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Dr. Amen Favorite

ProBrainBiotics

Name: ProBrainBiotics
Brand: BrainMD by Daniel Amen, MD
SKU: 106
Price: 44.95 USD
Availability: InStock
Rating: 4.7 (310 reviews)

The original, doctor-developed psychobiotic for better brain & gut health*

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Description

Formulated with just two clinically researched probiotic strains—Bifidobacterium longum BB536 and Lactobacillus rhamnosus R0011—this doctor-developed formula delivers targeted gut-brain support you can actually feel.*

BB536 is backed by over 50 published studies showing benefits for digestion, immunity, and gut microbiome balance.* R0011 has been shown to support healthy mood, stress resilience, and digestive comfort.* Together, they work to nourish your gut, strengthen your immune defenses, and keep your brain sharp.*

With a full 60-day supply in every bottle, ProBrainBiotics makes it easy to stay consistent—because when your gut is happy, your brain is too.*

Benefits

✔ Helps maintain healthy digestion & regularity*
✔ Supports mood, mental clarity & focus via the gut-brain axis*
✔ Promotes healthy immune function*
✔ Gentle enough for daily use*
✔ 60-day supply for consistent results and better value*
✔ Shelf-stable—no refrigeration required*

How to use

USE: Take 1 capsule daily with food, or as directed by your healthcare provider.*†

EARLY RESULTS: Some users notice digestive improvements—like reduced bloating and more regularity—within the first week.*†

LONG-TERM BENEFITS: With consistent daily use, you may experience improvements in mood, focus, and overall cognitive performance as your gut microbiome and brain stay in sync.*†

*†Results may vary based on individual health and fitness levels. Consistent use, in conjunction with a healthy lifestyle, is recommended.

DOCTOR’S RECOMMENDATION: Take Put Me To Sleep Naturally with NeuroVite Plus Multivitamin and Omega-3 Power for optimal sleep and brain-body benefits.*

Ingredients

Lactobacillus helveticus Strain R52
Bifidobacterium longum Strain R175

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Key Benefits

Digestion

Mood

Stress Support

Key Ingredients

Lactobacillus helveticus Strain R52

2.7 billion CFU

Lactobacillus helveticus Strain R52 is a beneficial probiotic that supports digestive health by maintaining the integrity of the intestinal lining.* It helps balance the gut microbiome, promoting the growth of healthy bacteria that aid digestion and nutrient absorption.* This strain also supports immune function by strengthening the gut’s natural defenses.* Together, these effects contribute to better digestion, enhanced immunity, and overall gut wellness.*

Bifidobacterium longum Strain R175

0.3 billion CFU

Bifidobacteria are beneficial probiotics that help break down complex carbohydrates, producing short-chain fatty acids that nourish and protect the cells lining the intestines.* These fatty acids support a healthy gut barrier, and when combined with Lactobacillus helveticus R0052, this strain enhances overall digestive health and helps strengthen the immune system.* Together, they promote a balanced gut microbiome, support nutrient absorption, and may help the body better manage occasional stress, contributing to improved well-being.*

Supported By Clinical Research

Probiotics May Support Digestive Regularity

Randomized controlled trial on probiotic strains and gut transit time

Bifidobacterium lactis HN019 was shown to improve bowel regularity and reduce gastrointestinal discomfort in a dose-dependent manner.
(Waller 2011)

Select Probiotics May Improve Mood and Stress Response

Clinical trial on psychobiotics and emotional wellbeing

A specific blend of Lactobacillus helveticus R0052 and Bifidobacterium longum R0175 was found to reduce psychological stress and support emotional balance in healthy adults.
(Messaoudi 2011)

Bifidobacteria May Reduce Inflammatory Response to Gluten

Cell study on immune modulation by probiotics

Bifidobacteria strains reduced inflammation caused by gliadin peptides, suggesting a protective role in gluten-sensitive individuals.
(Laparra & Sanz 2010)

Lactiplantibacillus plantarum May Enhance Cognitive Function

Randomized controlled trial in stressed individuals

Supplementation with L. plantarum HEAL9 improved attention and memory in moderately stressed participants.
(Onning 2023)

