Skip to content
Wellness Blog
Did You Know These Methylfolate Benefits Can Help with Mood?
Perhaps you’ve heard of the essential vitamin folate (aka vitamin B9). But what’s the difference between folate and methylfolate? And what’s folic acid? It can be a bit confusing, so let’s unpack each of these and see how they relate to each other. What’s the Difference Between Folate, Folic Acid, and Methylfolate? Folate Folate is a group of chemically complicated substances that supply the body with chemically simple methyl groups. The body can’t make folate from scratch, so we must get it from foods or dietary supplements. Folate is vital at every stage of life, from early development in the womb through birth, and all the way through adulthood. But for many people, lifestyle factors, some medications, and common gene mutations can deplete their folate stores. Folic Acid To help consumers maintain good nutritional folate status, many foods are being “fortified” with folic acid (FA). Also, dietary supplements that include folate typically provide it as FA. But FA doesn’t occur in plants or in any of our foods and is so chemically different from natural folates that it gunks up our folate enzymes and impairs our natural folate utilization. The body must produce an enzyme to make FA usable, and this enzyme’s conversion capacity is limited. As a result, some people may have unconverted FA in their bloodstream, which may lead to negative health effects such as nausea, diarrhea, irritability, and behavior changes. Methylfolate Methylfolate (technically methyltetrahydrofolate) is the pre-activated and most readily utilized form of the folate vitamin. The body has enzymes that rely on methylfolate (MF) specifically for its methyl groups, which are crucial for a broad range of brain and body functions. Methylfolate is the folate form most naturally preferred by the body, which is why the intestinal lining has “transport proteins” that bind to it and selectively absorb it into the blood. Similar proteins also move MF from the circulation into the brain tissue. The methyl chemical groups that come from folate are fundamental to practically all our life processes. It’s essential for all our cells, tissues, and organs to survive, grow, function, and maintain their structural integrity. MF also supports the entire array of functions in the bone marrow, liver, and all the other organs. All our cells need methylfolate to make their DNA, package it into genes, repair it when damage occurs, and regulate their overall gene activity (epigenetics). The brain’s nerve cells also need it to make their electrical insulation (myelin) and to make dopamine and serotonin. MF also works with vitamin B6 and B12 in the detoxication of homocysteine. Methylfolate promotes smooth and efficient folate metabolism for those who need it most: women of reproductive age, the elderly, the high proportion of individuals who carry folate enzyme mutations. For these individuals, and for the rest of us, methylfolate is the best dietary form of folate. Methylfolate Benefits Here are just a few methylfolate benefits: Fundamental to the growth, renewal, and functioning of our cells, tissues, and organs. Helps support a healthy mood, memory, cognition, and behavior. Enhances the clinically proven mood benefits of SAMe (s-adenosyl-methionine). Essential for the brain to make the key neurotransmitters serotonin, dopamine, and norepinephrine. Promotes the brain’s healthy production of melatonin, our major sleep hormone. Enhances the body’s regulation of homocysteine, a potentially toxic human metabolic product. Promotes healthy pregnancy and birth outcomes. While considering these impressive methylfolate benefits, it's also important to be aware of the potential dangers of not taking methylfolate. Folate Mutations When consumed, methylfolate doesn’t need to be converted into active folate – as the body’s most active folate form, it can be immediately used by our folate enzyme systems. One of the most common human gene mutations is the C677T mutation in the enzyme MTHFR (Methylene Tetrahydrofolate Reductase), whose function is to produce MF. More than 40 percent of individuals in some ethnic groups have this mutation, which is associated with impaired folate utilization from food. Taking MF by mouth bypasses this mutation: as premade, authentic MF, it doesn’t need to be produced by MTHFR. For people with C677T or various other, less common MTHFR mutations, methylfolate is a health breakthrough! Methylfolate Benefits for Mood Among its many positive actions in the brain and body, methylfolate can help support emotional balance. Methylfolate is a cofactor in the production of monoamines¹ dopamine, norepinephrine, and serotonin. In one study,² patients struggling with low mood reported significant improvements in their symptoms when using methylfolate. The results of two randomized, double-blind, parallel-sequential trials³ found that MF may help those with medication-resistant mood issues. The trial concluded that MF may be an effective, safe, and well tolerated treatment for patients with major mood problems. So, where can you get an ultra-pure source of this mood-, memory-, and cognitive-supporting vitamin? BrainMD’s MethylFolate Methylfolate is a form of the folate vitamin that’s better utilized than folic acid or other folates.* BrainMD’s MethylFolate is essential for mood, cognition, behavior, and overall brain and body health.* Methylfolate is the body’s most fully active form of folate, a vitamin that provides methyl groups (-CH3) which are crucial for a broad range of brain functions, including healthy mood.* In clinical trials, MF corrected methyl deficiency while promoting a positive mood and overall brain health.* Highly Bioavailable Source of Methyl Groups To be utilized by the body, dietary folates from foods or supplements must first be converted to methylfolate.* But the enzymes involved in this conversion process often carry mutations that can interfere with their activity.* High-quality MF supplements bypass these enzymes, directly supplying methyl to make SAMe and other methyl cofactors that manage the body’s extensive networks of methyl metabolism.* Promotes Metabolic Recycling of Homocysteine Homocysteine (HCy) is a byproduct of SAMe production from MF and the amino acid methionine.* If allowed to build up in the blood and other tissues, HCy can become toxic.* MF facilitates the recycling of HCy to methionine, which helps curb its toxic potential.* Supports Brain Health and DNA Methyl from MF is needed from the moment of fertilization of the human egg, through the development of the brain, heart and other organs, to birth, and across the lifespan.* All our cells need methyl groups to make their DNA, repair ongoing DNA damage, and regulate their utilization of DNA.* Put the Methyl in Your Folate Though folate is an effective vitamin, methylfolate is better utilized in the body than folate and synthetic folic acid.* Taking folate as MethylFolate can help provide nutritional support for your brain and body.* This versatile supplement is also fundamental to the growth and renewal of our cells, helps regulate potentially harmful homocysteine, promotes healthy pregnancy, and much more.* You can enjoy all the methylfolate benefits in BrainMD’s MethylFolate supplement. Try it today! At BrainMD, we’re dedicated to providing the highest purity nutrients to improve your physical health and overall well-being. For more information about MethylFolate and our full list of brain healthy supplements, please visit us at BrainMD. *These statements have not been evaluated by the FDA. This content is for informational purposes only. It is not meant to substitute for medical or healthcare advice from a physician, nor is it intended to diagnose, treat, cure, or prevent any disease. Consult your healthcare provider before beginning a new health regimen. References: 1. Stahl, S. M. (2008). L-methylfolate: A vitamin for your monoamines. Journal of Clinical Psychiatry, 69(9), 1352–1353. https://doi.org/10.4088/jcp.v69n0901 2. Shelton, R. C., Manning, J. S., Barrentine, L. W., & Tipa, E. V. (2013). Assessing effects of l-methylfolate in depression management: Results of a real-world patient experience trial. Primary Care Companion for CNS Disorders, 15(4), PCC.13m01520. https://doi.org/10.4088/PCC.13m01520 3. Papakostas, G. I., Shelton, R. C., Zajecka, J. M., Etemad, B., Rickels, K., Clain, A., Baer, L., Dalton, E. D., Sacco, G. R., Schoenfeld, D., Pencina, M., Meisner, A., Bottiglieri, T., Nelson, E., Mischoulon, D., Alpert, J. E., Barbee, J. G., Zisook, S., & Fava, M. (2012). L-methylfolate as adjunctive therapy for SSRI-resistant major depression: Results of two randomized, double-blind, parallel-sequential trials. American Journal of Psychiatry, 169(12), 1267–1274. https://doi.org/10.1176/appi.ajp.2012.11071114
Learn more
EPA vs DHA: Some of the Best Sources of Omega-3s
You probably know that omega-3 fatty acids are good for circulatory health. But did you know they’re also crucial for brain health? When it comes to the benefits of omega-3s, what supports a healthy heart also supports a healthy brain. EPA vs DHA Only two fatty acids have been proven essential for humans: linoleic acid (LA), the parent fatty acid of the omega-6 series, and alpha-linolenic acid (ALA), the parent fatty acid of the omega-3 series. Two of the most important omega-3 fatty acids are EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid). They’re called essential for a reason – our brains need these specific omega-3 essential fatty acids to function optimally. Here are some of the top health benefits of these long-chain fatty acids: EPA fatty acids are less abundant in brain cells than DHA fatty acids but are known to be essential for healthy inflammatory responses¹ and are necessary to produce new nerve cells. DHA is the most prevalent fatty acid found in the brain. It’s also vital to the creation and maintenance of all the cells in both the brain and the retina (which functionally is an extension of the brain). The human body requires premade EPA and DHA from our diet. Unfortunately, the standard American diet (SAD) has an unhealthy balance of fatty acids: we get an abundance of saturated and omega-6 fatty acids and not nearly enough omega-3s. Most of the omega-3s we do get must be converted to EPA and DHA, which the body doesn’t do efficiently. Power Team: EPA and DHA When it comes to EPA and DHA, there’s no competition. Though they have different features and functions, EPA and DHA are a highly effective power team. And like good teammates, they work hard to maximize the benefits of each other. Both are fundamental to the structure and functioning of all our cells, particularly our 200 billion brain cells. EPA and DHA are required for our brain’s nerve cells to make energy and to use that energy for their growth, maintenance, and repair. These fatty acids are practically vitamins because we must get most of our daily allowance of them from our diet. However, since the body is inefficient at converting plant ALA into EPA and DHA, we need to eat foods that contain these omega-3s preformed, namely cold-water fish. Considering costs, convenience, and the dangers of contamination of fish with mercury and hundreds of other environmental pollutants, many authoritative organizations recommend taking reputable, concentrated fish oil or algal oil supplements to ensure adequate daily intakes of EPA and DHA. If you’re looking for the best omega-3 supplement for your unique needs, here’s a closer look at BrainMD’s 3 high-quality, ultra-pure omega-3 supplements… 3 of the Cleanest Sources of Omega-3 Fatty Acids EPA & DHA Omega-3 Power Omega-3 Power is a potent fish oil concentrate that supplies substantial amounts of EPA and DHA.* EPA - Each 2-softgel serving of Omega-3 Power delivers 860 mg of this long-chain omega-3 fatty acid. DHA - Each 2-softgel serving of Omega-3 Power delivers 580 mg of this long-chain omega-3. A highly concentrated fish oil product, Omega-3 Power provides 1,600 mg of EPA, DHA, and other omega-3s to power your mood, focus, memory, cognition, and heart.* Our omega-3s are in the bioavailable triglyceride form, thoroughly tested for freshness and screened for 200+ contaminants.* Omega-3 Power Squeeze Omega-3 Power Squeeze is a pleasant-tasting fish oil liquid emulsion, customized for children and adults seeking an alternative to taking large capsules. It delivers 910 mg EPA and 590 mg DHA for a total of 1500 mg per serving. Top reasons to take Omega-3 Power Squeeze: Ultra-safe – The ultra-pure fish oil in Omega-3 Power Squeeze is extracted in its natural triglyceride form from sustainably harvested fish. The fish oil is tested by independent labs to exclude over 250 toxic contaminants, heavy metals, and other substances.* It is maintained fresh throughout the verification process and then is gently purified and emulsified for better absorption and taste.* Well Absorbed – The advanced emulsification technology behind Omega-3 Power Squeeze makes it better absorbed than standard fish oils.* Pleasant Tasting – One serving of this citrus-flavored emulsion gives the body considerably more EPA and DHA than a serving of conventional fish or krill oil, without the fishy smell/taste or unpleasant reflux problems.* Omega-3 Power Squeeze is a liquid omega-3 supplement that tastes like an orange creamsicle and is enjoyed by adults and children alike.* Vegan Omega-3 Power Vegan Omega-3 Power is a vegan algal oil capsule, customized for children and adults. It supplies clinically effective doses of omega-3s (700 mg EPA and 300 mg DHA), nutrients that are practically vitamins since the body can’t make them in the sufficient amounts needed to meet its requirements.* Many vegetarians supplement with flax seed, chia seed, or hemp seed oils, which contain the omega-3 ALA. It’s possible for the body to convert ALA to EPA and DHA, but it’s a difficult process.* EPA and DHA, typically found in fish, are the only forms of omega-3 the body readily uses.* A superior alternative to flax oil, Vegan Omega-3 Power features natural oil from marine algae² – a direct source of vegan EPA and DHA.* This highly concentrated formula rivals fish oil in its purity and potency.* Get Your EPA and DHA Today Getting adequate amounts of EPA and DHA is a great way to improve overall brain and body function and well-being.* While it’s possible to get some omega-3s from your diet, those who don’t regularly consume fish and vegans may benefit from taking a high EPA and DHA omega-3 supplement such as BrainMD’s Omega-3 Power, Omega-3 Power Squeeze, and Vegan Omega-3 Power.* Try them today! At BrainMD, we’re dedicated to providing the highest purity nutrients to improve your physical health and overall well-being. For more information about our full list of brain healthy supplements, please visit us at BrainMD. *These statements have not been evaluated by the FDA. This content is for informational purposes only. It is not meant to substitute for medical or healthcare advice from a physician, nor is it intended to diagnose, treat, cure, or prevent any disease. Consult your healthcare provider before beginning a new health regimen. References: 1. Calder, P. C. (2010). Omega-3 fatty acids and inflammatory processes. Nutrients, 2(3), 355–374. https://doi.org/10.3390/nu2030355 2. Priyadarsini, M., Nivetha, X. R., Mathimani, T., Anto, S., Krishnan, H. H., Glivin, G., Premalatha, M., Mariappan, V., & Sekhar, J. (2022). Omega-3 fatty acids from algae for health benefits. Materials Today: Proceedings, 66(Part 3), 1514–1518. https://doi.org/10.1016/j.matpr.2022.07.177
Learn more
Fish Oil Facts: Do You Know If You're Taking the Right Omega-3 Supplements?
