ProBrainBiotics Max


Dr. Amen’s NEW broad-spectrum super probiotic supplies 7 clinically studied probiotic strains for optimal intestinal support and inside-out health. Each strain is tested for identity, safety, and ease of use. 

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The Benefits


Promotes positive mood and emotional balance


Provides antioxidant support and immune system boosters
Brain Health

Brain Health

Supports optimal brain function with key brain-healthy nutrients


Promotes health digestion

Good Health Begins With Gut Health

With a premium blend of powerful probiotic strains and a total 30 billion CFU (colony-forming units) per day, ProBrainBiotics MAX is one of the most powerful and effective scientifically-researched probiotics available. These fully-defined probiotic strains benefit the brain (mood, stress, occasional anxious feelings), immunity (help to increase immune cell population), and gut health (bowel regularity and comfort, intestinal probiotic balance).

This broad-spectrum, one-a-day probiotic supplement is a breakthrough for human health.

Mood Problems? Feed Your Friendly Bacteria

In the U.S., at least 1 in 5 people experience mood problems. Clinical research shows that these individuals often are lacking in friendly gut bacteria. Strains R52 and R175 (both found in ProBrainBiotics MAX) are the first clinically confirmed psychobiotics to improve mood.²⁻⁴

Overwhelmed with anxiousness? Support a healthy response with stress with ProBrainBiotics MAX. The same R52 + R175 combination lowered the stress hormone cortisol in double-blind clinical research.³

Immune Issues? Build Better Immunity

A healthy gut microbiome promotes immune readiness. The friendly bacteria are continually being monitored by “sentinel” immune cells for potentially harmful antigens.

In two clinical trials, strains K31 and K32 enhanced the body’s immune response. Strain R71 improved students’ upper respiratory immune vigilance in one study. In two trials, HN19 elevated immune cell numbers in elderly individuals and showed promise for benefiting those with a weakened immunity.

Digestive Discomfort? Get That Good Gut Feeling

All 7 probiotic strains in ProBrainBiotics MAX offer supercharged intestinal benefits. In a double-blind, randomized, controlled trial conducted with people suffering from the effects of stress, the R52 + R175 psychobiotic combination lowered abdominal pain and nausea/vomiting.⁴

ProBrainBiotics MAX is unique for offering clinically defined probiotic strains with brain, immune, and intestinal benefits all in one daily capsule. The strains are internationally registered and tested for identity and safety. The capsules are blister packed to ensure freshness and long-term stability.


Key Scientific References:

  1. Yeh TL, others. The influence of prebiotic or probiotic supplementation on antibody titers after influenza vaccination: a systematic review and meta-analysis of randomized controlled trials. Drug Design, Development and Therapy 12:217 (2018). 

  2. Messaoudi M, others. Beneficial psychological effects of a probiotic formulation (Lactobacillus helveticus R0052 and Bifidobacterium longum R0175) in healthy human volunteers. Gut Microbes 2:256 (2011).

  3. Messaoudi M, others. Assessment of psychotropic-like properties of a probiotic formulation (Lactobacillus helveticus R0052 and Bifidobacterium longum R0175) in rats and human subjects. British Journal of Nutrition 105:755 (2011).

  4. Diop L, others. Probiotic food supplement reduces stress-induced gastrointestinal symptoms in volunteers: a double-blind, placebo-controlled, randomized trial. Nutrition Research 28:1 (2008).

The Formula
  • No Artificial Colorings
    No Artificial Coloring
  • No Artificial Flavorings
    No Artificial Flavoring
  • Egg Free
    Egg Free
  • Yeast Free
    Yeast Free
  • Gluten Free
  • Sugar Free
  • Corn Free
    Corn Free
Serving Size 1 Capsule
Servings Per Container 30
Amount Per Serving % DV *
Probiotic Strains 30 billion CFU 533 mg
Bifidobacterium lactis HN019™ 17.0 billion CFU  †
Lactobacillus helveticus Rosell®-52 4.5 billion CFU  †
Bifidobacterium bifidum Rosell®-71 3.0 billion CFU  †
Bifidobacterium longum BB536™ 2.0 billion CFU  †
Lactobacillus plantarum KABP™-031 1.5 billion CFU  †
Lactobacillus plantarum KABP™-032 1.5 billion CFU  †
Bifidobacterium longum Rosell®-175 0.5 billion CFU  †
1 CFU  = Colony-Forming Units, number of live bacteria
† Daily Value (DV) not established.

Other Ingredients: Vegetable cellulose (vegetarian capsule), microcrystalline cellulose, acacia gum, magnesium stearate.

Free from gluten, sugar, corn, nuts, egg, yeast, and artificial colorings or flavorings. Contains dairy and soy (traces).

