BrainMD Happy Saffron Plus ingredients: Longvida curcumin, affron saffron and zinc glycinate, under the heading Find Your Happiness

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Happy Saffron Plus

3-in-1 doctor-developed formula for improved mood, memory, and libido*

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Description

Make your brain and body happy! Happy Saffron Plus® combines clinically studied doses of award-winning affron® saffron extract, Longvida® curcumin, and zinc glycinate in their most bioavailable and efficacious forms to help improve your mood, memory, sexual function, stress, anxiousness, and more.*

Benefits

✔ Lift your mood, naturally – Clinically studied saffron supports emotional balance and mental wellness without harsh side effects*

✔ Sharpen your memory and focus – Longvida® curcumin is shown to improve working memory and cognitive performance*

✔ Revive your desire – Zinc and saffron work together to support healthy libido and sexual function*

✔ Reduce occasional anxiousness – Helps regulate key brain chemicals like serotonin, dopamine, and BDNF for a calmer, more resilient mind*

✔ Doctor-developed, clinically validated – Created by Dr. Daniel Amen and backed by 25+ human clinical studies*

How to use

USE: Take 3 capsules daily between meals, or as directed by your healthcare provider.*†

EARLY RESULTS: Clinical research shows that 400 mg of Longvida® curcumin, the same amount used in Happy Saffron Plus®, can boost working memory by 16% within just one hour of your first dose.*†

LONG-TERM BENEFITS: For optimal results, more happiness and less anxiousness, maintain consistent usage for at least three months. Benefits amplify over time.*†

*†Results may vary based on individual health and fitness levels. Consistent use, in conjunction with a healthy lifestyle, is recommended.

DOCTOR’S RECOMMENDATION: Take Happy Saffron Plus® with Omega-3 Power and NeuroVite Plus Multivitamin to help boost your mood and cognition.*

Ingredients

affron®️ saffron
LONGVIDA®️ Curcumin
Zinc

Third-Party Testing

Happy Saffron Plus is independently tested by Intertek, an ISO 17025 accredited third-party laboratory.

What's tested: Curcuminoid potency, plus screening for heavy metals, microbial contaminants, aflatoxins, pesticides, and adulterants.

Result: Passed.

How BrainMD tests every product

Key Benefits

Mood

Memory

Libido Support

Key Ingredients

We only use clinically researched ingredients backed by science.* Every formula is crafted with pure, high-quality nutrients at effective doses designed for safety, potency, and real results you can trust.*

Affron® Saffron

30mg

This highly concentrated, standardized saffron extract is derived from the saffron crocus, a spice traditionally used for over 2,600 years in the Middle East. Clinically studied at a dose of 28 mg per day, it has been shown to support a balanced mood, reduce feelings of anxiousness, and promote emotional well-being in both adults and adolescents.* Saffron’s active compounds help modulate neurotransmitters like serotonin and dopamine, contributing to its mood-enhancing effects.*

LONGVIDA® Curcumin

400 mg

Turmeric root has been used in traditional Asian medicine for over 2,600 years to support mood and overall well-being.* Its active compound, curcumin, has powerful antioxidant and anti-inflammatory properties that help protect brain cells and support emotional balance.* This highly absorbable form of curcumin has shown strong results in clinical studies at doses of 400 mg or more, improving mood, reducing stress, and supporting joint and immune health.* Its enhanced absorption ensures optimal effectiveness in the body.*

Zinc

20 mg

Zinc is an essential mineral involved in over 100 enzymes that support vital processes in the body.* It plays a key role in the healthy development and function of the eyes, brain, spinal cord, thymus gland, and digestive system.* Zinc is crucial for maintaining strong immunity, repairing and renewing skin and hair, and preserving DNA structure.* By supporting these systems, zinc promotes overall growth, healing, and resilience, making it vital for both physical health and immune defense.*

Supported by Clinical Research

Saffron Supports Positive Mood

Clinical studies in healthy adults

affron® saffron extract has been shown in human trials to help support mood and emotional well-being.*

(Kell 2017)

(Lopresti 2019)

Saffron Helps Promote Calm

Clinical research in adolescents

Controlled research shows saffron extract can help encourage calmness and balanced mood in youth.*

(Lopresti 2018)

Curcumin Supports Healthy Thinking

Studied in older adults

Research shows curcumin supplementation supports cognitive performance and healthy mood in aging populations.