Many people know that the omega-3 fatty acids found in fish oil are good for their circulatory health. But many are unaware that these fatty acids are crucial for brain health too. When it comes to the benefits of omega-3 supplements, it supports both a healthy heart and healthy mind. With strong evidence supporting omega-3s positive effects on the brain, heart and whole body, taking fish oil should be an essential part of your daily supplement regimen. This is especially true if you’re experiencing brain fog or memory struggles. A recent study revealed that, when combined, omega-3 fatty acids, aerobic exercise, and cognitive stimulation can prevent mild cognitive issues¹ and the decline of gray matter in the brain. Whether you’re still in the research phase, or if you currently take supplements and want to find out if you’ve selected the right kind, here are some quick facts you need to know about fish oil: Omega-3 Fatty Acid Facts The fish oils come from cold water fish and are rich sources of long-chain omega-3 fatty acids called EPA and DHA. These are essential for human health, functioning in all our cells and way more active than the shorter-chain omega-3s that come from plants. They are practically vitamins since the body can't make them from scratch but must get them from food. It has been scientifically demonstrated that your brain needs these essential omega-3 fatty acids to function optimally. Unfortunately, most Americans are deficient in omega-3s, and studies indicate that as many as 90% of adults have suboptimal levels of EPA and DHA.² What Are EPA and DHA? EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid) are both critical to building the cell membranes that all our cells use to survive and carry out their functions. EPA and DHA are essential for our brain cells to make the trillions of connections that enable the brain to work at all, and for peak cognitive, mood, and behavioral performance. The only practical way to ensure we get the recommended proper amounts of EPA and DHA we need is through foods or supplements. DHA makes up a large portion of the brain. EPA works with DHA to enable healthy blood flow to the brain, which supports memory, attention, mood and overall mental functioning. EPA and DHA work along with other fatty acids coming from our foods, to optimize the cell membrane functions of all the brain's nerve cells AND the equal numbers of cells that provide crucial support for their information processing functions. Deficiencies in these vital omega-3 fatty acids are associated with age-related cognitive decline, psychological disturbances, mood challenges, behavioral issues, and a broad array of other nervous system problems, as well as with issues with the circulation, joints, and other tissues and organs. Benefits of Omega-3 EPA and DHA The huge and rapidly-growing body of clinical research on EPA and DHA in fish oils indicates they are vital to the brain's blood flow,³ its overall information processing capabilities, and memory. This also includes other cognitive functions such as mood, the brain's executive functioning to make good decisions, and a calm and controlled demeanor. Omega-3 EPA and DHA are vital nutritional support for the healthy early development, maturation, and optimal functioning of the brain, heart and circulation, and all the body's other organs. They are also vital to the survival and optimal functioning of mind and body, across our entire lifespan. Which Fish Oil Supplement is Best? When searching for a high-quality fish oil supplement, keep these shopping tips in mind: Since toxins such as mercury and other heavy metals, solvents, dioxins, PCBs, furans, and more than 250 environmental pollutants can become concentrated in fish, it’s extremely important to choose a fish oil product that is highly purified and analyzed in a laboratory to verify that it is clean. Fish oil spoils easily. Look for a product that has added vitamin E, vitamin C, rosemary, or other safe and effective stabilizers. Avoid suppliers that are not reputable, because more and more fish oils are being diluted with oils that don't have omega-3 activity. Choose a product that has high amounts of EPA and DHA. The cheap fish oils can say "1000 mg" on the label but only provide 300 mg of EPA plus DHA, which for most people is not an adequate daily dose. Learn your Omega-3 Index, which is the percentage of EPA plus DHA in your body's cell membranes. It's the only way for you to know if you're getting enough EPA and DHA. It can cost as little as $55 online. You want to aim for an Index of between 8 and 12 percent. Omega-3-Rich Foods Focus your diet on foods that contain omega-3 fatty acids, which are found in chia seeds, flaxseeds, walnuts, avocados and leafy green vegetables. The body can convert some of these into small amounts of EPA and DHA, but cold-water fish such as salmon, tuna, mackerel, and sardines are the sources of actual, preformed EPA and DHA. Avoid farmed salmon and try to get these and other cold-water fish from Alaska or close to the Antarctic, where the ocean waters are the least contaminated. If getting EPA and DHA from your foods becomes a challenging task, consider a highly concentrated, purified fish oil or algal oil supplement. These will ensure you're not getting low-grade, toxin-filled omega-3s that your body may not even be able to convert. 2 Pure & Potent Omega-3 Supplements! OMEGA-3 POWER Omega-3 Power is a potent fish oil concentrate that supplies substantial allowances of EPA and DHA. EPA- Each 2-softgel serving of Omega-3 Power delivers 860 mg of this long-chain omega-3 fatty acid. Clinical trials established EPA’s importance for attention in children and adults.* Its necessity for heart and blood vessel health is undisputed.* DHA- Each 2-softgel serving of Omega-3 Power delivers 580 mg of this long-chain omega-3. DHA is structurally essential for the nerve cells to make their functional connections and supports healthy memory, mood and overall cognition.* EPA and DHA are required for our brain’s nerve cells to make energy and to use that energy for their growth, maintenance, and repair.* Since neither of these omega-3s can be efficiently made by the body, optimal intakes must come from foods and supplements.* Premium Fish Oil Without the Fishy Flavor Sourced from pelagic (not bottom-feeders) fish species with short lifespans (so that they don’t accumulate as many toxins), the fish oil in Omega-3 Power undergoes the most advanced purification process in the supplement industry.* Omega-3 Power is tested by independent labs to ensure freshness (lack of rancidity) and for over 250 potential environmental contaminants, including mercury, lead and other heavy metals, PCBs, PBBs, dioxins, furans, and a diverse range of other organic pollutants.* The oil in Omega-3 Power is also recognized by several international organizations as a sustainably managed ingredient.* VEGAN OMEGA-3 POWER Vegan Omega-3 Power is a vegan algal oil capsule, customized for children and adults. It supplies clinically effective doses of omega-3s (700 mg EPA and 300 mg DHA), nutrients that are practically vitamins since the body can’t make them in the sufficient amounts needed to meet its requirements.* We Searched the Seas for Omega-3s Many vegetarians supplement with flax seed, chia seed, or hemp seed oils, which contain the omega-3 ALA. But EPA and DHA, typically found in fish, are the only forms of omega-3 the body uses.* It’s possible for the body to convert ALA to EPA and DHA, but it’s a difficult process.* A superior alternative to flax oil, Vegan Omega-3 Power features natural oil from marine algae – a direct source of vegan EPA and DHA.* This highly concentrated formula rivals fish oil in its purity and potency.* Get all the power of fish oil without the fish! How Much Fish Oil Should I Take? Based on clinical research that examined how intakes of EPA and DHA improved the Omega-3 Index, we recommend that most adults take 1,400 to 2,800 mg of EPA and DHA omega-3 fatty acids a day.* Children should get at least 700 mg per 40 pounds of body weight.* If you want to remain at the top of your game, both mentally and physically, be sure to incorporate high-quality omega-3 supplements into your daily wellness regimen.* At BrainMD, we’re dedicated to providing the highest purity nutrients to improve your physical health and overall well-being. For more information about Omega-3 Power, Vegan Omega-3 Power and our full list of brain healthy supplements, please visit us at BrainMD. *These statements have not been evaluated by the FDA. This content is for informational purposes only. It is not meant to substitute for medical or healthcare advice from a physician, nor is it intended to diagnose, treat, cure, or prevent any disease. Consult your healthcare provider before beginning a new health regimen. References: Köbe, T., Witte, A. V., Schnelle, A., Lesemann, A., Fabian, S., Tesky, V. A., Pantel, J., & Flöel, A. (2016). Combined omega-3 fatty acids, aerobic exercise and cognitive stimulation prevents decline in gray matter volume of the frontal, parietal and cingulate cortex in patients with mild cognitive impairment. NeuroImage, 131, 226–238. https://doi.org/10.1016/j.neuroimage.2015.09.050 Richter, C. K., Bowen, K. J., Mozaffarian, D., Kris-Etherton, P. M., & Skulas-Ray, A. C. (2017). Total long-chain n-3 fatty acid intake and food sources in the United States compared to recommended intakes: NHANES 2003–2008. Lipids, 52(11), 917–927. https://doi.org/10.1007/s11745-017-4297-3 von Schacky, C. (2021). Importance of EPA and DHA blood levels in brain structure and function. Nutrients, 13(4), 1074. https://doi.org/10.3390/nu13041074
Learn more
Want the Best Rest? Here's Why You Need Serotonin for Sleep!
