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Smart Relief
60
Capsules
Retail Value: $49.95
Stop Living With Daily Discomfort
Tension. Stiff joints. That deep, nagging soreness. It can wear you down, physically and mentally.
Smart Relief is the only doctor-developed PEA supplement that targets both the body and the brain to relieve everyday discomfort at its source.*
✔ Dr. Amen’s 4-in-1 “Change Your Brain, Change Your Pain” formula*
✔ Targets nerve + joint discomfort at the source with Ultra-micronized PEA*
✔ Promotes long-term comfort and mobility—the longer you take it, the better it works*
✔ Supports a healthy inflammatory response*
✔ Includes clinically studied PEA, Boswellia, Ginger and Calcium Fructoborate for total brain, body & joint support*
Maximize Your Results: Pair with Omega-3 Power for even greater support against everyday aches and physical discomfort.*
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One-Time: 30% Off | First Subscribe & Save: 50% Off with code SMART 100% Happiness Guarantee - Love It or Your Money Back! |
Stiff knees? Lingering soreness? Feeling older than you are?
Stop masking discomfort.
Target it at the source with Smart Relief.
This revolutionary 4-in-1 daily formula goes beyond standard discomfort and joint relief by addressing what other products miss: the neurological loop that keeps your brain and body stuck in discomfort.*
Doctor-developed and backed by over 70 human studies, Smart Relief features clinically researched doses of Ultra-Micronized PEA, ApresFlex® Boswellia, Ginfort® Ginger Extract, and Promentum™ Calcium Fructoborate.*
It’s the only PEA supplement designed to target both the physical root of discomfort and the neurological signals that amplify it - without the fog, fatigue, or side effects common with OTC discomfort relief.*
USE: Take 2 capsules daily with food, or as recommended by your healthcare provider. For fast relief, may be taken every 6 hours. Do not exceed 4 capsules per 24 hours. To lower baseline discomfort, continue taking daily for at least 3 months.*†
EARLY RESULTS: Many users report relief within the first 24 hours.*†
LONG-TERM BENEFITS: Daily use for at least 3 months can help reduce baseline discomfort and support better mobility over time.*†
*†Results may vary based on individual health and fitness levels. Consistent use, in conjunction with a healthy lifestyle, is recommended.
✔ PEA (palmitoylethhanolamide)
✔ Promentum™ Calcium Fructoborate
✔ Ginfort® Ginger Root Extract
✔ ApresFlex® Boswellia Serrata Extract
Smart Relief is the only doctor-developed PEA supplement that targets both the body and the brain to relieve everyday discomfort at its source.*
✔ Dr. Amen’s 4-in-1 “Change Your Brain, Change Your Pain” formula*
✔ Targets nerve + joint discomfort at the source with Ultra-micronized PEA*
✔ Promotes long-term comfort and mobility—the longer you take it, the better it works*
✔ Supports a healthy inflammatory response*
✔ Includes clinically studied PEA, Boswellia, Ginger and Calcium Fructoborate for total brain, body & joint support*
✔ Love it or your money back | 100% Happiness Guarantee*
In stock
Free shipping on all subscriptions & US orders over $75*
Cancel Any Time | 100% Money Back Guarantee | Refund Policy
Key Benefits
Joints
Supports joint health and movement
Recovery
Promotes overall recovery from exercise and stress
Vitality
Provides the nutrients essential to health and longevity
Supplement Facts
| Supplement Facts | ||
|---|---|---|
| Serving Size: 2 Capsules Servings Per Container: 30 |
||
| Amount Per Serving | % Daily Value | |
| PEA (palmitoylethanolamide) | 600 mg | † |
| Promentum™ Calcium Fructoborate (minimum 2.5% Boron (5.5 mg)) |
220 mg | † |
| Ginfort® Ginger Root Extract (providing a minimum 22% gingerols (44 mg gingerols)) |
200 mg | † |
| ApresFlex® Boswellia Serrata Extract (providing a minimum of 20% AKBA (3-O-Acetyl-11 Keto-B-Boswellic Acids (20 mg))) |
100 mg | † |
| † Daily Value not established. | ||
| Other Ingredients: Vegetable cellulose (vegetarian capsule), microcrystalline cellulose, magnesium stearate. | ||
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Egg Free
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Gluten Free
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Nut Free
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Sugar Free
What to expect
Month 1
Your Body Begins to Respond
Clinically studied ingredients start supporting comfort, mobility, and healthy inflammatory balance.*
Month 2-3
Building Steady Results
Consistent use helps promote ongoing comfort, flexibility, and balance as your body adapts.*
Month 4 & Beyond
Sustained Comfort and Resilience
Continued daily use helps amplify the benefits and support long-term joint and overall wellness.*
Comprehensive Daily Nourishment
Cover Your Nutritional Bases
Even if you meet—or exceed—the government-recommended amount of daily servings of fruits and vegetables, you may still have nutrient deficiencies due to factors like genetics, stress, toxic exposures from other people's smoking or from other environmental pollutants, nutrient depletion by certain medications you may be taking, and consumption of alcohol. Cover your nutritional bases with the best doctor-developed, comprehensive multivitamin, multi-mineral supplement on the market.
