BrainMD Perimenopause Support+ perimenopause support supplement box with capsules on a lavender ledge

Smiling woman holding BrainMD Perimenopause Support+ perimenopause support supplement: your ticket off the rollercoaster

Perimenopause Support+ ingredients infographic: SheVari4 shatavari extract, Red Orange Complex, trans-resveratrol and vitamins D3 + K2

Perimenopause Support+ clinical study infographic: SheVari4 shatavari extract and a 70% reduction in perimenopause symptoms

Perimenopause Support+ benefits infographic: hot flash and night sweat support, mood, sleep, intimacy, bone health and quality of life

BrainMD Perimenopause Support+ supplement facts: SheVari4 shatavari extract, Red Orange Complex, trans-resveratrol, vitamins D3 and K2

Perimenopause Support+3rd month FREE when you subscribe · $33.96/mo · free shipping**

New Arrival

Perimenopause Support+

Q: Is Perimenopause Support+ hormone replacement therapy (HRT)?

No. Perimenopause Support+ is not hormone replacement. It's science-backed hormone support, formulated to work with your body's natural systems to improve comfort and quality of life, using clinically researched, non-hormonal ingredients.*

Q: Can I take Perimenopause Support+ if I use hormone replacement therapy (HRT)?

Perimenopause Support+ is a dietary supplement and is not intended to replace hormone replacement therapy (HRT). If you currently use HRT or take prescription medications, talk with your healthcare provider before adding Perimenopause Support+ to your routine.

Q: Who should take Perimenopause Support+?

Perimenopause Support+ is designed for women approaching or in perimenopause, typically ages 35–55, who are experiencing hormonal shifts, but are not yet post-menopausal.* It's built for women who may feel "off" but aren't sure why (mood changes, poor sleep, anxiety, exhaustion, or temperature discomfort) and who are looking for science-backed, nutrition-based support.*

Q: How do I take Perimenopause Support+?

Take one capsule daily, preferably with food, or as directed by your healthcare provider.*

Q: When can I expect to notice results?

Clinical research on SheVari4® showed a 43.1% reduction in symptom severity at 4 weeks and a 70.8% reduction at 8 weeks, using the validated Menopause Rating Scale (MRS).* With continued use beyond 12 weeks, women may notice ongoing support for quality of life and daily resilience.*

Q: What is SheVari4™?

SheVari4® is a clinically studied Shatavari (Asparagus racemosus) extract: an adaptogenic botanical traditionally used to support female health.* It's the core ingredient in Perimenopause Support+ and has been evaluated using validated menopause rating scales for its effect on perimenopausal symptoms.*

Q: Does Perimenopause Support+ fit with other BrainMD women's products?

Yes. Perimenopause Support+ is designed to bridge the gap between PMS Relief+ (monthly cycle support for reproductive-age women) and Menopause Essentials+ (ongoing support for post-menopausal health), completing a full-spectrum hormone support system for every stage of a woman's hormonal life.*

Q: Which BrainMD Women’s Formula Is Right for Me?

PMS Relief+ is designed to provide support around the monthly menstrual cycle.*Perimenopause Support+ is designed for the transitional years leading up to menopause.*Menopause Essentials+ is designed to support women after menopause.*

Once-daily nutritional support for the transition before menopause*

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Description

Perimenopause Support+ is a clinically researched formula designed to support women through the early hormonal transition that happens before menopause. A phase that's often misunderstood, overlooked, or misdiagnosed.*

Formulated with clinically studied SheVari4™ (Shatavari extract), Red Orange Complex, Trans-Resveratrol, Vitamin D3, and Vitamin K2, this once-daily capsule works to support hormonal balance, mood, sleep, energy, temperature regulation, comfort during intimacy, and overall quality of life.*

This isn't hormone replacement. It's science-backed hormone support, built to bridge the gap between PMS Relief+ and Menopause Essentials+ so women have support at every stage of their hormonal life.*

Benefits

✔ Helps promote healthy sleep, temperature regulation, sexual function, and vitality*
✔ Supports balanced energy levels and emotional well-being*
✔ Supports bone health during the hormonal transition*
✔ Works with your body's natural transition, without added hormones*
✔ Simple, once-daily capsule for consistent, long-term support*

How to use

USE: Take one capsule daily, preferably with food, or as recommended by your healthcare provider.*†

EARLY RESULTS: Women may experience improvements in vasomotor symptoms, mood, stress, and sleep within 4-8 weeks of use.*†

LONG-TERM BENEFITS: With continued daily use through 12 weeks and beyond, women may notice ongoing support for sleep, mood, stress, sexual function, and overall quality of life (without dependency) during the transition.*†

*†Results may vary based on individual health and hormonal status. Consistent use, in conjunction with a healthy lifestyle, is recommended.

