Brain Supplements: Do They Work, and What Should You Look For?

Everybody wants a better brain. 

Your brain health is central to your mental and spiritual health; your well-being in the present, your outlook on the future, and your ability to reminisce on the past. Even if you don’t have any current concerns with your clarity, memory, or mood, brain health is deeply connected to your physical health and longevity. 

A better brain means a better life. More and more people are recognizing the truth of this principle.

With this growing interest in brain health, millions of people are turning to brain supplements in hopes of improving their current brain function and protecting their long-term cognitive health.

But here's an important question: Do brain supplements actually work?

There is no simple answer to this question, because all brain supplements are not created equal. 

There are hundreds, if not thousands, of brain supplements on the market, and whether or not they “work” depends on a number of factors. Some nutritional supplements contain ingredients supported by scientific research. Others rely more heavily on marketing promises than meaningful clinical evidence. Even promising ingredients may not work equally well for everyone.

What we can give you is a guide for best practices when choosing a brain supplement. The key is understanding what you're taking, why you're taking it, and whether the supplement is built with your health as priority and hard science that supports it.

Brain Supplements At-a-Glance:

• Do they work? Some brain supplements show promise for memory, focus, and cognitive health, but results vary depending on a number of factors.
• Know the ingredients: Omega-3s, B vitamins, magnesium, citicoline, and other nutrients have different roles in brain health.
• Follow the science: Look for human clinical studies supporting the specific ingredient, form, and dose.
• Choose quality: Prioritize transparent labels, third-party testing, and reputable manufacturing.
• Safety matters: More isn't always better. Consider side effects, medication interactions, and individual health needs.
• Start with the basics: Supplements should complement (not replace) good sleep, exercise, healthy nutrition, and stress management.

What Are Brain Supplements?

Brain supplements are dietary supplements formulated to support aspects of brain health, including memory, attention, mental energy, mood, and cognitive function. They're sometimes called nootropics, although that term can also refer to medications and other substances intended to influence cognition.

Nootropic supplements often contain vitamins, minerals, essential fatty acids, amino acids, botanical extracts, adaptogens, or other compounds selected to benefit brain function.

Some of the most common ingredients in brain supplements include:

• Omega-3 fatty acids
• B Vitamins
• Magnesium
• Phosphatidylserine
• Citicoline
• Ginkgo biloba
• L-Theanine
• Creatine

These ingredients work through different biological pathways. Some provide nutrients needed for the structural health of brain cells, while others influence neurotransmitter production, cellular energy, or processes associated with learning and memory. 

An ingredient's role in brain biology, however, doesn't automatically mean that taking more of it will improve your thinking. And, a supplement can be biologically plausible without being clinically supported.

When researching an ingredient, we need to separate what is theoretical from what the data actually shows.

Do Brain Supplements Work?

Supplement marketing materials are under strict regulations about the information they can share from clinical studies. Reading the original peer-reviewed research behind the formulations is often a better way to understand how an ingredient works in the body, and what magnitude of results can be expected.

The best way to decide whether a supplement may work for your brain is to read the research, know what to look for on a product label, and talk with a trusted healthcare provider before you begin.

There are four important questions to ask when evaluating clinical research on a supplement:

1. What was studied? 

What was the form of the ingredient? What doses were administered? How long was the trial period? You can’t expect a different dose or different form of the ingredient to perform the same way, just like you can't expect immediate results from something that has only shown effects after 8 weeks.

2. Who was studied?

Look for demographic information about the study population. Would you fit this description? An ingredient that helps older adults with cognitive complaints may not elicit the same benefits in healthy college students.

3. What specifically improved in the study population?

Does it match your health goals? A supplement linked to better performance on an attention test cannot be assumed to also protect against cognitive decline.

4. How strong is the evidence?

A double-blind, placebo-controlled human trial provides valuable results, but multiple independently replicated human trials (or meta-analyses of many of those studies) provide much stronger support.

Common Brain Supplement Ingredients: What Does The Science Say?