From A to Zinc
Made by combining clinically researched brain boosters with optimally absorbed vitamins, essential minerals, other essential nutrients, conditionally essential nutrients, organically grown vegetable and fruit concentrates, beneficial herbal ingredients, and digestive enzymes to assist with their utilization, NeuroVite Plus offers an unmatched broad spectrum of nutrients and herbals to help your body and brain function at their best.
Everything You Need
NeuroVite Plus packs in over 1000% more of certain nutrients than the recommended Daily Value set forth by the FDA. That’s because unlike other companies, we based the levels of active ingredients used in our multivitamin on the daily dosing shown effective in clinical trials, not minimum amounts recommended to prevent deficiency. Research shows there is a huge dosing gap between preventing deficiency and experiencing measurably better health. Here at BrainMD, we aim for better health.
More Than a Multivitamin: Comprehensive Daily Nourishment + Brain Targeted Nutrition
Unlike other multivitamins, NeuroVite Plus contains a number of powerful nutrients clinically researched for better brain function.
PhosphatidylSerine (PS) The only nutrient granted two qualified health claims by the U.S. FDA related to its brain benefits.
Acetyl-L-Carnitine (ALC) Assists the brain in the production of the important neurotransmitter acetylcholine.
Alpha-Lipoic Acid (ALA) Clinical trials indicate that ALA can enhance nerve cell structure and function.
The first and only daily multivitamin created through the clinical experience of brain health expert Daniel G. Amen, MD
NeuroVite Plus combines more than 50 nutrients and plant extracts in their most active forms to give you whole body-mind nutrition in a way that drugstore multivitamins cannot do. It contains three of Dr. Amen’s hand-selected proprietary high-nutrient blends:
- The Brain Boosting Blend of clinically researched brain health nutrients.
- The Fruit and Vegetable Blend with the antioxidant equivalent of 5 servings of fruits and vegetables.
- The Digestive Enzyme Blend to support digestive health, metabolize foods and support your natural intestinal balance—which is critical for a healthy brain.
NeuroVite Plus Delivers Vibrant Health and Wellness in 5 Ways!
- Nourishes your body’s cells, tissues and organs – NeuroVite’s wide range of nutrients gives every part of your body the nutrients it’s hungry for.
- Promotes optimal brain function – NeuroVite’s high levels of important phytonutrients help sustain our intensely active brain cells.
- Supports the health of major organ systems – with lutein and zeaxanthin for the eyes, hesperidin for the circulation, and resveratrol for the heart.
- Protects against free radical damage with an array of antioxidants including vitamin C, vitamin E, alpha lipoic acid and CoQ10.
- Easily absorbed and tolerated, due to the very careful selection of its ingredients and its content of digestive enzymes.
Ingredients
PEA (Palmitoylethanolamide)
PEA is a naturally occurring fatty acid compound that supports physical comfort and recovery.* Ultra‑micronized for superior absorption, it works at the neurological level to calm overactive nerve signals and restore balance between the brain and body.* Clinical research shows PEA supports everyday comfort, mobility, and overall quality of life when taken consistently.*
Promentum™ Calcium Fructoborate
A patented, plant‑based complex of calcium, fructose, and boron, Promentum™ has been clinically shown to support joint comfort, reduce key inflammatory markers like C‑reactive protein, and promote healthy mobility.* By working at the cellular level, it helps build long‑term resilience and flexibility throughout the body.*
Ginfort® Ginger Extract
Ginfort® is a highly concentrated, clinically studied ginger extract standardized to 26% active compounds for enhanced potency and bioavailability. It provides fast‑acting relief while supporting a balanced inflammatory response, muscle relaxation, and circulatory health.* It’s safe to take and gentle on the stomach, without harsh side effects.*
ApresFlex® Boswellia Serrata Extract
ApresFlex® is a next‑generation Boswellia extract that helps maintain healthy inflammatory activity by inhibiting the 5‑LOX enzyme.* Backed by multiple clinical trials, it’s been shown to improve joint comfort, flexibility, and physical function in as little as five days, with continued improvements over time.* This highly absorbable form supports cartilage health and long‑term joint integrity for daily movement and comfort.*
Support Lasting Comfort for Body and Mind
Most supplements only address one aspect of physical comfort.
But lasting relief requires supporting the body and brain together.