DOCTOR’S RECOMMENDATION: Pair with Smart Collagen and Omega-3 Power for added support for skin, hair, joints, mood and overall brain health during the transition.*

Ingredients

Shatavari Extract (SheVari4™), 100 mg: clinically studied to support sleep, mood, energy, temperature regulation, and overall comfort*
Red Orange Complex, 100 mg: antioxidant support, plus emotional and intimate well-being*
Trans-Resveratrol, 150 mg: supports brain blood flow and cognition*
Vitamin D3, 50 mcg (2,000 IU): works with K2 to support bone density*
Vitamin K2 (as MK-7), 180 mcg: works with D3 to support bone density*

Key Benefits

Hormonal Balance

Sleep

Emotional Support

Energy

Key Ingredients

We only use clinically researched ingredients backed by science. Every formula is crafted with pure, high-quality nutrients at effective doses designed for safety, potency, and real results you can trust.

Shatavari

100 mg

Shatavari (Asparagus racemosus) is an adaptogenic botanical traditionally used to support female health.* SheVari4™ is the clinically studied core of this formula, a standardized concentrate of shatavari extract, evaluated using validated menopause rating scales and shown to support meaningful reductions in perimenopausal symptom severity over time.*

Red Orange Complex ingredient from blood oranges

Red Orange Complex® (ROC)

100 mg

Red Orange Complex is a botanical extract derived from the contents of three blood orange varieties. High in antioxidant activities, it has also been clinically studied for its role in supporting a return from anxiousness, sexual symptoms, and vaginal dryness during hormonal transition.* It helps protect cells from oxidative stress while supporting comfort during intimacy and overall well-being as hormones shift.*

Trans-Resveratrol

150 mg

Trans-Resveratrol is a natural compound found in red grapes and berries, valued for its antioxidant properties and its support of balanced inflammatory response.* It supports cellular health and may support metabolic and cognitive health during hormonal shifts, including improved blood flow to the brain and healthier glucose uptake with consistent use.*

Vitamin D3

50 mcg (2000 IU)

Vitamin D3 supports strong bones, a healthy immune system, and proper mood and cognitive function.* Because perimenopause brings declining estrogen (which raises the risk of vitamin D insufficiency) adequate D3 intake becomes especially important for supporting bone health during this transition.*

Vitamin K2

180 mcg

Vitamin K2 works alongside Vitamin D3 to guide calcium into bones and teeth rather than soft tissue, supporting bone mineral density and bone strength.* Together, D3 and K2 help support the skeletal health that can be challenged as estrogen declines.*

Perimenopause Support+ box and capsules with blood oranges and shatavari root

Supported By Clinical Research

SheVari4® Supports Sleep, Mood & Comfort

8-week clinical study in women ages 40–55

In a randomized, double-blind, placebo-controlled study, 100 mg of SheVari4™ daily supported significant improvements across multiple areas measured by the Menopause Rating Scale, including sleep, mood, anxiety, physical and mental exhaustion, sexual well-being, and vaginal comfort.*
(Swaroop 2026)

Shatavari Supports Perimenopausal Well-Being

8-week randomized clinical study in perimenopausal women

In a randomized, double-blind, placebo-controlled trial, Shatavari root extract supported improvements in Menopause Rating Scale scores, perceived stress, fatigue, vigor, and hot flash frequency over 8 weeks.*
(Mahajan 2025)

Red Orange Complex Supports Emotional & Intimate Well-Being

8-week randomized clinical study in older adults

Among female participants, 100 mg of Red Orange Complex supported improvements in nervousness, sexual well-being, and vaginal comfort, while also demonstrating antioxidant benefits.*
(Nobile 2022)

