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Dr. Amen FavoriteStaff Pick

ProBrainBiotics MAX

ProBrainBiotics MAX

7 clinically studied probiotic strains, 1 brain-boosting super probiotic*

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Description

ProBrainBiotics MAX is clinically formulated to support the gut-brain axis, the communication superhighway between your digestive system and your brain.*

With 7 targeted probiotic strains at a research-backed 30 billion CFU per capsule, this powerhouse formula nourishes a healthy gut microbiome to help improve mood, boost immunity, sharpen focus, support memory, and more.*

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Key Benefits

Mood

Immunity

Brain Health

Digestion

Key Ingredients

We only use clinically researched ingredients backed by science. Every formula is crafted with pure, high-quality nutrients at effective doses designed for safety, potency, and real results you can trust.
Gluten & Yeast Free
Gluten & Yeast Free

Bifidobacterium lactis Strain HN19

17 billion CFU
Bifidobacterium lactis Strain HN19 is a well-researched probiotic known for its ability to support digestive and immune health.* Naturally abundant in the guts of healthy individuals, this strain helps maintain a balanced microbiome by aiding digestion and promoting regularity.* HN19 has been shown to enhance immune function, support gum health, and improve overall gut performance.* It may also help “prime” the digestive system, creating a favorable environment for other beneficial probiotics to thrive.*

Lactobacillus helveticus Strain R52

4.5 billion CFU
Lactobacillus helveticus R52 is a clinically studied probiotic known for supporting both digestive and emotional well-being.* As an established psychobiotic, it influences the gut-brain axis to help improve mood and reduce feelings of stress.* When combined with Bifidobacterium longum R175, R52 has been shown to enhance emotional balance, promote a sense of calm, and support the body’s natural stress response.* This strain also contributes to healthy intestinal function, making it beneficial for both mental and digestive health.*

Bifidobacterium bifidum Strain R71

3 billion CFU
Bifidobacterium bifidum Strain R71 is a beneficial probiotic shown to support both gut and mental well-being.* In clinical studies, R71 helped improve sleep quality, digestive health, and immune function—particularly in individuals experiencing high stress, such as students during exam periods.* By supporting a balanced gut microbiome and the gut-brain connection, R71 may help the body manage stress more effectively, enhance relaxation, and promote better overall resilience during challenging times.*

Bifidobacterium longum Strain BB536

2 billion CFU
Bifidobacterium longum Strain BB536 is a highly studied probiotic known for its effectiveness in promoting digestive and immune health.* It helps maintain a healthy balance of gut bacteria, supports regular bowel movements, and may reduce occasional bloating and discomfort.* BB536 also plays a role in strengthening the gut barrier and enhancing immune system response.* Backed by extensive clinical research, this strain is a reliable choice for supporting long-term gut health and overall wellness.*

Lactobacillus plantarum Strain K31

1.5 billion CFU
Lactobacillus plantarum Strain K31 is a resilient probiotic originally isolated from healthy human infants.* Known for its ability to survive harsh digestive conditions, this strain helps support a balanced gut microbiome and promotes optimal intestinal function.* When used in combination with complementary strains, K31 has been shown to enhance immune system activity and strengthen the body’s natural defenses.* It also supports digestive comfort, nutrient absorption, and overall gastrointestinal health.*

Lactobacillus plantarum Strain K32

1.5 billion CFU
Lactobacillus plantarum Strain K32 is a scientifically studied probiotic known for its role in supporting gut health and immune function.* Though genetically distinct from Strain K31, K32 works synergistically with it to enhance the overall effectiveness of both.* Together, they help maintain a balanced gut microbiome, support healthy digestion, and reinforce the body’s natural immune defenses.* Strain K32 is especially valued for its resilience and ability to contribute to long-term intestinal and immune health.*

Bifidobacterium longum Strain R175

0.5 billion CFU
Bifidobacterium longum Strain R175 is one of the most common and well-established probiotic species in the human gut.* Classified as a psychobiotic, it supports the gut-brain axis and plays a role in mental well-being.* In clinical studies, R175—when paired with Lactobacillus helveticus R52—has been shown to enhance mood, reduce perceived stress, and support emotional resilience.* It also helps maintain digestive balance, making it beneficial for both mental and gut health.*

Supported By Clinical Research

Probiotics May Improve Bowel Regularity
Randomized clinical trial on probiotic impact on digestive function

Bifidobacterium lactis HN019 was shown to reduce gut transit time and improve gastrointestinal symptoms in a dose-dependent manner.
(Waller 2011)
BrainMD
Boost Digestion, Immunity, & Mood*

The Psychobiotic Advantage*

Your gut and brain are in constant conversation. When your gut is happy, your mood, focus, and energy get a serious upgrade.* ProBrainBiotics MAX packs 30 billion CFU of 7 powerhouse strains that go beyond digestion—helping you feel calmer, think clearer, and keep your immune system ready for anything.*

This isn’t your average probiotic. Every strain is hand-picked for a specific function—from easing daily stress to supporting mental sharpness to keeping your digestion smooth.* The result? A happier gut, a sharper mind, and a body that feels its best—day after day.*

Expert Reviews

“Support your gut, and it will love you back. This is a maximum-strength probiotics, scientifically formulated.”