Smart Relief is scientifically formulated to support a healthy inflammatory response and help the body adapt to everyday physical stressors—promoting comfort, flexibility, and mobility for an active lifestyle.*
With Ultra-micronized PEA to help maintain neurological calm and a trio of clinically studied joint support ingredients (Boswellia, Promentum™ Calcium Fructoborate, and Ginfort® Ginger Extract), Smart Relief helps you feel your best, day after day.*
Feel the Difference with Smart Relief
What to Expect With Smart Relief
Day 1
✔ Ultra-Micronized PEA begins supporting neurological calm and everyday comfort*
✔ Ginfort® Ginger Extract promotes soothing comfort that lasts for hours*
Week 1–2
✔ Supports comfort and flexibility as your body adapts to daily physical stressors*
✔ Promotes healthy mobility, joint comfort, and ease of movement*
Week 2–3
✔ Encourages more consistent daily comfort and balance*
✔ Clinically studied Boswellia and Promentum™ Calcium Fructoborate support a healthy inflammatory response*
Month 2–3
✔ Helps maintain long-term comfort and mobility*
✔ Supports joint resilience and physical well-being over time*
Video Testimonials
“Smart Relief targets discomfort at its source, both in the body and the brain. It’s backed by research, formulated with care, and trusted by our physicians at Amen Clinics every day.”
- Daniel G. Amen, MD
READ Why It Didn’t Make the Cut
Iron is a mineral essential for human health. It is typically linked to hemoglobin – the protein that transports oxygen around the body – and is also vital for energy production, antioxidant defense, DNA production, gene regulation, and the body’s detoxification process.Though commonly found in multivitamins, we purposely left it out.As a standalone supplement ingredient for those at risk of deficiency, iron is beneficial – we offer advanced iron in its most well-tolerated and well-absorbed form: ferrous bisglycinate, Ferrochel®. However, when combined with other nutrients (like it is in a comprehensive multivitamin), iron’s chemically reactive nature can degrade and potentially destroy the other ingredients it’s mixed with.Here’s everything else we intentionally left out.
• Brain & Memory Power Boost •
“I got my DREAMS back!”
- Claire R., Verified Buyer
Real People. Real Results.
In a recent Smart Relief user survey:
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9 out of 10 participants reported no side effects*†
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67% noticed better mobility and more comfortable joint movement*†
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75% said they felt noticeably more comfortable throughout the day*†
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Over 50% reported feeling improvement within the first 24 hours of use*†
*†Results are from a 2025 internal customer survey conducted by BrainMD. Participants received a complimentary bottle of Smart Relief in exchange for their feedback. Survey responses were collected after 4 weeks of consistent daily use. Individual results may vary.
• OUR CEO SAYS •
“A really awesome quote from Dr, Amen about how awesome this product is.”
- Daniel G. Amen, MD
Start Feeling Better from the Inside Out
Most people wait until everyday discomfort starts to interfere with the things they love.
But true comfort begins within—when your brain and body work in harmony to handle daily stress and movement challenges.
Smart Relief is designed to support healthy communication between your brain and body, helping you stay balanced, comfortable, and active every day.*
By taking it consistently, you’re helping your body adapt to everyday physical stressors and maintain greater ease of movement over time.*
Because it’s formulated for daily use, the benefits build, helping you feel more comfortable, resilient, and ready for whatever the day brings.*
If you’re ready to support lasting comfort and flexibility, start your Smart Relief routine today.*
Try It Risk-Free
We stand behind Smart Relief with a 100% Happiness Guarantee.
If you don’t love it for any reason, return it within 30 days for a full refund—no questions asked.
Just call or email our support team within 30 days of your purchase and we’ll make it right.
Refunds exclude original shipping costs. Applies to purchases made directly through BrainMD.com.
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Ardizzone A, Fusco R, Casili G, et al. Effect of Ultra-Micronized-Palmitoylethanolamide and Acetyl-l-Carnitine on Experimental Model of Inflammatory Pain. Int J Mol Sci. 2021;22(4):1967. Published 2021 Feb 17. doi:10.3390/ijms22041967.
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Gabrielsson L, Mattsson S, Fowler CJ. Palmitoylethanolamide for the treatment of pain: pharmacokinetics, safety and efficacy. Br J Clin Pharmacol. 2016;82(4):932-942. doi:10.1111/bcp.13020.
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Yu G, Xiang W, Zhang T, Zeng L, Yang K, Li J. Effectiveness of Boswellia and Boswellia extract for osteoarthritis patients: a systematic review and meta-analysis. BMC Complement Med Ther. 2020;20(1):225. Published 2020 Jul 17. doi:10.1186/s12906-020-02985-6.
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Rondanelli M, Fossari F, Vecchio V, et al. Clinical trials on pain lowering effect of ginger: A narrative review. Phytother Res. 2020;34(11):2843-2856. doi:10.1002/ptr.6730.
