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Dr. Amen Supplements: The Foundation He Recommends Before Anything Else
If you've spent any time looking into Dr. Amen supplements, you've probably noticed something: the list of nutrients, botanicals, and targeted formulations for different brain health goals is long. However, before he ever recommends nootropics, adaptogens, or specialty blends for unique needs, he starts in the same place every time. Three basics: A multivitamin An omega-3 A probiotic After decades of scanning brains at Amen Clinics and reviewing what actually supports positive changes to cognitive health, Dr. Amen keeps coming back to the same foundation because it works. Most people (even health-conscious ones) are unknowingly missing the basics. If you're the kind of person who reads ingredient labels, asks your doctor real questions, and wants to feel sharp at 45, 65, or 105, this is worth understanding. Not as a sales pitch, but as an actual explanation of why these three categories earn their spot at the front of the line in Dr. Amen’s favorite supplement list. Why Start Here? Yes, BrainMD® offers products that can provide extra support for things like focus, energy, blood-sugar control, or physical performance. But, your brain, like the rest of your body, requires some fairly unglamorous inputs for baseline function: it needs a full set of vitamins and minerals to run its chemistry, fat (specifically the right kind of fat) to build and maintain its physical structure, and a functioning gut, because your gut and brain are in constant conversation with each other. Skip any of those three, and the powerful additions you layer on top can’t function to their full potential. That's the logic behind BrainMD's foundational lineup, and it's why products like NeuroVite Plus Multivitamin, Omega-3 Power, and ProBrainBiotics show up again and again as Dr. Amen's favorite supplements. Step One: A Real Multivitamin Most multivitamins are built for general wellness, aimed at the broadest possible audience. NeuroVite Plus was built differently, for people who know brain health is the basis for whole body health. It contains the vitamins, minerals, and cofactors your brain specifically draws on to make neurotransmitters, manage inflammatory balance, and keep cellular energy production running. They’re also included in forms that your body can readily absorb and use, which can’t be said for all multivitamins. If you’re looking for even more comprehensive brain health support, BRIGHT MINDS™ Memory Multi is a great alternative product. Instead of a capsule, it’s a powdered full spectrum multivitamin and mineral formula, combined with active botanicals, antioxidants, and other nutrients clinically shown to support numerous aspects of memory, mood, and cognition.* In a large, three-year randomized trial following more than 2,000 older adults, daily multivitamin-mineral supplementation was associated with meaningfully better performance on measures of memory and executive function compared to placebo. It was the first large-scale study to suggest multivitamin use may help slow age-related cognitive changes [1]. A follow-up analysis comparing that trial with two others found the same pattern held up: better global cognition and episodic memory with daily multivitamin use [2]. None of this means a multivitamin is a substitute for medical care. What it does mean is that "just take a multivitamin" isn't throwaway advice. Nutrient gaps are common even in people who eat a well balanced diet, and a well-formulated multivitamin is one of the simplest ways to close them. Step Two: Omega-3s, Because Your Brain Is Mostly Fat Here's a fact that surprises people: your brain is close to 60% fat, and DHA (one of the two main omega-3s) is one of its primary structural building blocks. Your body doesn't make much of it on its own. It has to come from diet or supplementation, and most Americans simply don't eat enough fatty fish to get there. Omega-3 Power is BrainMD's answer to that gap, formulated with significantly more DHA and EPA per serving than most drugstore fish oil. The dosing isn't arbitrary. In the MIDAS trial, a randomized, placebo-controlled study of 485 older adults with mild memory complaints, six months of daily DHA supplementation led to meaningfully better performance on tests of learning and memory compared to placebo, an effect researchers likened to shaving several years off the participants' cognitive age [3]. Broader reviews of omega-3 research have also linked long-term supplementation to better-preserved white matter and gray matter volume over time [4]. Fish oil isn't a cure-all, and results across the broader research base are mixed. Some trials, especially shorter ones in people who already eat fish regularly, show smaller effects. But for the average person whose diet is genuinely low in omega-3s, topping up that supply appears to give the brain more of the literal material it needs to maintain its structure. Step Three: The Oft-Forgotten Probiotic This is the piece that catches most people off guard. What does gut bacteria have to do with brain fog or mood? More than you'd think. Your gut and brain are connected by a direct communication line, sometimes called the gut-brain axis, that runs through the vagus nerve, the immune system, and a whole slew of chemical messengers your gut bacteria help produce [5]. Plus, roughly 70% of your immune system actually lives in your gut, which means an out-of-balance microbiome doesn't just affect digestion, it can ripple into the inflammatory processes tied to mood and cognitive function [6]. This is exactly the territory "psychobiotics" (probiotic strains specifically studied for their effect on this gut-brain communication) were termed to describe [7]. In one randomized trial, a specific combination of Lactobacillus and Bifidobacterium strains was associated with a more balanced stress response and lower markers of stress in healthy adults over several weeks [8]. A broader review of more than fifty clinical trials found consistent signals of benefit from psychobiotic strains, particularly around mood-related outcomes [9]. ProBrainBiotics was formulated with this research in mind. It was built around strains studied specifically for gut-brain communication, not just general digestive support. For anyone who's diligent about diet and exercise, but has never thought about their microbiome, this is often the missing third leg of the stool. Putting Your Stack Together None of these three does its job in isolation. A multivitamin without enough dietary fat still leaves your brain short on raw building material. An omega-3 without the cofactors a multivitamin provides has less support for the metabolic work of actually using that fat well. And a gut under chronic inflammatory imbalance makes it harder for either one to do its job efficiently, because so much of the communication between body and brain runs straight through it. That's the logic behind treating these three as a foundation. Of course, you are encouraged to build outward from here. Some of Dr. Amen’s other personal favorite supplements are: Happy Saffron Plus® for mood and emotional well-being* Smart Mushrooms for mental performance and immune support* Smart Relief for body comfort and joint mobility* Peak Energy for a fast-acting alternative to caffeine* Adaptogens, superfoods, nootropics, whatever fits your specific goals, most products in the BrainMD line are complementary to the foundational products. Just don’t skip the base 3. If you're not sure where your own gaps might be, or where your brain and body could use a little extra boost, BrainMD's Brain Health Assessment is a great starting point. It takes about 5 minutes and you learn your brain type (there are 16 types), which will guide you to the best specific products for your unique needs. BrainMD’s full supplement collection is organized by health goal (focus, mood, sleep, memory, etc.) if you want to go beyond the basics once your foundation is in place. As always, talk with your doctor before starting any new supplement, especially if you're pregnant, nursing, managing a health condition, or taking prescription medication. Supplements are meant to complement, not replace, healthy habits (good sleep, regular movement, real food) and medical care when you need it. *These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease. References Baker, L. D., Manson, J. E., Rapp, S. R., Sesso, H. D., Gaussoin, S. A., Shumaker, S. A., & Espeland, M. A. (2022). Effects of cocoa extract and a multivitamin on cognitive function: A randomized clinical trial. Alzheimer's & Dementia. https://doi.org/10.1002/alz.12767 Vyas, C. M., Manson, J. E., Sesso, H. D., et al. (2024). Effect of multivitamin-mineral supplementation versus placebo on cognitive function: Results from the clinic subcohort of the COSMOS randomized clinical trial and meta-analysis of 3 cognitive studies within COSMOS. The American Journal of Clinical Nutrition. Yurko-Mauro, K., McCarthy, D., Rom, D., Nelson, E. B., Ryan, A. S., Blackwell, A., Salem, N., Jr., & Stedman, M. (2010). Beneficial effects of docosahexaenoic acid on cognition in age-related cognitive decline. Alzheimer's & Dementia, 6(6), 456–464. https://doi.org/10.1016/j.jalz.2010.01.013 Shahinfar, H., Yazdian, Z., Avini, N. A., Torabinasab, K., & Shab-Bidar, S. (2025). A systematic review and dose response meta analysis of Omega 3 supplementation on cognitive function. Scientific Reports, 15(1), 30610. Bonaz, B., Bazin, T., & Pellissier, S. (2018). The vagus nerve at the interface of the microbiota-gut-brain axis. Frontiers in Neuroscience, 12, Article 49. https://doi.org/10.3389/fnins.2018.00049 Belkaid, Y., & Hand, T. W. (2014). Role of the microbiota in immunity and inflammation. Cell, 157(1), 121–141. https://doi.org/10.1016/j.cell.2014.03.011 Dinan, T. G., Stanton, C., & Cryan, J. F. (2013). Psychobiotics: A novel class of psychotropic. Biological Psychiatry, 74(10), 720–726. https://doi.org/10.1016/j.biopsych.2013.05.001 Messaoudi, M., Lalonde, R., Violle, N., Javelot, H., Desor, D., Nejdi, A., Bisson, J.-F., Rougeot, C., Pichelin, M., Cazaubiel, M., & Cazaubiel, J.-M. (2011). Assessment of psychotropic-like properties of a probiotic formulation (Lactobacillus helveticus R0052 and Bifidobacterium longum R0175) in rats and human subjects. British Journal of Nutrition, 105(5), 755–764. https://doi.org/10.1017/S0007114510004319 Mosquera, F. E. C., Lizcano Martinez, S., & Liscano, Y. (2024). Effectiveness of psychobiotics in the treatment of psychiatric and cognitive disorders: A systematic review of randomized clinical trials. Nutrients, 16(9), Article 1352. https://doi.org/10.3390/nu16091352
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Psychobiotics: Supporting Brain Health Through the Gut
Explore the science of psychobiotics and learn how beneficial gut bacteria support the gut-brain axis, mood, stress resilience, and brain health.