1. Omega-3 Fatty Acids: Important Building Blocks for the Brain

Omega-3 fatty acids play important roles in brain cell membranes and signaling. Just like any machine, your brain needs the proper building materials to function optimally. Research shows that certain omega-3 fatty acids contribute to the structure of brain cells and participate in processes involved in neurotransmission and inflammation [1].

Two omega-3s are especially relevant:

• DHA (docosahexaenoic acid): A structural component of neuronal membranes [1].
• EPA (eicosapentaenoic acid): Involved in signaling pathways and processes that regulate inflammation [2].

DHA and EPA omega-3s are found primarily in fatty fish and are less common in the standard American diet than other forms of fatty acids [3]. 

What research suggests: According to the CDC, 98% of Americans have suboptimal omega-3 levels, and 54% have undesirably low levels on the Omega-3 Index [4]. 

Omega-3s are essential nutrients, and adequate intake is crucial for normal brain function [1,2]. Some studies indicate there are specific cognitive benefits to supplementation in certain populations [5]. Evidence is even stronger for the importance of omega-3s in overall nutrition and cardiovascular health [6].

Taken together, this information suggests that nearly all Americans could benefit from adding more omega-3s to their diet, through food or supplementation.

What to look for: Check the actual amounts of EPA and DHA, not just the total amount of fish oil. A capsule labeled "1,000 mg fish oil" may contain considerably less than 1,000 mg of combined EPA and DHA.

Dr. Amen specifically recommends omega-3 fatty acids higher in EPA than DHA for mood and attention, especially when inflammatory markers such as C-reactive protein are elevated.

In Change Your Brain Every Day, he recommends:

• 1,000–2,000 mg of combined EPA and DHA daily for most adults.
• 60% EPA and 40% DHA as his preferred general ratio.

2. B Vitamins: Essential for Nerve Function and Neurotransmitters

B vitamins help the body convert food into energy, and support neurotransmitter production and neurological function [7].

Three frequently discussed in brain health are:

• Vitamin B6
• Folate (vitamin B9)
• Vitamin B12

Vitamin B6 is particularly important because its active form, pyridoxal-5-phosphate (P5P), helps the brain produce serotonin, dopamine, GABA, and other neurotransmitters involved in emotional balance and attention [8]. Folate (B9) supports the biochemical pathways needed to produce neurotransmitters, while vitamin B12 works alongside folate to support healthy methylation, nerve function, and brain health [7].

These nutrients also participate in homocysteine metabolism. Elevated homocysteine is associated with several health risks, including cognitive decline [7].

What research suggests: Correcting insufficiencies, particularly in vitamin B12, is important for neurological health. Some studies have found that B-vitamin supplementation may slow certain measures of brain atrophy in selected people with mild cognitive impairment and elevated homocysteine [9].

What to look for: Choose appropriate forms and dosage based on nutritional status and clinical need. Methylcobalamin and cyanocobalamin are both established forms of B12, and methylfolate is an activated folate that may be more beneficial to those with certain MTHFR variants [10]. However, more expensive or heavily marketed forms are not automatically superior for everyone.

Avoid prolonged high-dose vitamin B6 without medical supervision because excessive intake can cause additional health issues [11].

3. Magnesium: Supports Normal Nerve Signaling

Magnesium is involved in hundreds of enzymatic reactions, including an important role in brain signaling, helping regulate neurotransmitters such as glutamate and GABA, which influence how brain cells communicate. It also helps regulate NMDA receptors, which are involved in learning, memory, and the brain's ability to form new connections [12]. 

Beyond the brain, magnesium supports normal muscle and nerve function, helping muscles contract and relax properly. Because physical tension and anxious feelings often go hand in hand, maintaining healthy magnesium levels may help support physical relaxation and a calmer state of mind [12].

What research suggests: Magnesium is essential for health, and minimum daily intake is not typically met by the standard American diet. Inadequate intake should be addressed for mental and physical health [12,13]. 

Magnesium citrate has an osmotic effect on the bowels and can help with occasional constipation. Magnesium glycinate is gentler on the digestive system and typically recommended for relaxation, stress, and preparing the body for sleep. Magnesium malate is especially absorbable, supports ATP production for energy and muscle function, and may help to ease tension and headaches [13].