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Scorei ID, Scorei RI. Calcium fructoborate helps control inflammation associated with diminished bone health. Biol Trace Elem Res. 2013;155(3):315-321. doi:10.1007/s12011-013-9800-y.
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Yong RJ, Mullins PM, Bhattacharyya N. Prevalence of chronic pain among adults in the United States. Pain. 2022;163(2):e328-e332. doi:10.1097/j.pain.0000000000002291.
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Petrosino S, Cordaro M, Verde R, et al. Oral Ultramicronized Palmitoylethanolamide: Plasma and Tissue Levels and Spinal Anti-hyperalgesic Effect [published correction appears in Front Pharmacol. 2024 Jun 18;15:1441203. doi: 10.3389/fphar.2024.1441203.]. Front Pharmacol. 2018;9:249. Published 2018 Mar 20. doi:10.3389/fphar.2018.00249.
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Stochino Loi E, Pontis A, Cofelice V, et al. Effect of ultramicronized-palmitoylethanolamide and co-micronized palmitoylethanolamide/polydatin on chronic pelvic pain and quality of life in endometriosis patients: An open-label pilot study. Int J Womens Health. 2019;11:443-449. Published 2019 Aug 12. doi:10.2147/IJWH.S204275.
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Bartolucci ML, Marini I, Bortolotti F, et al. Micronized palmitoylethanolamide reduces joint pain and glial cell activation. Inflamm Res. 2018;67(10):891-901. doi:10.1007/s00011-018-1179-y.
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Kimmatkar N, Thawani V, Hingorani L, Khiyani R. Efficacy and tolerability of Boswellia serrata extract in treatment of osteoarthritis of knee--a randomized double blind placebo controlled trial. Phytomedicine. 2003;10(1):3-7. doi:10.1078/094471103321648593.
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Yu G, Xiang W, Zhang T, Zeng L, Yang K, Li J. Effectiveness of Boswellia and Boswellia extract for osteoarthritis patients: a systematic review and meta-analysis. BMC Complement Med Ther. 2020;20(1):225. Published 2020 Jul 17. doi:10.1186/s12906-020-02985-6.
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Terry R, Posadzki P, Watson LK, Ernst E. The use of ginger (Zingiber officinale) for the treatment of pain: a systematic review of clinical trials. Pain Med. 2011;12(12):1808-1818. doi:10.1111/j.1526-4637.2011.01261.x.
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Grzanna R, Lindmark L, Frondoza CG. Ginger--an herbal medicinal product with broad anti-inflammatory actions. J Med Food. 2005;8(2):125-132. doi:10.1089/jmf.2005.8.125.
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Pietrzkowski Z, Phelan MJ, Keller R, Shu C, Argumedo R, Reyes-Izquierdo T. Short-term efficacy of calcium fructoborate on subjects with knee discomfort: a comparative, double-blind, placebo-controlled clinical study [published correction appears in Clin Interv Aging. 2021 Feb 02;16:203. doi: 10.2147/CIA.S293124.]. Clin Interv Aging. 2014;9:895-899. Published 2014 Jun 5. doi:10.2147/CIA.S64590.
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Hussain SA, Abood SJ, Gorial FI. The adjuvant use of calcium fructoborate and borax with etanercept in patients with rheumatoid arthritis: Pilot study. J Intercult Ethnopharmacol. 2016;6(1):58-64. Published 2016 Dec 8. doi:10.5455/jice.20161204021549.
Frequently Asked Questions
What is Smart Relief designed to support?
Smart Relief is formulated to support everyday comfort, mobility, and joint flexibility.* It helps your body maintain a healthy inflammatory response while calming the neurological signals that can amplify physical tension.*
How quickly can I expect results?
Some users report noticing improved comfort or flexibility within the first few days.* For others, it may take several weeks of consistent daily use to experience the full benefits. Fast‑acting ingredients like Ginfort® Ginger Extract and Ultra‑micronized PEA begin working within as little as 30 minutes, while long‑term ingredients like Boswellia and Calcium Fructoborate help build results over time.*
Is Smart Relief safe for everyday use?
Yes. Smart Relief is made with clinically studied, non‑habit‑forming ingredients and contains no NSAIDs or caffeine.* It’s gentle on the stomach and designed for ongoing use as part of your daily wellness routine.*
What makes Smart Relief different from other discomfort formulas?
Smart Relief is the only doctor-developed PEA supplement that supports both the physical root of discomfort and the communication pathways that can intensify it.* Each ingredient was selected based on clinical research and its complementary role in supporting inflammatory balance, mobility, and healthy signaling between the body and brain.*
Can I take Smart Relief with my other supplements or medications?
Smart Relief is generally well‑tolerated and can be taken alongside most dietary supplements.* However, if you are taking medications, pregnant, or managing a medical condition, please consult your healthcare provider before use.
Inside the Formula
Dr. Amen discusses his most potent nutritional weapon for a top-performing body and mind