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The Science Behind Dreams: What Real Research Reveals
Discover the science behind dreams and how research links dreaming to memory, emotions, sleep cycles, and overall brain health.
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How to Get Over Jet Lag: Science-Backed Strategies to Help Your Brain Adjust Faster
Learn how to get over jet lag with science-backed strategies that help your brain adjust faster. Discover tips on light exposure, hydration, sleep, and more
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Gummy Vitamins vs Pills: Does the Delivery Format Really Matter?
What kind of supplements do you prefer? There are many types of supplements including capsules, tablets, chewables, powders, gummies, liquids, energy bars, and more. With so many delivery formats available, it's natural to wonder: Are gummy vitamins as effective as pills? And does the form of a supplement really matter? The answer may surprise you. While different delivery formats each have their own advantages, the biggest factor isn't whether a supplement comes in a gummy or a capsule. It's the quality of the ingredients, the science behind the formulation, and whether you'll actually take it consistently. Let's take a closer look. Types of Supplements There’s a wide array of supplement types and delivery formats. Here are some of the major types of supplements and a few of their basic benefits and drawbacks. Gummy Vitamins Gummy supplements have come a long way over the past decade. While early gummy vitamins often relied on high amounts of sugar, artificial colors, and lower-potency formulas, today's premium gummies can deliver clinically researched ingredients in a convenient, enjoyable format. For many people, gummies make it easier to stay consistent with a daily supplement routine (especially those who dislike swallowing pills or simply prefer a chewable option). And consistency matters because even the highest-quality supplement can’t provide any benefit if it stays in the bottle. That said, not all gummies are created equal. Some products on the market contain sugar, artificial sweeteners, synthetic dyes, or ingredients in amounts too small to provide meaningful benefits. When choosing a gummy supplement, check the supplement facts panel first. Look for products that: Use clinically studied ingredients. Provide meaningful amounts of active ingredients. Do not use added sugar. Avoid unnecessary artificial colors and flavors. Are manufactured under strict quality standards. A great example is BrainMD's Happy Saffron Plus® Gummies, which combine clinically studied saffron extract with complementary nutrients in a delicious gummy designed to support a positive mood and emotional well-being. For adults who don't enjoy swallowing pills, they offer a convenient way to make mood support part of a daily wellness routine. When it comes to the gummy vitamins vs. pills debate, the better question isn't which format wins, it's which product is more thoughtfully formulated, and which one are you more likely to take consistently. A high-quality gummy can be an excellent delivery system for the right ingredients, while a poorly formulated pill isn't automatically better simply because it's a capsule or tablet. Capsules Pill capsules (“two-piece hardgels”) have a smooth, translucent outer shell that’s filled with a loose powder. They typically come in either a traditional gelatin shell or in a vegetarian (plant-based) shell. Capsules protect their contents against breakdown from direct exposure to the air and humidity. They’re generally easier to swallow than tablets and don’t leave behind an unpleasant taste in the mouth. Hardgels are preferred by people, especially parents of young kids, who opt to open the capsule and pour the powder over food or into a liquid or smoothie. One of the downsides is that capsules may contain lower doses of ingredients than tablets. Also, some may find large capsules just as difficult to swallow as tablets. Softgels Softgel pills typically contain liquid supplements inside a sealed gelatin shell. They are often used to encapsulate fish oil, vitamin D, and other fat-soluble vitamins. Softgels can be an excellent option for liquid ingredients. However, they cannot easily be opened or divided, and some consumers prefer to avoid gelatin-based products. Tablets Tablets are produced by compressing granules or powders into a hard pill. Many times, tablets are single-ingredient supplements, such as iron pills. One advantage of tablets is that they can provide higher amounts of ingredients compared to capsules and softgels. Also, tablets can be split (with a pill cutter) or crushed into a powder to make them easier to swallow. A common complaint against tablets is that they tend to be the hardest pill form to swallow. Also, without a coating, they may have a bitter or unpleasant taste. Unfortunately, to avoid that bitterness or to improve appearance, many tablets are coated with potentially unsafe substances (such as titanium dioxide)¹. Chewable Tablets Chewable tablets are useful for delivering larger amounts of an active ingredient that would otherwise take several hardgel or softgel capsules to deliver. As their name suggests, chewable tablets must be chewed before they’re swallowed. Chewables are ideal for those who don’t enjoy or have difficulty, swallowing pills. Since they must be chewed, chewables often are made to taste more pleasant than some other forms of supplements. As with gummy vitamins, there are a few potential pitfalls to be aware of. Many contain artificial colors and flavors that aren’t proven safe. Also, many chewables have sugar or artificial sweeteners, which are included to appeal to the customer’s tastebuds. Look for chewables that minimize sweeteners and artificial ingredients. Energy Bars The energy bar market has exploded in recent years, perhaps driven by the fast-paced nature of our society. Energy bars are often represented as providing a short-term energy boost to bridge the gap from one meal to the next. Some bars are marketed as food-based supplements that provide fats, proteins, and carbohydrates. Unfortunately, many have inferior sources of these food categories and fail to deliver a lasting energy boost. These convenient meal alternatives may (or many not) have a pleasant taste and may contain some vitamins, minerals, and other nutrients. However, many contain artificial colors, flavors, or sweeteners, which offset some of their benefit. For people with blood sugar problems, bars with lots of added sugar can hurt rather than help their mental focus or physical endurance. Liquids Some people just prefer to drink their vitamins. Liquid supplements have become more popular in recent years due to their convenience. Also, many maintain that a product’s efficacy is sustained over a longer period when it’s kept in the refrigerator. This actually isn’t the case because each time the bottle is opened – regardless of the temperature – the air that gets in delivers oxygen to the liquid, which degrades it. Rancidity sets in long before we can sense it by smell or taste. Liquid supplements can be naturally occurring or suspended in a liquid and may be preferred by people who have difficulty swallowing pills. Some of the benefits of liquid supplements are that its doses can be easily tailored and it doesn’t need to be mixed into liquid or water. Also, some research suggests that nutritional ingredients are more efficiently absorbed from liquid supplements compared to solid supplements.² Other than taking up space in your fridge, one of the biggest challenges with liquid supplements is that its taste tends to be amplified over normal supplements, which is a good thing if the product is pleasant tasting, but not so much if it isn’t. Also, liquid supplements tend to be pricier than their capsule or tablet counterparts and need artificial preservatives to keep them from prematurely breaking down. Powders Powdered supplements are dehydrated ingredients that must be dissolved in water or another liquid before being consumed. These nutrients can be added to fruit/vegetable juices, healthy smoothies, or even soups. As with those who prefer liquid supplements, powdered nutrients may be enjoyed as an alternative to pills and may be quickly absorbed. Powders may offer higher doses than pills since doses are easy to adjust. For some ingredients, the daily dose needed for health benefit is so high that a powder is the only choice a responsible manufacturer can make. The tradeoff is that powdered nutrients may have an unpleasant aftertaste. Also, the need to mix the powder into liquids requires more time spent in the kitchen and messes may be created in the combining process. Gummies vs. Capsules/Tablets Comparison Chart Feature Gummy Vitamins Traditional Pills (Capsules/Tablets) Best Suited For Targeted, low-dose micronutrients and concentrated botanicals (like saffron or vitamin D3) where consistency and taste support a daily routine. Bulky macrominerals (calcium, magnesium) and complex multi-ingredient formulas that require high physical volume. Primary Advantage High compliance; enjoyable to take consistently; excellent for accommodating low-dosage, concentrated extracts. Can hold dense, high-volume nutritional payloads in a single serving size. Active Ingredient Delivery Ideal for concentrated extracts that provide targeted support within a small milligram profile. Ideal for high-volume powder formulas and multi-nutrient combinations. What to Look For Clean formulations with minimal, natural sweeteners, avoiding artificial dyes or excess fillers. High-quality shells (like vegetable capsules) that dissolve reliably in the digestive tract. Which Supplement Format Is Best? There isn't a single delivery format that's best for everyone. Instead, consider your personal preferences, health goals, and the type of nutrient you're supplementing. Capsules are a great choice for many vitamins, minerals, and herbal ingredients. Softgels work especially well for oils and fat-soluble