The human brain naturally produces a soothing neurotransmitter called serotonin, mostly from the amino acid tryptophan that is derived from dietary proteins. Serotonin plays many important roles in the brain’s biochemistry and is intimately involved in maintaining an upbeat mood, boosting self-confidence, sustaining the body’s 24-hour rhythms, and facilitating sustained and deep sleep. Signs of Low Serotonin Unfortunately, far too many people aren’t naturally producing enough serotonin to consistently experience its calming, positive effects. Inadequate serotonin is linked to low mood, negative behaviors, unhealthy sleep patterns, and many other physical and mental problems. Signs of possible low serotonin or functional serotonin deficiency: Racing negative thoughts at night Difficulties with mental sharpness Carbohydrate cravings and binge eating Digestive and other intestinal problems Sleep problems Feeling overwhelmed and unhappy Headaches Anger and irritability Sleep Cycles Most people realize that the quality and quantity of their sleep can have a direct impact on how well they function during the day. But did you know that what you do during the day can affect how well you sleep at night? Getting appropriate levels (at least 10 to 30 minutes) of sunlight on your skin during the day can help maintain your body’s natural production of vitamin D3, which promotes the production of serotonin molecules. In the evening, the brain naturally converts serotonin into melatonin, the main sleep hormone. Getting sufficient levels of serotonin during the day may improve your chances of getting a good night’s sleep. Anything that disrupts this sleep/wake cycle, like excessive caffeine, alcohol or video game playing, can have adverse effects on your ability to effectively perform tasks at work, school or home. Insufficient and inconsistent sleep can increase irritability, moodiness and poor judgment. To remain at the top of your game, it’s recommended that you get between 7-9 hours of sleep each night. If you have difficulties turning off your brain before bedtime, or if you just need more calm in your life, here are 3 ways serotonin can help you stay in a restful state of mind… 3 Ways to Naturally Increase Serotonin For Sleep 1. Consistent Physical Exercise Exercise is a serotonin intervention – it boosts serotonin in your brain. Multiple research studies have demonstrated that exercise increases the blood levels of tryptophan,¹ which gets into the brain to make more serotonin available. Consistent physical exercise is one of the best ways to improve your serotonin levels and has many other positive effects on your brain and body health. 2. Increase Serotonin with Food Very few foods contain premade serotonin and once absorbed into the blood, it can’t get across the blood-brain barrier. However, tryptophan from food proteins does get across this barrier, so it is possible to support the brain’s serotonin needs by eating foods that boost the brain’s tryptophan levels. Some examples of foods rich in L-tryptophan are: spirulina, seeds (especially pumpkin), squash, chia, watermelon, grass-fed meats (beef, lamb, goat), free-range poultry (chicken, turkey, duck), wild caught salmon and tuna, peas and beans (not canned), tofu, tempeh, tahini, natto, edamame, eggs (especially the whites), and spinach. 3. Get Nutritional Support Getting high-quality sleep is essential to wellness. If you have problems falling asleep, a safe, scientifically formulated dietary supplement may help you achieve restful sleep. One of BrainMD’s highly effective, natural sleep aids is Serotonin Mood Support. Naturally Calming Serotonin for Sleep: Serotonin Mood Support BrainMD's Serotonin Mood Support is a natural solution that helps increase the production of calming brain waves, correct stress-related nutritional deficiencies, and promote relaxation that will enable good quality sleep.* It can help you handle the ups and downs of life with more composure.* This formula includes: [wc_box color="inverse" text_align="left" margin_top="" margin_bottom="" class=""] Vitamin B6 is fundamental to healthy brain function.* It’s also an essential cofactor for enzymes that make serotonin and other key transmitters.* It works in harmony with methylfolate and methyl-vitamin B12 to support the brain’s structural brain maintenance and functional efficiency.* Methylfolate is pre-activated and is the body’s most readily utilized form of the folate vitamin.* It’s better utilized than folic acid, which is a manufactured substance not found in nature.* Many people cannot efficiently convert folic acid into usable folate (methylfolate).* Methyl-cobalamin, the body’s most readily-utilized form of vitamin B12, is paired with methylfolate to help ensure the brain has sufficient methyl to make melatonin (our sleep hormone) and has the biochemical tools for renewing and maintaining its nearly 200 billion cells.* We avoid using cyano-cobalamin, which contains toxic cyanide.* Saffron is the world’s most expensive spice, saffron has a long history of being used to induce happiness.* Saffron concentrated extracts have consistently improved mood, stress, and other mental functions in many clinical trials.²* [/wc_box] Lifestyle habits such as consuming smart carbohydrates in moderation, seeking out healthy foods rich in tryptophan, and taking a dietary supplement like Serotonin Mood Support can work together to elevate mood and promote restful sleep.* Try Serotonin Mood Support today! At BrainMD, we’re dedicated to providing the highest purity nutrients to improve your physical health and overall well-being. For more information about Serotonin Mood Support and our full list of brain healthy supplements, please visit us at BrainMD. *These statements have not been evaluated by the FDA. This content is for informational purposes only. It is not meant to substitute for medical or healthcare advice from a physician, nor is it intended to diagnose, treat, cure, or prevent any disease. Consult your healthcare provider before beginning a new health regimen. References: 1. Melancon, M. O., Lorrain, D., & Dionne, I. J. (2012). Exercise increases tryptophan availability to the brain in older men age 57-70 years. Medicine & Science in Sports & Exercise, 44(5), 881-887. https://doi.org/10.1249/MSS.0b013e31823ede8e 2. Jackson, P. A., Forster, J., Khan, J., Pouchieu, C., Dubreuil, S., Gaudout, D., Moras, B., Pourtau, L., Joffre, F., Vaysse, C., Bertrand, K., Abrous, H., Vauzour, D., Brossaud, J., Corcuff, J. B., Capuron, L., & Kennedy, D. O. (2021). Effects of saffron extract supplementation on mood, well-being, and response to a psychosocial stressor in healthy adults: A randomized, double-blind, parallel group, clinical trial. Frontiers in Nutrition, 7, 606124. https://doi.org/10.3389/fnut.2020.606124
Learn more
What Is the Best Multivitamin for Men Over 50?
If you’re a man in or approaching your 50s, you’ve probably noticed that your body doesn’t quite work the way it used to. Don’t panic! You’re not alone. Signs of Aging in Men There are many signs that your age might be catching up with you if you’re a middle-aged male. Here are just a few: Loss of muscle mass/joint pain Low energy/fatigue Loss of ambition/low enthusiasm Reduced sex drive/erectile dysfunction Low mood/mood swings Poor concentration/memory problems Sleep issues/tiredness This is just a short list of symptoms; other, more serious, conditions may involve your heart or other organs. For many adult men, the culprit for their issues with energy, mood, and libido is low testosterone. Testosterone Testosterone is a hormone that’s important for male development. It’s responsible for the deepening of the voice, the growth of facial hair, and many other features traditionally associated with maleness. Also, testosterone is the primary hormone responsible for libido in men. Like many hormones, testosterone levels decrease with age. The aging process can leave some men with low testosterone levels that have been shown to increase feelings of anxiousness, low mood, and a host of other issues. Also, testosterone can be prematurely reduced (at any age) by long-term stress, exposure to environmental pollutants, insulin imbalance, narcotics use, and many other lifestyle factors. Andropause Most men approaching their 40s and 50s go through a form of menopause called andropause. The symptoms of andropause include lowered sex drive, mood issues, lack of motivation, fatigue, increased body fat, and decreased muscle mass, strength, and stamina. Nutritional Support One helpful way men can reduce the risk of age-related problems is to take high-quality supplements. Some have suggested that the foods currently available aren’t providing enough of the nutrients¹ the brain and body need. Despite your best efforts to follow a healthy diet, many foods are so low in nutrients that you’ll likely have a gap in nutrition. That’s where dietary supplements come in – they can help fill the gaps in your diet with the nutrients you’re missing. The foundation of every vitamin regimen should be a high-quality, broad-spectrum multivitamin and multimineral supplement. Why You Should Take a Multivitamin Many people have nutrient deficiencies stemming from the frequent consumption of foods associated with the standard American diet (SAD). According to one review,² this has led to widespread vitamin and mineral deficiencies in our nation. The Centers for Disease Control and Prevention (CDC) has estimated that a significant number of Americans³ don’t consume the recommended servings of fruits and vegetables per day. Since most adults aren’t getting enough vitamins in their diet, it’s recommended⁴ that everyone should take a broad-spectrum multivitamin supplement every day. Further bolstering the importance of taking a multivitamin supplement daily is a compelling study⁵ conducted in 2010 that included over 200 men between the ages of 30 and 55. The men were separated into two groups: one group took a multivitamin and the other took a placebo. At the end of one month, the men who took the multivitamin reported better mood and cognitive performance, and less stress and mental fatigue. If you’re looking for a premium, ultra-pure multivitamin, BrainMD is proud to offer NeuroVite Plus Multivitamin! NeuroVite Plus: Best Multivitamin for Men Over 50! BrainMD’s NeuroVite Plus Multivitamin is the first and only daily multivitamin that contains over 50 vitamins, minerals, and plant extracts developed through clinical studies.* NeuroVite Plus was formulated to provide whole-body wellness with additional key brain-healthy nutrients.* It offers advanced nutrition in a way that far surpasses big-box store or drugstore multivitamins.* 5 Benefits of NeuroVite Plus Multivitamin Though the benefits of this dynamic, broad-spectrum multivitamin are numerous, NeuroVite Plus can support your daily health by: [wc_box color="inverse" text_align="left" margin_top="" margin_bottom="" class=""] Nourishing your body’s cells, tissues, and organs with a wide range of essential and conditionally essential nutrients, all important for energy, health, and survival* Going beyond other multiples to further promote optimal brain function with important phytonutrients that help sustain brain cells* Supporting the health of all the body’s organ systems with the full range of vitamins, the essential dietary minerals (except iron and copper), lutein and zeaxanthin for the brain and eyes, resveratrol and hesperidin for the brain and circulation, and coenzyme Q10 (“CoQ”) for the heart* Shoring up the body’s antioxidant defenses with vitamins C and E, the essential minerals zinc, selenium, and manganese, the conditionally essential alpha lipoic acid, CoQ, lutein and zeaxanthin* Including a careful selection of beneficial food concentrates, as well as digestive enzymes to help ensure digestion and absorption* [/wc_box] But Wait, There’s More… In addition to high doses of core ingredients, NeuroVite Plus rounds out its formulation with two proprietary blends developed by Dr. Daniel Amen: Fruit and Vegetable Blend – promotes antioxidant versatility* Digestive Enzyme Blend – supports healthy digestion* Scientifically formulated with optimally bioavailable nutrients in their best-utilized and most effective forms, NeuroVite Plus is the only daily multivitamin for men that delivers comprehensive brain-boosting benefits.* Feed Your Brain The modern diet isn’t providing sufficient average intakes of various essential nutrients. While failing to get enough of these vitamins and essential nutrients may lead to serious, long-term health issues, feeding your brain and body with healthy foods and high-quality supplements can provide tremendous nutritional health support for you and everyone in your family. Nutritional research makes clear that everyone can benefit from taking a multiple vitamin-mineral supplement that’s concentrated, naturally derived, and made with integrity. For all the above, take NeuroVite Plus Multivitamin daily.