Methylfolate (MF), technically methyltetrahydrofolate, is a form of the folate vitamin that is better utilized than folic acid or other folates. MethylFolate is essential for mood, cognition, behavior, and overall brain and body health.

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The Benefits


Promotes positive mood and emotional balance


Supports numerous brain and other organ functions


Helps prevent homocysteine adverse effects

Methyl Support for Mood, Brain Health and Wellbeing

Methylfolate (MF) is the body's most fully active form of folate, a vitamin that provides methyl groups (-CH3) which are crucial for a broad range of brain functions, including healthy mood. In clinical trials, MF corrected methyl deficiency while promoting healthy mood and overall brain health.

Highly Bioavailable Source of Methyl Groups

Normally, to be utilized by the body dietary folates from foods or supplements must first be converted to methylfolate, identical to MF. But the enzymes involved in this conversion process often carry mutations that impair their activity, so that more than 1 in 4 people are inefficient at converting folates to MF. High-quality MF supplements bypass these enzymes, directly supplying methyl to make SAME (s-adenosyl-methionine) and other methyl cofactors that manage the body's extensive networks of methyl metabolism.

Promotes Metabolic Recycling of Homocysteine

Homocysteine (HCy) is a byproduct of SAMe production from MF and the amino acid methionine. If allowed to build up in the blood and other tissues, HCy can become toxic. MF facilitates the recycling of HCy to methionine, thereby curbing its toxic potential.

Supports Brain Health Across the Lifespan

Methyl from MF is needed from the moment of fertilization of the human egg, through the development of the brain, heart and other organs, to birth, and all across the lifespan. All our cells need methyl groups to make their DNA, repair ongoing DNA damage, and regulate their utilization of DNA.

The Formula
  • No Artificial Colorings
    No Artificial Coloring
  • No Artificial Flavorings
    No Artificial Flavoring
  • Egg Free
    Egg Free
  • Yeast Free
    Yeast Free
  • Dairy Free
    Dairy Free
  • Gluten Free
    Gluten Free
  • Sugar Free
    Sugar Free
  • Corn Free
    Corn Free
  • Soy Free
    Soy Free
  • Vegan
Supplement Facts
Serving Size 1 Capsule
Servings Per Container 30
Amount Per Serving % DV
Folate (as Quatrefolic methylfolate,
5-methyltetrahydrofolate, glucosamine salt)
5 mg 1,250%
* Daily Value (DV) not established.
Other Ingredients: Vegetable cellulose (vegetarian capsule), microcrystalline cellulose, silicon dioxide, magnesium stearate.

Free from sugar, dairy, gluten, wheat, yeast, soy, eggs, corn, and artificial colors or flavorings.
5 mg

This formula contains folate as methylfolate (MTHF). The brain requires MTHF to make neurotransmitters, to produce the myelin insulation of nerve cells, and to make the sleep hormone melatonin. It also helps the liver and other organs recycle the metabolic product homocysteine, to prevent it from building up to toxic levels.

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Supplement form Capsules Capsules Capsules
Health Benefits Mood Methyl Protective Calm Mood Appetite Mood Protective Methyl
Ingredients Folate Vitamin B6 Folate Vitamin B12 Satiereal Saffron Extract 5-Hydroxytryptophan Betaine
Frequently Asked Questions
How do I know whether I need this supplement?
Methylfolate is a great supplement to support mood, especially in conjunction with SAMe and Betaine TMG. It also supports memory and the other higher brain functions. Since MF is essential for fetal development, women of reproductive age would be prudent to monitor their folate status and consider taking this supplement. Alcohol, smoking, and oral contraceptives all can deplete the body's folate. Inherited mutations in folate-processing enzymes affect up to 1 in 2 individuals of some ethnic groups. Taking MethylFolate ensures these individuals will receive folate they can utilize. This supplement is also a superior folate source for those without such mutations precisely because it is so efficiently utilized.
This supplement is very potent. Is it safe?
Methylfolate's safety is well documented, and this (and higher potencies) have been used safely and with great success for many years. MethylFolate is indicated for correcting confirmed folate deficiency, for promoting healthy mood, and for any other situations where folate supplementation is recommended.
What's the best way to take this supplement?
The basic dose is 1 capsule daily, taken with food. This supplies 5000 micrograms (5 mg) of methylfolate. We recommend that when under a physician's supervision, up to 3 caps (15 mg) can be taken daily.
I'm currently taking methotrexate - will this supplement be a problem?
We advise anyone taking methotrexate to consult a nutritionally-informed physician before using this product.
Can vegetarians take this product?
Yes, it is suitable for vegetarians and vegans.
What is the functional relationship of this product with SAMe?
Our liver cells need methylfolate to make SAMe. MethylFolate generously facilitates this process. The body uses a lot of SAMe, so boosting internal SAMe production may improve the benefits of SAMe supplementation, whether for mood, joint health or liver health.
How does this product work with Betaine TMG (Trimethylglycine)?
BrainMD's product Betaine TMG is a neat backup methyl source. It works to bypass the methyl enzyme mutations, promote HCy recycling and generally support methyl metabolism. MethylFolate and Betaine TMG complement each other's beneficial actions, and both complement SAMe Mood & Movement 400.
Is this product compatible with other dietary supplements?
Yes, it is absolutely compatible with multiple vitamin/mineral supplements, fish oils, herbals, and other responsibly-formulated dietary supplements. Further, MethylFolate's multiple methyl actions tend to reinforce the benefits of other dietary supplements.