Methylfolate (MF), technically methyltetrahydrofolate, is a form of the folate vitamin that is better utilized than folic acid or other folates. MethylFolate is essential for mood, cognition, behavior, and overall brain and body health.
Methyl Support for Mood, Brain Health and Wellbeing
Methylfolate (MF) is the body's most fully active form of folate, a vitamin that provides methyl groups (-CH3) which are crucial for a broad range of brain functions, including healthy mood. In clinical trials, MF corrected methyl deficiency while promoting healthy mood and overall brain health.
Highly Bioavailable Source of Methyl Groups
Normally, to be utilized by the body dietary folates from foods or supplements must first be converted to methylfolate, identical to MF. But the enzymes involved in this conversion process often carry mutations that impair their activity, so that more than 1 in 4 people are inefficient at converting folates to MF. High-quality MF supplements bypass these enzymes, directly supplying methyl to make SAME (s-adenosyl-methionine) and other methyl cofactors that manage the body's extensive networks of methyl metabolism.
Promotes Metabolic Recycling of Homocysteine
Homocysteine (HCy) is a byproduct of SAMe production from MF and the amino acid methionine. If allowed to build up in the blood and other tissues, HCy can become toxic. MF facilitates the recycling of HCy to methionine, thereby curbing its toxic potential.
Supports Brain Health Across the Lifespan
Methyl from MF is needed from the moment of fertilization of the human egg, through the development of the brain, heart and other organs, to birth, and all across the lifespan. All our cells need methyl groups to make their DNA, repair ongoing DNA damage, and regulate their utilization of DNA.
No Artificial Coloring
No Artificial Flavoring
|Serving Size 1 Capsule
Servings Per Container 30
|Amount Per Serving||% DV|
|Folate (as Quatrefolic methylfolate,
5-methyltetrahydrofolate, glucosamine salt)
|* Daily Value (DV) not established.|
Vegetable cellulose (vegetarian capsule), microcrystalline cellulose, silicon dioxide, magnesium stearate.
Free from sugar, dairy, gluten, wheat, yeast, soy, eggs, corn, and artificial colors or flavorings.
This formula contains folate as methylfolate (MTHF). The brain requires MTHF to make neurotransmitters, to produce the myelin insulation of nerve cells, and to make the sleep hormone melatonin. It also helps the liver and other organs recycle the metabolic product homocysteine, to prevent it from building up to toxic levels.