What to look for: Pay attention to the form of magnesium and the dose provided in a supplement, and select according to your health goals and needs. 

High supplemental doses may cause diarrhea and other adverse effects. People with kidney concerns need to take particular caution because they may have difficulty eliminating excess magnesium [13].

4. Phosphatidylserine: A Component of Brain Cell Membranes

Phosphatidylserine (PS) is a naturally occurring phospholipid that helps maintain healthy brain cell membranes and supports communication between neurons. Because these processes are essential for learning, memory, and attention, researchers have investigated whether supplemental PS can support cognitive performance [14].

What research suggests: small clinical studies suggest that phosphatidylserine (PS) may support memory, learning, and recall, particularly in older adults experiencing age-related memory complaints, while preliminary research has also shown promising results for attention and impulsivity in children with attention challenges [15,16].

What to look for: Research has frequently used approximately 100–300 mg daily. Check whether the ingredient comes from soy or sunflower sources if you are require a soy-free alternative.

5. Citicoline: Supports Brain Cell Membrane Metabolism

Citicoline, also called CDP-choline, supplies compounds involved in phospholipid synthesis and choline metabolism. Choline is needed to produce acetylcholine, a neurotransmitter involved in memory and attention [17].

What research suggests: Certain forms of supplemental choline, particularly citicoline (CDP-choline), have shown promising results in some human studies. Research suggests citicoline may help improve aspects of attention, mental processing speed, and memory in certain populations, including some older adults and people experiencing cognitive difficulties [18,19].

What to look for: Human studies have used a variety of doses, commonly 250–1,000 mg CDP-choline daily [18,19]. Look for clear ingredient identification and avoid assuming that all forms of choline have equivalent effects.

6. Ginkgo Biloba: Supports Memory and Circulation

Ginkgo biloba is one of the most extensively studied herbal ingredients for cognitive health.

Its extracts contain flavonoids and terpene lactones that have been investigated for effects on oxidative stress and vascular function [20].

What research suggests: Some clinical trials and systematic reviews suggest that standardized Ginkgo biloba extracts, particularly EGb 761, may provide benefits for memory, cognitive function, and daily activities in people with cognitive impairment [21].

What to look for: Many clinical studies have used 120–240 mg daily of standardized ginkgo extract. Choose a standardized Ginkgo biloba leaf extract containing approximately 24% flavone glycosides and 6% terpene lactones, the concentrations used in many clinical studies. These compounds are associated with ginkgo's antioxidant activity, effects on circulation, and potential support for brain function [20,21].

Ginkgo may increase bleeding risk, particularly when combined with anticoagulant or antiplatelet medications, and may not be appropriate for people with seizure disorders [22].

7. L-Theanine: Support for Attention and Relaxation

L-Theanine is an amino acid naturally found in green tea that has gained attention for its ability to promote relaxation without typically causing drowsiness. Unlike sedatives, which can impair alertness, L-theanine may help support a state of calm, focused attention, which is particularly useful when stress or anxious thoughts make it difficult to concentrate [23].

What research suggests: Some small studies suggest that L-theanine may influence attention or stress-related measures. Research on L-theanine combined with caffeine has also found short-term improvements in certain attention tasks [23,24].

Unlike ingredients such as bacopa monnieri, which are generally studied over several weeks, L-theanine has been investigated for relatively immediate effects, often within approximately 30-60 minutes of supplementation. Some longer-term studies have also explored its potential effects on sleep quality and stress [23,25]

What to look for: Studies commonly use approximately 50-200 mg, sometimes in combination with caffeine. Consider whether the formulation contains stimulants, especially if you're sensitive to caffeine or experience anxiety or sleep difficulties [23-35].

8. Creatine: Supports Cognitive Energy

Creatine helps regenerate adenosine triphosphate (ATP), the molecule cells use for energy.

Although historically it has been marketed as a sports nutrition supplement, creatine is also active in the brain [26].

What research suggests: Several small clinical trials and systematic reviews have shown benefits to certain aspects of cognitive function, particularly memory and reasoning. Some studies suggest that creatine supplementation may be especially beneficial when the brain is under metabolic stress, such as during sleep deprivation or mentally demanding tasks [27,28].