Trans-Resveratrol Supports Brain Blood Flow & Cognition

14-week randomized study in postmenopausal women

In postmenopausal women, daily trans-resveratrol supported cerebrovascular responsiveness, verbal memory, and overall cognitive performance compared with placebo.*
(Evans 2017)

Vitamins D + K Support Bone Density

Meta-analysis of 8 randomized controlled trials

A meta-analysis of 8 randomized controlled trials involving 971 participants found that combined vitamin D and vitamin K supplementation supported total bone mineral density, with particularly favorable findings when vitamin K2 was used.*
(Kuang 2020)

Smiling woman holding a box and blister pack of BrainMD Perimenopause Support+ perimenopause support supplement

You’re not broken. Your hormones are changing.

Your Hormones Change. Your Brain Feels It.

Typically, in a woman’s 40s (highly variable), the perimenopausal transition begins as the ovaries begin producing less progesterone and estrogen. As estrogen interacts with brain systems involved in mood, memory, sleep, stress response, and temperature regulation, fluctuations during perimenopause can make you feel foggy, more anxious, more reactive, exhausted, or simply unlike yourself.

Beyond mental symptoms, you may notice:

Menstrual periods changing in regularity and flow
Trouble sleeping
Intense waves of heat and sweating
More frequent urinary tract infections
Vaginal dryness leading to discomfort during intimacy

The transition lasts an average of 4 years (but can range from 2 to 10) and ends at menopause, when you have gone 12 months without a menstrual period.

These changes are real. Perimenopause Support+ provides targeted nutritional support for both your brain and body throughout the transition.*

Daniel G. Amen, MD, founder of BrainMD, in his office

“Hormonal changes during perimenopause can affect the brain and body in ways many women don’t expect. That’s why I like a comprehensive approach. Perimenopause Support+ combines clinically researched ingredients to support mood, sleep, energy, hormonal balance, and overall well-being during this important transition.”

“Perimenopause shouldn’t leave women feeling like they have to just push through it. Perimenopause Support+ gives women targeted, science-backed support for the changes happening in their bodies, so they can feel more supported through every stage of the transition.”

“Perimenopause Support+ combines safe, well-researched nutrients along with time-proven herbal medicine in a formula that addresses acute symptoms as well as supporting longer-term health in perimenopause and beyond. This natural approach helps address the myriads of health issues that arise for women in this time of hormonal transition.”

BrainMD Perimenopause Support+ box with capsules and red orange slices, a hormone-free perimenopause support supplement

Stop Chasing One Symptom at a Time

Sleep problems, mood changes, low energy, hot flashes, and changes in intimacy can overlap because they are all part of the same hormonal transition.

At the center of Perimenopause Support+ is SheVari4™, a concentrated shatavari extract clinically studied using the validated Menopause Rating Scale. It supports sleep, mood, energy, temperature regulation, sexual well-being, and overall comfort during hormonal change.*

Red Orange Complex, trans-resveratrol, and vitamins D3 and K2 provide additional antioxidant, brain, cellular, and bone support. Together, these five clinically researched ingredients deliver comprehensive support in one daily capsule.*

Smiling woman about to take a Perimenopause Support+ capsule, a once-daily perimenopause support supplement

What To Expect

Day 1

SheVari4™, Red Orange Complex, and Trans-Resveratrol get to work supporting hormonal balance right from the first capsule.*

Week 4

Clinical data on SheVari4™ shows meaningful changes by 4 weeks, including balance for hot flashes, sleep problems, and anxiousness.*

Week 8

The SheVari4™ study found further improvements after eight weeks, including support for sleep, mood, energy, hot flashes, night sweats, sexual well-being, and vaginal comfort.*

12 Weeks+

Ongoing daily use supports lasting bone health, quality-of-life, and daily resilience through the hormonal transition, without dependency.*

FAQ

Got questions? We’ve got answers. Explore our FAQs or chat with our AI assistant for instant support.

Hand holding a box of BrainMD Perimenopause Support+ perimenopause support supplement with keys, earbuds and lip gloss

What makes Perimenopause Support+ different from other perimenopause products?

