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Dr. Amen Favorite

ProBrainBiotics

The original, doctor-developed psychobiotic for better brain & gut health*

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Description

Formulated with just two clinically researched probiotic strains, Bifidobacterium longum R0175 and Lactobacillus helveticus R0052, ProBrainBiotics delivers targeted gut-brain support you can actually feel.*

R0175 is backed by over 50 published studies showing benefits for digestion, immunity, and gut microbiome balance.* R0052 has been shown to support healthy mood, stress resilience, and digestive comfort.* Together, they work to nourish your gut, strengthen your immune defenses, and keep your brain sharp.*

With a full 60-day supply in every bottle, ProBrainBiotics makes it easy to stay consistent. Because when your gut is happy, your brain is too.*

Benefits

✔ Helps maintain healthy digestion & regularity*
✔ Supports mood, mental clarity & focus via the gut-brain axis*
✔ Promotes healthy immune function*
✔ Gentle enough for daily use*
✔ 60-day supply for consistent results and better value*
✔ Shelf-stable—no refrigeration required*

How to use

USE: Take 1 capsule daily with food, or as directed by your healthcare provider.*†

EARLY RESULTS: Some users notice digestive improvements—like reduced bloating and more regularity—within the first week.*†

LONG-TERM BENEFITS: With consistent daily use, you may experience improvements in mood, focus, and overall cognitive performance as your gut microbiome and brain stay in sync.*†

*†Results may vary based on individual health and fitness levels. Consistent use, in conjunction with a healthy lifestyle, is recommended.

DOCTOR’S RECOMMENDATION: Take ProBrainBiotics with NeuroVite Plus Multivitamin and Omega-3 Power for optimal gut-brain and brain-body benefits.*

Ingredients

Lactobacillus helveticus Strain R52
Bifidobacterium longum Strain R175

Key Benefits

Digestion

Mood

Stress Support

Key Ingredients

Lactobacillus helveticus Strain R52

2.7 billion CFU

Lactobacillus helveticus Strain R52 is a beneficial probiotic that supports digestive health by maintaining the integrity of the intestinal lining.* It helps balance the gut microbiome, promoting the growth of healthy bacteria that aid digestion and nutrient absorption.* This strain also supports immune function by strengthening the gut’s natural defenses.* Together, these effects contribute to better digestion, enhanced immunity, and overall gut wellness.*

Bifidobacterium longum Strain R175

0.3 billion CFU

Bifidobacteria are beneficial probiotics that help break down complex carbohydrates, producing short-chain fatty acids that nourish and protect the cells lining the intestines.* These fatty acids support a healthy gut barrier, and when combined with Lactobacillus helveticus R0052, this strain enhances overall digestive health and helps strengthen the immune system.* Together, they promote a balanced gut microbiome, support nutrient absorption, and may help the body better manage occasional stress, contributing to improved well-being.*

Supported By Clinical Research

Select Probiotics May Improve Mood and Stress Response

Clinical trial on psychobiotics and emotional wellbeing

A specific blend of Lactobacillus helveticus R0052 and Bifidobacterium longum R0175 was found to reduce psychological stress and support emotional balance in healthy adults.
(Messaoudi 2011)

Bifidobacteria May Reduce Inflammatory Response to Gluten

Cell study on immune modulation by probiotics

Bifidobacteria strains reduced inflammation caused by gliadin peptides, suggesting a protective role in gluten-sensitive individuals.
(Laparra & Sanz 2010)

From Your Gut To Your Brain*

The Smarter Probiotic Choice*

Forget the “kitchen sink” probiotics that throw in dozens of random strains with no clear purpose. ProBrainBiotics is different. With just two carefully chosen, clinically researched strains, it’s designed to work with your body to support digestion, immunity, and the gut-brain connection—the communication highway between your stomach and your mind.* The result? Less bloating, steadier digestion, and better mental clarity—every single day.*

✔ Supports healthy digestion & regularity*
✔ Promotes a balanced gut microbiome*
✔ Nourishes the gut-brain axis for improved mood & focus*
✔ Helps keep your immune system strong*

Daniel G. Amen, MD, founder of BrainMD and Amen Clinics

“ProBrainBiotics is the original brain-boosting probiotic—simple, clean, and clinically effective for gut, mood, and stress support.”

“These probiotic strains are one of the best-researched pairs for mood and digestion. This formulation makes it easy to support both with one capsule a day.”

"When the gut is balanced, the mind benefits too. I recommend ProBrainBiotics for patients wanting steady digestive health and mental sharpness without harsh formulas."

Targeted Support That Works*

Better Results, Better Value*

With 60 capsules per bottle, ProBrainBiotics gives you a full two months of daily gut-brain support—so you can stay consistent. And because it’s gentle, effective, and backed by decades of research, it’s safe for everyday use. Whether you want to improve digestion, boost immune health, or support your mood, ProBrainBiotics is your go-to probiotic for better health from the inside out.*

What To Expect

Day 1–7

Clinically studied probiotics begin activating in the gut microbiome—feeding friendly bacteria, balancing digestion, and supporting gut lining integrity. Some may notice less bloating or digestive discomfort within the first week.*

Week 2–4

As beneficial bacteria flourish, gut-brain communication improves. Clinical studies show users may experience better mood stability, reduced stress sensitivity, and a greater sense of calm and clarity by Week 3–4.*

Month 2

Emotional resilience continues to strengthen, supported by healthier neurotransmitter activity and better microbial diversity. Many report steadier energy, improved outlook, and smoother digestion.*

3 Months+

With daily use, ProBrainBiotics helps maintain a thriving gut microbiome—fueling the gut-brain axis for long-term support of mood, focus, digestion, and stress response.*

FAQ

How do I take ProBrainBiotics?