(Cox 2015)

Curcumin Helps Memory & Focus

Clinical study in adults

A published trial found curcumin supported memory, attention, and overall brain health in non-demented adults.

(Small 2018)

Zinc Helps Support Mood

Human & animal research

Studies suggest maintaining healthy zinc levels plays a role in emotional balance and calmness.*

(Russo 2011)

(Tassabehji 2008)

Happy Brain, Healthy Body*

Better Mood, Memory & Sexual Health*

Happy Saffron Plus® isn’t just doctor-developed, it's doctor-recommended, loved in 217 countries, and backed by over 25 human studies.*

In the largest clinical trial on saffron and mood to date, 72% of participants taking affron® (the exact extract in this formula) experienced meaningful mood improvement, many in just 5 weeks.*

With Longvida® curcumin for focus and memory, plus zinc glycinate for mood and sexual health, this 3-in-1 formula delivers fast, feel-good results - naturally.*

Daniel G. Amen, MD, founder of BrainMD, in his office

"This is one of my favorite formulas. Saffron has been studied for centuries, but the form we use—affron®—is backed by modern clinical trials. I take Happy Saffron Plus® daily because it works. Better mood, better memory, better overall brain health—naturally."

"This formula contains ingredients I used to recommend individually but BrainMD combines them in clinically validated doses for even better results. I’ve seen it help patients feel more emotionally balanced and mentally sharp within weeks."

"Saffron has long been used in ancient medicine, but affron® takes it to a new level. It’s clinically backed, bioavailable, and when paired with Longvida® curcumin and zinc glycinate, it becomes a powerhouse for brain health and emotional wellness."

"I love Happy Saffron Plus®! I was able to be off all anxiety/depression medications after 23 years. It works on multiple levels—mood, focus, and energy. It’s NAME-developed, rooted in science, and something I recommend regularly to my clients."

Healthier, Happier YOU*

Clinically Dosed. Doctor Trusted. Loved Worldwide.*

Most saffron supplements stop at mood. Happy Saffron Plus® goes further, targeting mood, memory, libido, stress, and sleep with three highly bioavailable, research-backed ingredients that work better together.*

✔ affron® Saffron Extract: The only saffron with 10+ human clinical studies on mood, stress, and sleep.

✔ Longvida® Curcumin: 285x more bioavailable than standard curcumin and clinically shown to enhance memory within hours.*

✔ Zinc Glycinate: An essential mineral that supports mood, hormones, and brain health.*

This formula isn’t just well-dosed, it’s strategically dosed. Each ingredient amplifies the effects of the others for a synergistic boost you can feel, without hormones, SSRIs, or side effects.*

What To Expect

Day 1 - Instant Memory Boost

Clinical research shows that 400 mg of Longvida® curcumin—the same amount used in Happy Saffron Plus®—can boost working memory by 16% within just one hour of your first dose.*

Week 4 - Sweet Dreams & Bright Moods

In just 4 weeks, 28 mg/day of affron® saffron helped improve mood and sleep, and reduced stress by 41% in clinical trials.*

Week 12 - More Happiness, Less Anxiousness

In 12 weeks, 28 mg/day of affron® saffron significantly improved mental health, reduced occasional anxiousness by 33% and low mood by 32%.*

Long-Term - Cumulative Brain & Body Benefits

Expect better mood, memory, and sexual health with continued use.*

FAQ

Got questions? We’ve got answers. Explore our FAQs or chat with our AI assistant for instant support.

What is the best saffron supplement for mood and brain health?

Look for a saffron supplement featuring a clinically studied extract at an effective dose, with additional ingredients that support brain health. BrainMD's Happy Saffron Plus® delivers 30 mg of affron® saffron, a highly concentrated extract backed by human clinical research for mood and emotional well-being.* It also combines Longvida® curcumin and zinc to support memory, cognitive function, and overall brain health.*

Can saffron help with stress and emotional balance?

Yes. Clinical research shows that saffron extract can support a healthy response to everyday stress, positive mood, and emotional well-being.* In one clinical trial, participants taking 28 mg of affron® saffron daily experienced a 41% reduction in perceived stress over four weeks.* Happy Saffron Plus® provides 30 mg of this clinically studied extract, along with Longvida® curcumin and zinc for comprehensive mood and brain health support.*

How does saffron support mood and emotional well-being?

