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Stress Relief Sleep
90
Capsules
Retail Value: $39.95
Take the stress out of sleep! This brain-targeted, melatonin-free formula helps you unwind, lower nighttime cortisol, and fall asleep—fast.* No grogginess. No habit-forming ingredients. Just deep, restorative rest when you need it most.*
✔ Helps your brain and body fully unwind after a high-stress day*
✔ Supports healthy cortisol levels for deeper, uninterrupted sleep*
✔ Fast-acting—feel the calming effects in just 30–60 minutes*
✔ Melatonin-free, non-habit forming, and 100% natural*
✔ Formulated by top brain health and sleep experts*
Maximize Results: Take Stress Relief Sleep with NeuroVite Plus Multivitamin and Omega-3 Power for optimal sleep quality and peak brainpower.*
Can’t Sleep Because of Stress?
Meet Your New Wind Down Formula.
When stress runs the show, sleep doesn’t stand a chance. Stress Relief Sleep is a fast-acting, melatonin-free formula that helps your brain and body fully relax so you can fall asleep, stay asleep, and wake up feeling like yourself again.*
No hormones. No grogginess. No habit-forming ingredients—just calm, restorative sleep, even on your most stressful nights.*
In clinical studies of KSM-66® Ashwagandha—the cutting-edge adaptogen in Stress Relief Sleep—cortisol levels dropped by up to 28% and 77% of participants reported feeling less anxiousness in just 60 days.* In a separate study, 49% of participants with severe sleep issues reported significant improvements in sleep quality after only 10 weeks!*
USE: Take 3 capsules with water 30–60 minutes before bedtime, or as directed by your healthcare provider. Not for children or those who are pregnant or breastfeeding.*
EARLY RESULTS: Noticeable feelings of calm and relaxation in under an hour!* Most users notice improved sleep within the first 1–2 nights.*†
LONG-TERM BENEFITS: Daily use supports stress, mood, and feelings of anxiousness—typically within 1 to 4 weeks.*†
*†Results may vary based on individual health and fitness levels. Consistent use, in conjunction with a healthy lifestyle, is recommended.
Stress Relief Sleep delivers fast-acting, melatonin-free support to lower cortisol, ease feelings of anxiousness, and improve sleep quality.*
✔ KSM-66® Ashwagandha (600 mg): Lowers cortisol, reduces feelings of anxiousness, and improves sleep quality in just 8–10 weeks.*
✔ L-Theanine (300 mg): Promotes alpha brain wave activity to support natural sleep without sedation or next-day mental grogginess or fogginess.*
✔ GABA (Gamma-Aminobutyric Acid, 300 mg): Calms overactive thoughts and prepares the brain for sleep.*
✔ Magnesium (as magnesium bisglycinate and magnesium malate,150 mg): Reduces time to fall asleep and promotes quality sleep.*
Take the stress out of sleep! This brain-targeted, melatonin-free formula helps you unwind, lower nighttime cortisol, and fall asleep—fast.* No grogginess. No habit-forming ingredients. Just deep, restorative rest when you need it most.*
✔ Helps your brain and body fully unwind after a high-stress day*
✔ Supports healthy cortisol levels for deeper, uninterrupted sleep*
✔ Fast-acting—feel the calming effects in just 30–60 minutes*
✔ Melatonin-free, non-habit forming, and 100% natural*
✔ Formulated by top brain health and sleep experts*
In stock
Free shipping on all subscriptions & US orders over $75*
Cancel Any Time | 100% Money Back Guarantee | Refund Policy
Key Benefits
Calm
Promotes a tranquil mind and body
Relaxation
Encourages relaxation in the body and mind
Sleep
Promotes sustained, restorative sleep
Supplement Facts
| Supplement Facts | ||
|---|---|---|
| Serving Size: 3 capsules Servings Per Container: 30 |
||
| Amount Per Serving | % Daily Value | |
| Magnesium (as bisglycinate and malate) | 150 mg | 36% |
| KSM-66® Ashwagandha Root Ext. ((Withania somnifera, root), standardized to min. 5% [30 mg] total withanolides) |
600 mg | †|
| L-Theanine | 300 mg | †|
| GABA (gamma-aminobutyric acid) | 300 mg | †|
| †Daily Value not established. | ||
| Other Ingredients: Microcrystalline cellulose, vegetable capsule (capsule shell), vegetable magnesium stearate, silica. | ||
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Gluten Free
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Nut Free
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Soy Free
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Vegan
What to expect
Month 1
Clinically studied nutrients get to work
Month 2-3
Nutritional deficiencies are corrected *varies by person
Month 4 & Beyond
Amplify the benefits & support long-term health
Comprehensive Daily Nourishment
Cover Your Nutritional Bases
Even if you meet—or exceed—the government-recommended amount of daily servings of fruits and vegetables, you may still have nutrient deficiencies due to factors like genetics, stress, toxic exposures from other people's smoking or from other environmental pollutants, nutrient depletion by certain medications you may be taking, and consumption of alcohol. Cover your nutritional bases with the best doctor-developed, comprehensive multivitamin, multi-mineral supplement on the market.