nutrients. Powders are ideal when larger amounts of an ingredient are needed. Liquids can be helpful for flexible dosing or those who have difficulty swallowing. Gummies are an excellent option for people who value convenience, great taste, and daily consistency. Ultimately, the best supplement is one you'll actually take consistently. Quality Matters More Than Format Whether you choose gummies, capsules, tablets, or powders, look beyond the delivery system. Choose supplements that are: Backed by science. Made with high-quality ingredients. Manufactured according to rigorous quality standards. Transparent about what's included, and what's left out. A thoughtfully formulated supplement can support your wellness goals regardless of its format. At BrainMD, we’re dedicated to providing the highest quality supplements to improve your physical health and overall well-being. For more information about our full list of brain healthy supplements, please visit us at BrainMD. These statements have not been evaluated by the FDA. This content is for informational purposes only. It is not meant to substitute for medical or healthcare advice from a physician, nor is it intended to diagnose, treat, cure, or prevent any disease. Consult your healthcare provider before beginning a new health regimen. References: ¹Skocaj, M., Filipic, M., Petkovic, J., & Novak, S. (2011). Titanium dioxide in our everyday life; is it safe? Radiology and Oncology, 45(4), 227–247. https://doi.org/10.2478/v10019-011-0037-0 ²Ko, J., Yoo, C., Xing, D., Gonzalez, D. E., Jenkins, V., Dickerson, B., Leonard, M., Nottingham, K., Kendra, J., Sowinski, R., Rasmussen, C. J., & Kreider, R. B. (2023). Pharmacokinetic analyses of liposomal and non-liposomal multivitamin/mineral formulations. Nutrients, 15(13), 3073. https://doi.org/10.3390/nu15133073
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Brain Hormones: What They Are and How to Support Them Naturally
The human brain is one of the most complex structures in existence, controlling everything from movement and memory to emotions and decision-making. At the center of this intricate system are brain hormones – chemical messengers that influence mood, behavior, cognition, sleep, appetite, and even social bonding. These hormones are essential for maintaining balance within the body and ensuring that the brain communicates effectively with other organs and systems. Though many people associate hormones with puberty or reproduction, brain hormones play a much broader role in daily life. Every emotion you feel, every burst of motivation, every night of restful sleep, and even your ability to cope with stress is connected to hormonal activity in the brain. Let’s take a closer look at what brain hormones are, how they work, the most important hormones involved in brain function, and how lifestyle choices can influence hormonal balance. What Are Brain Hormones? Brain hormones are chemical substances produced either directly in the brain or by endocrine glands controlled by the brain. They travel through the bloodstream or act within neural pathways to regulate physiological and psychological functions. The brain’s hormonal system is primarily managed by two important structures: Hypothalamus – the control center that links the nervous system to the endocrine system. Pituitary gland – often called the “master gland” because it regulates many other hormone-producing glands in the body. Together, these structures help maintain homeostasis, which is the body’s internal balance. Brain hormones may affect: Mood and emotions Stress response Sleep cycles Learning and memory Motivation and reward Hunger and metabolism Social bonding Sexual behavior An imbalance in these hormones can contribute to mental and physical health problems, including mood, sleep, weight, and cognitive issues. Here Are Some of the Major Brain Hormones and Their Functions Dopamine – The Motivation and Reward Hormone Dopamine is often referred to as the “feel-good” hormone, although its primary role is actually motivation and reward. When you achieve a goal, eat delicious foods, receive praise, or experience pleasure, dopamine levels rise. This hormone makes rewarding experiences feel satisfying. Functions of Dopamine Motivation and drive Pleasure and reward Focus and attention Learning and memory Motor control Healthy dopamine levels help people feel energized, productive, and motivated. Low Dopamine Levels Low dopamine may contribute to: Lack of motivation Fatigue Difficulty concentrating Low mood Excess Dopamine Too much dopamine activity has been associated with addictive or impulsive behaviors. Modern technology and social media can overstimulate dopamine pathways, leading to cycles of instant gratification and reduced attention spans. Serotonin – The Mood Stabilizer Serotonin is strongly linked to happiness, emotional stability, and well-being. While much of the body’s serotonin is produced in the gut, it can have a profound effect on the brain. Functions of Serotonin Regulates mood Supports sleep Influences appetite Helps with digestion Affects memory and learning Balanced serotonin levels contribute to emotional calmness and resilience. Low Serotonin Symptoms Low serotonin is often connected with: Mood issues Irritability Sleep problems Emotional instability Natural Ways to Support Serotonin Regular exercise Sunlight exposure Healthy sleep Foods rich in tryptophan Meditation and stress reduction Cortisol – The Stress Hormone Cortisol is produced by the adrenal glands but regulated through signals originating in the brain. It plays a key role in the body’s fight-or-flight response. Functions of Cortisol Manages stress response Regulates blood sugar Lessens inflammation Supports metabolism Helps maintain alertness In short bursts, cortisol is beneficial because it helps the body respond to danger or pressure. High Cortisol Long-term stress can keep cortisol levels elevated, leading to: Anxiousness Weight gain Sleep disturbances Memory problems High blood pressure Weakened immunity Modern lifestyles filled with work stress, digital overload, and lack of rest can activate cortisol production. Lowering Cortisol Naturally Deep breathing exercises Adequate sleep Physical activity Time spent in nature Reduced caffeine intake Healthy work-life balance Oxytocin – The Love and Bonding Hormone Oxytocin is often called the “love hormone” because it promotes emotional bonding and trust. It’s released during activities such as hugging, childbirth, breastfeeding, and positive social interaction. Functions of Oxytocin Encourages social connections Builds trust and empathy Supports maternal bonding Reduces stress and anxiousness Enhances emotional resilience Strong relationships and social support systems can increase oxytocin production and improve mental well-being. The Importance of Human Connection Research consistently shows that loneliness and social isolation can negatively affect mental and physical health.¹ Simple acts like eye contact, kindness, and physical affection can help stimulate oxytocin release. Melatonin – The Sleep Hormone Melatonin regulates the body’s circadian rhythm, also known as the sleep-wake cycle. The pineal gland releases melatonin in response to darkness, signaling the body that it’s time to prepare for sleep. Functions of Melatonin Promotes sleep Regulates biological rhythms Supports immune health Influences seasonal mood patterns Disrupted Melatonin Production Artificial light exposure – especially from cellphones and screens – can interfere with melatonin production. Low melatonin levels may lead to: Sleep disruptions Fatigue Poor concentration Mood changes Supporting Melatonin Naturally Limit screen time before bed Sleep in a dark room Maintain a regular sleep schedule Avoid caffeine late in the day Getting quality sleep is one of the most important ways to support brain health. Endorphins – The Natural Ache Relievers Endorphins are chemicals released by the brain to reduce physical discomfort and create feelings of pleasure. They are commonly associated with the “runner’s high” experienced after exercise. Functions of Endorphins Relieve aches Reduce stress Improve mood Promote relaxation Activities that can increase endorphins include: Exercise Laughter Music Dancing Meditation In addition to being natural ache relievers, endorphins can contribute significantly to emotional well-being and resilience. Adrenaline – The Energy Booster Adrenaline, also known as epinephrine, prepares the body for immediate action during stressful or exciting situations. Functions of Adrenaline Increases heart rate Boosts energy Sharpens focus Enhances reaction speed Adrenaline is useful during emergencies, athletic competition, or high-pressure situations. However, excessive adrenaline due to stress and worry can contribute to panic attacks, restlessness, and exhaustion. The Brain-Hormone Connection Brain hormones interact in highly complex networks. For example: Extreme stress increases cortisol, which can reduce serotonin and dopamine. Poor sleep can lower melatonin and disrupt dopamine balance. Positive social interactions help boost oxytocin and reduce cortisol. Exercise increases dopamine, serotonin, and endorphins simultaneously. This interconnected system helps explain how mental health can be influenced by multiple lifestyle factors. How Lifestyle Affects Brain Hormones 1. Nutrition The brain requires nutrients to produce hormones efficiently. Important nutrients include: Omega-3 fatty acids Protein Magnesium Zinc B vitamins Highly processed foods and excessive sugar intake may negatively impact hormonal balance and brain function. 2. Exercise Physical activity is one of the most effective ways to support brain hormones. Exercise can help: Increase dopamine Boost serotonin Release endorphins Reduce cortisol Even moderate activities like walking can improve mood and cognitive performance. 3. Sleep Sleep is essential for hormonal regulation. During sleep, the brain: Restores neurotransmitter balance Removes metabolic waste Consolidates memories² Regulates stress hormones Sleep deprivation can disrupt emotional regulation and decision-making. 