Creatine may offer even greater cognitive benefits to older adults and vegetarians, who have lower dietary creatine intakes [26,27]. 

What to look for: Creatine monohydrate is the most extensively studied form. Cognitive studies have used varying doses, often within the range of 3–20 grams daily, but an optimal dose for brain function has not been established. Higher doses are not necessarily better and can cause gastrointestinal symptoms. Individuals with kidney concerns should use extra caution [26,27].

How to Choose Brain Supplements

With so many products promising better memory and sharper focus, how can you tell which ones deserve your attention?

Start by looking beyond the front label.

1. Ingredients Supported by Human Research

An impressive-sounding ingredient list doesn't guarantee an effective supplement.

Look for randomized, placebo-controlled human studies whenever possible.

Research involving actual people is generally more informative for consumer decisions than isolated laboratory experiments or animal studies.

Consider whether the studies measured meaningful outcomes, such as task performance or improvements on a standardized rating scale, or whether evidence was gathered only on biological markers.

2. The Right Ingredient Forms

Different forms of the same nutrient or botanical may vary in composition, absorption, tolerability, and the amount of supporting research.

For example:

• Omega-3 supplements should clearly identify EPA and DHA content.
• Magnesium supplements should disclose elemental magnesium.
• Ginkgo products should identify the standardized extract used.
• Folate and B12 products should clearly state their chemical forms so you know if it is active upon absorption or requires conversion within the body.

More expensive doesn’t always mean most effective. The important question is whether the specific form has evidence supporting its intended use.

3. Research-Informed Dosages

One of the most common problems with brain supplement formulas is that they contain numerous recognizable ingredients, but only small amounts of each.

A product might advertise eight or ten ingredients without providing doses comparable to those studied in clinical trials. A better approach is to compare the amount of each ingredient with the doses used in relevant human research.

However, a research dose isn't automatically a recommended dose. The appropriate amount for you may depend on biological sex, age, health status, medications, intended use, and other safety considerations.

4. Transparent Labels

Look for a complete Supplement Facts panel that identifies the ingredients and their amounts per serving.

Be cautious with proprietary blends that list several ingredients under one combined weight without revealing individual quantities. It doesn’t mean the supplement doesn’t work, it's just more difficult to determine whether a product contains meaningful amounts of the ingredients you're interested in.

Transparency makes comparison easier and supports safer decision-making.

5. Third-Party Testing

Dietary supplements are not tested or approved by the FDA for safety and effectiveness before being marketed. This means that reputable manufacturers have to take it upon themselves to verify ingredient identity, purity, strength, and composition.

Independent testing or certification can provide additional assurance. Examples include programs associated with USP, NSF, or other qualified independent laboratories.

Depending on the certification, testing may assess ingredient identity, label accuracy, contaminants, and manufacturing standards.

Third-party testing does not prove that a supplement works. But it does show that the product contains what it says it contains, and that it meets specified quality standards.

6. Manufacturing Quality

Look for evidence that a manufacturer follows applicable current Good Manufacturing Practice (cGMP) requirements.

These standards address manufacturing processes, quality control, documentation, and other procedures intended to support product consistency.

7. Safety and Medication Interactions

Natural or nutritional doesn't always mean safe.

Brain supplements can cause side effects, interact with prescription medications, or be inappropriate for certain medical conditions.

People who are pregnant or breastfeeding, taking prescription medications, managing chronic medical conditions, or considering supplements for children should consult a qualified healthcare professional before supplementing.

It's also important not to combine multiple supplements without considering the effects of interactions or overlapping ingredients.

Common Myths About Brain Supplements

Myth #1: If a Supplement Is Natural, It Must Be Safe

Natural substances can have powerful biological effects. That's precisely why these supplements exist, and simultaneously why they sometimes require caution.

A plant-derived ingredient may influence blood clotting, blood pressure, neurotransmitter activity, or medication metabolism.

Safety depends on the substance, dose, individual, and circumstances, not whether an ingredient comes from nature.

Myth #2: More Ingredients Mean Better Results

A formula containing 20 ingredients isn't necessarily better than one containing three.