From A to Zinc
Made by combining clinically researched brain boosters with optimally absorbed vitamins, essential minerals, other essential nutrients, conditionally essential nutrients, organically grown vegetable and fruit concentrates, beneficial herbal ingredients, and digestive enzymes to assist with their utilization, NeuroVite Plus offers an unmatched broad spectrum of nutrients and herbals to help your body and brain function at their best.
Everything You Need
NeuroVite Plus packs in over 1000% more of certain nutrients than the recommended Daily Value set forth by the FDA. That’s because unlike other companies, we based the levels of active ingredients used in our multivitamin on the daily dosing shown effective in clinical trials, not minimum amounts recommended to prevent deficiency. Research shows there is a huge dosing gap between preventing deficiency and experiencing measurably better health. Here at BrainMD, we aim for better health.
More Than a Multivitamin: Comprehensive Daily Nourishment + Brain Targeted Nutrition
Unlike other multivitamins, NeuroVite Plus contains a number of powerful nutrients clinically researched for better brain function.
PhosphatidylSerine (PS) The only nutrient granted two qualified health claims by the U.S. FDA related to its brain benefits.
Acetyl-L-Carnitine (ALC) Assists the brain in the production of the important neurotransmitter acetylcholine.
Alpha-Lipoic Acid (ALA) Clinical trials indicate that ALA can enhance nerve cell structure and function.
The first and only daily multivitamin created through the clinical experience of brain health expert Daniel G. Amen, MD
NeuroVite Plus combines more than 50 nutrients and plant extracts in their most active forms to give you whole body-mind nutrition in a way that drugstore multivitamins cannot do. It contains three of Dr. Amen’s hand-selected proprietary high-nutrient blends:
- The Brain Boosting Blend of clinically researched brain health nutrients.
- The Fruit and Vegetable Blend with the antioxidant equivalent of 5 servings of fruits and vegetables.
- The Digestive Enzyme Blend to support digestive health, metabolize foods and support your natural intestinal balance—which is critical for a healthy brain.
NeuroVite Plus Delivers Vibrant Health and Wellness in 5 Ways!
- Nourishes your body’s cells, tissues and organs – NeuroVite’s wide range of nutrients gives every part of your body the nutrients it’s hungry for.
- Promotes optimal brain function – NeuroVite’s high levels of important phytonutrients help sustain our intensely active brain cells.
- Supports the health of major organ systems – with lutein and zeaxanthin for the eyes, hesperidin for the circulation, and resveratrol for the heart.
- Protects against free radical damage with an array of antioxidants including vitamin C, vitamin E, alpha lipoic acid and CoQ10.
- Easily absorbed and tolerated, due to the very careful selection of its ingredients and its content of digestive enzymes.
