mood problems. Clinical research shows that these individuals often are lacking in friendly gut bacteria. Strains R52 and R175 (both found in ProBrainBiotics MAX) are the first clinically confirmed psychobiotics to improve mood.²⁻⁴

Overwhelmed with anxiousness? Support a healthy response with stress with ProBrainBiotics MAX. The same R52 + R175 combination lowered the stress hormone cortisol in double-blind clinical research.³

Immune Issues? Build Better Immunity

A healthy gut microbiome promotes immune readiness. The friendly bacteria are continually being monitored by “sentinel” immune cells for potentially harmful antigens.

In two clinical trials, strains K31 and K32 enhanced the body’s immune response. Strain R71 improved students’ upper respiratory immune vigilance in one study. In two trials, HN19 elevated immune cell numbers in elderly individuals and showed promise for benefiting those with a weakened immunity.

Digestive Discomfort? Get That Good Gut Feeling

All 7 probiotic strains in ProBrainBiotics MAX offer supercharged intestinal benefits. In a double-blind, randomized, controlled trial conducted with people suffering from the effects of stress, the R52 + R175 psychobiotic combination lowered abdominal pain and nausea/vomiting.⁴

ProBrainBiotics MAX is unique for offering clinically defined probiotic strains with brain, immune, and intestinal benefits all in one daily capsule. The strains are internationally registered and tested for identity and safety. The capsules are blister packed to ensure freshness and long-term stability.


Key Scientific References:

  1. Yeh TL, others. The influence of prebiotic or probiotic supplementation on antibody titers after influenza vaccination: a systematic review and meta-analysis of randomized controlled trials. Drug Design, Development and Therapy 12:217 (2018). 

  2. Messaoudi M, others. Beneficial psychological effects of a probiotic formulation (Lactobacillus helveticus R0052 and Bifidobacterium longum R0175) in healthy human volunteers. Gut Microbes 2:256 (2011).

  3. Messaoudi M, others. Assessment of psychotropic-like properties of a probiotic formulation (Lactobacillus helveticus R0052 and Bifidobacterium longum R0175) in rats and human subjects. British Journal of Nutrition 105:755 (2011).

  4. Diop L, others. Probiotic food supplement reduces stress-induced gastrointestinal symptoms in volunteers: a double-blind, placebo-controlled, randomized trial. Nutrition Research 28:1 (2008).

Bifidobacterium lactis Strain HN19
Bifidobacterium lactis Strain HN19
17 billion CFU

Bifidobacteria are the most well studied human probiotics. Named for their branched, bifurcated shape, they are abundant in the gut microbiome of healthy people. HN19 has enhanced human immunity, improved gut function and gum health, and may “prime” the gut for other friendly probiotics.

Lactobacillus helveticus Strain R52
Lactobacillus helveticus Strain R52
4.5 billion CFU

This strain promotes intestinal function and is an established psychobiotic – it clinically improves mood. In combination with R175, R52 has enhanced mood and the ability to cope with stress.

Bifidobacterium bifidum Strain R71
Bifidobacterium bifidum Strain R71
3 billion CFU

R71 has improved sleep quality, immunity, and gut function in students under pre-examination stress.

Bifidobacterium longum Strain BB536
Bifidobacterium longum Strain BB536
2 billion CFU

After intensive clinical research, the BB536 strain is proven to promote gut health.

Lactobacillus plantarum Strain K31
Lactobacillus plantarum Strain K31
1.5 billion CFU

Originally obtained from human infants, these hardy strains have been used in 1:1 combination to enhance immunity and promote intestinal function.

Lactobacillus plantarum Strain K32
Lactobacillus plantarum Strain K32
1.5 billion CFU

Strain K32 was tested together with strain K31. They have separate and distinct DNA and other biologic characteristics, but reinforce each other’s benefits.

Bifidobacterium longum Strain R175
Bifidobacterium longum Strain R175
0.5 billion CFU

This species is the most widespread “bifido” in the human gut and is a psychobiotic. In two pioneering clinical trials, R175, paired with R52, successfully enhanced mood and the ability to cope with stress.

