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Betaine TMG

Betaine TMG

Supports methylation, mood, and brain energy*

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Description

Clinically studied, doctor-developed, and trusted by clinicians at Amen Clinics, Betaine TMG (Trimethylglycine) is a powerful methyl-donor used to support mental and cardiovascular health.*

By helping convert homocysteine into methionine, Betaine TMG supports methylation cycles crucial for neurotransmitters, energy, and detoxification.*

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Key Benefits

Mood

Methyl

Protective

Key Ingredients

We only use clinically researched ingredients backed by science. Every formula is crafted with pure, high-quality nutrients at effective doses designed for safety, potency, and real results you can trust.
Vegan
Gluten Free
Tree Nut Free
Soy Free
Sugar Free
Vegan
Gluten Free
Tree Nut Free
Soy Free
Sugar Free

Betaine

1000 mg
Betaine, also known as trimethylglycine (TMG), is a naturally occurring compound found in foods like beets and spinach that plays a key role in human metabolism.* It supports liver function, brain health, and cellular energy by donating methyl groups—essential for many biochemical processes.* Betaine is clinically shown to help lower homocysteine levels, a potentially harmful byproduct linked to cardiovascular risk.* It also helps protect the body’s antioxidant reserves, reducing oxidative stress.* With benefits for detoxification, heart health, and cellular balance, betaine is a valuable nutrient for overall wellness.*

Supported by Clinical Research

Betaine Helps Reduce Homocysteine Levels
Clinical studies in healthy men and women

Research suggests betaine may support cardiovascular health by promoting healthy methylation and lowering homocysteine levels.

(Steeng 2003)

(Olthof 2003)
BrainMD
Mood, Metabolism & More

Power Your Brain With Better Methylation

Methylation isn’t just medical jargon it’s a critical cellular process that impacts brain function, detox pathways, mood balance, and energy. Many of us especially those with the common MTHFR gene mutation—don’t methylate efficiently. Betaine TMG bypasses that roadblock, donating methyl groups directly to help optimize neurotransmitters, support detoxification, and keep homocysteine in a healthy range.*

Expert Reviews

“Naturally present in our cells, this powerhouse substance promotes healthy moods.”

Dr. Daniel Amen

Founder, BrainMD & Amen Clinics
“TMG is one of the unsung heroes of methylation—essential for neurotransmitter synthesis, mood regulation, and cardiovascular support. I often recommend Betaine TMG to those with elevated homocysteine, MTHFR variants, or fatigue. It’s a foundational nutrient that supports metabolism, mood, and long-term brain resilience.”

Nicole Avena, PhD

Chief Science Officer, BrainMD
BrainMD
Discover the Benefits of Methylation Support

Is Betaine TMG Right For You?

If you test low for folate or vitamin B12, it’s likely you’re not methylating well. Other tests that point to poor methylation include high blood levels of MMA (methylmalonic acid) or homocysteine, which can build up in the absence of folate. 
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What To Expect

Day 1 → Methylation Support Begins

From the very first dose, Betaine TMG begins donating methyl groups to support healthy methylation—a vital process for DNA repair, neurotransmitter balance, and detoxification.*
Week 2 → Energy & Stamina Support

As methylation pathways strengthen, many notice more consistent daily energy.* Betaine TMG also supports physical performance by aiding muscle endurance and recovery.*
Week 6 → Healthy Homocysteine Levels

Research shows that consistent intake of TMG helps lower homocysteine—a compound linked to cardiovascular and brain health.* Balanced homocysteine supports circulation, cognitive function, and long-term wellness.*
Week 12 → Long-Term Cellular Protection

With ongoing use, Betaine TMG supports optimal methylation and cellular resilience.* This translates into improved energy metabolism, cardiovascular protection, and support for lifelong brain health.*

FAQ

Got questions? We’ve got answers. Explore our FAQs or chat with our AI assistant for instant support.

BrainMD

How can I take Betaine TMG?

It’s recommended to take Betaine TMG at least two hours after eating to avoid poor absorption from competition with food.*

Overall rating: 4.5128207 / 5 from 39 reviews.

AI Generated Review Summary

Summary topics

Review topics: ["quality","impact","stomach","works","supplement","mood","change"].

Review highlights

Reviews

I think it is great

"I think it is great for helping me with methylation. Howver, I added it with neurovites and neurolink and felt a bit wired but tired so backed off for now. Will add in again soon"

— Joni E. (5/5)

I think it’s helping!

"This product seems to be helping. The hardest part is remembering to take between meals/ empty stomach."

— Kathryn H. (4/5)

Thumbs up

"So far so good"

— Justin K. (5/5)

Very helpful.

"Very helpful."

— Takoda H. (5/5)

Very impressed

"5 stars for sure. I started with 2 capsules a day for first week then went to 4 a day. It’s been 4 weeks now and I’ve increased weight for almost all sets. Not to mention that it increased my libido from the first week. I will keep buying this. Very impressed"

— NATHAN G. (5/5)

Good for ADHD'ers!

"Helps to manage my ADHD symptoms"

— Jennifer A. (5/5)

Great for digestion

"Helps digestion and liver"

— Alexandra C. (5/5)

The supplements are of fine

"The supplements are of fine quality and I've been benefitting from daily use."

— Sean K. (5/5)

Helps my mthfr

"Helps my mthfr"

— Carrie G. (5/5)

Love them all; BETAINE TMG,

"Love them all; BETAINE TMG, HAPPY saffron, and Brain Curcumins"

— Mary B. (5/5)

Q&A