PRIME DAY: 25% OFF sitewide with code PRIMETIME**
BrainMD Happy Saffron Plus: infographic, supplement bottle surrounded by icons and brief benefits of the product
BrainMD Happy Saffron Plus: smiling woman holding a supplement bottle against a yellow background
BrainMD Happy Saffron Plus: infographic, bottle and capsules next to brief descriptions of the supplement’s key benefits
Supplement Facts label for Happy Saffron Plus with ingredients, serving size and nutritional information.
TikTok ViralDr. Amen FavoriteStaff PickTrending

Happy Saffron Plus

Happy Saffron Plus

3-in-1 doctor-developed formula for improved mood, memory, and libido*

Subscribe & Save
One-time purchase
  • Free Shipping on Orders $75+
  • Subscribe & Save up to 25% + Free Shipping
  • 100% Money Back Guarantee

Description

Make your brain and body happy! Happy Saffron Plus® combines clinically studied doses of award-winning affron® saffron extract, Longvida® curcumin, and zinc glycinate in their most bioavailable and efficacious forms to help improve your mood, memory, sexual function, stress, anxiousness, and more.*

Key Benefits

Mood

Memory

Libido Support

Key Ingredients

We only use clinically researched ingredients backed by science.* Every formula is crafted with pure, high-quality nutrients at effective doses designed for safety, potency, and real results you can trust.*
Gluten Free
Sugar Free
Nut Free
Vegan
Gluten Free
Sugar Free
Nut Free
Vegan

Affron® Saffron

30mg
This highly concentrated, standardized saffron extract is derived from the saffron crocus, a spice traditionally used for over 2,600 years in the Middle East. Clinically studied at a dose of 28 mg per day, it has been shown to support a balanced mood, reduce feelings of anxiousness, and promote emotional well-being in both adults and adolescents.* Saffron’s active compounds help modulate neurotransmitters like serotonin and dopamine, contributing to its mood-enhancing effects.*

LONGVIDA® Curcumin

400 mg
Turmeric root has been used in traditional Asian medicine for over 2,600 years to support mood and overall well-being.* Its active compound, curcumin, has powerful antioxidant and anti-inflammatory properties that help protect brain cells and support emotional balance.* This highly absorbable form of curcumin has shown strong results in clinical studies at doses of 400 mg or more, improving mood, reducing stress, and supporting joint and immune health.* Its enhanced absorption ensures optimal effectiveness in the body.*

Zinc

20 mg
Zinc is an essential mineral involved in over 100 enzymes that support vital processes in the body.* It plays a key role in the healthy development and function of the eyes, brain, spinal cord, thymus gland, and digestive system.* Zinc is crucial for maintaining strong immunity, repairing and renewing skin and hair, and preserving DNA structure.* By supporting these systems, zinc promotes overall growth, healing, and resilience, making it vital for both physical health and immune defense.*

Supported by Clinical Research

Saffron Supports Positive Mood
Clinical studies in healthy adults

affron® saffron extract has been shown in human trials to help support mood and emotional well-being.*

(Kell 2017)

(Lopresti 2019)
BrainMD
Happy Brain, Healthy Body*

Better Mood, Memory & Sexual Health*

Happy Saffron Plus® isn’t just doctor-developed, it's doctor-recommended, loved in 217 countries, and backed by over 25 human studies.*

In the largest clinical trial on saffron and mood to date, 72% of participants taking affron® (the exact extract in this formula) experienced meaningful mood improvement, many in just 5 weeks.*

With Longvida® curcumin for focus and memory, plus zinc glycinate for mood and sexual health, this 3-in-1 formula delivers fast, feel-good results - naturally.*

Expert Reviews

"This is one of my favorite formulas. Saffron has been studied for centuries, but the form we use—affron®—is backed by modern clinical trials. I take Happy Saffron Plus® daily because it works. Better mood, better memory, better overall brain health—naturally."