Probiotic Strains Influence Brain-Related Protein Expression

Animal study on gut-brain communication

Bifidobacterium longum Rosell-175 and Lactobacillus rhamnosus JB-1 impacted brain protein profiles associated with emotional regulation.
(Jarosz 2023)

From Your Gut To Your Brain*

The Smarter Probiotic Choice*

Forget the “kitchen sink” probiotics that throw in dozens of random strains with no clear purpose. ProBrainBiotics is different. With just two carefully chosen, clinically researched strains, it’s designed to work with your body to support digestion, immunity, and the gut-brain connection—the communication highway between your stomach and your mind.* The result? Less bloating, steadier digestion, and better mental clarity—every single day.*

✔ Supports healthy digestion & regularity*
✔ Promotes a balanced gut microbiome*
✔ Nourishes the gut-brain axis for improved mood & focus*
✔ Helps keep your immune system strong*

“ProBrainBiotics is the original brain-boosting probiotic—simple, clean, and clinically effective for gut, mood, and stress support.”

“These probiotic strains are one of the best-researched pairs for mood and digestion. This formulation makes it easy to support both with one capsule a day.”

"When the gut is balanced, the mind benefits too. I recommend ProBrainBiotics for patients wanting steady digestive health and mental sharpness without harsh formulas."

Targeted Support That Works*

Better Results, Better Value*

With 60 capsules per bottle, ProBrainBiotics gives you a full two months of daily gut-brain support—so you can stay consistent. And because it’s gentle, effective, and backed by decades of research, it’s safe for everyday use. Whether you want to improve digestion, boost immune health, or support your mood, ProBrainBiotics is your go-to probiotic for better health from the inside out.*

What To Expect

Day 1–7

Clinically studied probiotics begin activating in the gut microbiome—feeding friendly bacteria, balancing digestion, and supporting gut lining integrity. Some may notice less bloating or digestive discomfort within the first week.*

Week 2–4

As beneficial bacteria flourish, gut-brain communication improves. Clinical studies show users may experience better mood stability, reduced stress sensitivity, and a greater sense of calm and clarity by Week 3–4.*

Month 2

Emotional resilience continues to strengthen, supported by healthier neurotransmitter activity and better microbial diversity. Many report steadier energy, improved outlook, and smoother digestion.*

3 Months+

With daily use, ProBrainBiotics helps maintain a thriving gut microbiome—fueling the gut-brain axis for long-term support of mood, focus, digestion, and stress response.*

FAQ

How do I take ProBrainBiotics?

Take one or two capsules daily with a meal, or as recommended by a physician.*

Who can benefit from taking ProBrainBiotics?

Nearly everyone is likely to benefit from this broad-spectrum probiotic supplement.* This includes the elderly, people who have been exposed to pollutants, and those with poor dietary habits or digestive problems.* Individuals with mood problems, dealing with excessive stress, or desiring a stronger immunity may benefit from this efficacious pairing of probiotic strains.*

Do I need to take a probiotic supplement every day or only for occasional support?

Probiotic supplements aren’t likely to give immediate relief for intestinal problems.* The live bacteria they supply must settle in, reproduce, and get to numbers that can become functionally significant in and amongst the trillions of other bacteria already in the gut.* The human gut is a complex, intricate matrix of micro-ecosystems with bacteria as major players, and adjustments take time.* Well-designed clinical trials can help inform us about the utility of any probiotic strain.* The clinically documented benefits of the strains in ProBrainBiotics are likely to increase over a period of weeks.*

Should I rotate my probiotic supplement every 3-4 months for maximum benefit?

No. There’s no clinical evidence this is necessary or even helpful.* With clinically researched strains that are highly likely to improve overall microbiome functioning, the longer they’re consumed the better the results tend to be.*

Are there any side effects to taking ProBrainBiotics?

No. As with other BrainMD products, this is a dietary supplement, not a drug, and isn’t habit-forming.* It’s free from dairy, glutens, sugar, corn, soy, nuts, eggs, yeast, and artificial colorings or flavorings.* It’s compatible with keto or paleo dietary patterns.*

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