BrainMD Smart Metabolic Burn berberine and OEA supplement, red bottle of vegan capsules

BrainMD Smart Metabolic Burn infographic: your appetite has a brain-body connection, showing signals between the brain and gut

BrainMD Smart Metabolic Burn ingredients: berberine for metabolic support and OEA (oleoylethanolamide) for fullness and appetite support

Woman with a capsule beside OEA clinical study results for BrainMD Smart Metabolic Burn: less hunger, fewer sweet cravings, greater fullness

Smiling man holding BrainMD Smart Metabolic Burn, a smarter way to manage your weight: fullness, craving, fat-burning and blood sugar support

BrainMD Smart Metabolic Burn what to expect timeline: satiety in weeks 1-2, glucose metabolism weeks 2-4, fat metabolism weeks 4-8

Hands holding a BrainMD Smart Metabolic Burn bottle and capsule with a quote from Daniel G. Amen, MD on supporting healthy weight management

GLP-1Doctor-Developed

Smart Metabolic Burn

Q: What makes Smart Metabolic Burn different from other berberine supplements?

It's more than berberine. Smart Metabolic Burn combines two forms of berberine (berberine HCl + dihydroberberine) with OEA, an ingredient studied for its role in fullness and appetite regulation. While berberine supports healthy metabolism, OEA adds support for feeling satisfied and managing cravings.* That means metabolic support and appetite support in one doctor-developed formula.

Q: What is OEA (oleoylethanolamide), and how does it help control appetite?

OEA is a naturally occurring compound produced in the small intestine that plays a role in communication between your gut and brain. It helps support the signals that tell your brain when you've had enough.* In clinical research, OEA supplementation has been associated with improvements in hunger, fullness, and sweet cravings. It's one of the ingredients that makes Smart Metabolic Burn different from traditional berberine supplements.

Q: Does Smart Metabolic Burn support GLP-1 naturally?

Smart Metabolic Burn supports healthy appetite regulation and natural fullness signals through its berberine + OEA formula.* GLP-1 is a hormone involved in appetite and blood sugar regulation, and researchers have explored how these ingredients interact with related metabolic pathways. However, Smart Metabolic Burn hasn't been clinically shown to increase GLP-1 levels and isn't a GLP-1 medication.

Q: Can Smart Metabolic Burn help with cravings and food noise?

That's one of the reasons OEA is in the formula. OEA supports natural fullness signals and healthy appetite regulation, helping you feel more satisfied as part of a balanced eating routine.* In clinical research, participants taking OEA reported improvements in hunger, desire to eat, and sweet cravings. Smart Metabolic Burn brings this researched ingredient together with berberine for metabolic and appetite support in one formula.*

Q: How much berberine and OEA are in Smart Metabolic Burn?

Each capsule contains 100 mg of a berberine blend (berberine HCl + dihydroberberine) and 125 mg of OEA (oleoylethanolamide).At the recommended two-capsule daily intake, that's 200 mg of the berberine blend + 250 mg of OEA to support healthy fat metabolism, natural fullness signals, and appetite regulation.*

Q: How long does it take to notice results from Smart Metabolic Burn?

Consistency matters, and individual experiences vary. OEA has been evaluated in a 60-day clinical study using 250 mg daily, the same daily OEA amount provided by Smart Metabolic Burn. Researchers reported improvements in hunger, fullness, sweet cravings, and certain weight-related measurements among participants taking OEA.These findings come from research on OEA as an individual ingredient, not a clinical trial of Smart Metabolic Burn, so they don't establish a specific results timeline for the finished formula.

Q: How do I take Smart Metabolic Burn?

Take one capsule twice daily, approximately 30 minutes before a meal, or as directed by your healthcare professional. For best results, use consistently alongside balanced nutrition, regular physical activity, and healthy daily habits.*

Q: Does Smart Metabolic Burn contain caffeine or other stimulants?

No caffeine. No added stimulants. Smart Metabolic Burn supports healthy metabolism and appetite regulation without relying on stimulant ingredients.* Its berberine + OEA formula is designed for everyday metabolic and weight-management support.

Berberine + OEA supplement for appetite control, metabolic health & GLP-1 support*

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Description

Tired of trying every weight loss solution without seeing results? Stuck in a weight loss plateau? Constantly battling thoughts about food? Wondering if there's a breakthrough product or natural appetite suppressant that can finally work for you? Introducing Smart Metabolic Burn.

