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Supplement Facts box - ingredients, doses and serving sizes for Smart Relief.
New ArrivalDr. Amen Favorite

Smart Relief

Smart Relief

4-In-1 Formula For Daily Aches & Discomfort*

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One-time purchase

Description

Stiff knees? Lingering soreness? Feeling older than you are? Stop masking discomfort. Target it at the source with Smart Relief.

This revolutionary 4-in-1 daily formula goes beyond standard discomfort and joint relief by addressing what other products miss: the neurological loop that keeps your brain and body stuck in discomfort.*

Doctor-developed and backed by over 70 human studies, Smart Relief features clinically researched doses of Ultra-Micronized PEA, ApresFlex® Boswellia, Ginfort® Ginger Extract, and Promentum™ Calcium Fructoborate.*

It's the only PEA supplement designed to target both the physical root of discomfort and the neurological signals that amplify it, without the fog, fatigue, or side effects common with OTC discomfort relief.*

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Key Benefits

Joints

Exercise Recovery

Vitality

Key Ingredients

Supplement Facts box - ingredients, doses and serving sizes for Smart Relief.
Vegan
Gluten Free
Sugar Free
Nut Free
Soy Free
Vegan
Gluten Free
Sugar Free
Nut Free
Soy Free

ApresFlex® Boswellia Serrata Extract

100 mg
ApresFlex® is a next‑generation Boswellia extract that helps maintain healthy inflammatory activity by inhibiting the 5‑LOX enzyme.* Backed by multiple clinical trials, it’s been shown to improve joint comfort, flexibility, and physical function in as little as five days, with continued improvements over time.* This highly absorbable form supports cartilage health and long‑term joint integrity for daily movement and comfort.*

PEA (Palmitoylethanolamide)

600 mg
PEA is a naturally occurring fatty acid compound that supports physical comfort and recovery.* Ultra‑micronized for superior absorption, it works at the neurological level to calm overactive nerve signals and restore balance between the brain and body.* Clinical research shows PEA supports everyday comfort, mobility, and overall quality of life when taken consistently.*

Ginfort® Ginger Root Extract

200 mg
Ginfort® is a highly concentrated, clinically studied ginger extract standardized to 26% active compounds for enhanced potency and bioavailability. It provides fast‑acting relief while supporting a balanced inflammatory response, muscle relaxation, and circulatory health.* It’s safe to take and gentle on the stomach, without harsh side effects.*

Promentum™ Calcium Fructoborate

220 mg
A patented, plant‑based complex of calcium, fructose, and boron, Promentum™ has been clinically shown to support joint comfort, reduce key inflammatory markers like C‑reactive protein, and promote healthy mobility.* By working at the cellular level, it helps build long‑term resilience and flexibility throughout the body.*
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Supported By Clinical Research

Palmitoylethanolamide (PEA) May Help Reduce Chronic Pain and Inflammation
Clinical trials and reviews on ultramicronized PEA and pain

PEA has been studied for its ability to reduce inflammatory pain, joint discomfort, and symptoms of chronic conditions like endometriosis and pelvic pain.
(Ardizzone 2021)
(Petrosino 2018)
(Stochino Loi 2019)
(Bartolucci 2018)
(Gabrielsson 2016)
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Don’t Wait For Discomfort To Get Worse

Relief You Can Feel

Most discomfort products only work one way—by temporarily dulling physical discomfort. But if your brain keeps firing “discomfort” signals, you’ll stay stuck in a cycle of soreness, stiffness, and tension. 

Smart Relief is different. It’s scientifically formulated to promote a healthy inflammatory response and support the body’s natural response to physical stress, providing comfort and mobility to support an active lifestyle.* 

With Ultra-micronized PEA to support neurological calm and a trio of joint support ingredients (Boswellia, Promentum™ Calcium Fructoborate, and Ginfort® Ginger Extract), this formula works fast and keeps working over time.*

Expert Reviews

“Smart Relief targets discomfort at its source, both in the body and the brain. It’s backed by research, formulated with care, and trusted by our physicians at Amen Clinics every day.”

Daniel G. Amen, MD

Founder, BrainMD & Amen Clinics
Pain formulas usually do one thing: cover up the problem. Smart Relief goes after the biology behind everyday discomfort with three powerful botanicals: curcumin, boswellia, and ginger. It works with your body, not against it. The result? Relief without the side effects - and comfort that actually lasts.

Jonny Bowden PhD, CNS

Board Certified Nutrition Specialist
"Smart Relief combines thoughtfully selected ingredients to help ease occasional discomfort and promote recovery. What I value most about this formula is its ability to support the body’s natural response to stress and tension, offering consumers a safe, effective way to feel more comfortable and maintain an active lifestyle."

Nicole Avena, PhD

Chief Science Officer, BrainMD
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Feel Like Yourself Again—Fast

Real People. Real Relief.

