Smart Mushrooms


Transform your coffee, tea, or smoothie into a cognitive and immunity booster drink with this full-spectrum mushroom powder. Formulated with six superfood mushrooms long-revered for their ability to promote energy, stress resistance, mental performance, and immunity, Smart Mushrooms delivers a dose of vitality with each scoop.*

In stock

Free shipping on all subscriptions & US orders over $75*

Cancel Any Time | 100% Money Back Guarantee | Refund Policy

Brain Health

Brain Health

Supports optimal brain function with key brain-healthy nutrients


Supports working memory while under mental strain


Provides antioxidant support and immune system boosters


Provides the nutrients essential to health and longevity
Supplement Facts
Serving Size 1 Scoop (3 g)
Servings Per Container 30
Amount Per Serving % DV *
Calories 12  
Total Fat 0.2 g 0%*
     Saturated Fat 0 g 0%*
Cholestorol 0 g 0%*
Total Carbohydrate 2 g 1%*
     Dietary Fiber 0.4 g 1%*
     Total sugars 1.6 g  
          Included 0 g Added Sugars    
Protein 0.4 g 1%*
Organic Lion's Mane (Hericium erinaceus)** 1000 mg
Organic Turhey Tail (Trametes veriscolor)*** 400 mg
Organic Cordyceps (Cordyceps militaris)** 400 mg
Organic Reishi (Ganoderma lucidum)** 400 mg
Organic Shiitake (Lentinula edodes)** 400 mg
Organic Agaricus (Agaricus blazei)*** 400 mg

**Mycelial biomass powder cultured on organic oats.

***Mycelial biomass and fruit body powders cultured on organic oats.

* Percent Daily Value is based on a 2,000 calorie diet.
† Daily Value (DV) not established.
Suggested Use: Add one scoop (3 grams) of smart Mushrooms to your coffee, tea, or smoothie (or to other food) to amplify your morning and kickstart your day. We recommend doubling your dose for the first 3 weeks to accelerate results. 


  • Sugar Free
  • Corn Free
    Corn Free
  • Soy Free
  • Artificial Additive Free
  • Gluten/Yeast Free
  • No Animal Products

Month 1

Clinically studied nutrients get to work

Month 2-3

Nutritional deficiencies are corrected (varies by person)

Month 4 & Beyond

Amplify the benefits & support long-term health

6 Functional Mushrooms, 1 Powerful Powder

Smart Mushrooms is firmly grounded in the most recent clinical and scientific research on medicinal mushrooms. It includes six mushrooms that have been revered for hundreds to thousands of years. All six are highly nutritious, and together they offer a broad spectrum of health benefits.

Benefits of Smart Mushrooms

The mushrooms in this formula are high in protein and fiber, low in calories and sodium, and contribute vitamins and minerals to the diet. They include glucans, unique fibers that can enhance immunity, provide antioxidant benefits, and promote healthy gut microbial balance. These six mushrooms are functional foods for the brain and entire body.

The Mane Event

Leading all other mushrooms in brain benefits, the lion’s mane mushroom contains unique hericenones and erinacines, which can increase nerve growth factor (NGF) in the brain. NGF supports acetylcholine circuits, which are required for focus, memory, and other cognitive functions.

Lion’s mane has shown promise in several clinical trials for improving cognition and mood. Its glucans also help boost immunity and support healthy bacterial balance in the gut.

Supporting Superfoods

Here’s a look at the other organic superfoods in Smart Mushrooms: 

  • Turkey Tail provides protein-bound glucan polysaccharides, intensively researched for their immune benefits.
  • Cordyceps fights fatigue, supports immunity, helps counter stress, and benefits blood flow and oxygen utilization.
  • Reishi’s immune and inflammatory response benefits help account for its 2,100-year popularity.
  • Shiitake provides the glucan called lentinan, which improves immunity, and also has lung, liver, cardiovascular, and gastrointestinal benefits. 
  • Agaricus has a variety of glucans with immune benefits, and supports healthy blood sugar, cholesterol, and liver functions.

The Smart Choice

Smart Mushrooms offers substantial promise for improving memory, mood, and other cognitive functions. Most of these mushrooms are proven tonic medicinals, offering a great variety of benefits for the brain and body. 

Smart Mushrooms can help increase energy, wellness, and high-level brain performance. It’s the Smart choice for immune and whole-body support!

