Here Are Some of the Best Benefits of Nitric Oxide
Medically Reviewed by Dr. Nicole Avena

Perhaps you’ve heard of nitric oxide (NO).

Over the last several decades, NO has become a popular topic of research among scientists. It’s also been linked to certain health benefits.

So, what is NO and how can it help you?

Benefits of Nitric Oxide

NO is a cellular messenger involved in nearly every cell and organ system in the body. It’s a signaling molecule in the nervous, circulatory, digestive, immune, reproductive, and respiratory systems.

Its primary action is to relax your blood vessels, which helps increase blood flow to your brain. Improved brain circulation can help neurons relay messages throughout your body.

Unfortunately, the amount of nitric oxide we produce declines as we get older. According to one study, those in their 40s only make about 60% of the NO they need daily. When the level of NO is off, it can lead to several health conditions.

The good news is that it’s possible to support your NO levels through supplementation. BrainMD is proud to offer its new nutraceutical…


Advanced Blood Flow Lifestyle 2


Advanced Blood Flow – Nitric Oxide Support

Advanced Blood Flow supports healthy nitric oxide levels in your brain, which helps increase blood flow throughout your body.*

Among its many benefits, Advanced Blood Flow:

  • Supports cardiovascular health and nitric oxide production*
  • Promotes healthy blood flow and circulation*
  • Supports cognitive function and gastrointestinal health*

Featuring clinically effective doses of high-quality nutrients, Advanced Blood Flow also supports cardiovascular, sexual, gut, and liver health.*

Advanced Blood Flow Ingredients

Advanced Blood Flow contains a trio of clinically tested ingredients that help naturally support levels of NO in the body.*

Here’s a closer look at the three ultra-pure nutrients in Advanced Blood Flow:

  • L-citrulline is a non-essential amino acid that’s a potent precursor to L-arginine, which helps boost the body’s NO metabolism and regulation. L-citrulline is produced in the liver and intestine. Though found in watermelon and other foods, it’s difficult to obtain enough L-citrulline from the diet alone.
  • Quercetin is a powerful flavanol that maintains oxidative balance within the body. Unlike L-citrulline, the body can’t synthesize it, so it must be obtained from the diet or supplements. Quercetin is found in apples, asparagus, and berries, and is thought to be best absorbed when consumed from onions. Unfortunately, when derived from food, quercetin absorption is reduced due to limited bioavailability.
  • Resveratrol is well known as the main constituent that makes wine heart healthy. Although it has been detected in more than 70 different plant species – and dietary sources including berries, apples, plums, Itadori tea, peanuts, and soy – wine is the main source of resveratrol for many people.

Since your diet may not contain enough of these foods and beverages, taking Advanced Blood Flow is a great way to ensure you’re getting adequate trans-resveratrol, which exerts anti-inflammatory activities.* Even though the ingredients in Advanced Blood Flow are found in food, the bioavailability is highly variable, depending on processing, cultivating, geographical location, and individual intestinal absorption capabilities.

Taking Advanced Blood Flow daily is an excellent way to ensure that you’re obtaining enough of the clinically tested, highly absorbable forms of these three powerful bioactive compounds.*

Advanced Blood Flow Benefits

Here are just a few ways Advanced Blood Flow can benefit the brain and body…

Antioxidant Support

Oxidative stress occurs when there’s an imbalance of pro-oxidants and antioxidants, contributing to damage on the molecular level. Once the antioxidant system becomes ineffective, damage to proteins, lipids, DNA, and RNA can occur. Aside from the many serious physical conditions associated with oxidative stress, it also can contribute to premature aging.

People who have higher intakes of antioxidants are typically healthier and live a longer life than those who don’t. Antioxidants can be obtained through the diet, however, their absorption and utilization is often hampered by bioavailability and an individual’s metabolism.

All 3 ingredients found in Advanced Blood Flow not only modulate NO levels, they also combat oxidative stress in the body, working to mitigate the negative consequences of unhealthy inflammatory status.*

Cardiovascular and Circulatory Health

Excessive production of free radicals can lead to increased oxidative stress and reduced NO availability, which is a known trigger of endothelial dysfunction. Given NO’s vital role in circulation, and anti-inflammatory and antithrombotic functions, adequate NO levels are necessary to maintain healthy blood flow in the circulatory system.

Given the overwhelming evidence that NO is involved in maintaining cardiovascular homeostasis, anyone with an underlying heart condition, including hypertension and heart failure, would benefit from daily supplementation.

The three components of Advanced Blood Flow have been shown to be cardio-protective.*

Gastrointestinal Health and Function

Gastrointestinal (GI) tract conditions or infections may have an inflammatory component. In many GI problems the gut barrier becomes more permeable and more susceptible to toxins that can trigger an unhealthy inflammatory response. Alterations in NO metabolism and signaling are associated with the development of liver and GI issues.

The ingredients in Advanced Blood Flow have been shown to reduce markers of inflammation and oxidative stress associated with severe bowel problems.*

Essential for Brain Health

Slowing the progression of cognitive decline and optimizing brain health has become an important area of research. Some research has shown that by 30 years of age cognitive abilities for many people start to decline, although this age is variable and can be higher for some. Regardless, taking a preventive approach at an early age can be a helpful strategy to prevent early cognitive decline.

As with every other organ in the body, NO plays a significant role in brain function. This partially explains why neurodegeneration occurs in many serious conditions with impaired NO homeostasis and bioavailability. NO is involved in learning, memory, and adult neurogenesis and has been implicated in a variety of health issues.

It’s a vital vasoactive molecule needed for cerebral blood flow and brain activity. When there’s dysfunction between the two, brain function and integrity may suffer, further supporting the importance of maintaining adequate NO levels.

Each of the components of Advanced Blood Flow have been shown to positively affect the central nervous system (CNS) through different mechanisms including signaling pathways associated with cell survival, cerebral blood flow, and reducing neuroinflammation.* The nutrients in Advanced Blood Flow have been shown to be neuroprotective against many problems of the CNS.* By suppressing neuronal injury resulting from inflammatory molecules and enzymes, the components in Advanced Blood Flow may have therapeutic benefit for a wide range of neurodegenerative complications.*

Helps Increase Libido

NO plays a significant role in sexual functioning. Many people with serious conditions report lower libido. This may be due to reduced NO production.

Increasing NO bioavailability with Advanced Blood Flow is a natural and effective way to increase libido and improve erectile function.*

Get In the Flow with NO

Advanced Blood Flow supports healthy nitric oxide levels in the brain, which helps increase blood flow throughout your body.*

Advanced Blood Flow is a capsule, customized for adults aged 18 and older. It supplies clinically effective doses of L-citrulline, trans-resveratrol and quercetin anhydrous, working to effectively raise your body’s levels of nitric oxide (NO) and its metabolites.*

Not only does this NO formula help cognitive function, it also supports cardiovascular, sexual, gut, and liver health, too.*

Try Advanced Blood Flow today!


At BrainMD, we’re dedicated to providing the highest purity nutrients to improve your physical health and overall well-being. For more information about Advanced Blood Flow and our full list of brain healthy supplements, please visit us at BrainMD.

*These statements have not been evaluated by the FDA. This content is for informational purposes only. It is not meant to substitute for medical or healthcare advice from a physician, nor is it intended to diagnose, treat, cure, or prevent any disease. Consult your healthcare provider before beginning a new health regimen.

Keith Rowe