Each ingredient in a high-quality brain supplement should have a purpose that complements or synergizes with the activities of other ingredients. Over-complicated formulations can make it harder to determine which ingredients are responsible for benefits or side effects. 

Myth #3: Higher Doses Work Better

More isn't always better when it comes to brain health.

Some nutrients have well-established upper intake limits, and excessive amounts can be harmful.

The goal should be an appropriate dose, based on clinical data and personal needs, not the largest dose possible.

Myth #4: You'll Notice a Dramatic Difference Immediately

Some ingredients can have noticeable short-term effects, while others have been studied to build in benefits over weeks or months.

A supplement that doesn't produce a noticeable sensation doesn’t mean it is ineffective. 

Some may produce no noticeable changes at all, depending on their mechanisms and targets. If you are taking a brain supplement designed to support structure and longevity, you are likely to feel less of a difference than if you are targeting mood or sleep, for example.

Does Everyone Need Brain Supplements?

Again, there’s no simple answer to this question. Everyone should care about their brain health, and supplements are one of many ways to care for your brain.

But, it is important to consider the wide ranges of current brain health, nutritional states, and individual goals. While everyone may benefit from some type of supplementation, the type of supplements each person will benefit from vary significantly.

For someone with nutrient insufficiencies, filling those gaps with supplements can be absolutely essential. Someone with more balanced nutrition levels may not feel any different on the same formula.

For someone who struggles with mood or anxiousness despite nutritional balance, a targeted botanical formula may help them feel brighter, calmer, or more focused. Someone with a balanced mood may not feel a change from the same botanical.

For someone with sleep trouble, a targeted sleep supplement may be completely life changing. But the same supplement might not provide any benefit to someone who sleeps soundly, easily.

The Foundation of Brain Health Comes First

While adding supplements can help with the way you think, feel, sleep, remember, focus, and more, consider whether you're also taking care of your brain through healthy everyday habits.

Some of the most valuable brain-health practices include:

1. Regular physical activity. Exercise supports cardiovascular health and is associated with better cognitive outcomes.
2. Restorative sleep. Sleep is essential for attention, learning, and memory consolidation.
3. Brain-healthy nutrition. A dietary pattern emphasizing vegetables, fruit, fish, legumes, nuts, whole grains, and minimally processed foods can help support overall health.
4. Blood pressure and metabolic health. Hypertension, diabetes, and other vascular risk factors can influence long-term cognitive health.
5. Stress management. Chronic stress can interfere with attention, sleep, and memory.
6. Lifelong learning and social connection. Staying mentally and socially engaged is associated with healthier cognitive aging.

Supplements should complement these foundations when appropriate, not replace them.

Brain Supplements FAQs

What are the best brain supplements for memory and focus?

There is no single best supplement for everyone. Omega-3s, B vitamins, citicoline, and other ingredients have been studied for cognitive outcomes, but the strength of evidence varies in different populations. The most appropriate choice for you depends on nutritional status, health conditions, and the specific goal.

Can brain supplements improve memory?

Some ingredients have shown improvements in particular memory measures in selected study populations. However, supplements should not be expected to produce immediate, dramatic, or universal improvements.

How long do brain supplements take to work?

It depends on the ingredient and the outcome being measured. Some products may affect alertness within hours, while most herbal ingredients have been studied over 8-12 weeks. Other products may not produce measurable benefits beyond a blood test.

Can I take multiple brain supplements together?

Combining supplements can increase the risk of excessive nutrient intake, duplicated ingredients, and medication interactions. Review the complete ingredient lists with a qualified healthcare professional before combining products.

Are brain supplements worth the money?

They may be worthwhile when they address a documented nutritional need or when an ingredient has evidence relevant to a specific goal. However, expensive formulas and impressive marketing claims do not guarantee meaningful results.

Making Smart Choices About Brain Supplements

Caring for your brain means maximizing and protecting your most valuable asset.

But how you go about it shouldn’t be by chasing the newest fad, buying the most expensive formula, or believing every promise made by marketing.

Make informed decisions based on science.

Some brain supplements contain ingredients with encouraging research behind them. Others have limited evidence, inconsistent findings, or doses that haven't been adequately studied. 