In a recent Smart Relief user survey: 

  • 9 out of 10 people reported no side effects* 
  • 67% noticed better mobility and less joint stiffness* 
  • 75% reported effective relief that lasted 6+ hours* 
  • Over 50% experienced improvement within the first 24 hours* 

Results are from a 2025 internal customer survey conducted by BrainMD. Participants received a complimentary bottle of Smart Relief in exchange for their feedback. Survey responses were collected after 4 weeks of consistent daily use. Individual results may vary.*
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What To Expect

Day 1

✔ Ultra-Micronized PEA begins calming overactive discomfort signals in as little as 30 minutes*
✔ Ginfort® Ginger extract delivers fast-acting relief that can last up to 6 hours*
Week 1–2

✔ Noticeable reduction in soreness, tension, and physical discomfort*
✔ Improved mobility, flexibility, joint support, and range of motion*
Week 2–3

✔ More consistent daily comfort without the side effects of common options*
✔ Clinically studied Boswellia and Promentum™ Calcium Fructoborate support a healthy inflammatory response*
Month 2–3

✔ Reduced baseline discomfort and improved physical function*
✔ Builds long-term joint relief, recovery, and resilience*

FAQ

Got questions? We’ve got answers. Explore our FAQs or chat with our AI assistant for instant support.

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What is Smart Relief designed to support?

Smart Relief is formulated to support everyday comfort, mobility, and joint flexibility.* It helps your body maintain a healthy inflammatory response while calming the neurological signals that can amplify physical tension.*

Overall rating: 4.64 / 5 from 25 reviews.

AI Generated Review Summary

Summary topics

Review topics: ["pain","dose","relief","difference","quality","feel","discomfort"].

Review highlights

Reviews

I love this product it

"I love this product it helps me be more alert ."

— Dorothy D. (5/5)

Definitely worth a try

"I started this not knowing that I was going to have a bad injury to my right shoulder arm wrist and hand, and that there would be significant delays in getting treatment due to issues in rural america, my blindness and not having adequate Transportation options. I can't take strong prescription drugs like opioids and can get away with very little of things like Advil, because they aggravate my chronic idiopathic pancreatitis. My understanding is that supplements like Smart Relief can take several months to reach maximum benefit. I've been taking it for two plus months, but I have seen some results in some of the pain issues that I was having before the injury to my arm, such as knee pain and sciatica. I will continue to take it. I am grateful that there's something out there that I can take that doesn't cause me the extreme pain of pancreatitis. kudos to brain MD"

— Donna H. (4/5)

Very Potent

"I felt a difference immediately when taking Smart Relief. The chronic pain in my shoulders and back from tension was relieved. it was amazing."

— Amrita M. (5/5)

Smart Relief does bring me relief. .

"This is another great quality supplement from Dr Daniel Amen,. . I appreciate the research and goodness he puts into his supplement line. . This supplement seems to support my neck and I am thankful to have it in my tool belt."

— Janelle G. (4/5)

So far so good.

"So far almost 2 months. I noticed a gradual improvement with mobility and not feeling as stiff in muscles and joints."

— Gloria W. (4/5)

Smart Relief

"I tried only taking 1 to see if I would or would not have any ill effects, I noticed nothing. I began 2 to help me relax & sleep better. They do help, yet I have less motivation the next day. It's difficult to get going and stay going. Could be my age, 75 that it stays in my system longer?"

— Carole F. (5/5)

I won't be without this supplement!!!

"This supplement is making a HUGE difference for me. I added a picture of myself so you can see that I'm a regular, everyday person; I just happen to live in pain. I have dealt with fibromyalgia and other chronic pain issues for over 25 years. In the last 2 years the pain has become acute. There have been very few products that have made a measurable difference. Until now. I've been taking this for a month, and haven't done anything else differently. It used to be that I woke up everyday with a headache, widespread muscle pain, tenderness around my joints, brain fog and on and on. On a scale of 1 to 10, this supplement has taken my pain from a seven down to a two. Some days it's even less than that. For me this is absolutely remarkable! I have never gone the traditional medical route to treat my condition because it just masks my symptoms. I believe this supplement is offering my body what it needs to help me heal."

— Stacy (5/5)

Hooray!

"This was great, except for the taking it in the afternoon was a bad idea. After I read the instructions, and took it in mornings, I could feel the difference!"

— Kimberly J. (5/5)

A product that actually works!!!!

"I was extremely surprised at how well this actually worked. I felt relief from pain in my knees after the first day of taking this, and it has only improved by continuing to take it daily. Thank you for providing this product. Very easy to remember to take it first thing every morning!!!"

— Cynthia S. (5/5)

Used it for a month

"Used it for a month and a half. So far I feel less sore in my joints."

— SW D. (5/5)

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