Saffron contains naturally occurring compounds that help support healthy neurotransmitter activity, including serotonin and dopamine, which play important roles in mood regulation.* The affron® saffron extract in Happy Saffron Plus® has been studied in human clinical trials for its ability to promote a positive mood, emotional balance, and a healthy response to everyday stress.* Supporting these important brain pathways is a key part of maintaining emotional well-being.

What makes Happy Saffron Plus® different from other saffron supplements?

Unlike single-ingredient saffron supplements, Happy Saffron Plus® combines three clinically researched ingredients in one doctor-developed formula: 30 mg of affron® saffron for mood support, 400 mg of Longvida® curcumin for memory and cognitive health, and 20 mg of zinc glycinate for normal brain function and overall wellness.* Developed by Dr. Daniel Amen, it's a comprehensive approach to supporting mood, memory, and brain health.*

How long does Happy Saffron Plus® take to work?

Some benefits may be noticeable early, while others develop with consistent use. Clinical research on Longvida® curcumin has demonstrated improvements in working memory within one hour, while studies on affron® saffron have shown improvements in mood and emotional well-being over 4–12 weeks.* For optimal results, take Happy Saffron Plus® consistently for at least three months. Individual results may vary.

Can saffron help support memory and cognitive function?

Saffron is best known for its mood-supporting benefits, but Happy Saffron Plus® goes further. Its formula includes Longvida® curcumin, an advanced, highly bioavailable form of curcumin studied for cognitive health.* Clinical research has demonstrated improvements in working memory, attention, and cognitive performance, complementing saffron's benefits for emotional well-being.* Together, these ingredients provide support for both mood and brain function.*

Does Happy Saffron Plus® come in gummies?

Yes. Happy Saffron Plus® is available in both capsules and gummies. Both formulas feature clinically studied affron® saffron, Longvida® curcumin, and zinc to support positive mood, emotional well-being, memory, and brain health.* Happy Saffron Plus® Gummies provide the same amounts of these three key ingredients per recommended daily serving in a convenient, sugar-free alternative for those who prefer gummies over capsules.

Shop Happy Saffron Plus® Gummies

How do I take Happy Saffron Plus®?

Adults should take 3 capsules daily between meals, or as directed by a healthcare professional. Consistent daily use is recommended to support mood, memory, and emotional well-being.* If you're pregnant, breastfeeding, taking medications, or have a medical condition, consult your healthcare professional before use.

Can children take Happy Saffron Plus®?

BrainMD's existing serving guidelines for children ages 4–18 are 1 capsule per 40 pounds of body weight, up to a maximum of 3 capsules daily. Saffron extract has also been studied for supporting emotional well-being in adolescents.* Always consult your child's healthcare professional before use to confirm whether the supplement and serving size are appropriate.

Can I take Happy Saffron Plus® with SSRIs or antidepressants?

If you're taking an SSRI or another antidepressant, consult your healthcare professional before adding Happy Saffron Plus® to your routine. Saffron contains naturally occurring compounds that may influence serotonin and other neurotransmitters involved in mood regulation.* Because supplements can interact with medications, your healthcare professional can help determine whether this combination is appropriate for you. Never stop or adjust prescribed medication without medical guidance.

How do I know my Happy Saffron Plus® is authentic?

Buy directly from BrainMD.com, Amen Clinics, or the official BrainMD storefronts on Amazon, Walmart.com, TikTok Shop, iHerb, and PureFormulas. BrainMD is not sold in physical retail stores. On any marketplace, check the seller name before purchasing, not just the product title or image.

Counterfeit and imitation products may use similar names or packaging but don't necessarily contain the same formula, ingredient amounts, or meet BrainMD's quality standards. Be cautious of unusually low prices or unfamiliar sellers.

Learn how to identify authentic products and report suspicious listings on our Counterfeit Awareness page. If you've already purchased a product you're unsure about, contact Customer Care before taking it.

Is Happy Saffron Plus® third-party tested?

Yes. Happy Saffron Plus® is independently tested by Intertek, an ISO 17025-accredited laboratory. Independent third-party testing provides an additional level of verification beyond a manufacturer's own quality controls.

Every BrainMD supplement is manufactured in the USA in facilities that follow current Good Manufacturing Practice (cGMP) standards and undergoes testing for identity, purity, and potency before release.

Learn more about our commitment to quality here.

Overall rating: 4.6870027 / 5 from 1131 reviews.