When evaluating brain supplements, remember five principles: look for human research, examine ingredient forms, check dosages, prioritize independent quality testing, and consider safety.

Most importantly, remember that better brain health is built through the choices you make consistently. Even the best-formulated supplement cannot replace good sleep, physical activity, healthy nutrition, stress management, and appropriate medical care.

Supplements may have a place in that plan. But they should be one part of a thoughtful, personalized approach, not the whole strategy.

Your brain deserves good science, not just good marketing.

 

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

This article is intended for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Consult your healthcare professional before starting supplements, particularly if you take medications, have a medical condition, or are pregnant or breastfeeding.

References

1. Bazinet, R. P., & Layé, S. (2014). Polyunsaturated fatty acids and their metabolites in brain function and disease. Nature reviews neuroscience, 15(12), 771-785. 
2. Calder, P. C. (2017). Omega-3 fatty acids and inflammatory processes: from molecules to man. Biochemical Society Transactions, 45(5), 1105-1115. 
3. Papanikolaou, Y., Brooks, J., Reider, C., & Fulgoni III, V. L. (2014). US adults are not meeting recommended levels for fish and omega-3 fatty acid intake: results of an analysis using observational data from NHANES 2003–2008. Nutrition journal, 13(1), 31. 
4. Powers, C. D., Sternberg, M. R., Mineva, E. M., Clifton, C. C., Leachman, J. R., Wambogo, E., & Pfeiffer, C. M. (2026). Over Half of the United States Population Had an Undesirably Low Omega-3 Index Based on Erythrocyte Membrane Measurements: Results From the Cross-Sectional NHANES From August 2021 to August 2023. Current developments in nutrition, 10(6), 107715. 
5. Suh, S. W., Lim, E., Burm, S. Y., Lee, H., Bae, J. B., Han, J. W., & Kim, K. W. (2024). The influence of n-3 polyunsaturated fatty acids on cognitive function in individuals without dementia: a systematic review and dose–response meta-analysis. BMC medicine, 22(1), 109. 
6. Rimm, E. B., Appel, L. J., Chiuve, S. E., Djoussé, L., Engler, M. B., Kris-Etherton, P. M., ... & Lichtenstein, A. H. (2018). Seafood long-chain n-3 polyunsaturated fatty acids and cardiovascular disease: a science advisory from the American Heart Association. Circulation, 138(1), e35-e47. 
7. Kennedy, D. O. (2016). B vitamins and the brain: mechanisms, dose and efficacy—a review. Nutrients, 8(2), 68. 
8. Parra, M., Stahl, S., & Hellmann, H. (2018). Vitamin B6 and its role in cell metabolism and physiology. Cells, 7(7), 84. 
9. Smith, A. D., Smith, S. M., De Jager, C. A., Whitbread, P., Johnston, C., Agacinski, G., ... & Refsum, H. (2010). Homocysteine-lowering by B vitamins slows the rate of accelerated brain atrophy in mild cognitive impairment: a randomized controlled trial. PloS one, 5(9), e12244. 
10. Prinz‐Langenohl, R., Brämswig, S., Tobolski, O., Smulders, Y. M., Smith, D. E. C., Finglas, P. M., & Pietrzik, K. (2009). [6S]‐5‐methyltetrahydrofolate increases plasma folate more effectively than folic acid in women with the homozygous or wild‐type 677C→ T polymorphism of methylenetetrahydrofolate reductase. British journal of pharmacology, 158(8), 2014-2021. 
11. Muhamad, R., Akrivaki, A., Papagiannopoulou, G., Zavridis, P., & Zis, P. (2023). The role of vitamin B6 in peripheral neuropathy: a systematic review. Nutrients, 15(13), 2823. 
12. De Baaij, J. H., Hoenderop, J. G., & Bindels, R. J. (2015). Magnesium in man: implications for health and disease. Physiological reviews, 95(1), 1-46. 
