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3-in-1 Brain Performance Protocol

3-in-1 Brain Performance Protocol

Dr. Amen’s daily protocol for peak performance*

$89.99
$89.99 $106.85
Includes:
  • Omega-3 Power
  • Advanced Blood Flow
  • Happy Saffron Plus

Description

Dr. Amen’s 3-in-1 Brain Performance Protocol targets three fundamental pillars of brain health—circulation, mood & motivation, and brain cell structure—with clinically studied nutrients designed to help your brain perform at its best.*

Advanced Blood Flow – Supports healthy circulation to your brain, delivering oxygen and nutrients for sharper thinking, quicker recall, and mental stamina.*

Happy Saffron Plus – Clinically studied saffron and mood-supporting nutrients help you stay positive, focused, and emotionally balanced—even in stressful moments.*

Omega-3 Power – Ultra-pure, highly concentrated EPA & DHA promote healthy cell membranes, improve communication between neurons, and protect long-term brain health.*

 

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Key Benefits

Brain Health

Healthy Aging

Cardiovascular Health

Mood

Omega-3 Power Key Ingredients

We only use clinically researched ingredients backed by science. Every formula is crafted with pure, high-quality nutrients at effective doses designed for safety, potency, and real results you can trust.
Supplement Facts label for Omega-3 Power with ingredients, serving size and nutritional information.

EPA

860 mg
EPA is a long-chain omega-3 fatty acid found in the membranes of every cell in the body.* It helps produce eicosanoids—messenger molecules that regulate vital functions in cells, tissues, and organs.* EPA plays a key role in supporting a healthy mood by balancing brain chemicals.* It also promotes cardiovascular health by helping maintain healthy blood vessels and heart function.* Overall, EPA is essential for emotional well-being, heart health, and proper cellular communication throughout the body.*

DHA

580 mg
DHA is a long-chain omega-3 fatty acid essential for building healthy cell membranes throughout the body.* It helps keep cell membranes flexible and fluid, allowing cells to function efficiently.* DHA is especially important in the brain, where it supports the formation of strong connections between nerve cells (synapses), promoting healthy memory, learning, and overall cognitive function.* By maintaining brain cell health, DHA plays a vital role in supporting mental clarity and long-term brain performance.*

Other Omega-3 Fatty Acids

160 mg
This formula also includes trace amounts of other omega-3 fatty acids that work alongside EPA and DHA to enhance their benefits.* These additional omega-3s support brain health by helping to improve cell communication.* Together, they promote better cognitive function, mood stability, and overall brain resilience, contributing to sharper focus and mental clarity.*

Advanced Blood Flow Key Ingredients

We only use clinically researched ingredients backed by science. Every formula is crafted with pure, high-quality nutrients at effective doses designed for safety, potency, and real results you can trust.

L-Citrulline

800 mg
L-citrulline is a naturally occurring amino acid that supports healthy blood flow and circulation by boosting the body’s production of nitric oxide, a compound that helps relax and widen blood vessels.* It is converted into L-arginine in the body, which plays a key role in heart health, energy production, and exercise performance.* Although our bodies make some L-citrulline, dietary sources are limited, making supplementation a helpful way to maintain optimal levels for cardiovascular support, endurance, and overall vitality.*

Quercetin Anhydrous

200 mg
Quercetin anhydrous is a potent antioxidant and anti-inflammatory plant compound found in foods like apples, onions, and berries.* It supports healthy circulation by boosting nitric oxide (NO) production and helping to prevent its breakdown, which promotes relaxed blood vessels and cardiovascular health.* Quercetin also helps maintain oxidative balance and supports immune response.* Because the body can’t produce quercetin on its own and natural food sources offer limited absorption—supplementing with a highly bioavailable form can help you gain its full benefits more effectively.*

Ginkgo Biloba Extract

120 mg
Ginkgo biloba extract, derived from the leaves of the ginkgo tree, is one of the most studied herbal supplements for cognitive health.* It supports healthy circulation, especially to the brain, which is essential for memory, focus, and mental clarity.* Ginkgo is rich in antioxidants that help protect brain cells from oxidative stress and age-related damage.* Clinical research suggests it may enhance mental sharpness and support overall brain function, particularly in aging populations.*

Trans-Resveratrol

30 mg
Trans-resveratrol is the highly bioavailable and active form of resveratrol, a powerful antioxidant polyphenol found in plants like grapes and berries.* It supports cardiovascular health by boosting nitric oxide levels, which improve blood flow and vessel function.* Trans-resveratrol also helps protect cells from oxidative stress, promotes a healthy inflammatory response, and supports healthy aging.* Compared to its less active form (cis-resveratrol), trans-resveratrol is more easily absorbed and utilized by the body, making it especially effective for overall wellness and cellular protection.*