Minimum CFU count 30 billion at time of manufacture.

Bifidobacterium lactis Strain HN19
Bifidobacterium lactis Strain HN19
17 billion CFU

Bifidobacteria are the most well studied human probiotics. Named for their branched, bifurcated shape, they are abundant in the gut microbiome of healthy people. HN19 has enhanced human immunity, improved gut function and gum health, and may “prime” the gut for other friendly probiotics.

Lactobacillus helveticus Strain R52
Lactobacillus helveticus Strain R52
4.5 billion CFU

This strain promotes intestinal function and is an established psychobiotic – it clinically improves mood. In combination with R175, R52 has enhanced mood and the ability to cope with stress.

Bifidobacterium bifidum Strain R71
Bifidobacterium bifidum Strain R71
3 billion CFU

R71 has improved sleep quality, immunity, and gut function in students under pre-examination stress.

Bifidobacterium longum Strain BB536
Bifidobacterium longum Strain BB536
2 billion CFU

After intensive clinical research, the BB536 strain is proven to promote gut health.

Lactobacillus plantarum Strain K31
Lactobacillus plantarum Strain K31
1.5 billion CFU

Originally obtained from human infants, these hardy strains have been used in 1:1 combination to enhance immunity and promote intestinal function.

Lactobacillus plantarum Strain K32
Lactobacillus plantarum Strain K32
1.5 billion CFU

Strain K32 was tested together with strain K31. They have separate and distinct DNA and other biologic characteristics, but reinforce each other’s benefits.

Bifidobacterium longum Strain R175
Bifidobacterium longum Strain R175
0.5 billion CFU

This species is the most widespread “bifido” in the human gut and is a psychobiotic. In two pioneering clinical trials, R175, paired with R52, successfully enhanced mood and the ability to cope with stress.

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Supplement form Capsules Capsules Capsules
Health Benefits Mood Immunity Brain Health Digestion Total Wellness Immunity Brain Health Digestion Digestion Mood Stress Support
Ingredients Bifidobacterium lactis Strain HN19 Lactobacillus helveticus Strain R52 Bifidobacterium bifidum Strain R71 Bifidobacterium longum Strain BB536 Lactobacillus plantarum Strain K31 Lactobacillus plantarum Strain K32 Bifidobacterium longum Strain R175 Vitamin A Vitamin C Vitamin D Vitamin E Vitamin K Thiamin Riboflavin Vitamin B3 View More Vitamin B6 Folate Vitamin B12 Biotin Pantothenic Acid Calcium Iodine Magnesium Zinc Selenium Manganese Chromium Molybdenum Vitamin E Choline Boron Silicon Lutein, carotenoid Zeaxanthin, carotenoid Hesperidin flavonoid complex Resveratrol Pterosilbene Organic Fruit & Vegetable Blend Proprietary Brain Boosting Blend Digestive Enzyme Blend Lactobacillus helveticus Strain R52 Bifidobacterium longum Strain R175

Dr. Amen talks about Omega-3 Power

Fortify your brain with the natural power of Omega-3s

Frequently Asked Questions
How can I take this supplement?
We recommend adults take 1 capsule (supplying a minimum 30 billion live probiotic units) daily, with food. Children ages 4 and up also can take this daily dose. This product is not intended for use during pregnancy.
Who can benefit from ProBrainBiotics Max?
Nearly everyone is likely to benefit from this broad-spectrum probiotic supplement. This includes the elderly, people who have been exposed to pollutants, and those with poor dietary habits or digestive problems. Individuals with mood problems, dealing with excessive stress, or desiring a stronger immunity may benefit from this efficacious combination of probiotic strains.
Can other BrainMD supplements complement or enhance the effectiveness of ProBrainBiotics Max?
Yes! NeuroVite Plus, Omega-3 Power, and Vitamin D3 5000 IU complement this product. The health of the intestinal lining requires all these nutrients, and probiotics work very closely with this lining. Also, vitamin D deficiency damages the gastrointestinal lining and is associated with microbiome imbalance (“dysbiosis”).
What makes ProBrainBiotics Max different from other probiotic products?
This probiotic supplement is unique because all seven of its strains have shown consistent benefits in clinical trials. The strains are internationally registered and are well defined for identity and safety. The capsules are blister packed to ensure freshness.
Are there any side effects to taking ProBrainBiotics Max?
No. As with other BrainMD products, this is a dietary supplement, not a drug, and isn’t habit-forming. It’s free from dairy, glutens, sugar, corn, soy, nuts, eggs, yeast, and artificial colorings or flavorings. It’s compatible with keto or paleo dietary patterns.