4. Stress Management Long-term stress can disrupt hormone balance³ and overall brain health. Healthy stress-management techniques include: Meditation Yoga Journaling Mindfulness Social support Relaxation exercises Reducing stress can help improve mental clarity and emotional stability. 5. Social Relationships Humans are social beings, and healthy hormones can have a positive effect on relationships. Supportive social interactions can help increase oxytocin, serotonin, and dopamine. Conversely, isolation and conflict may elevate cortisol and negatively affect emotional health. Find Better Balance Brain hormones are the invisible chemical messengers that shape nearly every aspect of the human experience. From motivation and happiness to stress and sleep, these substances influence how we think, feel, and behave every day. Maintaining healthy hormone balance can help optimize mental clarity, emotional resilience, physical energy, and overall quality of life. Simple lifestyle habits such as regular exercise, healthy nutrition, quality sleep, meaningful relationships, and stress management can positively affect brain chemistry. Though the many stressors of modern living can be overwhelming, implementing these healthy habits can empower you to make healthier choices – which can help you achieve better balance in life. At BrainMD, we’re dedicated to providing the highest quality supplements to improve your physical health and overall well-being. For more information about our full list of brain healthy supplements, please visit us at BrainMD. These statements have not been evaluated by the FDA. This content is for informational purposes only. It is not meant to substitute for medical or healthcare advice from a physician, nor is it intended to diagnose, treat, cure, or prevent any disease. Consult your healthcare provider before beginning a new health regimen. References: ¹Shankar, R. (2023). Loneliness, social isolation, and its effects on physical and mental health. Missouri Medicine, 120(2), 106–108. https://pmc.ncbi.nlm.nih.gov/articles/PMC10121112/ ²Paller, K. A., Creery, J. D., & Schechtman, E. (2021). Memory and sleep: How sleep cognition can change the waking mind for the better. Annual Review of Psychology, 72, 123–150. https://doi.org/10.1146/annurev-psych-010419-050815 ³Ranabir, S., & Reetu, K. (2011). Stress and hormones. Indian Journal of Endocrinology and Metabolism, 15(1), 18–22. https://doi.org/10.4103/2230-8210.77573
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Stress Physiology: How Stress Affects Your Body and Brain
Stress is an unavoidable part of human life. From looming deadlines and financial pressures to physical threats and emotional challenges, stressors come in many forms. To fully appreciate the impact of stress, we must explore stress physiology – the complex interplay between the brain, nervous system, endocrine system, and body – an intricate process that governs how we respond to perceived threats. What Is Stress? Fundamentally, stress is a biological response designed to protect and sustain life. It’s the body’s response to any demand or challenge that disrupts homeostasis, the internal balance necessary for optimal functioning. These stressors may be short-term (such as narrowly avoiding a car accident), or long-term (such as ongoing work pressure or illness). Good Stress/Bad Stress People tend to see stress in a negative light, but stress is both good and bad. A certain amount of stress is actually good because it can motivate you to meet your goals. Low level stress also can help you with resilience, problem-solving, and adapting to everyday challenges. Stress becomes a problem when it’s intense, recurring, or remains unresolved over a sustained period. At that point, stress can take its toll and become harmful to your health. If left unchecked, excessive stress can lead to serious physical, mental, emotional, and social problems. The Two Main Stress Pathways The body’s physiological stress response system operates through two main systems: The Sympathetic-Adreno-Medullary (SAM) Axis This system governs the immediate “fight-or-flight” response: The hypothalamus activates the sympathetic nervous system. The adrenal medulla releases catecholamines – primarily adrenaline (epinephrine) and noradrenaline (norepinephrine). Effects include: Increased heart rate and blood pressure Rapid breathing Dilated pupils Increased glucose availability Heightened alertness This response system prepares the body to react quickly to danger. The Hypothalamic-Pituitary-Adrenal (HPA) Axis The HPA axis regulates longer-term stress responses: The hypothalamus releases corticotropin-releasing hormone (CRH). CRH stimulates the pituitary gland to release adrenocorticotropic hormone (ACTH). ACTH prompts the adrenal cortex to release cortisol. Often called the “stress hormone,” cortisol has widespread effects: Increases blood sugar levels Suppresses the immune system Affects metabolism Influences memory and mood Unlike the SAM axis, which usually acts within seconds, the HPA axis operates within minutes or even hours. Types of Stress Short-term Stress Short-term stress can be beneficial. It enhances focus, boosts energy, and improves performance. This is sometimes referred to as eustress, or positive stress. Examples: Preparing for a presentation Competing in sports Responding to a sudden emergency The body typically returns to homeostasis once the stressor passes. Long-term Stress Problems arise when stress becomes prolonged or repeated without adequate recovery. Sustained activation of the stress response can lead to dysregulation in multiple systems. Physiological consequences include: Persistent elevated cortisol Impaired immune function Increased inflammation Cardiovascular strain Digestive issues Over time, this can contribute to heart, weight, and mood issues. Allostasis and Allostatic Load To understand the effects of long-term stress, some scientists use the concepts of allostasis and allostatic load. Allostasis: The process by which the body achieves stability through change. Allostatic Load: The cumulative wear and tear on the body from repeated stress. When the stress response system is activated too frequently, or fails to shut off properly, the body may experience allostatic overload. The Role of the Autonomic Nervous System The autonomic nervous system (ANS) regulates involuntary bodily functions and has two key areas: Sympathetic Nervous System (SNS) Activates the fight-or-flight response Revs up energy production Parasympathetic Nervous System (PNS) Promotes “rest and digest” functions Conserves energy and supports recovery A healthy stress response depends on a dynamic balance between these two systems. Long-term stress is often the result of excessive sympathetic activity and insufficient parasympathetic recovery. Stress and the Immune System Stress can have a profound effect on immune function. Short-term stress can enhance immune readiness by mobilizing immune cells. Long-term stress can suppress immune function and increase susceptibility to infections. Prolonged elevation of stress can impair immune defenses and delay recovery. Stress and the Cardiovascular System Stress can negatively impact heart health. Increased heart rate and blood pressure during periods of stress can strain blood vessels. Severe stress contributes to increased risk of cardiovascular issues. Behavioral responses to stress – such as poor diet, smoking, and lack of exercise – may further exacerbate these risks. Stress and the Brain Stress perception begins in certain regions of the brain: Amygdala: Detects threats and triggers emotional responses, such as fear. Hippocampus: Processes memories and helps contextualize stressors. Prefrontal Cortex: Regulates decision-making and can help determine if something is a threat or not. When a stressor is identified, the amygdala signals the hypothalamus, which initiates the body’s stress response systems. Stress Hormones Though cortisol is the most well-known stress hormone, others can play important roles too: Adrenaline (Epinephrine): Rapid response to acute stress Norepinephrine: Enhances alertness and focus Dopamine: Influences motivation and reward pathways Serotonin: Affects mood and emotional balance Stress can disrupt the balance of these neurotransmitters, contributing to mood and behavioral issues. Individual Responses to Stress Not everyone responds to stress in the same way. Several factors can influence stress physiology: Genetics Early life experiences Personality traits Social support Coping abilities Individuals with strong social connections often show reduced physiological stress responses. Recovery: The Missing Piece A critical but often overlooked aspect of stress physiology is recovery. Just as the body initially reacts to a stressor, it also must return to a healthy baseline after the stressor has been removed or overcome. Effective recovery mechanisms include: Activation of the PNS Reduction in cortisol levels Regulation of energy levels Without adequate recovery, stress can accumulate and lead to a host of mental and physical issues. Here Are 6 of the Best Ways to Manage Stress Actively managing stress is an important aspect of stress physiology. Effective strategies include: 1. Physical Activity Exercise helps regulate cortisol levels,¹ improves mood, and enhances resilience. 2. Sleep Quality sleep is essential for restoring physiological balance and regulating stress hormones. 3. Mindfulness and Meditation These practices help reduce sympathetic activity and enhance parasympathetic activity. 4. Nutrition A balanced diet supports metabolic² and hormonal health, reducing vulnerability to stress. 5. Social Connection Social support³ helps relieve stress responses and improves overall well-being. 