* At BrainMD, we’re dedicated to providing the highest purity nutrients to improve your physical health and overall well-being. For more information about NeuroVite Plus Multivitamin and our full list of brain healthy supplements, please visit us at BrainMD. *These statements have not been evaluated by the FDA. This content is for informational purposes only. It is not meant to substitute for medical or healthcare advice from a physician, nor is it intended to diagnose, treat, cure, or prevent any disease. Consult your healthcare provider before beginning a new health regimen. References: 1. Passarelli, S., Free, C. M., Shepon, A., Beal, T., Batis, C., & Golden, C. D. (2024). Global estimation of dietary micronutrient inadequacies: A modelling analysis. The Lancet Global Health, 12(10), e1590–e1599. https://doi.org/10.1016/S2214-109X(24)00276-6 2. Blumberg, J. B., Frei, B. B., Fulgoni, V. L., Weaver, C. M., & Zeisel, S. H. (2017). Impact of frequency of multi-vitamin/multi-mineral supplement intake on nutritional adequacy and nutrient deficiencies in U.S. adults. Nutrients, 9(8), 849. https://doi.org/10.3390/nu9080849 3. Lee-Kwan, S. H., Moore, L. V., Blanck, H. M., Harris, D. M., & Galuska, D. (2017). Disparities in state-specific adult fruit and vegetable consumption — United States, 2015. Morbidity and Mortality Weekly Report, 66(45), 1241–1247. https://www.cdc.gov/mmwr/volumes/66/wr/mm6645a1.htm 4. Fletcher, R. H., & Fairfield, K. M. (2002). Vitamins for chronic disease prevention in adults: Clinical applications. JAMA, 287(23), 3127–3129. https://doi.org/10.1001/jama.287.23.3127 5. Kennedy, D. O., Veasey, R., Watson, A., Dodd, F., Jones, E., Maggini, S., & Haskell, C. F. (2010). Effects of high-dose B vitamin complex with vitamin C and minerals on subjective mood and performance in healthy males. Psychopharmacology, 211(1), 55–68. https://doi.org/10.1007/s00213-010-1870-3
Learn more
This is the Best Instantized Creatine Monohydrate for Your Brain and Body
Creatine is a natural substance found in the human body. Many people supplement with creatine to enhance workout performance. But did you know that creatine also has benefits for brain health? Let’s take a closer look at the many benefits of creatine and how it can potentially help you. What Is Creatine? Creatine is a naturally occurring compound found in our muscles, liver, and kidneys. It plays a crucial role in maintaining muscle mass, supporting neurological function, and releasing cellular energy – specifically during short-term, high-intensity activities such as weightlifting or sprinting. Our bodies produce 1-2 grams of creatine daily through dietary intake of fish and other lean meats, along with synthesizing it from amino acids. For those who may require more creatine each day, supplementing with creatine capsules or powders might be a smart option. How Does Creatine Work? Whenever we perform physical activities that require short bursts of energy, our bodies use adenosine triphosphate (ATP) as the primary source of energy. However, ATP stores are quickly depleted within 10-15 seconds of intense exercise. This is where creatine can play a vital role in supporting healthy energy levels. When ingested into the body, creatine turns into phosphocreatine (PCr), which can donate phosphate molecules to help replenish ATP stores. This means that by taking creatine supplements, you may increase your overall levels of PCr and potentially improve your ability to perform high-intensity exercises with less fatigue. Creatine and the Brain Creatine is well-known for its benefits to skeletal muscle tissue. However, when taken as a supplement, creatine is less known for its impressive use by the brain.¹ Within the brain, creatine supports anti-inflammatory pathways and has been shown to prevent the toxic buildup of reactive oxygen species (ROS)² by coupling with ATP in the mitochondria, or by scavenging radical species outside the cell. These processes allow for improved cognitive processing and memory recall by facilitating ATP homeostasis during periods of rapid or altered brain ATP turnover, such as during complex cognitive tasks or periods of sleep deprivation. Is Creatine Right for You? A common misconception about creatine is that it’s just for athletes. The good news is that anyone can reap the benefits of creatine supplementation. That’s why BrainMD created Smart Creatine+, which focuses on both cognitive and physical performance to support overall well-being. Smart Creatine+ Reach your fitness goals faster, support cognitive function, and experience the power of instantized creatine monohydrate with Smart Creatine+, the cleanest and purest creatine monohydrate available on the market.* Our advanced formula offers 100% soluble creatine without the gritty taste or bloating often associated with other leading creatine monohydrate products.* Top Benefits of Smart Creatine+ Smart Creatine+ is scientifically formulated to support: Physical and mental performance* Brain health, cognitive processing, and memory* Increased energy production, endurance, and ATP homeostasis* Lean muscle mass, strength, and recovery* Reduced frequency of injuries* Who Can Benefit from Smart Creatine+? This potent supplement is recommended for those seeking to support cognition, memory, and physical performance.* These individuals include… Older Adults: Studies show that creatine supplementation in this population can help increase muscle mass and strength, decrease fatigue, support skeletal muscle maintenance, and improve the performance of daily activities – independent of exercise training.³* Active Adults: Athletes⁴ and active individuals may benefit from creatine supplementation.* Since creatine pulls water into muscle cells, it supports faster recovery and elevated endurance during physical activity.* Those Seeking Support for Memory and Cognition: Creatine can help the brain produce energy, which supports memory⁵ and cognition.* Quick Facts About Smart Creatine+ Naturally instantized for maximum absorption* 100% soluble and highly bioavailable creatine monohydrate* Higher creatine content, less creatinine than other creatine products* 5-gram dose, based on clinical research* Formulated by leading doctors and experts in brain health and nutrition* Smart Creatine+ Ingredient Creatine Monohydrate NutraAssure® iCreatine® is a premium, patented form of creatine monohydrate formulated for maximum absorption, superior solubility, and easy digestion.* One of only two creatine monohydrates in the world to fully comply with the USP Monograph (the global gold standard) for creatine monohydrate, iCreatine® may help support cognitive function, physical performance, and overall health.* Smart Creatine+ FAQ [wc_box color="inverse" text_align="left" margin_top="" margin_bottom="" class=""] How should I take Smart Creatine+? It’s recommended for adults to mix one scoop with water daily as a dietary supplement, preferably with a meal. When taking this supplement, it’s important to drink plenty of water throughout the day as creatine pulls water inside the cells.* Always use this product as directed by a doctor or healthcare professional. Can this supplement support my cognitive health? As a preventative measure, taking creatine may help support healthy brain aging and protect against cognitive decline and memory loss.* Will this product make me drowsy if I take it during the day? No. This supplement is designed to help support cognitive and physical performance and has no ingredients that can make you feel drowsy or fatigued.* What makes this product different from the competition? Unlike many forms of creatine, Smart Creatine+ offers instantized creatine, which dissolves completely in water.* That means the creatine reaches your muscles instead of floating around in your gut making you feel bloated or crampy.* Do any other BrainMD products complement or enhance the effectiveness of this supplement? Two of the best products to take alongside Smart Creatine+ are Brain & Memory Power Boost and Restful Sleep; they support cognition and help ensure you get quality sleep.* This combination of supplements can serve as the solid foundation for a well-balanced, brain-focused daily supplement routine. Is this product safe to take during pregnancy? As with any supplement, if you’re pregnant, nursing, taking medications, have a medical condition or have difficulty swallowing, consult with your doctor before use.* Does this product have any side effects? Creatine may cause stomach discomfort, water retention (weight gain), and diarrhea in some individuals.* Dehydration is another side effect if you don’t drink enough water throughout the day while taking the supplement.* Can this product make me dependent or addicted? Creatine is a naturally occurring compound in the body and doesn’t lead to dependence. Does Smart Creatine+ contain any allergens? No. It’s free of gluten, soy, corn, eggs, dairy, sugar, lactose, artificial colors or flavors, and GMOs. [/wc_box] Get Smart! Smart Creatine+ is a multifaceted supplement, designed for anyone looking to support their cognitive and physical performance.* Our advanced, no bloat, naturally instantized formula offers 100% soluble and highly bioavailable creatine for improved absorption, drinkability, and digestion.* Try Smart Creatine+ today! [wc_button type="primary" url="/smart-creatine" title="Shop Smart Creatine+" target="blank" url_rel="" icon_left="" icon_right="" position="center" class=""]SHOP SMART CREATINE+[/wc_button] At BrainMD, we’re dedicated to providing the highest purity nutrients to improve your physical health and overall well-being. For more information about Smart Creatine+ and our full list of brain healthy supplements, please visit us at BrainMD. *These statements have not been evaluated by the FDA. This content is for informational purposes only. It is not meant to substitute for medical or healthcare advice from a physician, nor is it intended to diagnose, treat, cure, or prevent any disease. Consult your healthcare provider before beginning a new health regimen. References: 1. Roschel, H., Gualano, B., Ostojic, S. M., & Rawson, E. S. (2021). Creatine supplementation and brain health. Nutrients, 13(2), 586. https://doi.org/10.3390/nu13020586 2. Arazi, H., Eghbali, E., & Suzuki, K. (2021). Creatine supplementation, physical exercise, and oxidative stress markers: A review of the mechanisms and effectiveness. Nutrients, 13(3), 869. https://doi.org/10.3390/nu13030869 3. Rawson, E. S., & Venezia, A. C. (2011). Use of creatine in the elderly and evidence for effects on cognitive function in young and old. Amino Acids, 40(5), 1349-1362. https://doi.org/10.1007/s00726-011-0855-9 4. Buford, T. W., Kreider, R. B., Stout, J. R., Greenwood, M., Campbell, B., Spano, M., Ziegenfuss, T., Lopez, H., Landis, J., & Antonio, J. (2007). International Society of Sports Nutrition position stand: Creatine supplementation and exercise. Journal of the International Society of Sports Nutrition, 4, 6. https://doi.org/10.1186/1550-2783-4-6 5. Prokopidis, K., Giannos, P., Triantafyllidis, K. K., Kechagias, K. S., Forbes, S. C., & Candow, D. G. (2023). Effects of creatine supplementation on memory in healthy individuals: A systematic review and meta-analysis of randomized controlled trials. Nutrition Reviews, 81(4), 416–427. https://doi.org/10.1093/nutrit/nuac064
Learn more
This Is Why You Need To Know These 3 Unexpected Benefits of Saffron