The Problem With Most ProbioticsThe Problem With Most Probiotics

The Problem With Most Probiotics

Your gut microbiome – the collection of bacteria inside your gut – affects more than just your digestion. It also influences your immunity, mood, and stress levels. That’s why probiotic supplements can be a game-changer.

But, buyer beware! Some probiotic strains are clinically studied while others aren't. Plus, different probiotic strains have different benefits – they’re not interchangeable.

For these reasons, it’s essential that you know the exact strains of the probiotics you’re taking. Unfortunately, most products don’t give you that information.

7 Clinically Tested Probiotic Strains7 Clinically Tested Probiotic Strains

7 Clinically Tested Probiotic Strains

A high-quality probiotic, ProBrainBiotics MAX was carefully crafted with seven probiotic strains, all of which are clinically tested and fully identified (with their genus, species, and strain names). These strains are:

  1. Bifidobacterium lactis HN19™
  2. Lactobacillus helveticus Rosell®-52
  3. Bifidobacterium bifidum Rosell®-71
  4. Bifidobacterium longum BB536™
  5. Lactobacillus planatrum KABP™-031
  6. Lactobacillus planatrum KABP™-032
  7. Bifidobacterium longum Rosell®-175


“Support your gut, and it will love you back. This is a maximum-strength probiotics, scientifically formulated.”

- Daniel G. Amen, MD 

  • READ Why It Didn’t Make the Cut

    Iron is a mineral essential for human health. It is typically linked to hemoglobin – the protein that transports oxygen around the body – and is also vital for energy production, antioxidant defense, DNA production, gene regulation, and the body’s detoxification process.
    Though commonly found in multivitamins, we purposely left it out.
    As a standalone supplement ingredient for those at risk of deficiency, iron is beneficial – we offer advanced iron in its most well-tolerated and well-absorbed form: ferrous bisglycinate, Ferrochel®. However, when combined with other nutrients (like it is in a comprehensive multivitamin), iron’s chemically reactive nature can degrade and potentially destroy the other ingredients it’s mixed with.
    Here’s everything else we intentionally left out.

• Brain & Memory Power Boost •

“I got my DREAMS back!”

- Claire R., Verified Buyer

The Probiotic Supplement That Supports Digestion, Immunity & MoodThe Probiotic Supplement That Supports Digestion, Immunity & Mood

The Probiotic Supplement That Supports Digestion, Immunity & Mood

  • Digestion. Looking for a probiotic for digestion? All seven probiotic strains featured in ProBrainBiotics MAX have digestive benefits.* In a clinical trial among people suffering from the effects of stress, strains R52 and R175 reduced abdominal pain and nausea/vomiting.*
  • Immunity. Clinical research has found strains KABP™-31 and KABP™-32 enhanced the body’s immune response, while strain R71 improved upper respiratory immune vigilance and strain HN19™ increased immune cell populations.*
  • Mood & Stress. The combination of strains R52 and R175 has been clinically shown to improve mood and lower the stress hormone cortisol.*


“A really awesome quote from Dr, Amen about how awesome this product is.”

- Daniel G. Amen, MD 

Potent, Safe, and ProtectedPotent, Safe, and Protected

Potent, Safe, and Protected

ProBrainBiotics MAX features a high potency of 30 billion CFU (colony forming units) per capsule, so it’s ideal for people who need maximum support. The strains are internationally registered, an assurance of their safety, and fully identified, so you know exactly what you’re taking. And to make sure these tiny organisms are still alive when they reach you, this high-quality probiotic is sealed in blister packs that protect against moisture and air, which enhances its stability.