6. Cognitive Strategies Reframing stressors and developing coping skills can help alter how the brain perceives threats. The Future of Stress Research Advances in neuroscience and endocrinology continue to deepen our understanding of stress physiology. Emerging areas of research include: The gut-brain axis and its role in stress Epigenetic changes influenced by extreme stress Personalized stress management interventions These insights may lead to more targeted and effective treatments for stress-related challenges. Manage Your Stress Physiology Stress physiology reveals that stress isn’t inherently harmful – it’s a vital adaptive mechanism. However, when stress becomes excessive, it can disrupt many systems in the body. Understanding how stress operates, at a biological level, can help us better manage it. Balancing activation with recovery, recognizing individual limits, and adopting healthy coping strategies are essential steps toward maintaining both physical and mental health. In a world filled with constant demands, coping with stress isn’t about eliminating it, but about working with it, adapting to it, and ultimately, recovering from it. At BrainMD, we’re dedicated to providing the highest quality supplements to improve your physical health and overall well-being. For more information about our full list of brain healthy supplements, please visit us at BrainMD. These statements have not been evaluated by the FDA. This content is for informational purposes only. It is not meant to substitute for medical or healthcare advice from a physician, nor is it intended to diagnose, treat, cure, or prevent any disease. Consult your healthcare provider before beginning a new health regimen. References: ¹Li, X., Huang, J., & Zhu, F. (2025). The optimal exercise modality and dose for cortisol reduction in psychological distress: A systematic review and network meta-analysis. Sports, 13(12), 415. https://doi.org/10.3390/sports13120415 ²Li, B., Tang, X., & Le, G. (2023). Dietary habits and metabolic health. Nutrients, 15(18), 3975. https://doi.org/10.3390/nu15183975 ³Ozbay, F., Johnson, D. C., Dimoulas, E., Morgan, C. A., Charney, D., & Southwick, S. (2007). Social support and resilience to stress: From neurobiology to clinical practice. Psychiatry (Edgmont), 4(5), 35–40. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2921311/
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Here Are the 9 Vital Functions of Vitamin D for Your Health
Vitamin D, which is technically a hormone rather than a vitamin, is a crucial nutrient. Unfortunately, many Americans – even those who eat a good diet – are deficient in vitamin D.¹ Though definitions of vitamin D deficiency can vary, experts agree that it has nearly reached epidemic status. Analysis of the ongoing national survey data from the US Centers for Disease Control indicates that a majority of Americans may not be getting sufficient vitamin D. One way to get a natural vitamin D boost is from exposure to sunlight. But since we're wearing more sunscreen while outside and spending more time inside, our levels of vitamin D have fallen in recent decades. Why does that matter? Some research has linked vitamin D deficiency to serious, long-term health issues.² Those who think of vitamin D only as the “sunshine vitamin” may fail to fully understand the significant ways vitamin D affects their brain, body and overall health.³ Let's take a closer look at how vitamin D works in key areas of the brain and body, as well as how to increase levels of this essential vitamin...naturally! Here Are 9 Vital Functions of Vitamin D Immunity Vitamin D receptors are found all over the body, including the immune cells. Research has clearly shown that vitamin D deficiency is part of the seasonal nature of cold and flu outbreaks⁴ – less sunlight means less vitamin D, which can lead to lower immunity and more illness. Bones It’s well-documented that vitamin D is essential for the proper absorption of calcium, and it’s been shown to greatly reduce fracture risk in two ways. First, it helps with the formation of stronger bones; second, vitamin D helps improve balance and prevent falls by enhancing muscle contraction.⁵ Muscles One of the byproducts of vitamin D’s breakdown, called 1,25(OH)2D, enters muscle cells and affects the nucleus. Once there, the vitamin D metabolite enhances the cell’s contraction ability. Since muscles work by contraction and relaxation, a muscle’s ability to contract is essential to its strength and response to outside forces. As such, vitamin D helps make muscles stronger in a very direct way. Lungs As many studies indicate, vitamin D plays a role in keeping our lungs healthy due to vitamin D possessing a range of anti-inflammatory properties – with greater concentrations of vitamin D resulting in greater lung health benefits.⁶ Heart Research has demonstrated an inverse relationship between vitamin D levels in the blood and high blood pressure (HBP or hypertension). In other words, the lower the vitamin D, the higher the blood pressure. The excess strain and resulting damage from high blood pressure can cause the coronary arteries serving the heart to slowly narrow and harden, greatly increasing the risk of a heart attack. Kidneys Because vitamin D is a fat-soluble vitamin, it helps to regulate kidney function and plays a very beneficial role in treating serious kidney issues.⁷ Mood When it comes to being happy, the scientific evidence is clear. The lower your vitamin D levels, the more likely you are to feel blue rather than happy. Vitamin D deficiency has long been associated with higher incidences of low mood. Interestingly, in a 2014 study, the positive effect of vitamin D3 on mood was comparable to the effects of the anti-depressants.⁸ Weight Loss When you don’t have enough vitamin D, you can feel hungry all the time, no matter how much you eat. That's because low levels of vitamin D can interfere with the effectiveness of leptin, the appetite hormone that tells you when you're full. When vitamin D is replenished and back to normal levels, leptin’s actions are restored, thus creating feelings of satiety and aiding in weight loss. Cognitive Function In the past few years, many studies have linked shortage of vitamin D with cognitive issues in older men and women. Research has demonstrated that vitamin D has a variety of neuroprotective roles, including helping to rid the brain of beta-amyloid, an abnormal protein that is believed to be a major cause of severe memory issues.⁹ Other studies have shown that seniors with very low levels of vitamin D are at an increased risk of serious, long-term memory issues. Recommended Daily Vitamin D In the US, the current recommended daily dose of vitamin D is 600 IU. However, most experts agree that this is well below the physiological needs of most individuals. Some experts have suggested that all adults should take at least 2000 IU of vitamin D daily, but for many people, this daily dose doesn’t raise their vitamin D levels into a healthy range. What Can Help? BrainMD offers two high-quality, ultra-pure vitamin D formulas: Vitamin D3 5000 Vitamin D3 5000 delivers 5,000 IU of your body’s preferred form (cholecalciferol) in one high-potency capsule—supporting brain function, emotional well-being, immune strength, and bone health.* Vitamin D3 + K2 This powerful combination of vitamin D3 (as cholecalciferol) and vitamin K2 (as MK-7) helps strengthen bones, promote cardiovascular health, fight oxidative stress, support the immune system, preserve cognitive function and more.* Let the Sunshine (Vitamin) In! These powerful vitamins work hard to promote strong bones, support cognitive functioning, and maintain a healthy circulatory system.* Try Vitamin D3 5000 and Vitamin D3 + K2 today!* At BrainMD, we’re dedicated to providing the highest quality supplements to improve your physical health and overall well-being. For more information about our full list of brain healthy supplements, please visit us at BrainMD. *These statements have not been evaluated by the FDA. This content is for informational purposes only. It is not meant to substitute for medical or healthcare advice from a physician, nor is it intended to diagnose, treat, cure, or prevent any disease. Consult your healthcare provider before beginning a new health regimen. References: 1. Cui, A., Xiao, P., Ma, Y., Fan, Z., Zhou, F., Zheng, J., & Zhang, L. (2022). Prevalence, trend, and predictor analyses of vitamin D deficiency in the US population, 2001–2018. Frontiers in Nutrition, 9, 965376. https://doi.org/10.3389/fnut.2022.965376 2. Holick, M. F., & Chen, T. C. (2008). Vitamin D deficiency: A worldwide problem with health consequences. The American Journal of Clinical Nutrition, 87(4), 1080S–1086S. https://doi.org/10.1093/ajcn/87.4.1080S 3. Aranow, C. (2011). Vitamin D and the immune system. Journal of Investigative Medicine, 59(6), 881–886. https://doi.org/10.231/JIM.0b013e31821b8755 4. Cannell, J. J., Vieth, R., Umhau, J. C., Holick, M. F., Grant, W. B., Madronich, S., Garland, C. F., & Giovannucci, E. (2006). Epidemic influenza and vitamin D. Epidemiology and Infection, 134(6), 1129–1140. https://doi.org/10.1017/S0950268806007175 5. Bischoff-Ferrari, H. A., Dawson-Hughes, B., Willett, W. C., Staehelin, H. B., Bazemore, M. G., Zee, R. Y., & Wong, J. B. (2004). Effect of vitamin D on falls: A meta-analysis. JAMA, 291(16), 1999–2006. https://doi.org/10.1001/jama.291.16.1999 6. Hughes, D. A., & Norton, R. (2009). Vitamin D and respiratory health. Clinical and Experimental Immunology, 158(1), 20–25. https://doi.org/10.1111/j.1365-2249.2009.04001.x 7. Williams, S., Malatesta, K., & Norris, K. (2009). Vitamin D and chronic kidney disease. Ethnicity & Disease, 19(4 Suppl 5), S5–8–S5–11. 8. Spedding, S. (2014). Vitamin D and depression: A systematic review and meta-analysis comparing studies with and without biological flaws. Nutrients, 6(4), 1501–1518. https://doi.org/10.3390/nu6041501 9. Banerjee, A., Khemka, V. K., Ganguly, A., Roy, D., Ganguly, U., & Chakrabarti, S. (2015). Vitamin D and Alzheimer’s disease: Neurocognition to therapeutics. International Journal of Alzheimer’s Disease, 2015, 192747. https://doi.org/10.1155/2015/192747
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One of the Best Ways to Relieve Stress & Anxiousness!