Ingredients
KSM-66 Ashwagandha Root Extract
The most clinically studied form of ashwagandha, KSM-66® helps the body adapt to stress by lowering cortisol and calming anxious thoughts—two major roadblocks to sleep. In multiple double-blind, placebo-controlled trials, KSM-66® reduced cortisol by up to 28%, improved mood, and promoted better sleep.* This full-spectrum root extract also supports memory, cravings, and libido—making it a smart solution for high-stress seasons and long-term well-being.*
Magnesium
Magnesium is essential for our health and survival—but most adults don’t get enough. Stress, alcohol, aging, and even common medications can all deplete your magnesium stores, increase cortisol and disrupt your sleep cycle.* This formula delivers a highly absorbable form of magnesium to help relax muscles, facilitate sleep onset, and induce a state of calm. It also supports mood, brain function, and stress resilience.*
L-Theanine
L-theanine is a naturally occurring amino acid found in green tea that helps regulate brain waves and stress-related neurotransmitters.* It boosts alpha wave activity for faster relaxation and has been shown to lower cortisol, ease anxious thoughts, and improve sleep quality—without sedation or mental fog the next morning.* It’s ideal for high-performers who need to switch off at night and show up sharp the next day.*
GABA
GABA is the brain’s primary calming neurotransmitter, essential for managing stress, relaxation, and sleep onset.* This supplement provides bioidentical GABA shown in clinical research to promote calm, reduce feelings of anxiousness, and support smoother transitions into sleep—especially when combined with L-theanine.*
Stress Ruins Sleep. Let’s Fix That.
Stress doesn’t stop when your head hits the pillow—and when it hijacks your sleep, your brain pays the price.*
High cortisol doesn’t just delay sleep—it disrupts memory, focus, mood, and recovery.*
And poor sleep? It sends cortisol even higher.*
That’s why Stress Relief Sleep is designed to break the cycle—fast.*
With clinically studied ashwagandha, magnesium, GABA, and l-theanine, this brain-targeted formula helps you calm down, fall asleep, and stay asleep—naturally.*
✔ Fall asleep faster*
✔ Stay asleep longer*
✔ Wake up feeling clear, not cloudy*
No hormones.
No grogginess.
Just deep, restorative sleep, even on your most stressful nights.*
Turn Off Your Brain, Turn On Your Calm.
Tired but wired?
Struggling to fall—or stay—asleep?
Stress Relief Sleep helps your brain downshift fast.*
In just 30–60 minutes, you’ll feel a calming wave that supports deep, natural sleep—without melatonin or next-day mental fog.*
✔ Rapid relaxation without sedation*
✔ Fall asleep fast, stay asleep longer*
✔ No grogginess. No habit-forming ingredients*
Make Stress Relief Sleep your nightly ritual—and let your brain finally offload the day.*
Video Testimonials
“Stress and poor sleep are two of the biggest threats to brain health. Stress Relief Sleep is designed to calm the brain, lower cortisol, and help you get the restorative sleep your brain needs to perform at its best.”
- Daniel G. Amen, MD
READ Why It Didn’t Make the Cut
Iron is a mineral essential for human health. It is typically linked to hemoglobin – the protein that transports oxygen around the body – and is also vital for energy production, antioxidant defense, DNA production, gene regulation, and the body’s detoxification process.Though commonly found in multivitamins, we purposely left it out.As a standalone supplement ingredient for those at risk of deficiency, iron is beneficial – we offer advanced iron in its most well-tolerated and well-absorbed form: ferrous bisglycinate, Ferrochel®. However, when combined with other nutrients (like it is in a comprehensive multivitamin), iron’s chemically reactive nature can degrade and potentially destroy the other ingredients it’s mixed with.Here’s everything else we intentionally left out.
• Brain & Memory Power Boost •
“I got my DREAMS back!”
- Claire R., Verified Buyer
The Stress-Sleep Cycle: What’s Really Keeping You Up At Night
You’re tired—but wired.
That’s cortisol, your body’s primary stress hormone, flooding your system and keeping your brain stuck in high alert mode.*
When cortisol stays elevated at night, it:
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Delays sleep onset*
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Disrupts deep sleep cycles*
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Increases feelings of anxiousness and next-day exhaustion*
Stress Relief Sleep is formulated to break that cycle—fast.
It delivers a clinically studied amount of KSM-66® Ashwagandha, shown to:
✔ Lower cortisol levels by up to 28% in 60 days*
✔ Improve sleep quality within 10 weeks*
✔ Reduce anxiousness and improve mood by 70%+*
The result?