Happy Saffron Plus Key Ingredients

We only use clinically researched ingredients backed by science.* Every formula is crafted with pure, high-quality nutrients at effective doses designed for safety, potency, and real results you can trust.*

Affron® Saffron

30mg
This highly concentrated, standardized saffron extract is derived from the saffron crocus, a spice traditionally used for over 2,600 years in the Middle East. Clinically studied at a dose of 28 mg per day, it has been shown to support a balanced mood, reduce feelings of anxiousness, and promote emotional well-being in both adults and adolescents.* Saffron’s active compounds help modulate neurotransmitters like serotonin and dopamine, contributing to its mood-enhancing effects.*

LONGVIDA® Curcumin

400 mg
Turmeric root has been used in traditional Asian medicine for over 2,600 years to support mood and overall well-being.* Its active compound, curcumin, has powerful antioxidant and anti-inflammatory properties that help protect brain cells and support emotional balance.* This highly absorbable form of curcumin has shown strong results in clinical studies at doses of 400 mg or more, improving mood, reducing stress, and supporting joint and immune health.* Its enhanced absorption ensures optimal effectiveness in the body.*

Zinc

20 mg
Zinc is an essential mineral involved in over 100 enzymes that support vital processes in the body.* It plays a key role in the healthy development and function of the eyes, brain, spinal cord, thymus gland, and digestive system.* Zinc is crucial for maintaining strong immunity, repairing and renewing skin and hair, and preserving DNA structure.* By supporting these systems, zinc promotes overall growth, healing, and resilience, making it vital for both physical health and immune defense.*

Supported By Clinical Research

L-Citrulline Enhances Nitric Oxide Production and Vascular Function
Pharmacokinetic and mechanistic study

L-citrulline has been shown to improve endothelial function and nitric oxide metabolism, which supports healthy circulation and blood pressure.

(Schwedhelm 2008)
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Stay Sharp, Steady, & Strong*

Aging Is Inevitable, How You Age Is Not*

Dr. Amen’s 3-in-1 Brain Performance Protocol combines three supplements he takes every day: Happy Saffron Plus to boost mood and focus while easing stress and tension,* Omega-3 Power to fuel cognitive function with essential omega-3 fatty acids your body can’t make on its own,* and Advanced Blood Flow to optimize circulation and strengthen brain reserve.* Each formula was handpicked to support one of the brain’s core needs. Together, they create a simple, clinically grounded system for thinking sharper, feeling more energized, and protecting your brain for the future.*

Expert Reviews

“The Brain Performance Bundle combines three supplements I take every day–Happy Saffron Plus to increase happiness and focus and decrease stress and anxiousness, Omega-3 Power to support cognitive function and provide essential omega-3 fatty acids your body can’t make on its own, and Advanced Blood Flow to improve blood flow and increase brain reserve.”

Dr. Daniel Amen

Founder, BrainMD & Amen Clinics
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Backed By Thousands Of Brain Scans*

The Protocol Brain Doctors Trust*

Boost your brain with Dr. Amen’s handpicked protocol. Each formula was carefully chosen based on decades of clinical practice, thousands of brain scans, and real patient results. The Brain Performance Protocol addresses three critical areas—circulation, mood, and cell structure—that work together to keep your brain resilient, your thinking clear, and your energy steady.* Trusted by Amen Clinics and brain health doctors nationwide, it’s a smarter way to support your brain—every day.*
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What To Expect

Day 1 – Fuel Your Brain

Your brain starts receiving a daily supply of targeted nutrients to support healthy circulation, mood balance, and optimal cell function.*
Week 2 – Sharper, Steadier Days

Omega-3s and mood-supporting saffron begin working to promote focus, calm resilience, and mental stamina—helping you feel more consistent throughout the day.*
Month 1 – Noticeable Cognitive Boost

Improved blood flow, better cell communication, and balanced mood start translating into clearer thinking, quicker recall, and more productive days.*
Month 3 & Beyond – Long-Term Brain Resilience

Consistent use helps protect brain cells, maintain memory, and keep your mind performing at its best—now and for years to come.*

FAQ

Got questions? We’ve got answers. Explore our FAQs or chat with our AI assistant for instant support.

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Why does this supplement contain antioxidants?

Studies have found that the antioxidants in this formula are especially important in nitric oxide production and metabolism, especially when compared to the antioxidant components found in foods.*