By naturally supporting your GLP-1 pathways, the same hormonal signals targeted by popular weight-loss solutions, Smart Metabolic Burn helps promote feelings of fullness, maintain steady blood sugar, and encourage healthy fat metabolism.*

This means fewer cravings, better portion control, and a metabolism that's primed to work more efficiently.*

Benefits

✔ Supports the body’s natural GLP-1 pathways*
✔ Supports natural fullness signals & healthy appetite regulation*
✔ Helps manage cravings & support portion control*
✔ Supports healthy fat metabolism & weight management*
✔ Supports healthy blood sugar levels already within the normal range*
✔ Supports healthy body composition*

How to use

USE: Take 1 capsule twice per day, approximately 30 minutes before a meal.*†

EARLY RESULTS: Begin to notice fewer between-meal cravings, better portion control, and a greater sense of satisfaction after eating.*†

LONG-TERM BENEFITS: Berberine + OEA work together to support healthy fat metabolism, blood sugar levels already within the normal range, and sustainable weight management.* Clinical research on OEA has shown improvements in hunger, fullness, weight, and waist circumference in just 8 weeks.†

*†Results may vary based on individual health and fitness levels. Consistent use, in conjunction with a healthy lifestyle, is recommended.

DOCTOR’S RECOMMENDATION: Pair Smart Metabolic Burn with Craving Control for extra support managing cravings, emotional eating, and mood, or Balance My Blood Sugar for additional support maintaining healthy blood sugar levels already within the normal range.*

Ingredients

Berberine
Oleoylethanolamide (OEA)

Third-Party Testing

Smart Metabolic Burn is independently tested by Intertek, an ISO 17025 accredited third-party laboratory.

What's tested: Active ingredient potency, measured against the label.

Result: Passed.

How BrainMD tests every product

Key Benefits

Weight Management

Blood Sugar Balance

Digestion

Craving Support

Key Ingredients

We only use clinically researched ingredients backed by science. Every formula is crafted with pure, high-quality nutrients at effective doses designed for safety, potency, and real results you can trust.

Berberine

99.5 mg

Berberine is a plant-derived compound traditionally used in Ayurvedic and Chinese medicine to support metabolic health.* It works by activating AMPK, a key enzyme that helps regulate blood sugar, fat metabolism, and energy balance.* Berberine has been shown to support healthy glucose and lipid levels, making it a powerful tool for managing weight and metabolic function.* This formula features berberine HCl and dihydroberberine (DHB)—highly bioavailable forms for enhanced absorption and effectiveness.*

Oleoylethanolamide

125 mg

Oleoylethanolamide (OEA) is a naturally occurring compound that supports healthy weight management by helping regulate appetite and fat metabolism.* It works by activating PPAR-α, a receptor that promotes the breakdown of fats and reduces blood lipid levels.* OEA signals fullness to the brain, helping reduce overall food intake, while also stimulating lipolysis—the process of breaking down stored fat for energy*. As a result, it may support healthy body weight and metabolic function when combined with a balanced lifestyle.*

Supported By Clinical Research

OEA HAS BEEN STUDIED FOR HUNGER, FULLNESS & WEIGHT MANAGEMENT

Randomized, double-blind, placebo-controlled clinical trial | 60 days | 60 enrolled, 56 completed

Researchers studied 250 mg of OEA daily and reported improvements in hunger, sweet cravings, feelings of fullness, body weight, waist circumference, and body fat percentage among participants taking OEA.

These findings support continued research into OEA's role in appetite regulation and healthy weight management.*

CLINICAL RESEARCH: Payahoo L, Khajebishak Y, Barzegari A, et al. Oleoylethanolamide increases the expression of PPAR-α and reduces appetite and body weight in obese people: A clinical trial. Appetite. 2018;128:44–49. doi:10.1016/j.appet.2018.05.129.

VIEW STUDY

BERBERINE HAS BEEN STUDIED FOR HEALTHY LIPID METABOLISM

Randomized, double-blind, placebo-controlled clinical trial | 144 participants

Researchers evaluated 500 mg of berberine twice daily and observed improvements in several blood lipid measurements compared with placebo.