Better sleep, better mornings, and a brain that’s finally off high alert.
• OUR CEO SAYS •
“A really awesome quote from Dr, Amen about how awesome this product is.”
- Daniel G. Amen, MD
KSM-66® Ashwagandha: The Gold Standard in Stress Relief
Not all ashwagandha is created equal.
KSM-66® Ashwagandha is the most clinically studied ashwagandha extract in the world—standardized to the root and extracted using a clean, water-based process for full-spectrum potency.*
It’s been shown to:
✔ Lower cortisol*
✔ Improve sleep*
✔ Boost resilience, mood, and clarity—even under pressure*
It may also support healthy weight, reduce food cravings, and improve sexual function—making it one of the most versatile, performance-driven adaptogens available.*
Stress Relief Sleep delivers the clinically studied amount of KSM-66® Ashwagandha (600 mg per serving), so you get real, measurable results where they matter most.*
Smarter Sleep, Backed By Science
Stress Relief Sleep was developed by leading brain and sleep experts to help you wind down, sleep deeper, and wake up sharper—without melatonin, hormones, or harsh sedatives.*
✔ Fast-acting calm in under 1 hour*
✔ 100% melatonin-free & non-habit forming*
✔ Brain-targeted support for stress, anxiousness, and emotional balance*
✔ Doctor-developed and safe for nightly use*
✔ Backed by clinical studies on cortisol, sleep, and mood*
This is sleep, done smarter—and stress-free.*
- Lopresti AL. The effects of psychological and environmental stress on micronutrient concentrations in the body: a review of the evidence. Advances in Nutrition 11,103-112 (2020).
- Russell G, Lightman S. The human stress response. Nature Reviews in Endocrinology 15: 525–534 (2019).
- Smiley A, others. The association between sleep duration and metabolic syndrome: the NHANES 2013/2014. Nutrients 11, 2582:13 pages (2019).
- Huang Q-M, others. Association of insomnia symptoms and trajectories with the risk of functional disability: a prospective cohort study. Geriatrics 24, 492:9 pages (2024).
- American Psychological Association. Stress in America 2023 (November). www.apa.org (accessed Jan 9, 2025).
- Saleem S, others. Withania somnifera L: Insights into the phytochemical profile, therapeutic potential, clinical trials, and future prospective. Iranian Journal of Basic Medical Sciences 23:1501 (2020).
- Dongre S, others. Efficacy and safety of ashwagandha (Withania somnifera) root extract in improving sexual function in women: a pilot study. Biomed Research International 2015, 284154:9 pages (2015).
- Chandrasekhar K, others. A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of ashwagandha root in reducing stress and anxiety in adults. Indian Journal of Psychological Medicine 34(3):255 (2012).
- Langade D, others. Efficacy and safety of ashwagandha (Withania somnifera) root extract in insomnia and anxiety: A double-blind, randomized, placebo-controlled study. Cureus 11(9):22 pages (2019).
- Choudhary D, others. Body weight management in adults under chronic stress through treatment with ashwagandha root extract: A double-blind, randomized, placebo-controlled trial. Journal of Evidence-Based Complementary & Alternative Medicine 22(1):96 (2017).
- Salve J, others. Adaptogenic and anxiolytic effects of ashwagandha root extract in healthy adults: A double-blind, randomized, placebo-controlled clinical study. Cureus 11(12):12 pages (2019).
- Langade D, others. Clinical evaluation of the pharmacological impact of ashwagandha root extract on sleep in healthy volunteers and insomnia patients: A double-blind, randomized, parallel-group, placebo-controlled study. Journal of Ethnopharmacology 264, 113276:11 pages (2021).
- Kelgane SB, others. Efficacy and tolerability of ashwagandha root extract in the elderly for improvement of general well-being and sleep: A prospective, randomized, double-blind, placebo-controlled study. Cureus 12(2), e7083:18 pages (2020).
- National Institutes of Health (NIH) Office of Dietary Supplements. Magnesium fact sheet for health professionals (18 pages). www.ods.od.nih.gov, accessed November 23, 2021.
- Institute of Medicine (IOM) Food and Nutrition Board. Dietary Reference Intakes: Calcium, Phosphorus, Magnesium, Vitamin D and Fluoride. Washington, DC: National Academy Press (1997).