Take one or two capsules daily with a meal, or as recommended by a physician.*

Who can benefit from taking ProBrainBiotics?

Nearly everyone is likely to benefit from this broad-spectrum probiotic supplement.* This includes the elderly, people who have been exposed to pollutants, and those with poor dietary habits or digestive problems.* Individuals with mood problems, dealing with excessive stress, or desiring a stronger immunity may benefit from this efficacious pairing of probiotic strains.*

Do I need to take a probiotic supplement every day or only for occasional support?

Probiotic supplements aren’t likely to give immediate relief for intestinal problems.* The live bacteria they supply must settle in, reproduce, and get to numbers that can become functionally significant in and amongst the trillions of other bacteria already in the gut.* The human gut is a complex, intricate matrix of micro-ecosystems with bacteria as major players, and adjustments take time.* Well-designed clinical trials can help inform us about the utility of any probiotic strain.* The clinically documented benefits of the strains in ProBrainBiotics are likely to increase over a period of weeks.*

Should I rotate my probiotic supplement every 3-4 months for maximum benefit?

No. There’s no clinical evidence this is necessary or even helpful.* With clinically researched strains that are highly likely to improve overall microbiome functioning, the longer they’re consumed the better the results tend to be.*

Are there any side effects to taking ProBrainBiotics?

No. As with other BrainMD products, this is a dietary supplement, not a drug, and isn’t habit-forming.* It’s free from dairy, glutens, sugar, corn, soy, nuts, eggs, yeast, and artificial colorings or flavorings.* It’s compatible with keto or paleo dietary patterns.*

Overall rating: 4.711765 / 5 from 340 reviews.

AI Generated Review Summary

ProBrainBiotics, a doctor-developed probiotic supplement, is praised for its quality and effectiveness in supporting gut health, mood, and stress resilience. Customers report feeling clearer and more energetic, with a stronger immune system. With a 60-day supply, it offers a consistent way to nourish the gut and enhance brain function.

Summary topics

Product Quality (6%): It was highlighted by customers that the quality of the product is great and top-notch.
Supplement Effectiveness (6%): Customers raved about the ProBrainBiotic supplement, praising its effectiveness and affordable price.
Mood and Stress Effect (4%): Customers expressed appreciation for the product's ability to positively affect their mood and ability to deal with stress.
Gut Health (4%): Customers loved the gut health product, as it made their gut stronger and their mind stronger.
Immune System Support (3%): It was observed by customers that this product helps improve gut health and immune system, with a stronger immune system.

Review topics: ["feel","quality","stomach","issues","results","ingredients","body","shipping","improvement","benefits","symptoms","price","discomfort","probiotic","difference","supplement","probrainbiotics","effect","health","brain","works","gut","mood","bloating","dairy","order","change","digestion","outlook","system"].

Review highlights

"I was looking for a reliable ProBiotic- and the ProBrainBiotic is a good supplement." — Ellyn T.
"For a stong and healthy gut health equals a stronger immune system." — Lorraine A.
"healthy gut healthy brain" — Roberta W.

Reviews

Great Probiotic!

"I'm very happy with ProBrainbiotics! I've experienced no discomfort at all in switching probiotics, and am experiencing positive effects in my digestion and brain. I feel like I am much better able to multi-task again. I'm caring for my Mom with dementia and learning first hand how important it is to take care of your body and your mind through the years. This product is vital self care for me."

— Darci Y. (5/5)

BrainMD supplements

"We haven't had a bad experience with any of the supplements from BrainMD. I am glad that the proBrainbotics do not cause my son a stomachache. We will be getting follow up blood work in a few months and are hoping to see the numbers change, however so far, the regime we discussed with Amen Clinics has been very beneficial."

— Jaxsen D. (5/5)

Neutral

"To be honest, I don’t notice anything different in the way I feel. I’m not sure how taking probiotics of any kind from anyone is supposed to affect my health and well being, I’m a big fan of Dr. Amen, though, and trust him and his advice."

— Mary K. (3/5)

I have used probiotics for

"I have used probiotics for many years. I chose ProBRAINbiotics after comparing it to a number of other brands. I like the number of colony forming units of the two bacteria strains that appear to be of importance in choosing a probiotic. It helps that it does not require refrigeration."

— Elaine C. (5/5)

Good

"I seem to notice a difference in my bowels when I take this and when I don't when I take it I have a lot less gas bloating. Haven't noticed much about the brain but does help my digestive issues."

— Donna M. (4/5)

Makes my tummy better

"I have a sensitive stomach and taking this ProBiotic makes my stomach feel so much better every time I take it."

— Carmen T. (5/5)

Best Probiotic!

"Best probiotic I ever used and doesn’t upset your stomach like most brands."

— Maurice P. (5/5)

Bought it for family member

"Bought it for family member who was having some memory issues. Also with dietary changes and this brain probiotic, we’ve seen some improvement"

— Diane R. (5/5)

Seems good!

"Its easy to take with a meal, no bad taste and i feel great"

— Karla N. (5/5)

Good for my brain and my gut

"I switched to this probiotic a few years back. It has never bothered my stomach and allows me piece of mind that my gut brain connection is being fed!"

— Tara T. (5/5)

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