Sometimes it seems like there's no way to turn off the steady stream of stress. Whether it’s taxes, a deadline at work, family conflict, dealing with an illness, school exams, or needing to make an important decision, it's safe to say that all of us have experienced stress in one form or another. In today’s fast-paced world, it's virtually impossible to avoid. What is Stress? Contrary to popular belief, not all stress is bad. It's a part of normal living that helps us be productive and is reported by folks at all ages.¹ In fact, stress actually can be a positive that helps us learn things like: Resilience Problem solving How to adapt to everyday challenges Stress becomes a problem when it's intense, recurring, or remains unresolved over a period of time. At that point, stress takes a toll and can be very damaging. It can affect the way we learn, our behavior, peace of mind, and ultimately, our health. By some estimates, as much as 90% of all illness is initiated and aggravated by stress.² Over the long term, it can increase your chances of developing diseases like blood sugar and heart issues, substance abuse, and feelings of anxiousness. What is Anxiousness? Many people use the terms stress and anxiousness interchangeably in everyday conversation. But there is a difference. Stress is a response to the pressures we feel in life. These pressures, in turn, cause adrenaline to be released. Too much adrenaline produced for an extended period can lead to low mood, a rise in blood pressure, and other negative effects. One of these negative effects is anxiousness. It's the process by which a person becomes scared and apprehensive of what lies ahead, and often manifests itself in physical problems like dizziness, pain, shortness of breath, and panic attacks. In other words, stress is a response to an existing stress-causing factor (stressor). Anxiousness is the continued experience of stress that is out of proportion to the stressor or that continues well after the stressor is gone. Though they are closely related, not all people who experience stress will experience anxiousness. Properly managing your stress is a critical factor in preventing anxiousness and the host of other problems that it can lead to. Be sure to educate yourself on the strategies to manage stress. Everyday Stress Relief Everyday Stress Relief helps replenish your brain and body’s stores of magnesium, a mineral crucial for practically all our life processes and which can be depleted during times of increased stress.* This science-based supplement also includes herbal extracts clinically proven to have calming and anti-stress effects, helping to ease anxiousness without causing sleepiness.* This formula helps you cope with apprehension, tension, worry, and fatigue.* It includes: Magnesium – magnesium is a major mineral important for us to make energy and keep our brain connections (“synapses”) fine-tuned so that we can stay calm, balanced and maintain a mentally focused demeanor in the face of stress.* Taurine – a nutrient classified as conditionally-essential because some people need it from their diet, taurine has versatile benefits for electrical transmission in the brain.* It also supports the adrenal glands, which are crucial for coping with stress.* Holy Basil – holy basil (Ocimum sanctum, also called Tulsi), is revered both in Europe and the East for improving adaptation to occasional anxiousness, feelings of exhaustion, forgetfulness and other problems related to stress.* L-theanine – derived from green tea, l-theanine is a unique amino acid found in clinical trials to improve mood, reduce anxiousness, and cognition as well as the quality of sleep in people coping with stress.* Relora® – a unique mix of two herbs (Magnolia officinalis and Phellodendron amurense) that can enhance healthy management of the stress hormone cortisol while easing tension, anger, negative mood, and confusion.* This safe, non-sedating, and non-habit-forming formula combines the multiple beneficial actions of these well-studied herbs and nutrients to help your brain and body cope with stress on multiple levels.* Relieve Stress & Anxiousness One of the best ways to manage stress and improve your mood is with Stress & Mood supplements like Everyday Stress Relief.* They’ve been formulated with the highest-quality nutrients and ingredients to help you feel calm, content, and better able to manage stress or mental strain.* Try Everyday Stress Relief today! At BrainMD, we’re dedicated to providing the highest quality supplements to improve your physical health and overall well-being. For more information about our full list of brain healthy supplements, please visit us at BrainMD. *These statements have not been evaluated by the FDA. This content is for informational purposes only. It is not meant to substitute for medical or healthcare advice from a physician, nor is it intended to diagnose, treat, cure, or prevent any disease. Consult your healthcare provider before beginning a new health regimen. References: 1. McManus, E., Haroon, H., Duncan, N. W., Elliott, R., & Muhlert, N. (2022). The effects of stress across the lifespan on the brain, cognition and mental health: A UK biobank study. Neurobiology of Stress, 18, 100447. https://doi.org/10.1016/j.ynstr.2022.100447 2. Salleh, M. R. (2008). Life event, stress and illness. Malaysian Journal of Medical Sciences, 15(4), 9–18.
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7 of the Best Ways to Naturally Increase Dopamine
Does it feel like you never have enough energy? Do you find it hard to concentrate? Have you lost your zest for life? If you answered yes to any of these, your neurotransmitters may be out of balance. What Are Neurotransmitters? Neurotransmitters (or transmitters) are small molecules that communicate information between neurons or other brain cells, both within your brain and to and from the rest of your body.¹ Most typically, a nerve cell, when electrically stimulated, releases transmitters that travel to other cells and bind with sensors on those cells (receptors) that turn those cells on or off. Transmitters influence and regulate the functioning of practically every cell, tissue, and organ in your body. While the exact number isn’t known, the human body has at least 60 different transmitters. Since the body’s transmitter systems are also intricately involved with its hormone systems, neurotransmitter imbalances can cause serious health problems. Balanced Brain Transmitters Transmitters coordinate and regulate every feature of your mind and body. More important than the activity of any one transmitter system is the overall balance between all the systems in the brain. When your brain transmitters are balanced, you may think more clearly, feel happier, and experience greater well-being. But when your transmitters are out of balance, you may experience difficulties in every area of your life. Proper neurotransmitter system balance is essential for living a brain-healthy life. The better your transmitters work with each other, the closer you’ll be to having optimal mental function. Transmitters such as acetylcholine, serotonin‚ norepinephrine, glutamate, dopamine‚ and GABA play key roles in optimal brain functioning‚ which is essential to healthy behaviors and decision-making. What is Dopamine? Dopamine is the main neurotransmitter responsible for making you feel motivated.² In fact, it’s often called the “motivation molecule.” Dopamine provides the drive and focus you need to be productive. It’s heavily involved with your attention span, focus, follow-through, motivation, and ability to experience pleasure. Dopamine helps deliver a sense of satisfaction when playing sports, learning something new, accomplishing a task or project, or getting a promotion at work. Dangers of the “Dopamine Fix” There are both healthy and unhealthy ways to get a dopamine fix. Unfortunately, many of the things people do to boost their focus and energy end up backfiring, as dopamine overactivation increases risk for addiction. Anything potentially addicting, like nicotine, excessive caffeine, alcohol/drugs, or sugar-laden/fat-filled treats, can increase brain dopamine activity and cause compulsive behaviors in your life. These unhealthy ways of getting a quick dopamine boost tend to increase the brain’s demand for dopamine. This can hinder the brain’s natural function, which can result in a disruption of the natural dopamine production process and low dopamine system activity in the long-term. Signs of Dopamine System Imbalance Having a dopamine system imbalance can cause significant functional issues in your brain. Underactivity of dopamine can be associated with: Fatigue Apathy Lack of focus Forgetfulness Moodiness Sleep issues Sugar cravings Lower motivation Poor motor control Fortunately, there are also healthy ways to balance your brain’s dopamine system. Here are some of the best ways to support healthy dopamine activity in your brain with vitamins, minerals, herbs, and other natural ingredients… 7 Healthy Nutrients to Help Naturally Increase Dopamine in Your Brain Cocoa Flavanols Chocolate is made from the beans that mature in the seed pods of the tropical Theobroma cacao plant. For centuries, dark chocolate has been honored for its healing and medicinal qualities. Aztecs and ancient Mayans even drank theirs in a brew made from natural cacao beans; they believed it provided strength and energy. When the Europeans first brought cacao home from the Americas, they used it as an all-purpose tonic to treat dozens of health conditions. Some Europeans referred to chocolate as “the food of the gods.” Chocolate has been shown to increase blood flow to the brain.³ Also, dark chocolate contains health-promoting properties that support a positive mood, the ability to think clearly, and a healthy cardiovascular system. Chocolate contains a wide variety of brain-active substances, including salsolinol, which binds to dopamine receptors and likely contributes to the mood-enhancing effects. Chocolate also contains the amino acid l-tryptophan, which can be converted to serotonin (the “don’t worry, be happy” neurotransmitter) activity in your brain. Curcumin Curcumin is an umbrella name for the three main active curcuminoids of turmeric known to improve health: curcumin, demethoxy-curcumin and bis-demethoxycurcumin. Each brand of curcumin concentrate prepared from the turmeric root has a different ratio of these three curcuminoids. Modern science has extensively researched the curcumin complex of curcuminoids and established their powerful antioxidant and inflammatory response benefits. Curcumin brands have a myriad of clinically proven actions, including benefits to memory and mood. Animal studies suggest curcumin’s mood benefits may be linked to dopamine elevation, perhaps also with elevation of serotonin and norepinephrine activity (single transmitters rarely affect complex brain functions such as mood on their own). In addition to supporting the brain, curcumin has been shown to help the eyes, heart and circulation, joints, intestinal tract, skin, prostate, muscles, nerves, and numerous other human tissues. Magnesium Sometimes called the relaxation mineral, magnesium is necessary for all our cells to make and use energy. It maintains our DNA and gene structure and is required for more than 300 energy-processing enzymes in the body. Sadly, surveys consistently find that nearly half of all American adults may be deficient in magnesium.