The findings contribute to berberine's clinical research history in metabolic health.*

CLINICAL RESEARCH: Derosa G, D'Angelo A, Bonaventura A, et al. Effects of berberine on lipid profile in subjects with low cardiovascular risk. Expert Opin Biol Ther. 2013;13(4):475–482. doi:10.1517/14712598.2013.776037.

VIEW STUDY

BERBERINE HAS BEEN STUDIED FOR GLUCOSE & METABOLIC HEALTH

Randomized, double-blind, placebo-controlled clinical trial | 49 participants | 60 days

In a human clinical study, researchers evaluated a specialized berberine phospholipid supplement and reported improvements in glucose and insulin measurements compared with placebo.

The findings add to research on berberine's role in metabolic health, although the formulation and dose differed from Smart Metabolic Burn.*

CLINICAL RESEARCH: Rondanelli M, Gasparri C, Petrangolini G, et al. Berberine phospholipid exerts a positive effect on the glycemic profile of overweight subjects with impaired fasting blood glucose (IFG): a randomized double-blind placebo-controlled clinical trial. Eur Rev Med Pharmacol Sci. 2023;27(14):6718–6727. doi:10.26355/eurrev_202307_33142.

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OEA HAS BEEN STUDIED FOR BODY COMPOSITION

Randomized, triple-blind, placebo-controlled clinical trial | 76 participants | 12 weeks

In a clinical trial involving participants following a calorie-restricted diet, researchers reported greater reductions in fat mass and increases in fat-free mass with OEA supplementation compared with placebo.

The findings suggest a potential role for OEA in body-composition research alongside dietary changes.*

CLINICAL RESEARCH: Tutunchi H, Ostadrahimi A, Saghafi-Asl M, et al. Expression of NF-κB, IL-6, and IL-10 genes, body composition, and hepatic fibrosis in obese patients with NAFLD—Combined effects of oleoylethanolamide supplementation and calorie restriction: A triple-blind randomized controlled clinical trial. J Cell Physiol. 2021;236(1):417–426. doi:10.1002/jcp.29870.

VIEW STUDY

THE BRAIN–BODY CONNECTION

Your Appetite Has a Mind of Its Own

Ever finish a meal and still feel hungry? Your appetite isn’t just about willpower. Your gut and brain are constantly communicating about when you’re hungry and when you’ve had enough.

One of the compounds involved in that conversation is OEA (oleoylethanolamide), a naturally occurring lipid produced in the small intestine that helps signal fullness to the brain.

Smart Metabolic Burn combines OEA with berberine to support both sides of the weight-management equation: healthy metabolism and natural appetite regulation.*

OEA supports natural fullness signals, healthy appetite regulation, and craving management.*
Berberine supports healthy fat metabolism and blood sugar levels already within the normal range.*

Daniel G. Amen, MD, founder of BrainMD, in his office

“This all-new nutritional supplement combines the power of two potent compounds—berberine and oleoylethanolamide (OEA)---to prime your body for metabolic wellness. It acts like a natural appetite suppressant that activates fat-burning and is clinically formulated to support healthy weight management."

"Metabolic health fuels mental health. Berberine and OEA support key metabolic pathways to help curb appetite, boost fat burning, and keep blood sugar steady for better brain energy."

BEYOND BERBERINE

Your Metabolism Is Only Part Of The Story

Berberine has been studied in dozens of clinical trials for its effects on blood sugar, insulin sensitivity, and metabolic health. But healthy weight management involves more than metabolism. Hunger, cravings, and fullness matter, too.

That's why Smart Metabolic Burn combines two forms of berberine (berberine HCl + dihydroberberine) with OEA, an ingredient researched for its role in appetite regulation, in one doctor-developed formula.*

✔ Healthy Fat Metabolism: Supports your body's natural fat metabolism processes.*

✔ Blood Sugar Support: Helps maintain healthy blood sugar levels already within the normal range.*

✔ Fullness Support: Supports the natural signals that help you recognize when you've had enough.*

✔ Craving Support: Supports healthy appetite regulation and craving management.*

Support your metabolism. Satisfy your appetite.*

What To Expect

Week 1–2

Feel the shift as OEA (oleoylethanolamide) kicks in, signaling satiety to your brain. Cravings calm down, portions feel satisfying, and you’re no longer ruled by constant snacking.*