13. Pardo, M. S. M. R., Vilar, M. S. E. G., Martín, P. D. I. S. M., & Martín, P. D. M. A. C. (2021). Bioavailability of magnesium food supplements: A systematic review. Nutrition, 89, 111294. 
14. Glade, P. D. M. J., & Smith, D. K. (2015). Phosphatidylserine and the human brain. Nutrition, 31(6), 781-786. 
15. Kato-Kataoka, A., Sakai, M., Ebina, R., Nonaka, C., Asano, T., & Miyamori, T. (2010). Soybean-derived phosphatidylserine improves memory function of the elderly Japanese subjects with memory complaints. Journal of clinical biochemistry and nutrition, 47(3), 246-255. 
16. Hirayama, S., Terasawa, K., Rabeler, R., Hirayama, T., Inoue, T., Tatsumi, Y., ... & Jäger, R. (2014). The effect of phosphatidylserine administration on memory and symptoms of attention‐deficit hyperactivity disorder: A randomised, double‐blind, placebo‐controlled clinical trial. Journal of human nutrition and dietetics, 27, 284-291. 
17. Secades, J. J., & Gareri, P. (2022). Citicoline: pharmacological and clinical review, 2022 update. Rev Neurol, 75(s05), S1-S89. 
18. McGlade, E., Locatelli, A., Hardy, J., Kamiya, T., Morita, M., Morishita, K., ... & Yurgelun-Todd, D. (2012). Improved attentional performance following citicoline administration in healthy adult women. Food and Nutrition Sciences, 3(6), 769-773. 
19. Nakazaki, E., Mah, E., Sanoshy, K., Citrolo, D., & Watanabe, F. (2021). Citicoline and memory function in healthy older adults: a randomized, double-blind, placebo-controlled clinical trial. The Journal of nutrition, 151(8), 2153-2160. 
20. Mahadevan, S., & Park, Y. (2008). Multifaceted therapeutic benefits of Ginkgo biloba L.: chemistry, efficacy, safety, and uses. Journal of food science, 73(1), R14-R19. 
21. Tan, M. S., Yu, J. T., Tan, C. C., Wang, H. F., Meng, X. F., Wang, C., ... & Tan, L. (2014). Efficacy and adverse effects of ginkgo biloba for cognitive impairment and dementia: a systematic review and meta-analysis. Journal of Alzheimer’s disease, 43(2), 589-603. 
22. Bent, S., Goldberg, H., Padula, A., & Avins, A. L. (2005). Spontaneous bleeding associated with Ginkgo biloba: a case report and systematic review of the literature. Journal of general internal medicine, 20(7), 657-661. 
23. Kimura, K., Ozeki, M., Juneja, L. R., & Ohira, H. (2007). L-Theanine reduces psychological and physiological stress responses. Biological psychology, 74(1), 39-45. 
24. Haskell, C. F., Kennedy, D. O., Milne, A. L., Wesnes, K. A., & Scholey, A. B. (2008). The effects of L-theanine, caffeine and their combination on cognition and mood. Biological psychology, 77(2), 113-122. 
25. Haskell, C. F., Kennedy, D. O., Milne, A. L., Wesnes, K. A., & Scholey, A. B. (2008). The effects of L-theanine, caffeine and their combination on cognition and mood. Biological psychology, 77(2), 113-122. 
26. Candow, D. G., Forbes, S. C., Ostojic, S. M., Prokopidis, K., Stock, M. S., Harmon, K. K., & Faulkner, P. (2023). “Heads up” for creatine supplementation and its potential applications for brain health and function. Sports Medicine, 53(1), 49-65. 
27. Xu, C., Bi, S., Zhang, W., & Luo, L. (2024). The effects of creatine supplementation on cognitive function in adults: a systematic review and meta-analysis. Frontiers in nutrition, 11, 1424972. 
28. Gordji-Nejad, A., Matusch, A., Kleedörfer, S., Jayeshkumar Patel, H., Drzezga, A., Elmenhorst, D., & Bauer, A. (2024). Single dose creatine improves cognitive performance and induces changes in cerebral high energy phosphates during sleep deprivation. Scientific reports, 14(1), 4937. 
29. Bent, S., Goldberg, H., Padula, A., & Avins, A. L. (2005). Spontaneous bleeding associated with Ginkgo biloba: a case report and systematic review of the literature. Journal of general internal medicine, 20(7), 657-661.