According to the National Institutes of Health (NIH), over 1 in 5 Americans¹ suffer with mental health issues each year, and an estimated 78 million will be afflicted at some point in their lives. Left untreated, mood issues can have serious personal, relational, occupational, financial, and social consequences. The Problem with Mood Problems In the past, some people associated mood problems with a weak will, a character flaw, or heredity. Recent brain research has revealed that these challenges are, in large part, the result of chemical changes in the brain. Depressive thoughts are associated with low activity of certain neurotransmitters in the brain, especially serotonin, norepinephrine, and dopamine, as well as less than optimal levels of nutrients such as folate, vitamin B12, vitamin D, and omega-3 fatty acids. When people with persistent anxious or depressive thoughts seek help (typically from a primary care physician or therapist), most receive medication as the only intervention. However, these medications often have significant side effects, especially in the areas of sexual dysfunction, weight gain, and relapse. Natural Mood Support Cultures around the world have cherished saffron for centuries and have cultivated it for a variety of purposes. Saffron has been used as a culinary spice, digestive aid, aphrodisiac, and mood-booster. It's the only spice able to give color, flavor, and aroma to foods. Derived from the female reproductive parts (stigma) of the flower of Crocus sativus, saffron is produced today just as it has been since ancient times…by hand. The stigmas must be carefully handpicked and dried since machines can’t perform this delicate work. It’s staggering to consider that it takes 4,500 Crocus sativus flowers just to produce one ounce of saffron spice. This labor-intensive extraction process has made saffron the most expensive spice in the world. Saffron = Mood Boost Saffron has been extensively researched in double-blind clinical trials, especially for mood. Several meta-analyses (sophisticated statistical analyses of pooled data from as many as 12 trials) found saffron to be highly effective for mood. Saffron is a valuable addition to comprehensive personalized regimens for mood improvement. Just how saffron works to have this highly impressive mood effect isn't clear at this time. What is clear is that saffron has considerable antioxidant power, due to a uniquely diversified content of carotenoids known as crocins, along with picrocrocin, safranal and well over 100 other plant chemicals with potential health benefits. Some of these work within cell membranes, which are fundamental to the body's ability to make and use energy, and to the brain's trillions of synapses that functionally connect the nerve cells. In addition to its well-established mood benefits, there are other, lesser-known, aspects of saffron that can help support a healthy lifestyle… 3 Unexpected Benefits of Saffron That Can Improve Your Health 1. Supports Learning and Memory Five clinical trials conducted to date suggest saffron has a beneficial impact on cognitive function.² As with mood, the current clinical evidence suggests saffron could be a useful addition to a personalized regimen to improve memory and perhaps also learning, concentration, and other higher brain functions that can deteriorate with advancing age. 2. Helps Suppress Cravings A patented saffron extract called Satiereal® was found to reduce food cravings and other inappropriate food habits in a clinical trial. It reduced feelings of hunger and lowered the frequency of snacking by supporting appetite moderation and healthy weight management. 3. Promotes Healthy Libido Another benefit of saffron observed in its clinical trials for mood, is that it improved sex drive in men and women who experienced difficulties while on a mood medication regimen. Saffron + Curcumin Research has demonstrated that curcumin, the complex of 3 naturally occurring active chemicals in the turmeric root, is a potent and safe ingredient for people with mood and memory challenges. A study published in the Journal of Affective Disorders looked at the efficacy of both curcumin and saffron³ in treating major mood issues. In this randomized, double-blind, placebo-controlled study of 123 individuals with major mood disorder, it was shown that doses of curcumin and combined curcumin/saffron were effective in reducing anxious and depressive thoughts. If you struggle with maintaining a positive mood or just want to have more happiness in your life, try BrainMD’s mood-boosting saffron supplement... Happy Saffron Plus The breakthrough formula in Happy Saffron Plus was scientifically designed to promote a positive mood. It brings together nutraceutical preparations of the two most traditionally revered “happiness herbals” – saffron flower extract and curcumin from the turmeric root – with zinc, a mineral essential for life and vital for positive mood. Why You Need It In the U.S., at least 1 in 5 people endure serious mood problems, and at least 1 in 4 experience significant feelings of anxiousness. Happy Saffron Plus was developed from clinical research with three nutraceuticals for brightening mood, coping with anxious feelings, and enhancing focus while under mental strain. Benefits of Happy Saffron Plus Based on considerable clinical and other scientific research, this formula offers: Powerful support for positive mood Increased capacity for coping with anxiousness Enhanced alertness while under stress What’s in Happy Saffron Plus? Here’s a closer look at the 3 ultra-pure, high-potency ingredients in Happy Saffron Plus: affron® Standardized Saffron Extract This is a highly concentrated and standardized nutraceutical extract of saffron, a spice that has been used in the Middle East for at least 2600 years. Modern clinical research with this specific ingredient fully supports the traditional reverence for saffron's mood-elevating effects. In clinical trials at a dose of just 28 mg per day, this extract has performed extremely well for improving mood and anxiousness in both adults and adolescents. In a recent trial it was also found to improve quality of sleep in adults with sleep complaints. Longvida® Optimized Curcumin Extract The turmeric root has paralleled saffron as an herbal greatly revered for its wide range of benefits, for at least 2600 years. However, consuming turmeric root doesn't get much curcumin into the bloodstream, and nutraceutical technology has now overcome this problem. The Longvida® curcumin preparation, developed at the University of California, Los Angeles, features excellent absorption of curcumin and has worked well in clinical trials at 400 mg per day or higher. Besides being found to improve mood in clinical trials, Longvida was recently shown to improve memory as well. Zinc, as Glycinate This mineral is essential for the functioning of at least 300 enzymes essential for our life processes, and about 2,000 different human proteins. People with mood problems typically have low blood levels and supplementing with zinc often enhances mood. In contrast to zinc sulfate can cause digestive discomfort, zinc glycinate is very well tolerated. Boost Your Bliss This combination of zinc with affron® saffron and Longvida® curcumin offers great promise to elevate mood, perhaps even in individuals who may not feel they have a mood problem. All three of these ingredients are documented to improve mood in controlled human clinical trials. Happier people tend to be healthier, live longer, have better relationships, and experience more success in life. Boost your bliss with Happy Saffron Plus. Try it today! At BrainMD, we’re dedicated to providing the highest purity nutrients and standardized herbal ingredients to support your mood, focus, and overall well-being. For more information about Happy Saffron Plus and our full list of supplements, please visit us at BrainMD. *These statements have not been evaluated by the FDA. This content is for informational purposes only. It is not meant to substitute for medical or healthcare advice from a physician, nor is it intended to diagnose, treat, cure, or prevent any disease. Consult your healthcare provider before beginning a new health regimen. References: 1. National Institute of Mental Health. (n.d.). Mental illness. National Institute of Mental Health. Retrieved February 28, 2025, from https://www.nimh.nih.gov 2. Akhondzadeh, S., Shafiee Sabet, M., Harirchian, M. H., Togha, M., Cheraghmakani, H., Razeghi, S., Hejazi, S. H., Yousefi, M. H., Alimardani, R., Jamshidi, A., Zare, F., & Moradi, A. (2010). Saffron in the treatment of patients with mild to moderate Alzheimer's disease: A 16-week, randomized and placebo-controlled trial. Journal of Clinical Pharmacy and Therapeutics, 35(5), 581–588. https://doi.org/10.1111/j.1365-2710.2009.01133.x 3. Lopresti, A. L., & Drummond, P. D. (2017). Efficacy of curcumin, and a saffron/curcumin combination for the treatment of major depression: A randomised, double-blind, placebo-controlled study. Journal of Affective Disorders, 207, 188–196. https://doi.org/10.1016/j.jad.2016.09.047
Learn more
This Is What You Need to Know About Adaptogenic Mushrooms
Did you know that mushrooms are fungi? Technically, they’re the spore-bearing fruiting body of a fungus. They can grow above ground, on soil, or on its food source. Mushrooms have been used for their medicinal benefits for centuries. They’re also a unique food that can add flavor and texture to a wide variety of meals. Let’s look at some of the beneficial substances that are abundant in mushrooms. Powerful Substances Found in Mushrooms Ergothioneine and Glutathione Mushrooms contain ergothioneine and glutathione, as well as other desirable substances thought to contribute to human health and well-being. Ergothioneine is a powerful antioxidant that doesn’t get destroyed during the cooking process and may enhance immunity. Glutathione is an extremely important antioxidant that can help protect against free radicals. One recent study¹ found that mushrooms are one of the richest dietary sources of ergothioneine and glutathione, potent antioxidants that may protect against oxidative stress and age-related diseases by combating free radicals. Glucans Glucans are a fibrous substance in the cell wall of mushrooms that have been shown to have immune-enhancing abilities² by increasing production of immune “fighter” cells, and supporting the health of the digestive tract where most of the immune tissue in our body resides. Glucans act as a food source for beneficial bacteria in our gut, provide antioxidant activity, and signal the presence of potentially harmful pathogens, thus triggering an essential immune response. Beta-glucans (a unique category of large, branching, complex carbohydrates) don’t affect blood sugar, but can enhance immune activity against infections. Adaptogens According to the Cleveland Clinic, “Adaptogens are plants and mushrooms that help your body respond to stress, anxiety, fatigue and overall wellbeing. You can take adaptogens by adding them to food or beverages or take them as tinctures. Adaptogens bring your body back to a steady balance by managing both physical and mental stressors.”³ The first thing to know about adaptogenic mushrooms is that they aren’t hallucinogenic in nature. However, they can help increase focus and reduce the negative effects of stress. Capsules and powders containing adaptogenic mushrooms have become increasingly popular and prevalent in the world of health and wellness. Here’s a closer look at three of the most well-know and well-studied adaptogenic mushrooms… 3 Types of Adaptogenic Mushrooms [wc_box color="inverse" text_align="left" margin_top="" margin_bottom="" class=""] Cordyceps Cordyceps (Cordyceps militaris), the orange caterpillar fungus, is among the most exotic mushrooms. Cordyceps is widely revered in the East for its benefits to vitality and overall wellness. It helps fight fatigue, supports immunity, helps counter stress, and benefits blood flow and oxygen utilization. Cordyceps is unique for having nucleosides, nutrients essential for our cells to make energy. Nucleosides are also essential building blocks for the DNA of our genes, and for RNA which has numerous vital functions including protein production. It has been found to support immunity in multiple clinical trials. Lion’s Mane Perhaps due to its appearance or name, lion’s mane (Hericium erinaceus) is one of the most well-known mushrooms. Leading all other mushrooms in brain benefits, the lion’s mane mushroom contains unique hericenones and erinacines, which can increase nerve growth factor (NGF)⁴ in the brain. NGF supports nerve cell maintenance and survival, especially in acetylcholine circuits, which are required for focus, memory, as well as for nervous system control of the other organs. Physical activity helps increase brain-derived neurotrophic factor (BDNF), which promotes improved brain function. According to studies, decreased levels of BDNF may increase susceptibility to stress and mood issues. Lion’s mane has shown promise in several clinical trials for improving cognition and mood. Reishi Reishi (Ganoderma lucidum) has been revered for over 2,000 years in Asia as “the mushroom of immortality.” These mushrooms help support the adrenal glands, which secrete cortisol, the body’s primary stress hormone. The mushroom also may help protect against stressors such as low oxygen levels and extreme cold temperatures, and to help people adjust to high altitude environments.⁵ In addition to beta-glucans, reishi contains triterpenes, which can boost both NGF and BDNF while also contributing to immunity and healthy inflammatory response. Reishi has potential to improve human brain health even as it sustains immunity. [/wc_box] These mushrooms are proven tonic medicinals, offering a wide variety of benefits for the brain and body. You’ll find these potent, adaptogenic mushrooms in BrainMD’s… Smart Mushrooms Smart Mushrooms is firmly grounded in the most recent clinical and scientific research on medicinal mushrooms.* It includes six mushrooms that have been revered for hundreds to thousands of years.* All six are highly nutritious, and together they offer a broad spectrum of health benefits.