⁴ This powerful nutrient helps to regulate blood sugar, blood pressure, and maintain normal heart rhythm and blood flow. Magnesium supports electrical activity in the brain and aids the brain’s ability to process information. Magnesium is fundamental to the functioning of the brain’s trillions of synapses, the connections between neurons and other cells where dopamine and virtually all the other transmitters released from one cell influence a “downstream” cell. Magnesium helps promote memory, positivity, and quality sleep. It’s used by the body for healthy aging, digestive efficiency, to prevent calcium overload, and to strengthen the immune system as an antioxidant. For those with weight challenges, kidney stones, or heart problems, this nutrient can help promote a healthier well-being. Tyrosine Tyrosine is an amino acid required to produce three major brain neurotransmitters: dopamine, epinephrine, and norepinephrine. Your adrenal glands, located on top of your kidneys, work with your brain to manage stress. These glands also utilize tyrosine to produce more of these key brain neurotransmitters. Your body uses tyrosine to create chemical messengers that can help conditions that start in the brain, including low mood and prolonged fatigue. Vitamin D Vitamin D is best known for building bones. However, this highly potent vitamin is essential for overall brain and body health. Vitamin D function involves regulating the brain and other organs and may be involved in the healthy regulation of as many as 900 human genes. Vitamin D is actually a hormone builder. Once made in the skin or taken as a supplement, it becomes converted by the liver and kidney into a hormone (“secosteroid”) that’s so important to health that its receptors are found throughout the brain and practically all our tissues. Vitamin D plays a critical role in the brain’s early development, its ongoing maintenance, and in its functions that underlie healthy mood and many of the most basic cognitive functions including learning and making memories. Vitamin D promotes the actions of serotonin, dopamine, and other key brain neurotransmitters. Optimal vitamin D levels promote positive mood, support your overall brain function, and generally improve your well-being. Sadly, vitamin D deficiency is currently epidemic worldwide: CDC reports more than 9 in 10 Americans aren’t getting enough of it from their foods.⁵ Fish Oil Omega-3 fatty acids are vital for our brain cells – and all our cells – to make the energy they need to function. EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid) fatty acids are essential to the functioning of all our 30 trillion cells. They’re building blocks for the membrane systems that do most of the heavy lifting for our cells. We require premade EPA+DHA from our diet. Unfortunately, the modern diet has an unhealthy balance of fatty acids: we get an abundance of saturated and omega-6 fatty acids and not nearly enough omega-3s. Also, most of the omega-3s we do get must be converted to EPA+DHA, which the body doesn’t do effectively. Numerous surveys indicate populations that don’t consume adequate amounts of seafood (such as the U.S.) don’t get sufficient supplies of EPA and DHA from their diet. Since plant foods don’t supply them, the main dietary sources of EPA and DHA are cold-water fish and dietary supplements. Considering the widespread contamination of seafood by mercury and other toxins, many experts advise that taking a purified fish oil supplement could be a smart choice. Omega-3 DHA is absolutely crucial for the brain’s synapses to work. The routine actions of dopamine and other major transmitters hinge on there being sufficient DHA in the nerve cell membranes that make the synapse junction. Panax Ginseng One of the most popular medicinal substances in the world, ginseng is a root that contains naturally occurring ginsenosides. These play a role in improving focus, sharpening memory, and supporting overall well-being. Ginseng promotes the release of nitric oxide, a very small molecule but a very important transmitter, which opens blood vessels and improves blood flow to the brain and muscles. Panax ginseng, also known as Asian ginseng, is a potent adaptogen. It’s the best-studied of the ginsengs and leads all other ginsengs for its almost immediate mental focus benefits. Animal studies indicate it has numerous beneficial actions in the brain, one of which involves increasing the activity of the dopamine system. Balanced Brain, Balanced Life Maintaining healthy lifestyle habits, such as daily exercise, consuming whole foods, and taking dietary supplements, can help keep your brain transmitters balanced. Having a balanced brain can lead to a balanced life, so support healthy dopamine activity with these natural ingredients. At BrainMD, we’re dedicated to providing the highest quality supplements to improve your physical health and overall well-being. For more information about our full list of brain healthy supplements, please visit us at BrainMD. These statements have not been evaluated by the FDA. This content is for informational purposes only. It is not meant to substitute for medical or healthcare advice from a physician, nor is it intended to diagnose, treat, cure, or prevent any disease. Consult your healthcare provider before beginning a new health regimen. References: 1. Teleanu, R. I., Niculescu, A.-G., Roza, E., Vladâcenco, O., Grumezescu, A. M., & Teleanu, D. M. (2022). Neurotransmitters—Key factors in neurological and neurodegenerative disorders of the central nervous system. International Journal of Molecular Sciences, 23(11), 5954. https://doi.org/10.3390/ijms23115954 2. Bromberg-Martin, E. S., Matsumoto, M., & Hikosaka, O. (2010). Dopamine in motivational control: Rewarding, aversive, and alerting. Neuron, 68(5), 815–834. https://doi.org/10.1016/j.neuron.2010.11.022 3. Socci, V., & Tempesta, D. (2017). Enhancing human cognition with cocoa flavonoids. Frontiers in Nutrition, 4, Article 19. https://doi.org/10.3389/fnut.2017.00019 4. Workinger, J. L., Doyle, R. P., & Bortz, J. (2018). Challenges in the diagnosis of magnesium status. Nutrients, 10(9), 1202. https://doi.org/10.3390/nu10091202 5. Reider, C. A., Chung, R.-Y., Devarshi, P. P., Grant, R. W., & Mitmesser, S. H. (2020). Inadequacy of immune health nutrients: Intakes in US adults, the 2005–2016 NHANES. Nutrients, 12(6), 1735. https://doi.org/10.3390/nu12061735
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Infrared Brain Light Cap: How Red Light Therapy Can Help You!
Maybe you’ve heard about red light therapy – the non-invasive treatment that’s taking the wellness world by storm. But what is it and can it really help you? Let’s take a closer look at how red light therapy works and its potential benefits. What Is Red Light Therapy? Red light therapy uses low-level wavelengths of red and near-infrared light (NIR) to support the body’s natural recovery processes. Unlike ultraviolet (UV) light, which can damage the skin, red light penetrates the skin safely. It’s commonly delivered through LED panels, handheld devices, or full-body beds, allowing the light to reach the skin and underlying tissues without heat or discomfort. At a cellular level, red light therapy works by stimulating the mitochondria – the “power plants” of our cells. The light helps mitochondria produce more adenosine triphosphate (ATP), a type of natural energy that cells need to function and repair themselves. With increased cellular energy, the body may be better equipped to improve circulation, repair damaged tissues, and promote overall cellular health. Potential Benefits of Red Light Therapy Red light therapy has gained popularity for its wide range of potential benefits. Many people use it to support skin health, as it may help improve the appearance of fine lines, wrinkles, acne, and uneven skin tone by encouraging collagen production. Others turn to red light therapy for muscle recovery, joint comfort, and reduced soreness after exercise, making it popular among athletes and fitness enthusiasts. Beyond skincare and physical recovery, red light therapy is also being explored for its potential effects on mood,¹ sleep, and overall wellness. Some users report feeling more relaxed or energized after red light therapy sessions. Why Do Red Light Wavelengths Matter? Red light therapy works by delivering specific wavelengths of light that penetrate the skin and interact with cells in different ways. Each wavelength is measured in nanometers (nm) and determines how deeply the light can travel into the body and which tissues it affects. Shorter red wavelengths, typically around 630–660 nm, are absorbed more readily by the skin’s surface layers. These wavelengths are commonly associated with skin-focused benefits such as supporting collagen production, improving skin tone, and helping reduce the appearance of fine lines and blemishes. Because they primarily target the epidermis and upper dermis, they’re often used in facial and cosmetic treatments. Longer wavelengths, particularly NIR light in the 810–880 nm range, penetrate much deeper into the body. This allows them to interact with muscles, joints, and connective tissues, making them popular for recovery and overall cellular health. When combined, red and near-infrared wavelengths create a more comprehensive therapy by addressing both surface-level skin health and deeper structural recovery, which is why many modern red light therapy devices include multiple wavelengths for full-body benefits. Red Light Therapy and Brain Health Red light therapy has potential positive effects on brain health, particularly through a process known as photobiomodulation. When specific red and near-infrared wavelengths are applied to the head, they can penetrate the scalp and skull to reach brain tissue. Once absorbed, this light interacts with mitochondria inside neurons, helping support cellular energy production. This increase in cellular energy may enhance overall brain function, supporting processes such as focus, mental clarity, and cognitive performance. In addition to energy support, red light therapy may influence brain health by improving blood flow. NIR light has been shown to encourage vasodilation, which increases oxygen and nutrient delivery to brain cells while assisting in the removal of metabolic waste. These effects have sparked interest in red light therapy as a supportive tool for stress management, mood regulation, and age-related cognitive health. While research is ongoing, early findings suggest that targeted light therapy could play a valuable role in maintaining brain resilience and optimizing neurological wellness² as part of a broader brain-health routine. With so many potential benefits for body and brain wellness, BrainMD is proud to offer the newest innovation in at-home brain support… Infrared Brain Light Cap The Infrared Brain Light Cap is powered by clinical-grade red light technology to support clearer thinking, greater calm, and better mental energy.