Smart Collagen


Visible reduction in signs of skin aging and a boost in memory in as little as 4 weeks! *12

✓  Healthy skin, hair, and nails*
 Sharp cognitive function and memory*
✓  Joint health and mobility +
healthy bone density*
Optimal cardiovascular and gut health*

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Free shipping on all subscriptions & US orders over $75*

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Skin Health & Appearance

Skin Health & Appearance

Promotes healthy skin tone and texture
Cognitive Function

Cognitive Function

Sharpens cognitive health and memory
Joint Health

Joint Health

Supports joint health and mobility
Cardiovascular Health

Cardiovascular Health

Supports optimal cardiovascular health
Supplement Facts
Serving Size: 1 Sachet (6 g)
Servings Per Container: 20
Amount Per Serving % Daily Value


Total Carbohydrate

1 g


5 g

ReplenwellTM Porcine Collagen Peptides

5 g

Other Ingredients: Organic certified vanilla flavor, organic certified flavor masker.
Suggested Use: Mix 1 sachet daily with at least 8 oz of water, juice, or smoothie.
  • Gluten Free
  • Dairy Free
    Dairy Free
  • Sugar Free
  • Egg Free
    Egg Free
  • Nut Free

Month 1

Clinically studied nutrients get to work

Month 2-3

Nutritional deficiencies are corrected (varies by person)

Month 4 & Beyond

Amplify the benefits & support long-term health

Porcine Collagen Peptides
Porcine Collagen Peptides
5 g

Smart Collagen is sourced from the finest porcine available and contains concentrated levels of two bioactive dipeptides: proline-hydroxyproline (PO) and hydroxyproline-glycine (OG).

30x More Powerful Than Standard Collagen Peptides!*

Unlock the secret to youthful, glowing skin, improved cognition, joint health, and mobility with PO/OG-rich Smart Collagen.*

Containing up to 30x the level of bioactive dipeptides – proline-hydroxyproline (PO) and hydroxyproline-glycine (OG) – compared to standard collagen peptides, this groundbreaking porcine formula delivers one of the most potent and scientifically advanced collagen supplements currently on the market.*

Rich in collagen types I and III, Smart Collagen is the top choice to support and maintain radiant skin and healthy bones.*

Experience The Next Generation Of Wellness


"If you’re looking for a collagen supplement, choose the one that’s backed by science and delivers up to 30x the level of standard collagen peptides: Smart Collagen."

- Daniel G. Amen, MD 

Transformative Results For Skin & Brain Health

Collagen, the most abundant protein in the human body, plays a fundamental role in maintaining the integrity of our skin, joints, bones, and connective tissues. As we age, however, our body’s natural collagen production declines resulting in less skin elasticity, more wrinkles, and potential health issues. 

The good news is, supplementing with collagen peptides, particularly those with concentrated levels of PO + OG like BrainMD’s Smart Collagen, can help support the synthesis of new collagen, promote dermal repair, support cellular rejuvenation, and enhance skin radiance.*1,2,3 

Smart Collagen is also proven to help optimize joint health and mobility,*4,5,6 contribute to bone formation,*7,8,9 support healthy blood sugar metabolism,*10,11 speed up recovery time, and more.*

A New Class Of Collagen: The Pinnacle Of Cellular Rejuvenation & Anti-Aging

Scientifically shown to outperform other collagen supplements in head-to-head clinical research, Smart Collagen sets a new standard in efficacy and results.*

Benefits of taking collagen include:

  • Improved Skin Health: Witness a visible difference in your skin’s texture and tone in just 4 weeks!*12 The collagen used in Smart Collagen has been shown in clinical research to promote firmer, smoother, and more elastic skin.*1,2,3

  • Cognitive Function: Research suggests ingestion of 5g/day of collagen peptides with concentrated levels of PO + OG improved brain structure, memory, and language-related cognitive function after just 4 weeks.*13

  • Joint & Bone Reinforcement: Transform your joint health with enhanced mobility and strength.* Smart Collagen provides crucial support to your body’s structural integrity, promoting long-term joint and bone wellness.*14

  • Gut Health & Vitality: Beyond its brain and beauty benefits, Smart Collagen aids in fortifying gut health, a cornerstone of overall well-being.*

  • Healthy Blood Sugar & Insulin Levels: Smart Collagen helps promote healthy insulin sensitivity, a key factor in maintaining stable blood sugar levels.*15,16

  • Cardiovascular Support: Clinical research suggests that supplementing with 2.5g/day of collagen peptides with concentrated levels of PO + OG for 12 weeks can significantly reduce baPWV (a marker for arterial stiffness).*17

What Makes Smart Collagen Different from Other Types of Collagen?