* Here’s a breakdown of the many powerful superfoods you’ll find in Smart Mushrooms: Lion’s Mane has shown promise in several clinical trials for improving cognition and mood, and its glucans also help boost immunity.* Turkey Tail provides protein-bound glucan polysaccharides, intensively researched for their immune benefits.* Cordyceps fights fatigue, supports immunity, helps counter stress, and benefits blood flow and oxygen utilization.* Reishi’s immune and inflammatory response benefits help account for its 2,000-year popularity.* Shiitake provides the glucan called lentinan, which improves immunity, and also has lung, liver, cardiovascular, and gastrointestinal benefits.* Agaricus has a variety of glucans with immune benefits, and supports healthy blood sugar, cholesterol, and liver functions.* Smart Mushrooms offers substantial promise for improving memory, mood, and other cognitive functions.* This functional, full-spectrum superfood blend features six USA grown organic mushrooms, scientifically formulated to promote vitality, stress resistance, immune support, energy, wellness, and high-level brain performance.* It’s the Smart choice for immune and whole-body support.* Eat More Mushrooms Though they may be beneficial for many people, adaptogenic mushrooms may not be a safe choice for everyone. It’s a good idea to speak with a healthcare professional before eating adaptogenic mushrooms or taking them in capsule or powdered form in supplements. If you’re looking for ways to get more mushrooms into your diet, check out these delicious mushroom recipes. At BrainMD, we’re dedicated to providing the highest quality supplements to improve your physical health and overall well-being. For more information about Smart Mushrooms and our full list of brain healthy supplements, please visit us at BrainMD. *These statements have not been evaluated by the FDA. This content is for informational purposes only. It is not meant to substitute for medical or healthcare advice from a physician, nor is it intended to diagnose, treat, cure, or prevent any disease. Consult your healthcare provider before beginning a new health regimen. References: 1. Beelman, R. B., Kalaras, M. D., & Richie, J. P. (2017). Mushrooms: A rich source of the antioxidants ergothioneine and glutathione. Food Chemistry, 233, 429-433. 2. Kidd, P. M. (2000). The use of mushroom glucans and proteoglycans in cancer treatment. Alternatives in Medicine Review, 5(1), 4-27. https://pubmed.ncbi.nlm.nih.gov/10696116/ 3. Cleveland Clinic. (n.d.). Adaptogens. Cleveland Clinic. Retrieved February 20, 2025, from https://my.clevelandclinic.org/health/drugs/24189-adaptogens 4. Ma, B.-J., Shen, J.-W., Yu, H.-Y., Ruan, Y., Wu, T.-T., & Zhao, X. (2010). Hericenones and erinacines: Stimulants of nerve growth factor (NGF) biosynthesis in Hericium erinaceus. Mycology: An International Journal on Fungal Biology, 1(2), 92-98. https://doi.org/10.1080/21501201003735556 5. Sharma, P., Tulsawani, R., & Agrawal, U. (2019). Pharmacological effects of Ganoderma lucidum extract against high-altitude stressors and its subchronic toxicity assessment. Journal of Food Biochemistry, 43(12), e13081. https://doi.org/10.1111/jfbc.13081
Learn more
Menopause Essentials+: Say Goodbye to Hot Flashes and Night Sweats!
Menopause is the stage in a woman’s life when she stops menstruating. What some have termed “the change” actually involves 3 distinct phases: Perimenopause – generally starts in the mid-40s and is the time when a woman’s ovaries gradually stop producing eggs Menopause – usually occurs between ages 45-55 and marks the end of a woman’s reproductive years Postmenopause – occurs when a woman hasn’t had a period for an entire year It can take anywhere from 7-14 years to fully move through these stages. During menopause, the body’s production of the hormones estrogen and progesterone can vary significantly. These hormonal shifts can cause unpleasant symptoms such as hot flashes, mood swings, and sleep problems. To help alleviate these unwanted symptoms, it’s important to maintain a healthy lifestyle during this pivotal time. One way to accomplish this is by taking high-quality supplements like BrainMD’s new… Menopause Essentials+ Formulated with clinically-effective doses of essential vitamins and proprietary ingredients, Menopause Essentials+ offers comprehensive menopausal symptom support.* Designed specifically for women navigating perimenopause and menopause, Menopause Essentials+ is clinically studied to help: Lessen hot flashes and night sweats* Regulate mood and energy* Balance hormone levels* Enhance skin and hair health* Maintain healthy body weight* Support libido* Menopause Essentials+ Ingredients Navigating perimenopause and menopause can be challenging, but Menopause Essentials+ is here to support you every step of the way.* This premium dietary supplement is expertly formulated with clinically effective doses of key ingredients to help alleviate a wide range of menopause symptoms and promote overall well-being.* These high-purity ingredients include: [wc_box color="inverse" text_align="left" margin_top="" margin_bottom="" class=""] EstroG-100® A proprietary blend of Cynanchum wilfordii, Phlomis umbrosa, and Angelica gigas root extracts, EstroG-100® has been clinically shown to improve hot flashes, night sweats, vaginal dryness,¹ and fatigue. Red Orange Complex® (ROC) Sourced from the sun-soaked fields Sicily, ROC® (Citrus sinensis [L.] Osbeck), has been clinically shown in eight human trials to decrease inflammation,² oxidative stress, and DNA damage. It promotes collagen synthesis, supports healthy glutathione levels, and improves skin radiance and moisturization. ROC® also can reduce wrinkle depth and alleviate menopause symptoms such as hot flashes, night sweats, and sleep problems. Trans-Resveratrol Known for its heart-healthy benefits, trans-resveratrol exerts anti-inflammatory activities and supports mental performance, circulation, and skin health. It helps reduce blood glucose levels and insulin resistance, enhancing overall metabolic health. Vitamin D3 Essential for bone health, vitamin D3 helps reduce systemic inflammation and improve muscle strength. It supports optimal blood levels to reduce metabolic disturbances and improve overall health during menopause. Vitamin K2 (MK-7) Vitamin K2 helps support bone strength and circulation. It aids in preventing arterial calcification and enhances the transport of calcium to the bones. [/wc_box] Who Can Benefit from Menopause Essentials+? Women experiencing weight gain and metabolic changes: Menopause Essentials+ contains ingredients that can help mitigate weight gain, improve insulin sensitivity, reduce inflammation, and support a healthier metabolism.* Women with thinning hair and dry skin: The supplement promotes collagen synthesis, improves skin elasticity and moisturization, and supports hair growth with its antioxidant-rich ingredients.* Women at risk of bone loss: With vitamins D3 and K2, Menopause Essentials+ supports bone mineral density and reduces the risk of fractures and age-related bone loss.* Women dealing with fatigue, mood swings, and cognitive issues: The blend of trans-resveratrol and ROC® helps support cognitive performance, mood, and overall well-being, while enhancing mental clarity and reducing feelings of anxiousness.* Women suffering from hot flashes and night sweats: The potent combination of EstroG-100® and ROC® can help reduce the frequency and severity of hot flashes and night sweats, helping you stay comfortable and sleep better.* Here’s Why You Can Trust Menopause Essentials+ Scientifically Backed: Each ingredient in Menopause Essentials+ is included at clinically effective doses to help ensure users receive the maximum benefit from this advanced nutrient formulation.* Broad Symptom Support: The combination of ingredients in Menopause Essentials+ targets a wide array of menopause symptoms, from physical issues like hot flashes and night sweats to cognitive and emotional challenges like mood swings and fatigue.* High-Quality Ingredients: Ethically sourced and manufactured in state-of-the-art facilities, Menopause Essentials+ guarantees high purity, potency, and safety.* Menopause Essentials+ FAQ [wc_box color="inverse" text_align="left" margin_top="" margin_bottom="" class=""] Who should take Menopause Essentials+? Menopause Essentials+ is ideal for women experiencing perimenopause or menopause symptoms such as hot flashes, night sweats, fatigue, weight gain, thinning hair, dry skin, and cognitive issues.* It’s also beneficial for women at risk of bone loss or those looking to improve their overall metabolic health.* If you’re looking for a natural, hormone-free solution to support your well-being during menopause, this product is for you.* How do I take Menopause Essentials+? As a dietary supplement, take Menopause Essentials+ twice daily (2 capsules) with water, preferably with a meal, or as directed by a doctor. This ensures you receive the clinically tested, highly absorbable doses of each ingredient, which can help manage your menopause symptoms.* Can this product make me dependent or addicted? No. Like other BrainMD products, this is a dietary supplement, not a drug, and isn’t habit-forming.* Does this product have any side effects? Menopause Essentials+ is formulated with natural ingredients and is generally well-tolerated.* However, if you have any specific allergies or medical conditions, it’s always advisable to consult with your healthcare provider before starting any new supplement. Is this product safe to take during pregnancy or while breastfeeding? This product isn’t intended for use during pregnancy or when breastfeeding.* What other supplements complement this product? Menopause Essentials+ can be taken with other BrainMD supplements, such as Omega-3 Power, Smart Creatine+, and Smart Collagen to help enhance overall wellness, support hormonal balance, and improve skin health.* Can I take Menopause Essentials+ with other medications or supplements? Menopause Essentials+ can be taken alongside most medications and supplements.* However, to avoid any potential interactions, it’s best to consult with your healthcare provider, especially if you’re on medications for a serious health condition. How long does it take to see results with Menopause Essentials+? Based on leading research, women can expect to notice improvements in their symptoms within a few weeks of consistent use.* However, for optimal results, it’s recommended to take Menopause Essentials+ for at least 8-12 weeks.* Does Menopause Essentials+ contain any allergens? No. It’s free of dairy, eggs, nuts, sugar, soy, yeast, gluten, and artificial colors and flavors. Also, it’s suitable for vegans and is non-GMO. [/wc_box] Support For Every Stage Menopause Essentials+ is meticulously crafted to provide effective doses of clinically-tested, highly absorbable, and bioactive compounds.* Taking Menopause Essentials+ daily can help ensure you receive the powerful benefits of these ingredients, which can help you navigate menopause with greater confidence and comfort.* Invest in your health and well-being with this comprehensive supplement designed to support you through every stage of menopause and beyond.* Try Menopause Essentials+ today! At BrainMD, we’re dedicated to providing the highest quality supplements to improve your physical health and overall well-being. For more information about Menopause Essentials+ and our full list of brain healthy supplements, please visit us at BrainMD. *These statements have not been evaluated by the FDA. This content is for informational purposes only. It is not meant to substitute for medical or healthcare advice from a physician, nor is it intended to diagnose, treat, cure, or prevent any disease. Consult your healthcare provider before beginning a new health regimen. References: 1. Chang, A., Kwak, B.-Y., Yi, K., & Kim, J. S. (2012). The effect of herbal extract (EstroG-100) on pre-, peri-, and post-menopausal women: A randomized double-blind, placebo-controlled study. Phytotherapy Research, 26(4), 510–516. https://doi.org/10.1002/ptr.3597 2. Grosso, G., Galvano, F., Mistretta, A., Marventano, S., Nolfo, F., Calabrese, G., Buscemi, S., Drago, F., Veronesi, U., & Scuderi, A. (2013). Red orange: Experimental models and epidemiological evidence of its benefits on human health. Oxidative Medicine and Cellular Longevity, 2013, 157240. https://doi.org/10.1155/2013/157240
Learn more
Here Are Some of the Best Tips for How to Overcome the Winter Blues