Week 4–6

Berberine goes to work, helping balance glucose and insulin so you can finally skip the energy crashes. Sugar cravings shrink, your mood steadies, and you notice more consistent stamina throughout the day.*

Week 8–12

Consistent daily use supports real improvements in metabolism, body composition, and waistline goals. Many people notice healthier weight, a stronger metabolism, and momentum that makes it easier to stay on track.*

3 Months+

Smart Metabolic Burn doesn’t just stop at quick wins—it builds over time. With continued use, you’ll feel more in control of your cravings, experience better energy, and support long-term weight management, cardiovascular health, and metabolic resilience.*

FAQ

Questions about Smart Metabolic Burn? We’ve got answers. Explore our FAQs or chat with our AI assistant for instant support.

What is Smart Metabolic Burn, and how does it work?

Smart Metabolic Burn is a doctor-developed berberine + OEA (oleoylethanolamide) supplement that supports two important parts of weight management: your metabolism and your appetite. Berberine supports healthy fat metabolism and blood sugar levels already within the normal range, while OEA supports natural fullness signals, healthy appetite regulation, and craving management.* It's a smarter way to support your weight-management goals from both sides.

What makes Smart Metabolic Burn different from other berberine supplements?

It's more than berberine. Smart Metabolic Burn combines two forms of berberine (berberine HCl + dihydroberberine) with OEA, an ingredient studied for its role in fullness and appetite regulation. While berberine supports healthy metabolism, OEA adds support for feeling satisfied and managing cravings.* That means metabolic support and appetite support in one doctor-developed formula.

What is OEA (oleoylethanolamide), and how does it help control appetite?

OEA is a naturally occurring compound produced in the small intestine that plays a role in communication between your gut and brain. It helps support the signals that tell your brain when you've had enough.* In clinical research, OEA supplementation has been associated with improvements in hunger, fullness, and sweet cravings. It's one of the ingredients that makes Smart Metabolic Burn different from traditional berberine supplements.

Does Smart Metabolic Burn support GLP-1 naturally?

Smart Metabolic Burn supports healthy appetite regulation and natural fullness signals through its berberine + OEA formula.* GLP-1 is a hormone involved in appetite and blood sugar regulation, and researchers have explored how these ingredients interact with related metabolic pathways. However, Smart Metabolic Burn hasn't been clinically shown to increase GLP-1 levels and isn't a GLP-1 medication.

Can Smart Metabolic Burn help with cravings and food noise?

That's one of the reasons OEA is in the formula. OEA supports natural fullness signals and healthy appetite regulation, helping you feel more satisfied as part of a balanced eating routine.* In clinical research, participants taking OEA reported improvements in hunger, desire to eat, and sweet cravings. Smart Metabolic Burn brings this researched ingredient together with berberine for metabolic and appetite support in one formula.*

How does berberine support metabolism and weight management?

Berberine has been studied in human clinical trials for its role in glucose metabolism, insulin sensitivity, and lipid metabolism. In Smart Metabolic Burn, berberine supports healthy fat metabolism and blood sugar levels already within the normal range.* Paired with OEA for fullness and appetite support, it helps address more of the factors involved in healthy weight management.

How much berberine and OEA are in Smart Metabolic Burn?

Each capsule contains 100 mg of a berberine blend (berberine HCl + dihydroberberine) and 125 mg of OEA (oleoylethanolamide).

At the recommended two-capsule daily intake, that's 200 mg of the berberine blend + 250 mg of OEA to support healthy fat metabolism, natural fullness signals, and appetite regulation.*

How long does it take to notice results from Smart Metabolic Burn?

Consistency matters, and individual experiences vary. OEA has been evaluated in a 60-day clinical study using 250 mg daily, the same daily OEA amount provided by Smart Metabolic Burn. Researchers reported improvements in hunger, fullness, sweet cravings, and certain weight-related measurements among participants taking OEA.

These findings come from research on OEA as an individual ingredient, not a clinical trial of Smart Metabolic Burn, so they don't establish a specific results timeline for the finished formula.

How do I take Smart Metabolic Burn?

Take one capsule twice daily, approximately 30 minutes before a meal, or as directed by your healthcare professional. For best results, use consistently alongside balanced nutrition, regular physical activity, and healthy daily habits.*

Does Smart Metabolic Burn contain caffeine or other stimulants?