Dr. Daniel Amen

Founder, BrainMD & Amen Clinics
"This formula contains ingredients I used to recommend individually but BrainMD combines them in clinically validated doses for even better results. I’ve seen it help patients feel more emotionally balanced and mentally sharp within weeks."

Dr. Jonny Bowden PhD, CNS

Board Certified Nutrition Specialist
"Saffron has long been used in ancient medicine, but affron® takes it to a new level. It’s clinically backed, bioavailable, and when paired with Longvida® curcumin and zinc glycinate, it becomes a powerhouse for brain health and emotional wellness."

Peggy Perez

Brain Health Professional, NASM CPT & CES, IIS Health Coach
"I love Happy Saffron Plus®! I was able to be off all anxiety/depression medications after 23 years. It works on multiple levels—mood, focus, and energy. It’s NAME-developed, rooted in science, and something I recommend regularly to my clients."

Erica Williams

Brain Health Professional, Elite Brain Health Coach, Life Coaching & Consulting Associates
BrainMD
Healthier, Happier YOU*

Clinically Dosed. Doctor Trusted. Loved Worldwide.*

Most saffron supplements stop at mood. Happy Saffron Plus® goes further, targeting mood, memory, libido, stress, and sleep with three highly bioavailable, research-backed ingredients that work better together.*

✔ affron® Saffron Extract: The only saffron with 10+ human clinical studies on mood, stress, and sleep.

✔ Longvida® Curcumin: 285x more bioavailable than standard curcumin and clinically shown to enhance memory within hours.*

✔ Zinc Glycinate: An essential mineral that supports mood, hormones, and brain health.*

This formula isn’t just well-dosed, it’s strategically dosed. Each ingredient amplifies the effects of the others for a synergistic boost you can feel, without hormones, SSRIs, or side effects.*
BrainMD

What To Expect

Day 1 - Instant Memory Boost

Clinical research shows that 400 mg of Longvida® curcumin—the same amount used in Happy Saffron Plus®—can boost working memory by 16% within just one hour of your first dose.*
Week 4 - Sweet Dreams & Bright Moods

In just 4 weeks, 28 mg/day of affron® saffron helped improve mood and sleep, and reduced stress by 41% in clinical trials.*
Week 12 - More Happiness, Less Anxiousness

In 12 weeks, 28 mg/day of affron® saffron significantly improved mental health, reduced occasional anxiousness by 33% and low mood by 32%.*
Long-Term - Cumulative Brain & Body Benefits

Expect better mood, memory, and sexual health with continued use.*

FAQ

Got questions? We’ve got answers. Explore our FAQs or chat with our AI assistant for instant support.

BrainMD

Overall rating: 4.681776 / 5 from 1081 reviews.

AI Generated Review Summary

Happy Saffron Plus, a supplement combining affron® saffron extract, Longvida® curcumin, and zinc glycinate, is praised for significantly improving mood and reducing anxiety. Customers report noticeable mood enhancement and relaxation, though some experience drowsiness. The product is highly regarded for its efficacy and lack of side effects.

Summary topics

  • Mood Boost (14%): Customers appreciated the incredible boost on their mood / I’’m more positive and definitely feel happier.
  • Mood Improvement (5%): Customers keep praising the noticeable and significant improvement in mood and temperament after using this herbal supplement.
  • Mood Impact (9%): It was highlighted by customers that this supplement significantly improved their mood and significantly reduced anxiety levels.
  • Supplement Results (4%): It was reported by customers that they are happy with the results, finding them to be immediate and outstanding.
  • Mood Difference (15%): A significant number of customers remarked that they noticed a significant difference in their mood after using the product.

Review topics: ["feel","husband","improvement","issues","results","benefits","energy","shipping","ingredients","quality","impact","felt","dose","bottle","stomach","price","boost","wife","difference","mood","saffron","supplement","effect","works","change","depression","order","brain","pills","life"].