Like it or not, winter is here. For some people, this season is filled with enjoyable things, like: crisper air, snowy vistas and winter sports. But for others, the colder months represent a downturn in mood and energy that leaves them feeling sad, lethargic, and fatigued. Some refer to this as the "winter blues." There are several reasons why a change in seasons can negatively affect a person’s thoughts and feelings.¹ Due to colder temperatures and inclement weather, the tendency for many people is to stay inside where it’s warm and hunker down for the winter. Spending more time indoors can create physiological changes in the brain, which can have a significant impact on attitude and outlook. Also, getting insufficient sunlight can trigger the winter blues. Signs of Winter Blues Many people deal with low mood during the winter months. Whether initiated by the demands of work, relationship challenges, or excessive stress, negative thoughts can come on without warning. Low mood can contribute to adverse physical consequences and also can lead to possible mental health concerns. The signs of winter blues may include: Negative or guilty thoughts Mental fogginess Purposefully avoiding social interaction Overeating and emotional eating Periods of low appetite Difficulty with concentration and memory Since many people dismiss these issues as just feeling down, they may not get the help they need, which can result in serious mental or emotional difficulties. Nutrient Deficiencies A variety of things can affect your mood, but one reason why a change in seasons can cause negative mood is lack of nutrients: [wc_box color="inverse" text_align="left" margin_top="" margin_bottom="" class=""] Low Serotonin The human brain naturally produces a neurotransmitter called serotonin. Serotonin plays many important roles in the brain’s functioning and is involved in maintaining quality sleep, positive mood, self-confidence, and even healthy appetite and social engagement. The winter months tend to keep people indoors, which can lead to weight gain, low energy, negative mood and a falloff in serotonin brain activity. As the neurotransmitter that plays a vital role in mood, a serotonin activity decrease is often linked with an increase in depressive thoughts and feelings. Fluctuations in Melatonin Changing seasons can affect your mood and sleep. Melatonin may help your body adapt to these changes. When sudden drops in this hormone occur, mood and sleep can get out of sync, causing either increased sleep, low mood or mood swings. Taking melatonin may help promote positive mood and maintain normal sleep cycles. If your normal melatonin production is off, a supplement with melatonin may help you feel more balanced. Vitamin D Deficiency Getting necessary amounts of vitamin D can be particularly challenging during the winter season when there are fewer hours of sunlight and when the sun itself is less intense. However, failure to make or absorb enough vitamin D can lead to health problems and other mental and physical difficulties.² The lower your vitamin D levels, the more likely you’ll be to feel blue rather than happy. Low levels of vitamin D have been associated with higher incidences of stress, anxious thoughts and mood issues. [/wc_box] There are many ways you can naturally improve your outlook and help alleviate the issues that come with low mood. Here are just a few… 6 of the Best Ways to Beat the Winter Blues 1. Stay Connected Social connections are incredibly important to your overall well-being. Since the health habits of the people you spend time with can have a dramatic impact on your own health, surround yourself with people who are happy, upbeat, and kind. Also, for personal growth, you need people in your life who will push, teach, and guide you. Spending time in a community of like-minded people is a wonderful way to boost your bliss hormones, such as oxytocin. Focusing your energy on positive people can affect your everyday life and longevity. 2. Supplemental Light Source Daily exposure to appropriate levels (even just 10 to 30 minutes a day) of direct sunlight can boost vitamin D3 levels which can help improve your mood. If you find it challenging to get enough natural light during the winter, consider buying a light box or vitamin D lamp for your home or work desk. These alternate light sources simulate noontime sunshine without the UV rays that cause skin cancers. Be sure to purchase a light box that’s proven to increase vitamin D levels, features several different settings to prevent eyestrain and is as close to the natural sunlight spectrum as possible. 3. Good Mood Foods Since your brain uses more than 20% of your body’s total energy, it requires high-quality food with specific vitamins and nutrients to use as fuel throughout the day. What you eat can greatly affect your brain’s overall performance. Making healthier choices in your diet will not only help control your waistline, it can also help lift your mood and provide a long-lasting increase in energy and focus. Add a variety of mood-boosting foods to your next grocery list. 4. Take a Trip If getting enough UVA (ultraviolet A) rays from the sun proves difficult during the winter months, especially for those who live in the northern half of the U.S., consider saving up some money during the summer for a vacation to a sunny destination (the Caribbean, for instance) during the winter. This will make enduring the cold, dark months more bearable, and boost your vitamin D levels. 5. Pamper Yourself If you typically feel down or get stressed out during the winter months, look for ways to pamper yourself. Getting a massage can do more than just improve your physical function. Clinical studies indicate that a massage is beneficial for improving mood³ and coping with stress. Massages can help to reduce the stress hormone cortisol and increase the activity of such neurotransmitters as dopamine and serotonin. 6. Get Dietary Supplement Support Whether you find yourself having negative thoughts, or if you feel that your stress levels have nearly reached the breaking point, BrainMD offers a range of powerful supplements for mood and stress that can help turn your day around.* These brain-directed supplements have been formulated with the highest quality ingredients that can help you feel calm, content, and able to manage stress or mental strain.* Adopting these healthy habits can help improve your mood during the winter months. At BrainMD, we’re dedicated to providing the highest quality supplements to improve your physical health and overall well-being. For more information about our full list of brain healthy supplements, please visit us at BrainMD. *These statements have not been evaluated by the FDA. This content is for informational purposes only. It is not meant to substitute for medical or healthcare advice from a physician, nor is it intended to diagnose, treat, cure, or prevent any disease. Consult your healthcare provider before beginning a new health regimen. References: 1. National Institute of Mental Health. (n.d.). Seasonal affective disorder. National Institutes of Health. https://www.nimh.nih.gov/health/topics/seasonal-affective-disorder 2. Silva, M. R. M., Barros, W. M. A., da Silva, M. L., da Silva, J. M. L., Souza, A. P. S., da Silva, A. B. J., Fernandes, M. S. S., de Souza, S. L., & Souza, V. O. N. (2021). Relationship between vitamin D deficiency and psychophysiological variables: A systematic review of the literature. Clinics (Sao Paulo), 76, e3155. https://doi.org/10.6061/clinics/2021/e3155 3. Sharpe, P. A., Williams, H. G., Granner, M. L., & Hussey, J. R. (2007). A randomised study of the effects of massage therapy compared to guided relaxation on well-being and stress perception among older adults. Complementary Therapies in Medicine, 15(3), 157-163. https://doi.org/10.1016/j.ctim.2007.01.004
Learn more
This Is How to Boost Your Attention and Energy with Choline Supplements
Do you feel like you don’t have enough energy to get through the day? Is it difficult for you to finish things once you’ve started them? Do you find it hard to concentrate? If you answered yes to any of those questions, you might be low in choline and could benefit from choline supplements. What is Choline? Though not traditionally regarded as a vitamin, choline was recently reclassified as an essential nutrient. Choline is fundamental to all our cell, tissue, and organ functions, and is crucial for brain function. Choline also is very important for a healthy pregnancy. The U.S. Govt. has made recommendations for adequate dietary intake of choline. Surveys indicate that as many as 9 of 10 Americans, including most pregnant and lactating women,¹ have intakes well below the recommended Adequate Intake for choline. Choline and the Brain Choline is an essential molecular building block for acetylcholine, our most abundant and versatile nerve transmitter. As its name suggests, acetylcholine has choline as part of its molecular structure. Brain circuits that use this transmitter are called cholinergic, and cholinergic neurotransmission is crucial for memory, learning,² mental clarity, focus, and concentration. Choline also plays an important role in maintaining cell membranes, the thin molecular sheets that define most of the structure and functioning of all our cells. Choline is part of the structure of phosphatidylcholine, a key membrane building block. Choline and Methyl Groups Choline is fundamental to all life as a source of methyl groups, each a deceptively simple combination of one carbon atom with three hydrogen atoms. Choline is a major dietary source of methyl groups, which the brain needs for making the neurotransmitter epinephrine, the sleep hormone melatonin, and the myelin insulation of its nerve cells. The brain and other organs routinely have a high demand for methyl, and choline’s methyl groups back up the methyls we obtain from dietary methylfolate and methyl vitamin B12. As a methyl backup, choline also helps ensure healthy gene function. Our neurons and all our other cells require methyl to make and maintain their DNA, to turn their genes on and off (epigenetic controls), for growth and maintenance, to regulate homocysteine which is a potentially toxic metabolic byproduct, and for numerous other life functions. The liver is the body’s main methyl coordinator and needs choline to make bile for healthy digestive function; choline deficiency is associated with liver fat buildup (“fatty liver”) and risk for ongoing liver damage. Liver problems also can drain the energy of the entire body. Choline-rich Foods Our bodies normally can make a small amount of choline, but some people have gene mutations that impair their capacity to make it. Though all of us rely on food sources for some of our daily intake, a large percentage of women, children, and older men are not receiving adequate choline in their diets. Choline deficiency can increase the risk of poor concentration, poor memory, and other cognitive impairments, especially as we age. Choline can be found in many foods, including liver, beef, salmon, cod, cauliflower, and Brussel sprouts. Many refer to eggs as a “brain food,” since the yolks are rich in choline. Choline is especially present in animal products, so vegetarians and vegans are more prone to experiencing a deficiency in choline. Although eating a varied diet increases the likelihood that you are consuming enough choline, you may consider trying a supplement that contains choline – especially if you find yourself struggling with memory, focus, attention, or learning. BrainMD recognizes choline’s importance by including it in our premier multiple, NeuroVite Plus Multivitamin. Choline is also featured in two of our specialized brain supplements. 2 Powerful Choline Supplements to Boost Your Attention and Energy Focus & Energy It’s not uncommon for people to have periods where they feel tired or unfocused. BrainMD’s Focus & Energy was designed to promote sharpness, improve mental and physical productivity, and prevent fatigue without lowering blood sugar.* Unlike many other dietary supplements, Focus & Energy provides nutritional and medicinal plant concentrates that are traditionally used as adaptogens and are clinically researched for these benefits.* Focus & Energy is formulated specifically to reinforce the brain and body’s ability to fight fatigue and adapt to stress.* Its 55 milligrams of choline makes a substantial contribution to the recommended intakes.* It contains a potent green tea extract, high in EGCG and other polyphenol antioxidants, chosen specifically to intensify blood flow that enables oxygen and nutrient delivery to the brain.* Focus & Energy also contains three highly concentrated plant adaptogens, renowned for helping brain and body cope with mental or physical stress: Ashwagandha is an Ayurvedic medicinal revered over thousands of years for its mental sharpening benefits.* Modern clinical research reveals it is also superb for coping with stress³ and occasional anxiety.* Rhodiola thrives in the most extreme Siberian climates and is a favorite in the East. This concentrate is doubly standardized and has shown strong anti-stress benefits in clinical trials.* Asian (Panax) ginseng leads all other ginsengs for its almost immediate mental focus benefits.