Top 5 Reasons to Add Betaine Supplements to Your Daily Regimen
Medically Reviewed by Dr. Nicole Avena

Have you ever heard of betaine? If not, here’s what you need to know about this unique nutrient.

What Is Betaine?

Betaine, or trimethylglycine (TMG), is a substance made in the body. TMG can be found in foods too, such as beetroot. It also can be found in certain supplements.

Betaine has several potential health benefits, including improved mood, energy, and heart health. It helps convert potentially harmful homocysteine into the antioxidant methionine. Also, TMG is involved in the process called methylation, which is crucial for DNA production.

Methylation Basics

Methylation is the body’s process of transferring various compounds between methyl groups. It’s needed to manufacture the vitamins folate and B12, as well as amino acids, neurotransmitters, hormones, red blood cells, DNA, and RNA.

Methylation can have far-reaching impacts on both your mental and physical health. Unfortunately, some people have poor bodily methylation. The methylation process is complex; just one genetic mutation can adversely impact the process. When that happens, your body and brain can experience negative effects such as poor focus, memory, and hormone regulation.

If you’re looking to improve your body’s methylation, consider taking a high-quality betaine supplement like…


Benefits of Betaine 1 | BrainMD

BrainMD’s Betaine TMG

Betaine TMG is a supplement that can support your body’s methylation process, which is important for the proper functioning of your cardiovascular, nervous, and endocrine (hormone) systems.* Your body also needs betaine for detoxification and energy production.*

The Ultimate Methylation Aid

This high-quality TMG supplement may improve your body’s methylation.* Not to be confused with betaine HCl, Betaine TMG is the amino acid glycine with three methyl groups attached to it. Once ingested, those methyl groups break apart from the glycine, increasing your body’s methyl pools which help aid in the methylation process.*

TMG bypasses the folate enzyme MTHFR. That means even if you have the common gene mutation C677T, which hampers methylation, you can still benefit from Betaine TMG.

What Are the Benefits of Betaine?

Helps Support Mood – the compound S-adenosylmethionine (SAMe) is well-studied for promoting a positive mood. Taking TMG may help increase SAMe’s efficacy, which can provide mood benefits.*

Helps Neutralize Homocysteine – TMG helps clear excess homocysteine, a harmful amino acid, out of the body by converting it to methionine.* It also may be helpful for those who’ve had limited success maintaining healthy homocysteine through folate supplementation.

Helps Build Muscle – at a dosage of 2.5 grams per day, TMG can help improve power and body composition.*

Is Betaine TMG Right For You?

If you’re low in folate or vitamin B12, it may be that you aren’t methylating well. Other tests that point to poor methylation include high blood levels of MMA (methylmalonic acid) or homocysteine, which can build up in the absence of folate.

You may benefit from a high-quality betaine supplement like Betaine TMG if you’re experiencing:

  • Stress and low mood
  • Hormone imbalance
  • Poor ability to detoxify
  • Histamine intolerance
  • Low energy

Betaine TMG Ingredient

Betaine, or trimethylglycine (TMG), is a small molecule that’s integral to human metabolism. We get betaine from beets (hence its name), spinach, and a few other foods. It helps conserve the body’s antioxidant defenses and is a potent means for controlling potentially toxic homocysteine.* It also may help support the proper functioning of the brain, liver, and other organs.*

Betaine TMG FAQ

How do I know if I need this supplement?

Inherited mutations of the enzymes that obtain methyl from folate and vitamin B12 are common in many adults. Taking Betaine TMG can help bypass these metabolic limitations.* Also, anyone who’s having mood difficulties can add this supplement to their daily routine. Those already taking SAMe may experience improved benefits from taking Betaine TMG.*

What’s the best way to take this supplement?

It’s recommended to take Betaine TMG at least two hours after eating to improve its absorption into the bloodstream.

How much should I take for best results?

A good maintenance dose is one capsule (500 mg) once or twice daily between meals. To enhance SAMe for mood, it’s recommended that you take at least one capsule for each 800 mg of SAMe. To promote healthy homocysteine metabolism, take 2 capsules once or twice daily.

Can vegetarians take this product?

Yes, it’s suitable for vegetarians and vegans.

Is this product the same as Betaine HCl?

No. HCl is a different dietary supplement, a digestive aid. Betaine TMG is designed to promote overall brain and body health.

What others are saying about Betaine TMG…

“For me, this supplement had a dramatic impact – lowered my feelings of stress and made my mood brighter (more prone to laughing and noticing & appreciating even little things).” – Holly P.

“Betaine, tyrosine, GABA, and magnesium in combination are shifting my memory and tremor issues. I’m grateful!” – Joseph U.

Naturally present in our cells, this powerhouse substance promotes healthy moods.” – Daniel G. Amen, MD

Benefits of Betaine

Betaine TMG offers many potential health benefits, including:

  • Positive mood and emotional balance*
  • Support for brain function*
  • Improved efficacy of SAMe*
  • Enhanced power and body composition*
  • Balanced homocysteine metabolism*

Also, individuals who are unable to achieve healthy homocysteine regulation by taking folate and vitamin B12 may experience improved methylation by taking betaine.

Betaine is safe to take, and some individuals may benefit from even higher intakes of the nutrient than what’s recommended for daily consumption. As with any wellness intervention, it’s strongly suggested that you consult with a nutritionally informed practitioner before taking any new dietary supplement.


At BrainMD, we’re dedicated to providing the highest purity nutrients to improve your physical health and overall well-being. For more information about Betaine TMG and our full list of brain healthy supplements, please visit us at BrainMD.

*These statements have not been evaluated by the FDA. This content is for informational purposes only. It is not meant to substitute for medical or healthcare advice from a physician, nor is it intended to diagnose, treat, cure, or prevent any disease. Consult your healthcare provider before beginning a new health regimen.

Keith Rowe