Review highlights

  • "Having the best mood, uplifting energy is possible with this wonderful supplement." — Roxanna L.
  • "I’ve noticed a tremendous difference and improvement in my anxiety, depression, mood and sleep better." — Luz T.
  • "My Mood Is Regulating Well And It’s Also Increased My Sexual Function As Well!!" — WILLIAM I.

Reviews

Shift Work mood help

"I work a DuPont, rotating 12 hour, shift schedule. In the past, this schedule has led to poor mood and overall outlook when transitioning from days to nights and nights to days. It was real work to find enjoyment in moments that should be fun. Happy Saffron Plus has noticeably improved my mood while transitioning between work schedules. I feel like the “real” me again, instead of the “shift work” me! I’m enjoying the little things in life again. Thanks Dr. Amen for this product!"

— Ben Z. (5/5)

Happy works

"Most important benefit- lowest dose quiets my intrusive hours. My psychiatrist says it does raise serotonin a small amount but for me, it works differently than my SSRI. No side effects on one capsule per day"

— Carol R. (5/5)

I ordered extra so I never run out!

"What a game changer for me. I recently went through heavy grief while coming out of seasonal depression 6 months of winter. I started taking Happy Saffron in May and within a few weeks my mood felt lighter and happier. It's now September, 5 months supplementing with Happy Saffron and I catch myself smiling for no reason!! 🙌"

— Brooke J. (5/5)

The Supplement I never want to miss!

"I've been taking Happy Saffron for years now, and it's one supplement I genuinely do not want to miss a dose as I can tell a difference when I do. One thing I think is important to share: when I first started taking it, I did not notice a difference right away. I kept taking it consistently, and somewhere around the 3 month mark, BAM! I suddenly realized more energy and I just really felt good. I wondered what had changed and then I remembered hearing Dr. Amen explain that it takes some time and consistent use to notice the benefits in the beginning. Highly, highly recommend starting and having a subscription so it just arrives to never miss a dose. Its not cheap but worth every penny."

— AMC (5/5)

Of all the things I've tried over the years. . . I love this product line SO MUCH!

"After taking Dr. Amen's online quiz to identify my ADHD type, (I'm a 15), I bought the recommended regimen and felt great. (More stable, fewer mood swings, less anxiety, better focus, sustained energy all day. ) I did run out, however, and noticed a BIG difference without them. I like the new me, so I just started the auto-ship subscription. (My husband would never agree to the expense of going to a clinic, but doing this was a no-brainer!) THANK YOU FOR MAKING THIS SO EASY FOR ME TO BE BETTER!"

— Dawn S. (5/5)

It works!

"Tried just one as I am cautious with new products and shortly after noticed I was singing in my head- a definite sign that a better mood was at hand. Told my grown daughter and she promptly took 3. She texted me the next day asking for the name of your product which I was delighted to share."

— Patricia F. (5/5)

Great product!

"If you have any curiosity about this product, try it! I noticed a little burst of ‘let me be productive’ about an hr after I took a single pill of 3 dose rec. I love this for anyone that has been recommended to take antidepressants. I don’t know about the chemistry and obviously listen to your dr. But it is worth a try. I really notice a difference on the days I don’t take it. My only rec is take the full dose earlier in the day if your sleep is sensitive to what you ingest."

— Amy P. (5/5)

Happy Saffron Plus

"I have been very pleased with the results of using Happy Saffron. It took me a little bit of time tweaking the dosage for my body. I eventually found I felt better by taking 2 capsules in the morning and 1 capsule in the evening. I have taken it for at least 3 yrs and grateful how much better I feel!"

— Barbara E. (5/5)

Happy Saffron

"I love the happy saffron product. It has a visible effect on overall mood throughout the day. The supplement combined with daily exercise works like magic. I do not skip a day!"

— Dessi Z. (5/5)

"I really love this product! It’s one of those things where you may not notice a huge difference while you’re taking it, but if you stop, you definitely notice. It’s hard to explain, but that alone tells me it’s doing something good! I’ve been really happy with it and will absolutely continue taking it."

— Christopher (5/5)

Q&A