* This concentrate is loaded with 15% brain-active ginsenosides and has been subjected to intensive research, with excellent results.* If you’re looking for a safe, effective, and natural way to support your mental focus while conserving your mental and physical energy, Focus & Energy is an excellent choice.* And unlike the energy rush, you can get from your stimulant of choice (coffee, diet soda, caffeine pills), there’s no dramatic drop in mood and energy with this dietary supplement.* Focus & Energy is safe, natural, and non-habit forming.* Attention Support Attention Support can increase your attention span while helping you stay relaxed and calm.* Increase your (or your child’s) potential with Attention Support’s natural focus boosters.* Its ingredients were picked for their clinically proven benefits for attention, concentration, calm, and overall self-control.* It also promotes healthy memory and learning in both children and adults.* This formula includes: Choline – a vitamin-like nutrient that supports the brain’s production of acetylcholine, which is also the nerve transmitter that triggers our muscles to contract.* Magnesium – magnesium is fundamental to the brain’s ability to generate energy, maintain its nerve cell connections, and conduct the electrical activity that underlies all its functions.* PhosphatidylSerine (PS) – as a cell membrane building block, PS is highly concentrated in the brain and is clinically proven to support healthy attention, learning, and memory.* Pycnogenol® – a uniquely powerful antioxidant concentrate that promotes the delivery of blood to the brain, Pycnogenol® is the most extensively researched of all the herbal antioxidants.* Vitamin B6 – an essential cofactor for a number of enzymes involved in the production of several neurotransmitters linked to attention and a healthy mood.* Zinc – an essential mineral, required by at least 100 enzymes and crucial for antioxidant protection of the brain, is often found deficient in people with mood problems.* Attention Support gives your brain the nutrients it needs, so its self-regulating processes can keep on top of challenges and allow you to stay focused and productive.* To be successful in today’s world, you need a clear mind and sharp focus. Focus & Energy and Attention Support are two of the best ways to help you achieve your goals.* At BrainMD, we’re dedicated to providing the highest purity nutrients to help give you the attention, focus, and energy you need to do the things you love. For more information about our full list of brain healthy supplements, please visit us at BrainMD. *These statements have not been evaluated by the FDA. This content is for informational purposes only. It is not meant to substitute for medical or healthcare advice from a physician, nor is it intended to diagnose, treat, cure, or prevent any disease. Consult your healthcare provider before beginning a new health regimen. References: Brunst, K. J., Wright, R. O., DiGioia, K., Enlow, M. B., Fernandez, H., Wright, R. J., & Kannan, S. (2014). Racial/ethnic and sociodemographic factors associated with micronutrient intakes and inadequacies among pregnant women in an urban US population. Public Health Nutrition, 17(9), 1960–1970. https://doi.org/10.1017/S1368980013003224 Huang, Q., Liao, C., Ge, F., Ao, J., & Liu, T. (2022). Acetylcholine bidirectionally regulates learning and memory. Journal of Neurorestoratology, 10(2), 100002. https://doi.org/10.1016/j.jnrt.2022.100002 Baker, C., Kirby, J. B., O'Connor, J., Lindsay, K. G., Hutchins, A., & Harris, M. (2022). The perceived impact of Ashwagandha on stress, sleep quality, energy, and mental clarity for college students: Qualitative analysis of a double-blind randomized control trial. Journal of Medicinal Food, 25(12), 1095–1101. https://doi.org/10.1089/jmf.2022.0042
Learn more
How to Have Better Balance in Your Life
To be your best, you need your brain to be its best. When your brain works right, you tend to be effective, thoughtful, creative and energetic. But when your brain function is out of balance, you may have problems with mood, stress, impulsivity, anger, inflexibility, memory, work performance, and your relationships. It’s estimated that your brain has 86 billion nerve cells,¹ with each one connected to other cells by up to ten thousand individual connections. They communicate using electrical signals and messenger chemicals called neurotransmitters. Neurotransmitter Essentials Neurotransmitters (or just transmitters) are substances selectively produced and released by individual nerve cells to pass across the trillions of junctions between the cells (synapses) and coordinate clear communications both within your brain, and between your brain and the rest of your body. These back-and-forth transmissions influence practically every cell, tissue, and biological decision in your body. As transmitters are released by the nerve cells, they quickly travel across the synapse and impact receptors, proteins built into the receiving cell. These tiny antennas, and the transmitters to which they respond, make up a transmitter system. Proper neurotransmitter balance via the harmonious coordination of their systems is essential for living a brain healthy life. The better your transmitters work with each other, the closer you are to having optimal mental function. Transmitters such as serotonin‚ dopamine‚ and GABA play key roles in healthy brain functioning‚ which is essential to healthy behaviors and decision-making. More important than the activity of any one transmitter system is the overall balance between all the systems in the brain. When your brain transmitters are balanced, you may think more clearly, feel happier, and experience greater well-being. But when your transmitters are out of balance, you may experience difficulties in every area of your life. If you feel overly stressed or out of whack, the good news is that you can change how your brain functions. Try these 6 tips for achieving better balance in your brain and life… 6 of the Best Ways to Stay Balanced in Life 1. Prioritize Your Goals If working on all your goals at once becomes overwhelming, set up a hierarchy. Select a few things you absolutely must accomplish, several things you want to complete and many things that would be nice to finish in the future. Not only will this organizational structure allow you to focus on the essentials, it will also help to reduce the debilitating pressure of trying to juggle so many objectives at one time. 2. Soothing Tunes It’s no surprise that listening to music can increase pleasurable feelings, improve mood, boost energy, raise your brain’s dopamine activity and help with focus and concentration. Remaining in a relaxed state of mind is easier to accomplish when you have a happy tune running through your head. Listen to brain-enhancing music specifically composed to enhance mood, gratitude, motivation, and inspiration. 3. Happy Place As a coping mechanism, many people retreat to a “happy place.” Choose a haven, a place where you feel comfortable and that you can imagine with all your senses. If it’s the beach, visualize the ocean, feel the sand between your toes and the warm sun on your skin. Your haven can be any real or imaginary place where you’d like to spend time. Spend at least 10 minutes a day on this relaxing, life-changing exercise. You should feel calmer in a short period of time. 4. Brain-healthy Smoothie Unlike a caffeinated, sugar-laden breakfast on the run, choosing a healthy protein smoothie can help stabilize your blood sugar and prevent energy crashes. Getting a healthy serving of protein provides the brain with the nutrition you need to do your best thinking. Not only can protein smoothies provide high value nutrition, they also hydrate your brain and body too. Our bodies dehydrate during the night, so re-hydrating the brain first thing in the morning is a great way to get your mental function flowing and attain better balance throughout the day. 5. Deep Breathing Deep breathing is an effective relaxation technique that can be done anywhere, anytime. Whenever you feel angry, moody or stressed, take a deep breath, hold it for one or two seconds, then slowly exhale for about five seconds. Do this about 10 times and you’ll start to feel more relaxed. It’s much easier to achieve a balanced mood when you slow down and become more efficient with your breathing. 6. Get Nutritional Support If you have excessive stress or anxious/negative thoughts, help has arrived. BrainMD provides potent, high-purity nutrients to support the brain’s neurotransmitter systems. These brain-directed supplements have been formulated with the most clinically researched, highest quality ingredients that can help you feel calm, content, and able to manage stress or mental strain. Here are 2 of our top supplements to keep your brain and body balanced… NeuroLink BrainMD’s NeuroLink supports a diverse array of such key transmitters as adrenaline, noradrenaline, dopamine, serotonin, GABA, and glutamate.* NeuroLink provides an exclusive blend of nutrients that can help you maintain a positive mood, keep your focus, and deal with stressful challenges by helping your neurotransmitters stay in balance.* 5-HTP– In the brain, 5-HTP (5-hydroxytryptophan) is readily converted to serotonin to help maintain mental and emotional well-being, reduce anxious feelings, promote calm and relaxation, and enhance the quality of sleep.* GABA – This amino acid, technically gamma-aminobutyric acid, regulates excitability of nerve circuits in the brain and is considered the brain’s main calming neurotransmitter.* Taurine – Taurine, another amino acid, helps stabilize our nerve cell electrical activity and is known to enhance GABA’s calming effects.* Tyrosine – Tyrosine is required for the production of the neurotransmitters dopamine, adrenaline and noradrenaline. Having sufficient tyrosine in the brain promotes mental clarity in dealing with stress.* NeuroLink helps relieve stress, improve mood and provide better balance, so you can feel brighter again.* Serotonin Mood Support Our brain produces the naturally soothing neurotransmitter called serotonin. Serotonin plays many important roles in the brain’s biochemistry and is involved in maintaining healthy mood and promoting feelings of calmness. Serotonin Mood Support was developed to promote serotonin activity in the brain.* This formula includes: Vitamin B6 – This vitamin is fundamental to healthy brain function.* Vitamin B6 is also an essential cofactor for enzymes that make serotonin and other key transmitters.* Methylfolate – Methylfolate is pre-activated and is the body’s most readily utilized form of the folate vitamin.* It is better utilized than folic acid, which is a manufactured substance not found in nature.* Methylfolate is paired in this formula with methyl-vitamin B12 to help ensure the brain has sufficient methyl to make melatonin (our sleep hormone) and has the biochemical tools for renewing and maintaining its nearly 200 billion cells.* Saffron – The world’s most expensive herb, saffron has a long history of traditional use for inducing happiness.* Saffron has consistently improved mood,² stress, and other mental functions in many clinical trials.* Lifestyle habits such as consuming smart carbohydrates in moderation and taking a dietary supplement like Serotonin Mood Support can work together to elevate mood and promote calm.* Adopting these brain healthy habits can help to improve your emotional well-being and provide better balance in your life. At BrainMD, we’re dedicated to providing the highest quality supplements to improve your physical health and overall well-being. For more information about NeuroLink, Serotonin Mood Support and our full list of brain healthy supplements, please visit us at BrainMD. *These statements have not been evaluated by the FDA. This content is for informational purposes only. It is not meant to substitute for medical or healthcare advice from a physician, nor is it intended to diagnose, treat, cure, or prevent any disease. Consult your healthcare provider before beginning a new health regimen. References: 1. National Institutes of Health. (2023, October 31). Scientists build largest maps to date of cells in human brain. NIH Research Matters. Retrieved February 7, 2025, from https://www.nih.gov/news-events/nih-research-matters/scientists-build-largest-maps-date-cells-human-brain 2. Jackson, P. A., Forster, J., Khan, J., Pouchieu, C., Dubreuil, S., Gaudout, D., Moras, B., Pourtau, L., Joffre, F., Vaysse, C., Bertrand, K., Abrous, H., Vauzour, D., Brossaud, J., Corcuff, J. B., Capuron, L., & Kennedy, D. O. (2021). Effects of saffron extract supplementation on mood, well-being, and response to a psychosocial stressor in healthy adults: A randomized, double-blind, parallel group, clinical trial. Frontiers in Nutrition, 7, 606124. https://doi.org/10.3389/fnut.2020.606124
Learn more