* The Science of Red & Near-Infrared Light Photobiomodulation therapy (PBMT) is a non-invasive technology that uses red and NIR light to promote the health and functioning of your cells.* These wavelengths help support your brain’s natural energy and circulation pathways.* PBMT also supports the release of nitric oxide, which is essential for healthy blood flow.* The Right Wavelengths The Infrared Brain Light Cap uses a precise combination of red (629 nm) and NIR (850 nm) light; the wavelengths most studied for supporting healthy circulation, cellular energy, emotional balance, and cognitive clarity.* These wavelengths have been shown to gently penetrate the scalp and skull³ to support the wellness systems your brain depends on daily.* Importance of Pulsed Light Not all light therapy is the same. Research suggests pulsed light may stimulate stronger biological responses than continuous light,⁴ especially in brain-related PBMT applications.* The Infrared Brain Light Cap uses hundreds of super-luminous LEDs and automatically cycles through 7 pulsed frequencies during each 20-minute session, delivering a dynamic PBMT experience.* Its targeted, pulsed red light helps support healthy circulation, antioxidant status, cellular energy (ATP) production,⁵ emotional balance, and overall cognitive performance.* Benefits of the Infrared Brain Light Cap Supports clearer thinking & cognitive performance* Helps promote a calmer, more emotionally balanced mood* Encourages steady, consistent mental energy* Supports healthy brain circulation for daily function* Advanced Brain Support As technology becomes more accessible, red light therapy may prove to be a versatile tool for those looking to enhance their health and well-being naturally.* Whether your goal is clearer thinking, better emotional balance, or more consistent energy, the Infrared Brain Light Cap makes advanced brain support simple, reliable, and accessible – right at home.* Try the Infrared Brain Light Cap today! NOTE: Though this device is FDA-cleared to increase circulation and relieve minor aches and physical discomfort, it is not intended to diagnose, treat, cure, or prevent any disease. Results and experiences may vary. At BrainMD, we’re dedicated to providing the highest quality supplements to improve your physical health and overall well-being. For more information about the Infrared Brain Light Cap and our full list of brain healthy supplements, please visit us at BrainMD. *These statements have not been evaluated by the FDA. This content is for informational purposes only. It is not meant to substitute for medical or healthcare advice from a physician, nor is it intended to diagnose, treat, cure, or prevent any disease. Consult your healthcare provider before beginning a new health regimen. References: ¹Wang, L., Mao, L., Huang, Z., Switzer, J. A., Hess, D. C., & Zhang, Q. (2025). Photobiomodulation: Shining a light on depression. Theranostics, 15(2), 362–383. https://doi.org/10.7150/thno.10450 ²Hamblin, M. R. (2016). Shining light on the head: Photobiomodulation for brain disorders. BBA Clinical, 6, 113–124. https://doi.org/10.1016/j.bbacli.2016.09.002 ³Henderson, T. A., & Morries, L. D. (2015). Near-infrared photonic energy penetration: Can infrared phototherapy effectively reach the human brain? Neuropsychiatric Disease and Treatment, 11, 2191–2208. https://doi.org/10.2147/NDT.S78182 ⁴Tang, L., Qin, H., Lin, S., & Liu, M. (2023). Effects of pulsed red and near-infrared light on neuroblastoma cells—Pilot study on frequency and duty cycle. Photonics, 10(3), 315. https://doi.org/10.3390/photonics10030315 ⁵Nairuz, T., Cho, S., & Lee, J.-H. (2024). Photobiomodulation therapy on brain: Pioneering an innovative approach to revolutionize cognitive dynamics. Cells, 13(11), 966. https://doi.org/10.3390/cells13110966
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7 Ways to Reduce Holiday Stress and Make the Seasons More Joyful
For many people, the holiday season represents a joyful time of the year. But for others, it’s a period of added stress that can result in exhaustion, weight gain, mounting debt, and…relatives. Seems like every family has at least one relative who creates drama during the holidays. Think about the “crazy maker” at your family gatherings and see if they’re among this cast of characters: Uncle Jim is intoxicated by 4 pm. He has brutally honest conversations with anyone he can corner. He excels at sticking his nose where it doesn’t belong and instigating arguments. Then there’s Cousin Lucy. She still holds a grudge over the rude comment Uncle Jim made to her last year. Of course, she’s “confidentially” shared this story with every member of the family. And what about Grandpa Joe? He sits in the corner of the living room and watches TV all day. Even though he refuses to participate in family games or activities, he complains about being bored all the time. So, how can you handle someone who thrives on making everyone else around them miserable? If someone in your family loves to stir the pot during family gatherings, here are some practical steps you can take to reduce holiday stress. 7 Practical Ways to Prevent a Crazy Maker from Ruining Your Holiday 1. Show Kindness When greeting your quarrelsome relative, find something nice to say about them. Complimenting them on their outfit, hairstyle, or other accessory may help improve their disposition. This preemptive gesture of goodwill may help to set a positive tone for the family gathering and help prevent holiday stress. Kind words can create a positive feedback loop – the person giving the compliment often ends up feeling just as uplifted as the receiver of the compliment. As difficult as it may be at first, get in the habit of complimenting your disagreeable relative. Who knows, you may be able to find common ground with them, which can be a win for everyone in the family. 2. Get Moving If you need a break from a movie marathon or if you just want to work off that extra slice of turkey or ham, get the family outside for some fresh air and exercise. Engage in a brain-safe activity or take a long walk. Walking can help you clear your mind, decrease anxious thoughts, improve your mood,¹ and burn some calories all at the same time. Physical exercise boosts blood flow to the brain. When everyone in the family is thinking clearly, better decisions and behaviors should follow. It’s always better to stimulate the brain with physical activity than family drama. 3. Avoid Alcohol Many people think serving alcohol at a holiday gathering will help settle everyone down, but it actually can act like rocket fuel for impulsivity and family conflict (especially when consumed by the Uncle Jim’s of the world). Alcohol stimulates your appetite, prolongs the time you sit during a meal and is associated with continued eating even when you feel full. Alcohol exerts substantial influence on the circulation in your pancreas, which increases the production of insulin.² This can lead to low blood sugar levels, which can negatively affect your decision-making. Instead of alcohol, serve a low-sugar, hot apple cider – it makes the house smell amazing and will warm cold hands after outdoor family fun. 4. Minimize Conflict Many people can function well with stress, but not well without it. Conflict-seeking behavior can be used as a form of self-medication to wake up the brain, and some people can get addicted to it. This can cause family friction and lead to even more holiday stress. Resist the urge to participate in discussions that can offend or create family strife. Always look for a way to redirect negative tirades or inappropriate conversations. If that doesn’t work, isolate the offending individual from the rest of the group to prevent them from ruining the holidays. 5. Eliminate Sugar There’s mounting evidence that sugar is toxic. Excessive sugar intake, which is linked to insulin imbalance, heart problems, and other organ issues, is responsible for 35 million deaths a year globally.³ If you find it difficult to resist holiday treats, be sure to steer clear of the dessert table (and make sure your troublemaking relative does the same). Sugar increases erratic brain cell firing and has been implicated in aggression. Low blood sugar levels are associated with overall lower brain activity, which means more cravings and more bad decisions, like reaching for a sugary snack or soda. The best way to regulate your blood sugar is to eat a healthy snack every 3 to 4 hours. Natural snacks, like whole fruits, seeds, and nuts, are portable and are ideal for fending off hunger between meals. 6. Say Sorry Perhaps there’s something in our DNA that makes us want to be right all the time, but many people have a hard time saying sorry. Even if you feel like you’ve been wronged, say you’re sorry to your antagonizing relative. Offering an apology can help build a bridge in a relationship, and the other person might be grateful that you took the initiative in trying to resolve the disagreement. In the end, it’s far better to apologize than to cast blame and cause a meltdown at the dinner table. 7. Be Mindful In our “take care of number one” society, our focus tends to be on ourselves rather than on others. Try to be more mindful of those around you. If they have a need, try to meet it. Force yourself to stay attentive in every conversation. Be an active listener and make eye contact with the person talking to you. Chances are, they’ll appreciate you taking the time to really listen to them, which in turn will make you grateful for being able to participate in a meaningful conversation. Reduce Holiday Stress Implementing these proactive strategies can help safeguard you and your family from a crazy maker so that you can enjoy a fun-filled and stress-free holiday. The BrainMD team wishes you and yours a safe, healthy, and happy Holiday Season! At BrainMD, we’re dedicated to providing the highest purity nutrients to improve your physical health and overall well-being. For more information about our full list of brain healthy supplements, please visit us at BrainMD. These statements have not been evaluated by the FDA. This content is for informational purposes only. It is not meant to substitute for medical or healthcare advice from a physician, nor is it intended to diagnose, treat, cure, or prevent any disease. Consult your healthcare provider before beginning a new health regimen. References: 1. Mayo Clinic Staff. (2021, March 19). Exercise and stress: Get moving to manage stress. Mayo Clinic. https://www.mayoclinic.org/healthy-lifestyle/stress-management/in-depth/exercise-and-stress/art-20044469 2. Steiner, J. L., Crowell, K. T., & Lang, C. H. (2015). Impact of alcohol on glycemic control and insulin action. Biomolecules, 5(4), 2223–2246. https://doi.org/10.3390/biom5042223 3. Arnone, D., Chabot, C., Heba, A.-C., Kökten, T., Caron, B., Hansmannel, F., Dreumont, N., Ananthakrishnan, A. N., Quilliot, D., & Peyrin-Biroulet, L. (2022). Sugars and gastrointestinal health. Clinical Gastroenterology and Hepatology, 20(9), 1912–1924.e7. https://doi.org/10.1016/j.cgh.2021.12.011
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