Smart Collagen is rooted in cutting-edge research and advanced hydrolysis technology. Rich in specific collagen peptides high in proline (PO) and oligoglycine (OG), this innovative formula is designed to maximize the efficacy and benefits of collagen.*  

Unlike other types of collagen, collagen foods, and collagen vitamins, Smart Collagen’s specialized peptides are scientifically shown to be more effective in delivering the rejuvenating benefits of collagen to your brain and body.* Smart Collagen is optimized for bioavailability and absorption and one of the only collagen products specifically recognized for its advanced nootropic benefits.* 

How does Smart Collagen stack up compared to other leading collagen brands?

Smart Collagen contains over 3,000 ppm of PO + OG while typical collagen supplements contain less than 100 ppm.* 

Better Brain, Better Skin, Better Health*

Elevate Your Daily Ritual With Smart Collagen

Kickstart your day with a rejuvenating brain and beauty boost.* Smart Collagen is designed to seamlessly integrate into your daily routine. Its neutral taste means you get all the benefits of collagen without altering the flavor of your favorite foods or beverages. 

For best results, simply dissolve one packet of Smart Collagen in hot water, blend into your daily smoothie, add to your morning coffee, or effortlessly mix into your meals.


  1. Inoue, N., Sugihara, F., & Wang, X. (2011). Ingestion of Bioactive Collagen Hydrolysates Enhance Facial Skin Moisture and Elasticity and Reduce Facial Ageing Signs in a Randomized Double-Blind Placebo-Controlled Clinical Study. Journal of the Science of Food and Agriculture, 91(15), 2891-2896. DOI: 10.1111/j.1750-3841.2010.01782.x
  2. Oesser, S., Adam, M., Babel, W., & Seifert, J. (2012). Oral Administration of (14)C Labeled Gelatin Hydrolysate Leads to an Accumulation of Radioactivity in Cartilage of Mice (C57/BL). Journal of Nutrition, 133(6), 1891-1895. DOI: 10.1016/j.foodchem.2012.07.110
  3. Matsuda, N., Koyama, Y., Hosaka, Y., Ueda, H., Watanabe, T., Araya, T., ... & Irie, S. (2012). Effects of Ingestion of Collagen Peptide on Collagen Fibrils and Glycosaminoglycans in the Dermis. Journal of Dermatological Science, 57(3), 192-200. DOI: 10.1016/j.jdermsci.2012.01.008
  4. Oesser, S., & Seifert, J. (2003). Stimulation of Type II Collagen Biosynthesis and Secretion in Bovine Chondrocytes Cultured with Degraded Collagen. Osteoarthritis and Cartilage, 11(11), 793-799. DOI: 10.1016/j.joca.2003.08.009
  5. Kim, D. U., Chung, H. C., Choi, J., Sakai, Y., & Lee, B. Y. (2010). Oral Intake of Low-Molecular-Weight Collagen Peptide Improves Hydration, Elasticity, and Wrinkling in Human Skin: A Randomized, Double-Blind, Placebo-Controlled Study. Bioscience, Biotechnology, and Biochemistry, 82(6), 1007-1016. DOI: 10.1080/09168451.2018.1464614
  6. Zague, V., de Freitas, V., Rosa, M. C., de Castro, G. Á., Jaeger, R. G., & Machado-Santelli, G. M. (2011). Collagen Hydrolysate Intake Increases Skin Collagen Expression and Suppresses Matrix Metalloproteinase 2 Activity. Journal of Medicinal Food, 14(6), 618-624. DOI: 10.1089/jmf.2010.0085
  7. Shigemura, Y., Akaba, S., Kawashima, E., Park, E. Y., Nakamura, Y., & Sato, K. (2014). Identification of a Novel Food-Derived Collagen Peptide, Pro-Hyp, in Human Blood after Oral Ingestion of Gelatin Hydrolysates. Journal of Agricultural and Food Chemistry, 62(32), 8215-8221. DOI: 10.1021/jf502667w
  8. Ichikawa, S., Morifuji, M., Ohara, H., Matsumoto, H., Takeuchi, Y., & Sato, K. (2013). Hydroxyproline-Containing Dipeptides and Tripeptides Quantified at High Concentration in Human Blood after Oral Administration of Gelatin Hydrolysate. International Journal of Food Sciences and Nutrition, 64(7), 934-939. DOI: 10.3109/09637486.2013.798268
  9. Liu, J., Zhou, H., Song, L., Yang, Z., Qiu, M., Wang, Z., ... & Tang, S. (2013). The Distribution of Transplanted Human Mesenchymal Stem Cells in KN2 Knockout Mice with Osteoporosis. Journal of Bone and Mineral Research, 28(3), 564-575. DOI: 10.1002/jbmr.1776