Clinically Researched BenefitsClinically Researched Benefits

Clinically Researched Benefits

As a company firmly rooted in science, we use only clinically researched ingredients that create real results. Here’s what you can expect from taking ProBrainBiotics MAX:

  • More friendly bacteria in your gut*
  • Healthy, comfortable digestion*
  • Better immune system function*
  • Positive mood and emotional balance*
  • A healthy response to everyday stress*
Frequently Asked Questions
How can I take this supplement?
We recommend adults take 1 capsule (supplying a minimum 30 billion live probiotic units) daily, with food. Children ages 4 and up also can take this daily dose. This product is not intended for use during pregnancy.
What makes ProBrainBiotics Max different from other probiotic products?
This probiotic supplement is unique because all seven of its strains have shown consistent benefits in clinical trials. The strains are internationally registered and are well defined for identity and safety. The capsules are blister packed to ensure freshness.
Who can benefit from ProBrainBiotics Max?
Nearly everyone is likely to benefit from this broad-spectrum probiotic supplement. This includes the elderly, people who have been exposed to pollutants, and those with poor dietary habits or digestive problems. Individuals with mood problems, dealing with excessive stress, or desiring a stronger immunity may benefit from this efficacious combination of probiotic strains.
Can other BrainMD supplements complement or enhance the effectiveness of ProBrainBiotics Max?
Yes! NeuroVite Plus, Omega-3 Power, and Vitamin D3 5000 IU complement this product. The health of the intestinal lining requires all these nutrients, and probiotics work very closely with this lining. Also, vitamin D deficiency damages the gastrointestinal lining and is associated with microbiome imbalance (“dysbiosis”).
Are there any side effects to taking ProBrainBiotics Max?
No. As with other BrainMD products, this is a dietary supplement, not a drug, and isn’t habit-forming. It’s free from dairy, glutens, sugar, corn, soy, nuts, eggs, yeast, and artificial colorings or flavorings. It’s compatible with keto or paleo dietary patterns.
Are there any adverse effects – such as bloating, gas, and intestinal discomfort – from taking ProBrainBiotics Max?
The products most likely to have these undesired effects contain prebiotics – various forms of complex carbohydrates. It’s common to experience gurgling or other intestinal discomfort after taking a probiotic + prebiotic product. ProBrainBiotics MAX doesn’t have that problem because it doesn’t contain prebiotics.
Does ProBrainBiotics Max require refrigeration?
The live bacteria in probiotics are sensitive to exposure to air, as occurs when a bottle is opened. Refrigeration slows this damage processes but can’t stop it. ProBrainBiotics MAX doesn’t require refrigeration – it contains extra bacterial cells to allow for loss over time when stored at room temperature. We also sealed the capsules individually in blister packs, to protect them from damage due to ongoing exposure to air.
Most supplements require consistent daily intake for optimal results. Is that the case with probiotics, or can they be taken for occasional support and relief?
Probiotic supplements aren’t likely to give immediate relief for intestinal problems. The live bacteria they supply must settle in, reproduce, and get to numbers that can become functionally significant in and amongst the trillions of other bacteria already in the gut. The human gut is a complex, intricate matrix of micro-ecosystems with bacteria as major players, and adjustments take time. Well-designed clinical trials can help inform us about the utility of any probiotic strain. In the case of ProBrainBiotics MAX, the clinically documented benefits of the 7 strains are likely to appear and expand over a period of weeks.
Are there other supplements I should take with probiotics?
It’s recommended to take a clinically verified probiotic supplement every day, along with a broad spectrum multiple vitamin-mineral like NeuroVite Plus and a pure omega-3 concentrated fish oil, such as Omega-3 Power.
Should I rotate my probiotic every 3-4 months for maximum benefit?
No. There’s no clinical evidence this is necessary or even helpful. With clinically researched strains that are highly likely to improve overall microbiome functioning, the longer they’re consumed the better the results tend to be.
What should you look for when choosing a probiotic supplement?
A probiotic strain can perform well in cultures, or in experimental animals, but the only way to know that it will consistently help people is to put it through clinical trials. Here are 4 things to look for: 1. The Supplement Facts box must list the probiotics as strains, not just as species. For example, the species Lactobacillus helveticus has many different strains which have differing degrees of benefit. Lactobacillus helveticus strain Rosell®-52 has specific properties that make it beneficial, distinct from other strains of Lactobacillus helveticus. 2. The strains used must have clinical research to support the benefits claimed for them. 3. The bacterial counts (CFUs, Colony-Forming Units) must be sufficient to cover the counts that worked in clinical trials. 4. The benefits claimed for a probiotic product must be based on scientific research, preferably the expert consensus of results from randomized, double-blinded, and placebo-controlled human clinical trials.

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