No caffeine. No added stimulants. Smart Metabolic Burn supports healthy metabolism and appetite regulation without relying on stimulant ingredients.* Its berberine + OEA formula is designed for everyday metabolic and weight-management support.

Are there any side effects or medication interactions?

Berberine may cause digestive discomfort, including nausea, diarrhea, constipation, or an upset stomach. It may also interact with certain medications, particularly those used to manage blood sugar. Consult your healthcare professional before use if you take medications, use other supplements, or have an existing medical condition. Discontinue use and seek medical advice if you experience an adverse reaction.

Can I take Smart Metabolic Burn while pregnant, breastfeeding, or trying to conceive?

Smart Metabolic Burn isn't recommended during pregnancy or breastfeeding. If you're pregnant, nursing, planning to become pregnant, or trying to conceive, speak with your healthcare professional before using this or any weight-management supplement.

Overall rating: 4.377451 / 5 from 204 reviews.

AI Generated Review Summary

Smart Metabolic Burn is a supplement that supports GLP-1 pathways to promote feelings of fullness, steady blood sugar, and healthy fat metabolism. Customers report varied results, with some experiencing significant weight loss and others not seeing any change. The supplement is praised for reducing cravings and providing energy, but opinions on its effectiveness differ.

Summary topics

Feeling Energized (6%): Customers raved about how this supplement made them feel more energized and clear-headed.
Weight Loss Results (17%): Opinions vary, with some users reporting great and excellent results, while others did not see any changes.
Effectiveness of Smart Metabolic Burn (6%): It was observed by customers that Smart Metabolic Burn is highly recommended and effective for weight loss.
Supplement Effectiveness (8%): Customers expressed appreciation for the supplement, stating that it is amazing and the best they have ever tried.
Cravings Reduction (6%): In general, customers found the food supplement to be effective in reducing cravings and weight loss.

Review topics: ["weight","results","quality","issues","feel","stomach","energy","difference","bottle","sugar","cravings","supplement","smart metabolic burn","appetite","works","change","food","pounds","effect","capsules","loss","doctor","headaches","exercise","service","order","control","snack","foods","haven\u2019t"].

Review highlights

"I would recommend this supplement , you do have to combine it with a healthy diet and exercise." — Andrea C.
"I have been taking Smart Metabolic Burn for 6 months now, the results are excellent!" — Jim G.
"i really love the Smart Metabolic Burn, would definitely purchase again." — Alex H.

Reviews

New product for me

"I have not taken this consistently enough to give a great review yet. I have been more consistent this week and I do think the food noise I typically have has decreased. I am a week away from my cycle and at this point, I am usually eating any and everything, but I feel more in control and this is the only product I have added into my routine. I look forward to seeing how it works long-term."

— Brooke T. (4/5)

A must!

"My husband and I have been using smart metabolic burn for quite some time now, as a daily part of our nutraceutical stack for blood sugar control and metabolic health. At 60+ we feel it's important to supplement our diet and exercise habits with quality products. Amen products are a big part of our supplementation."

— Michelle (5/5)

So far so good

"Just started this supplement, too early to tell but I like combination of berberine and OEA."

— Sarah F. (4/5)

Smart Metabolic Burn

"I purchased this product and love how it curved my appetite and helped me with weight loss"

— Patrice D. (5/5)

It's starting to crank up my metabolism

"I've started taking this like a week ago. . . I can tell my bowel movements are starting to normalize since taking this. I feel like it's helping crank things up for me. I'm really hoping to start seing changes in the scale soon!"

— Hermila J. (5/5)

Great

"Great"

— Nancy W. (5/5)

Smart Metabolic Burn

"I don’t like that you have to take 30 minutes before a meal"

— Angela L. (3/5)

Smart Metabolic Burn

"I have to admit that I don’t take this product as describing on the label! When I do take it, it’s working for several hours. That’s all I have to say about it!!"

— fred g. (5/5)

I’ve used this product for

"I’ve used this product for over a year and believe it has been instrumental in helping me lose 54 pounds and keeping it off. When taking before breakfast and before dinner, I experience fewer sugar cravings, more energy, and a bit less food noise throughout the day. Highly recommend!"

— Kimberly P. (5/5)

Smart metabolic burn

"Did not see much improvement in energy"

— Elizabeth F. (5/5)

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