MethylFolate

30
Capsules

Finally, a folate supplement with superior bioavailability. Our high-potency MethylFolate supplement features folate in the fully activated, readily absorbed form of methylfolate, making it perfect for individuals with mood challenges, MTHFR genetic mutations, and attention issues.*

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Mood

Mood

Promotes positive mood and emotional balance
Methyl

Methyl

Supports numerous brain and other organ functions
Protective

Protective

Helps prevent homocysteine adverse effects
Supplement Facts
Serving Size 1 Capsule
Servings Per Container 30
Amount Per Serving % DV
Folate (as Quatrefolic methylfolate,
5-methyltetrahydrofolate, glucosamine salt)
5 mg 1,250%
* Daily Value (DV) not established.
Other Ingredients: Vegetable cellulose (vegetarian capsule), microcrystalline cellulose, silicon dioxide, magnesium stearate.

Free from sugar, dairy, gluten, wheat, yeast, soy, eggs, corn, and artificial colors or flavorings.
  • Sugar Free
  • Corn Free
    Corn Free
  • Soy Free
  • Artificial Additive Free
  • Gluten/Yeast Free
  • No Animal Products

Month 1

Clinically studied nutrients get to work

Month 2-3

Nutritional deficiencies are corrected (varies by person)

Month 4 & Beyond

Amplify the benefits & support long-term health

Your Brain + Body's Preferred Form Of Folate

Methylfolate (MF) is the body's most fully active form of folate, a vitamin that provides methyl groups (-CH3) which are crucial for a broad range of brain functions, including healthy mood. In clinical trials, MF corrected methyl deficiency while promoting healthy mood and overall brain health.

HIGHLY BIOAVAILABLE SOURCE OF METHYL GROUPS

Normally, to be utilized by the body dietary folates from foods or supplements must first be converted to methylfolate, identical to MF. But the enzymes involved in this conversion process often carry mutations that impair their activity, so that more than 1 in 4 people are inefficient at converting folates to MF. High-quality MF supplements bypass these enzymes, directly supplying methyl to make SAME (s-adenosyl-methionine) and other methyl cofactors that manage the body's extensive networks of methyl metabolism.

PROMOTES METABOLIC RECYCLING OF HOMOCYSTEINE

Homocysteine (HCy) is a byproduct of SAMe production from MF and the amino acid methionine. If allowed to build up in the blood and other tissues, HCy can become toxic. MF facilitates the recycling of HCy to methionine, thereby curbing its toxic potential.

SUPPORTS BRAIN HEALTH ACROSS THE LIFESPAN

Methyl from MF is needed from the moment of fertilization of the human egg, through the development of the brain, heart and other organs, to birth, and all across the lifespan. All our cells need methyl groups to make their DNA, repair ongoing DNA damage, and regulate their utilization of DNA.

Methyl Support for Mood, Brain Health and Wellbeing

Methylfolate (MF) is the body's most fully active form of folate, a vitamin that provides methyl groups (-CH3) which are crucial for a broad range of brain functions, including healthy mood. In clinical trials, MF corrected methyl deficiency while promoting healthy mood and overall brain health.

Highly Bioavailable Source of Methyl Groups

Normally, to be utilized by the body dietary folates from foods or supplements must first be converted to methylfolate, identical to MF. But the enzymes involved in this conversion process often carry mutations that impair their activity, so that more than 1 in 4 people are inefficient at converting folates to MF. High-quality MF supplements bypass these enzymes, directly supplying methyl to make SAME (s-adenosyl-methionine) and other methyl cofactors that manage the body's extensive networks of methyl metabolism.

Promotes Metabolic Recycling of Homocysteine

Homocysteine (HCy) is a byproduct of SAMe production from MF and the amino acid methionine. If allowed to build up in the blood and other tissues, HCy can become toxic. MF facilitates the recycling of HCy to methionine, thereby curbing its toxic potential.

Supports Brain Health Across the Lifespan

Methyl from MF is needed from the moment of fertilization of the human egg, through the development of the brain, heart and other organs, to birth, and all across the lifespan. All our cells need methyl groups to make their DNA, repair ongoing DNA damage, and regulate their utilization of DNA.

Ingredients
Folate
Folate
5 mg

This formula contains folate as methylfolate (MTHF). The brain requires MTHF to make neurotransmitters, to produce the myelin insulation of nerve cells, and to make the sleep hormone melatonin. It also helps the liver and other organs recycle the metabolic product homocysteine, to prevent it from building up to toxic levels.

Folic Acid vs. Methylfolate

Most folate vitamins use inexpensive, synthetic folic acid. This is a problem, because folic acid can’t be used by the body until it is converted to methylfolate.

Unfortunately, many people can’t efficiently make this conversion due to a common genetic mutation (MTHFR). 

If your body can’t convert folic acid to methylfolate, you’re missing out on the benefits of this vitamin for mood, brain and organ function, as well as protection from homocysteine, an amino acid that may be harmful to the heart.*

Methylfolate: The Best Form Of Folate

Methylfolate is the most active form of folate. It bypasses the need for conversion because it’s already chemically identical to the folate present in all your cells. That means this folate supplement is readily absorbed and utilized, even if you have the common MTHFR C677T mutation – which affects up to 40% of the population.