- Zhou H, others. Intracellular magnesium optimizes transmission efficiency and plasticity of hippocampal synapses by reconfiguring their connectivity. Nature Communications 15, 3406:20 pages (2024).
- Boyle NB, others. The effects of magnesium supplementation on subjective anxiety and stress - a systematic review. Nutrients 9, 429:22 pages (2017).
- Pickering G, others. Magnesium status and stress: The vicious cycle concept revisited. Nutrients 12, 3672: 21 pages (2020).
- Abbasi B, others. The effect of magnesium supplementation on primary insomnia in elderly: A double-blind placebo-controlled clinical trial. Journal of Research in Medical Sciences 17(12):1161 (2012).
- Held K, others. Oral Mg2+ supplementation reverses age-related neuroendocrine and sleep EEG changes in humans. Pharmacopsychiatry 35:135-143 (2002).
- Zogovic D, others. Pituitary-gonadal, pituitary-adrenocortical hormones and IL-6 levels following long-term magnesium supplementation in male students. Journal of Medical Biochemistry 33:291-298 (2014).
- Williams JL, others. The effects of green tea l-theanine consumption on the ability to manage stress and anxiety levels: A systematic review. Plant Foods in Human Nutrition 75(1):12 (2020).
- Kobayashi K, others. Effects of L-theanine in the release of alpha-brain waves in human volunteers. Journal of the Japanese Society of Bioscience Biotechnology and Agrochemistry 72:153 (1998) (in Japanese, with English abstract and figure legends).
- Lu K, others. The acute effects of l-theanine in comparison with alprazolam on anticipatory anxiety in humans. Human Psychopharmacology 19(7):457 (2004).
- Ritsner MS, others. L-theanine relieves positive, activation, and anxiety symptoms in patients with schizophrenia and schizoaffective disorder: An 8-week, randomized, double-blind, placebo-controlled, 2-center study. Journal of Clinical Psychiatry 72(1):34 (2011).
Frequently Asked Questions
How do I take Stress Relief Sleep?
Take 2 capsules with water 1–2 hours before your desired bedtime. If you’re still feeling alert after an hour, you may take an additional capsule as needed.* This formula is not recommended for children, or for use during pregnancy or breastfeeding.* Always follow label directions or consult your healthcare provider before use.*
Why doesn’t Stress Relief Sleep contain melatonin?
Melatonin isn’t the only way to get better sleep—and for many people, it’s not the right one. Stress Relief Sleep is melatonin-free by design. Instead, it uses clinically studied ingredients like KSM-66® Ashwagandha, L-theanine, GABA, and Magnesium to help lower cortisol and calm the brain naturally—without hormones, sedatives, or next-day grogginess.*
Can I become dependent on Stress Relief Sleep?
No. Stress Relief Sleep is a non-habit-forming dietary supplement—not a sedative or sleep drug.* It’s designed to support your body’s natural ability to relax and fall asleep by calming the brain and lowering cortisol.* You can take it nightly with confidence, knowing it works with your system—not against it.*
Will Stress Relief Sleep make me drowsy during the day?
Not at all. Stress Relief Sleep is formulated to promote deep, restful sleep without next-day drowsiness. It contains no melatonin or sedative herbs—just research-backed nutrients that help calm the brain and lower cortisol, so you can sleep well and wake up sharp.*
Can I take Stress Relief Sleep while pregnant or breastfeeding?
This product is not recommended during pregnancy or breastfeeding due to limited clinical research.* Always consult your healthcare provider before use.*
Is Stress Relief Sleep safe for children?
This supplement was formulated for adults and is not recommended for use in children.*
Which other supplements work well with Stress Relief Sleep?
For optimal results, pair Stress Relief Sleep with NeuroVite Plus Multivitamin for daily brain-supportive nutrients, and Omega-3 Power for concentrated EPA and DHA.* Together, these supplements help support the brain’s natural sleep processes, stress reliance, and emotional balance—day and night.*
Inside the Formula
Dr. Amen discusses his most potent nutritional weapon for a top-performing body and mind