Lion’s Mane Mushroom (Hericium erinaceus)
Lion’s Mane Mushroom (Hericium erinaceus)

This edible mushroom has been used in traditional Chinese medicine for over 1,000 years. Its unique terpene substances (hericenones and erinacines) stimulate Nerve Growth Factor (NGF) production in the brain. NGF supports acetylcholine circuits, which are required for focus, memory, and other cognitive functions. Lion’s Mane also is rich in beta-glucans, a special type of fiber that promotes healthy immunity.

Reishi Mushroom  (Ganoderma lucidum)
Reishi Mushroom (Ganoderma lucidum)

Reishi has been revered for over 2,000 years in Asia as “the mushroom of immortality.” In addition to beta-glucans, Reishi contains triterpenes. These chemical compounds can boost Nerve Growth Factor, which supports acetylcholine circuits, and Brain Derived Neurotrophic Factor, which supports the maturation of new nerve cells and overall brain adaptability. Reishi has potential to improve human brain health even as it sustains immunity.

Shiitake Mushroom  (Lentinula edodes)
Shiitake Mushroom (Lentinula edodes)

Shiitake has been a medicinal and food mushroom for over 2,000 years. It’s the source of lentinan, a beta-glucan particularly well studied for its immunity benefits. Shiitake can promote healthy cholesterol and triglyceride levels already within normal range. It also contains the unique antioxidant ergothioneine, which likely plays a beneficial role in human health.

Turkey Tail (Trametes versicolor, also known as Coriolus versicolor)
Turkey Tail (Trametes versicolor, also known as Coriolus versicolor)

Turkey Tail is too fibrous to be routinely consumed as food, but from its mycelia come two beta-glucan polysaccharides that are bound to proteins, each intensively researched for immune benefits. Polysaccharide-K (PSK) has been studied mainly in Japan, Polysaccharide-Peptide (PSP) mostly in China. Both PSK and PSP are well documented to improve human immunity.

Cordyceps Militaris
Cordyceps Militaris

Cordyceps militaris, the orange caterpillar fungus, is among the most exotic mushrooms. It has been found to boost immunity in multiple clinical trials. Cordyceps is unique for having nucleosides, nutrients essential for our cells to make energy. Nucleosides are also essential building blocks for the DNA of our genes, and for RNA which has numerous vital functions including protein production. Cordyceps is widely revered in the East for its benefits to vitality and overall wellness.

Agaricus (Agaricus blazei)
Agaricus (Agaricus blazei)

The Agaricus blazei mushroom originated in Brazil and is now also widely accepted in Japan and other Asian countries, where it is used as both food and medicine. It is a rich source of protein, fiber, and B vitamins. It has a variety of immune supporting glucans, and clinical research indicates it supports liver health, along with cholesterol and blood sugar levels already within normal range.

Time-Tested SuperfoodsTime-Tested Superfoods

Time-Tested Superfoods

Medicinal mushrooms have a long history of use in many different cultures – including China, Japan, and Brazil – dating back hundreds, even thousands, of years. They are valued for their broad spectrum of health benefits, including enhanced cognition, immune function, and gut health.*

Smart Mushrooms is a superfood mushroom powder blend featuring six treasured medicinal mushrooms – lion’s mane, turkey tail, cordyceps, reishi, shiitake, and agaricus – to nourish your body and mind.

The Power Of Beta GlucansThe Power Of Beta Glucans

The Power Of Beta Glucans

The key to medicinal mushrooms’ power is beta glucans. Here are the basics of beta glucans:

  • Located within mushroom cell walls, beta glucans are soluble fibers that enhance immunity and support gut health.*
  • Beta glucans trigger the activation of “early warning” immune cells, helping you nip immune challenges in the bud.*
  • They also serve as food for the friendly bacteria in your gut, increasing their numbers and crowding out the bad guys.*

All the mushrooms featured in Smart Mushrooms are naturally high in beta glucans.


“Everyone in my family takes this well-researched medicinal mushroom blend to enhance immunity and promote gut health.”

- Daniel G. Amen, MD 

  • READ Why It Didn’t Make the Cut

    Iron is a mineral essential for human health. It is typically linked to hemoglobin – the protein that transports oxygen around the body – and is also vital for energy production, antioxidant defense, DNA production, gene regulation, and the body’s detoxification process.
    Though commonly found in multivitamins, we purposely left it out.
    As a standalone supplement ingredient for those at risk of deficiency, iron is beneficial – we offer advanced iron in its most well-tolerated and well-absorbed form: ferrous bisglycinate, Ferrochel®. However, when combined with other nutrients (like it is in a comprehensive multivitamin), iron’s chemically reactive nature can degrade and potentially destroy the other ingredients it’s mixed with.
    Here’s everything else we intentionally left out.