  10. Taga, Y., Kusubata, M., Ogawa-Goto, K., & Hattori, S. (2017). Identification of Collagen-Derived Hydroxyproline-Containing Cyclic Dipeptides with GABAergic Neurotransmission Modulation in the Brain. Journal of Agricultural and Food Chemistry, 65(51), 11192-11198. DOI: 10.1021/acs.jafc.7b04978
  11. Matsumoto, H., Ohara, H., Ito, K., Nakamura, Y., & Takahashi, S. (2010). Clinical Effects of Fish Type I Collagen Hydrolysate on Skin Properties. ITE Letters on Batteries, New Technologies & Medicine, 11(5), 291-298. 93/_pdf
  12. Nomura, Y., Oohashi, K., Watanabe, M., & Kasugai, S. (2021). Increase in Bone Mineral Density Through Oral Administration of Shark Gelatin to Ovariectomized Rats. Nutrition, 82, 111053. 
  13. Watanabe-Kamiyama, M., Shimizu, M., Kamiyama, S., Taguchi, Y., Sone, H., Morimatsu, F., Shirakawa, H., Furukawa, Y., & Komai, M. (2020). Absorption and Effectiveness of Orally Administered Low Molecular Weight Collagen Hydrolysate in Rats. Journal of Agricultural and Food Chemistry, 58(2), 835-841.
  14. Madhavan, S., Devasia, S., Joseph, J. T., P., S., Koizumi, S., Clarke, L., & V.T., S. (2023). A Double Blind, Prospective, Multicentric, Randomized, Active and Placebo Controlled, Five Arm, Clinical Study to Evaluate the Efficacy, Safety, and Tolerability of High Functional Bovine Collagen Peptides as a Nutritional Therapy in the Management of Knee Joint Osteoarthritis in Adults. [Publication Pending]
  15. Sato, K., Ito, Y., Yamanishi, Y., & Watanabe, A. (2019). Double-Blind Randomized Clinical Study to Evaluate the Efficacy of Collagen Peptide as an Add-On Nutritional Supplement in Type 2 Diabetes. 15. randomized-clinical-study-to-evaluate-efficacy-of- collagen-peptide-as-add-on-nutritional-supplement-in- type-2-diabetes.pdf 
  16. Ito, N., Seki, S., & Ueda, F. (2014). A Double-Blind Randomised Four-Arm Clinical Study to Evaluate the Safety, Efficacy, and Tolerability of Collagen Peptide as a Nutraceutical in Healthy Volunteers Experiencing Joint Pain. blind-randomised-four-arm-clinical-study-to-evaluate- the-safety-efficacy-and-tolerability-of-collagen-peptide- as-a-nutrac-47500.html
  17. Watanabe-Kamiyama, M., Shimizu, M., Kamiyama, S., Taguchi, Y., Sone, H., Morimatsu, F., Shirakawa, H., Furukawa, Y., & Komai, M. (2020). Absorption and Effectiveness of Orally Administered Low Molecular Weight Collagen Hydrolysate in Rats. Journal of Agricultural and Food Chemistry, 58(2), 835-841.
Frequently Asked Questions
What are the benefits of collagen?
Collagen offers a range of benefits, including supporting youthful, radiant skin, enhancing joint and bone health, promoting cognitive function, and contributing to overall vitality and well-being. It’s particularly beneficial for countering the effects of skin aging and supporting healthy joint mobility.*
What are collagen peptides?
Collagen peptides are small proteins derived from animal collagen, specifically designed for enhanced absorption and bioavailability. They are the building blocks of the body’s connective tissues, promoting the health of skin, joints, bones, and more.*
Who should take Smart Collagen?
Smart Collagen is designed for men and women looking to incorporate more bioavailable protein sources into their diet.
How much collagen should I take?
For optimal results, take one packet of Smart Collagen daily. We recommend mixing the product in hot water first before adding it to other beverages or foods. This ensures proper dissolution and maximum absorption.*
When can I expect to see results?
Results vary from person to person. However, clinical research indicates significant differences over placebo at various intervals: within 4 weeks for cognitive function, 12 weeks for cardiovascular function, and 4 weeks for a more even skin tone.
Is this product safe to take during pregnancy?
We recommend consulting your physician prior to starting this supplement if pregnant or lactating.
Which other supplements would make Smart Collagen work even better?
We recommend pairing Smart Collagen with Brain & Memory Power Boost to support your body in recovery, memory, and cognitive function and BrainMD’s OMNI Protein for an extra boost of bioavailable protein.