Dr. Daniel Amen

Founder, BrainMD & Amen Clinics
"Your gut is your second brain, and if it’s unhealthy, your first brain will suffer. ProBrainBiotics MAX is one of the most advanced probiotics I’ve seen for targeting mood, memory, and focus—while also supporting digestion."

Justine Lette

Brain Health Professional & Mental Health Specialist
BrainMD
Proven, Potent Results*

Targeted Gut-Brain Support That Works*

ProBrainBiotics MAX is built for real results you can actually feel.* Every capsule is blister-packed for freshness, so the full 30 billion CFU make it to your gut alive and ready to work.*

You’ll love how it fits into your life:

✔ No refrigeration. No hassle.*

✔ Gentle enough for daily use—no bloating or digestive discomfort.*

✔ Results you can notice: more energy, less stress, smoother digestion.*

Take it every morning and feel the difference—in your gut, your mood, and your day.*
BrainMD

What To Expect

Day 1–7

High-potency probiotics begin colonizing the gut microbiome. Some users notice early improvements in digestion—such as less bloating, gas, or discomfort—as gut balance starts to shift.*
Week 2–4

With consistent use, beneficial strains support healthier immune signaling and gut barrier function. Many report steadier digestion, improved bowel regularity, and fewer stress-related stomach symptoms.*
Month 2

Mood and emotional balance improve as psychobiotic strains help regulate the gut-brain axis. Clinical studies show reduced cortisol levels, better resilience to stress, and improved outlook by this stage.*
3 Months+

Continued use helps maintain a thriving gut microbiome that supports long-term brain, mood, and immune health. You may notice better focus, steadier energy, and more consistent well-being from the inside out.*

FAQ

Got questions? We’ve got answers. Explore our FAQs or chat with our AI assistant for instant support.

BrainMD

How can I take this supplement?

We recommend adults take 1 capsule (supplying a minimum 30 billion live probiotic units) daily, with food.* Children ages 4 and up also can take this daily dose.* This product is not intended for use during pregnancy.*

Overall rating: 4.7559056 / 5 from 127 reviews.

AI Generated Review Summary

ProBrainBiotics MAX is a clinically formulated supplement designed to enhance the gut-brain axis. Customers praise its effectiveness in improving mood, boosting immunity, and supporting memory. The product contains 7 targeted probiotic strains at 30 billion CFU per capsule, contributing to a healthy gut microbiome.

Summary topics

  • Gut Health (4%): Customers raved about how these probiotics have made their gut happier and their brain healthier.
  • Probiotic Effectiveness (20%): A significant number of customers brought up that this probiotic is excellent and the best they have ever tried.

Review topics: ["improvement","quality","results","issues","feel","packaging","balance","works","difference","service","probiotic","gut","max","health","vitamins","effect","support","brain","brain biotics","supplement","probrainbiotics","bloating","system","change","upset","capsules","diet","mood","capacity"].

Review highlights

  • "Love this product high quality I already reorder so don’t run out" — Kristin S.
  • "Happy gut, happy brain!" — Karen S.
  • "The cost and quality are great!" — Pamela L.

Reviews

Great for the gut!

"As somebody who was diagnosed years ago with IBS, probiotics have been a lifesaver for me. I love these because it does more than just help the gut, it also helps the brain, and who couldn't use that? It has definitely helped my gut to be more consistent and have an enormous reduction in flare-ups which used to have a huge impact on my quality of life. This is the only supplement company I trust because their stuff really works! Thank you!"

— Valerie K. (5/5)

Pro brain biotics

"Excellent improving my focus and motivation"

— Gwen D. (5/5)

ProBrainProbioticsMax

"I have been using this product for about 3 years and trust it is working for me. I take it daily and go about my business. I am a fan of Dr. Ames and use several of his sponsored products."

— Frank N. (5/5)

Probrainbiotics

"Promoting healthy intestinal balance - noticing a big difference."

— Kelly G. (5/5)

ProBrain

"Since taking the probiotic I’ve felt better and have really experienced better health. I rarely get sick now and when I do , recovery time is shorter. My husband even takes them now"

— Jodie C. (5/5)

Gentle formula

"I have been taking this every morning for over 8 months. I have not had any digestive upsets or any sickness. I highly recommend this product."

— Nancy S. (5/5)

Probiotics

"Really liked this product. It's probiotics which help the brain as well. Highly recommend"

— Carmen M. (5/5)

probrainotics

"Very easy to swallow. Does not have to be refrigerated and no stomach discomfort."

— Karen G. (5/5)

ProBrainBiotics Max We have had a GUT FULL! 4 years actually.

"My ASD, ADHD and Speech/language impaired son has been taking it every day, first thing in the morning, for 4 years now and we have had 2 sets of Spect brain scans and seen a massive change in his repairing his blood flow through his brain. ProBrainBiotics Max has helped balance his gut bacteria, so his brain gets the right chemicals from his food and the other fantastic Brain MD supplements. Fussy Children don't always eat the right foods for their gut. Brain MD has been there for us whilst teaching my son the importance of different natural foods for a healthy gut, as the gut and Brain are linked. My son talks now, mostly nonviolent now, and has no Autism symptoms visibly noticeable to his peers and his ADHD is considerably better so he can concentrate. I can't help but feel the ProBrainbiotics Max was a big Helping factor to achieve this. Thank you BrainMD"

— Deborah G. (5/5)

Wonderful

"The perfect Probiotics."

— PATRICK R. (5/5)

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