• Brain & Memory Power Boost •

“I got my DREAMS back!”

- Claire R., Verified Buyer

Meet The MushroomsMeet The Mushrooms

Meet The Mushrooms

  • Lion’s Mane has several clinically demonstrated brain benefits.* It’s been shown to support cognitive function, reduce anxiousness and improve outlook, and preserve memory in three separate studies at dosages ranging from 500-1,050 mg/day.*
  • Organic Turkey Tail (Trametes Versicolor) contains two beta glucans linked to better immunity.*
  • Cordyceps is a source of the nucleoside adenosine, crucial for energy production.*
  • Reishi is known as “the mushroom of immortality.” It enhances the activity of immune cells, and preclinical research suggests it also supports brain health.*
  • Shiitake is widely used in Japan and China for its immune system benefits.*
  • Agaricus hails from Brazil and is commonly used in Asia to support immunity.*


“A really awesome quote from Dr, Amen about how awesome this product is.”

- Daniel G. Amen, MD 

Why Smart Mushrooms?Why Smart Mushrooms?

Why Smart Mushrooms?

What makes Smart Mushrooms a smart choice?

  • A superfood powder mushroom drink formulated by Dr. Daniel Amen with a focus on brain health and immunity*
  • All mushrooms are grown organically under carefully controlled conditions
  • A gluten-free product, made from mushrooms cultivated on gluten-free oats
  • Powder form is easy-to-use: just add to coffee, tea, soups, or smoothies
  • Mushroom powder provides a larger dose than possible in pills (3 grams of functional mushrooms per serving), and may increase efficacy
Clinically Researched BenefitsClinically Researched Benefits

Clinically Researched Benefits

As a company firmly rooted in science, we use only clinically researched ingredients that create real results. Here are some of the benefits of taking Smart Mushrooms superfood powder:

  • Total-body wellness*
  • Enhanced energy and vitality*
  • Optimal brain function*
  • Improved immune response*
  • Antioxidant protection*
Compare with Similar Products

Compare with Similar Products

Smart Mushrooms
In stock
Neuro Greens Superfood
In stock
Brain Boost On-The-Go
In stock
Customer Rating
Supplement form Powder Powder Powder
Health Benefits Brain Health Cognition Immunity Vitality Brain Health Vitality Total Wellness Immunity Focus Performance Energy
Ingredients Lion’s Mane Mushroom (Hericium erinaceus) Reishi Mushroom (Ganoderma lucidum) Shiitake Mushroom (Lentinula edodes) Turkey Tail (Trametes versicolor, also known as Coriolus versicolor) Cordyceps Militaris Agaricus (Agaricus blazei) Spirulina (Arthrospira platensis) Chlorella (Chlorella vulgaris) Kale Broccoli Carrot Strawberry Acerola Cherry Pomegranate Extract View More Blueberry Blackberry Blackcurrant Beet Root Lion’s Mane Mushroom (Hericium erinaceus) Maitake Mushroom (Grifola frondosa) Reishi Mushroom (Ganoderma lucidum) Shiitake Mushroom (Lentinula edodes) Goji Berry Extract (Lycium barbarum) Kelp (Vitakelp®) (Ascophyllum nodosum) Inulin Apple Flaxseed (defatted) Moringa (Moringa oleifera) Green Tea Extract (Camellia sinensis, leaf concentrate) Spirulina Raspberry Vitamin B6 Folate Vitamin B12 Calcium Phosphorus Potassium L-Theanine Proprietary Organic Fruit Blend
Frequently Asked Questions
Who can benefit from Smart Mushrooms?
Practically everyone, including adults and children age 4 or older. Smart Mushrooms is recommended for individuals seeking to sharpen their mental performance while improving their immune readiness.
How can I use this supplement?
Add one scoop (3 grams) of Smart Mushrooms to your favorite beverage, smoothie, or food. To accelerate results, you may double your dose for the first 3 weeks.
How are the mushrooms in Smart Mushrooms cultured?
These six medicinal mushrooms are all grown in controlled cultures. The lion’s mane, reishi, cordyceps, and shiitake powders come from mycelia cultured on organic oats. The turkey tail and Agaricus powders are from mycelial and fruiting bodies cultured on organic oats.
Does Smart Mushrooms contain allergens?
No. Smart Mushrooms is free from dairy, glutens, sugar, corn, soy, nuts, eggs, yeast, and artificial colorings or flavorings. It is non-GMO, certified USDA Organic, vegan, keto friendly and paleo friendly.

Dr. Amen talks about Omega-3 Power

Fortify your brain with the natural power of Omega-3s