Most perimenopause products focus on a single symptom, like hot flashes or mood. Perimenopause Support+ is different. Built around SheVari4™, a clinically studied Shatavari extract, it was formulated to support the full range of experiences women typically report during the hormonal transition before menopause, including those involving mood, sleep, energy, and bone health.*

Is Perimenopause Support+ hormone replacement therapy (HRT)?

No. Perimenopause Support+ is not hormone replacement. It's science-backed hormone support, formulated to work with your body's natural systems to improve comfort and quality of life, using clinically researched, non-hormonal ingredients.*

Can I take Perimenopause Support+ if I use hormone replacement therapy (HRT)?

Perimenopause Support+ is a dietary supplement and is not intended to replace hormone replacement therapy (HRT). If you currently use HRT or take prescription medications, talk with your healthcare provider before adding Perimenopause Support+ to your routine.

What are the benefits of Perimenopause Support+?

Perimenopause Support+ is designed to support multiple aspects of well-being during the hormonal transition, including:

✔ Hormonal balance during midlife*
✔ Mood & emotional well-being*
✔ Sleep quality*
✔ Energy levels*
✔ Bone density & skeletal health*
✔ Healthy sexual function & vaginal comfort*
✔ Overall quality of life*

Who should take Perimenopause Support+?

Perimenopause Support+ is designed for women approaching or in perimenopause, typically ages 35–55, who are experiencing hormonal shifts, but are not yet post-menopausal.* It's built for women who may feel "off" but aren't sure why (mood changes, poor sleep, anxiety, exhaustion, or temperature discomfort) and who are looking for science-backed, nutrition-based support.*

How do I take Perimenopause Support+?

Take one capsule daily, preferably with food, or as directed by your healthcare provider.*

When can I expect to notice results?

Clinical research on SheVari4® showed a 43.1% reduction in symptom severity at 4 weeks and a 70.8% reduction at 8 weeks, using the validated Menopause Rating Scale (MRS).* With continued use beyond 12 weeks, women may notice ongoing support for quality of life and daily resilience.*

What is SheVari4™?

SheVari4® is a clinically studied Shatavari (Asparagus racemosus) extract: an adaptogenic botanical traditionally used to support female health.* It's the core ingredient in Perimenopause Support+ and has been evaluated using validated menopause rating scales for its effect on perimenopausal symptoms.*

Does Perimenopause Support+ fit with other BrainMD women's products?

Yes. Perimenopause Support+ is designed to bridge the gap between PMS Relief+ (monthly cycle support for reproductive-age women) and Menopause Essentials+ (ongoing support for post-menopausal health), completing a full-spectrum hormone support system for every stage of a woman's hormonal life.*

Which BrainMD Women’s Formula Is Right for Me?

PMS Relief+ is designed to provide support around the monthly menstrual cycle.*
Perimenopause Support+ is designed for the transitional years leading up to menopause.*
Menopause Essentials+ is designed to support women after menopause.*

Can I take Perimenopause Support+ if I’m pregnant or breastfeeding?

Perimenopause Support+ is not recommended for women who are pregnant or nursing. If you are trying to become pregnant, speak with your healthcare provider before starting any dietary supplement.

Overall rating: 5.0 / 5 from 2 reviews.

AI Generated Review Summary

Summary topics

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Review highlights

Reviews

Better sleep, fewer hot flashes, and bone support

"I’ve been taking Perimenopause Support+ for several weeks now and I’m really happy with it. I’m sleeping better, feeling noticeably less moody, and I’ve had fewer hot flashes. It’s made a real difference in my day-to-day. I also love that it includes Vitamin D and K2. Bone health becomes more important during perimenopause as estrogen declines, and these two work together to improve overall bone health. It’s reassuring to have a natural option for this season of life. Highly recommend!"

— Ann Z. (5/5)

So Far So Good!

"It's a little early to tell the full effects, but I've noticed already in the first week that my hot flashes and night sweats have pretty much disappeared! I've also been feeling way more anxious than ever and it seems like this is starting to help calm me. Excited to see what else will improve."

— Elizabeth M. (5/5)

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