AI Generated Review Summary

Happy Saffron Plus is noted for its positive impact on mood, anxiety, and overall mental health. Users report feeling better, calmer, and more in control of their emotions. The supplement is also highly recommended for mild anxiety and occasional depression, with noticeable improvements in mood and anxiety levels.

Summary topics

Saffron Content (10%): It was reported by customers that Happy Saffron Plus is a game changer for them.
Mood Improvement (11%): Customers appreciated the saffron supplement as it significantly improved their mood and boosted their libido.
Feeling Better (12%): Customers loved feeling better, calmer, and more in control of emotions when taking the product.
Anxiety and Depression (3%): It was reported by customers that they highly recommend this supplement for mild anxiety and mild occasional depression.

Review topics: ["results","quality","feel","issues","improvement","benefits","energy","felt","husband","ingredients","bottle","price","dose","impact","stomach","shipping","boost","wife","difference","mood","saffron","supplement","effect","works","change","depression","order","brain","pills","life"].

Review highlights

"Having the best mood, uplifting energy is possible with this wonderful supplement." — Roxanna L.
"I’ve noticed a tremendous difference and improvement in my anxiety, depression, mood and sleep better." — Luz T.
"My Mood Is Regulating Well And It’s Also Increased My Sexual Function As Well!!" — WILLIAM I.

Reviews

Wife's Favorite Supplement

"Saffron Plus is my wife's favorite supplement. So many times she says "I need my Happy Saffron. " It's been wonderful for her moods. The more we learn about saffron and its benefits, the more we are committed to it. I love the quality of the Brain MD brand. I did a check on AI and asked for a comparison to another brand. Brain MD was rated as unmatched for quality. Love it!"

— Chris M. (5/5)

Happy Saffron

"We use supplements instead of medication’s at our treatment center for drug and alcohol addiction. At RYAN Healing center, we have seen a huge difference in switching to the supplements in general. One of our favorites is the happiest saffron for those who have hard to reach depression. We have found that it has successfully mitigated depression in our residence. That previously could not seem to break free of it. We are so excited to partner with brain MD in our organization, our nonprofit organization please go to www.ryanhealingcenter.*** to learn more about us!"

— Jennifer B. (5/5)

Noticed a difference very quickly!

"Very happy with my decision to start taking happy saffron. Works as intended and I noticed more mental clarity and even better reproductive health very quickly!"

— Holly D. (5/5)

Game changer

"I needed something gentle but effective. I came across this, knowing the benefit of saffron, I made the purchase. Such a subtle but effective way to increase the functionality of the brain. I am a life coach and am a community leader, so I don't have the opportunity to go through lows and highs of the day with my clarity and thoughts. This was a perfect addition to my day, that just brought ease."

— Anida (5/5)

Happy Saffron Plus

"This is an amazing supplement! I love it! I will continue to take it and tell others . Thank you Dr Amen 😊🙏✅"

— Denise M. (5/5)

Happy Saffron Plus

"I've been very happy (no pun intended) with the results I have been getting With Happy Saffron plus. I definitely feel less stressed and more relaxed in dealing with life's day-to-day challenges."

— Talentino A. (5/5)

Yes, happy!

"I'm so glad I started taking this supplement! I was taking 5-HTP for the serotonin. When Dr. Amen suggested it was dopamine, that made sense! Now I'm not grabbing my phone to play arrow games for the dopamine kicks (as much)!"

— Martha K. (5/5)

The best by far!

"I immediately liked the effects of Happy Saffron. Improved mood and sharper mind. After a while i tried other brands and taking separate supplements but quickly returned to Brain MD, simply the best."

— Lisa W. (5/5)

Shift Work mood help

"I work a DuPont, rotating 12 hour, shift schedule. In the past, this schedule has led to poor mood and overall outlook when transitioning from days to nights and nights to days. It was real work to find enjoyment in moments that should be fun. Happy Saffron Plus has noticeably improved my mood while transitioning between work schedules. I feel like the “real” me again, instead of the “shift work” me! I’m enjoying the little things in life again. Thanks Dr. Amen for this product!"

— Ben Z. (5/5)

I was in a bit

"I was in a bit of a depressive funk and somebody suggested this before I try actual medicine. Let me tell you life-changing. I greatly appreciate this product and all that Dr. Amen!!!!"

— Christina B. (5/5)

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