Methylfolate also supplies the body with methyl to make SAMe, which is important for mood, energy, joint, and liver health.*

• OUR CEO SAYS •

“With MethylFolate, you can support a wide array of critical brain functions, including mood support, across your entire lifespan.”

- Daniel G. Amen, MD 

  • READ Why It Didn’t Make the Cut

    Iron is a mineral essential for human health. It is typically linked to hemoglobin – the protein that transports oxygen around the body – and is also vital for energy production, antioxidant defense, DNA production, gene regulation, and the body’s detoxification process.
    Though commonly found in multivitamins, we purposely left it out.
    As a standalone supplement ingredient for those at risk of deficiency, iron is beneficial – we offer advanced iron in its most well-tolerated and well-absorbed form: ferrous bisglycinate, Ferrochel®. However, when combined with other nutrients (like it is in a comprehensive multivitamin), iron’s chemically reactive nature can degrade and potentially destroy the other ingredients it’s mixed with.
    Here’s everything else we intentionally left out.

• Brain & Memory Power Boost •

“I got my DREAMS back!”

- Claire R., Verified Buyer

Powerful Brain & Body Benefits

MethylFolate by BrainMD supports a broad range of brain and body functions, including:

  • Positive Mood. Your brain uses methylfolate to make neurotransmitters – chemicals that influence how you feel. Human clinical research has shown that methylfolate promotes a healthy mood, especially in people with low folate.*
  • Homocysteine Protection. Homocysteine is a harmful amino acid that can build to toxic levels in the blood unless B vitamins, including folate, help break it down. Healthy homocysteine levels are linked to good brain and cardiovascular health.*
  • Brain/Organ Function. Methylfolate provides methyl, which is used by all the cells in your body and brain to make and repair DNA.*

• OUR CEO SAYS •

“A really awesome quote from Dr, Amen about how awesome this product is.”

- Daniel G. Amen, MD 

High-Potency For Advanced Support

With 5,000 mcg of folate per capsule, our MethylFolate is a high-potency folate supplement that should ideally be used under a physician’s supervision. It’s best suited for people with low folate and/or:

  • Mood challenges. People with mood problems are often low in folate.*
  • MTHFR C677T gene mutation. This mutation is common across the population, but especially in people of Hispanic descent.
  • Attention issues. High doses of folate are recommended for children who struggle with attention and behavior.*

Clinically Researched Benefits

As a company firmly rooted in science, we use only clinically researched ingredients that create real results. Here are some of the benefits of MethylFolate:

  • Excellent absorption and utilization of folate*
  • Positive mood and emotional balance*
  • Protection against homocysteine buildup*
  • Support for brain and organ function*
  • Better attention, behavior, and socialization in children*
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Customer Rating
Price $29.95 $49.95 $14.95
Supplement form Capsules Capsules Capsules
Health Benefits Mood Methyl Protective Calm Mood Appetite Mood Protective Methyl
Ingredients Folate Vitamin B6 Folate Vitamin B12 Satiereal Saffron Extract 5-Hydroxytryptophan Betaine
Frequently Asked Questions
How do I know whether I need this supplement?
Methylfolate is a great supplement to support mood, especially in conjunction with SAMe and Betaine TMG. It also supports memory and the other higher brain functions. Since MF is essential for fetal development, women of reproductive age would be prudent to monitor their folate status and consider taking this supplement. Alcohol, smoking, and oral contraceptives all can deplete the body's folate. Inherited mutations in folate-processing enzymes affect up to 1 in 2 individuals of some ethnic groups. Taking MethylFolate ensures these individuals will receive folate they can utilize. This supplement is also a superior folate source for those without such mutations precisely because it is so efficiently utilized.
This supplement is very potent. Is it safe?
Methylfolate's safety is well documented, and this (and higher potencies) have been used safely and with great success for many years. MethylFolate is indicated for correcting confirmed folate deficiency, for promoting healthy mood, and for any other situations where folate supplementation is recommended.
What's the best way to take this supplement?
The basic dose is 1 capsule daily, taken with food. This supplies 5000 micrograms (5 mg) of methylfolate. We recommend that when under a physician's supervision, up to 3 caps (15 mg) can be taken daily.
I'm currently taking methotrexate - will this supplement be a problem?
We advise anyone taking methotrexate to consult a nutritionally-informed physician before using this product.
Can vegetarians take this product?
Yes, it is suitable for vegetarians and vegans.
What is the functional relationship of this product with SAMe?
Our liver cells need methylfolate to make SAMe. MethylFolate generously facilitates this process. The body uses a lot of SAMe, so boosting internal SAMe production may improve the benefits of SAMe supplementation, whether for mood, joint health or liver health.
How does this product work with Betaine TMG (Trimethylglycine)?
BrainMD's product Betaine TMG is a neat backup methyl source. It works to bypass the methyl enzyme mutations, promote HCy recycling and generally support methyl metabolism. MethylFolate and Betaine TMG complement each other's beneficial actions, and both complement SAMe Mood & Movement 400.
Is this product compatible with other dietary supplements?
Yes, it is absolutely compatible with multiple vitamin/mineral supplements, fish oils, herbals, and other responsibly-formulated dietary supplements. Further, MethylFolate's multiple methyl actions tend to reinforce the benefits of other dietary supplements.
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