PhosphatidylSerine (PS) – Brain Boosting Ingredients | BrainMD

Brain-Boosting Ingredients Series – PhosphatidylSerine (PS) 

What are the basic ingredients for a brain healthy life? It all starts with pure and potent nutrients. BrainMD’s supplements are made with high-quality ingredients that can help improve brain health and the functioning of many other organs in the body.

In this blog series, we’re taking a closer look at the origins, uses, and recipes for some of our key ingredients so that you can incorporate them into your diet and daily supplement regimen.

One ingredient we’re proud to recommend is PhosphatidylSerine (PS), the most proven nutrient for memory and brain health.

What is PhosphatidylSerine?

PhosphatidylSerine, pronounced fos-fa-tie-dil-see-reen, is a phospholipid nutrient present in all our cells but especially concentrated in the brain’s nerve cells. PS is crucial for enhancing recall and for promoting healthy attention, learning and mental sharpness. PS has been extensively researched in humans, animals, and cultured cells, and is the most proven nutrient for memory.

PS is a universal building block for cell membranes, the dynamic structures that link the nerve cells into trillions of information transfer connections (synapses). The brain’s billions of nerve cells also need PS to package neurotransmitters into membrane structures for subsequent release into the synapses. PS is fundamental to the membranes of mitochondria, the microscopic power plants that generate energy for all our cells.

The Origin of PhosphatidylSerine

PS is naturally produced by the body and is found in practically all foods, but mostly at very low levels. One of the richest sources of PS is cow brain, but not many people eat brain and concerns over diseases make this a risky and unappealing source of PS. PS is also present in organ meats, like liver and kidneys. Cow’s milk has a small amount of PS.

The best food source of PS is chicken egg yolks, which also provide a host of important nutrients. A great way to ensure daily intakes of PS at levels sufficient to improve brain function is to take a PS dietary supplement. Earlier PS supplements came from soy, which can be allergenic. BrainMD’s NeuroPS is derived from sunflower, a vegetarian source that’s free of soy allergens.

Benefits of PhosphatidylSerine

There are 5 major benefits of taking PS supplements:

Improves Memory and Learning

PS improved verbal fluency and enhanced learning and recall of names, faces, words, and numbers in double-blind clinical trials. PS is better documented for these benefits than any other nutrient.

Promotes Attention

In a double-blind clinical trial with children aged 4-14 years, the group that received PS at 200 mg per day showed improved attention, self-control, and short-term memory, when compared to those receiving a placebo.

Drives Major Brain Neurotransmitter Systems

PS is an essential building block for cell membranes, which organize enzymes and other proteins into molecular complexes to optimize the body’s life processes. PS promotes the actions of at least 4 major brain neurotransmitters: acetylcholine, dopamine, serotonin, and norepinephrine.

Essential for Our Brain Cells to Make Energy

Our brain uses more than 20% of our body’s total energy. The brain’s energy-guzzling nerve cells are the largest in the body. Our brain cells rely on mitochondria to make more than 90% of their energy. PS is essential for the mitochondria to function.

Promotes Overall Brain Health

PS is essential for the brain not only to make energy, but to manage its trillions of nerve cell connections. PS promotes brain health at all stages of life, from childhood through adulthood.

Common Uses

PS has the best track record for improving memory, as recognized by the U.S. FDA with two allowed Qualified Health Claims. Also, as a major cell membrane building block, PS works closely with omega-3 EPA and DHA to promote efficient synaptic functioning that contributes to healthy mood and behavior. PS is commonly used for improving attention and academic performance in children. PS is safe and well-tolerated.


Berries are loaded with antioxidants and have a host of health benefits. Blueberries, referred to as “brain berries” among neuroscientists, may help delay short-term memory loss. If you like berries in your smoothie, you’ll love this delicious recipe for a Brain-Smart Smoothie.

As the leader in brain-directed supplements, BrainMD has made PS a priority ingredient in many of our memory products. For more information about NeuroPS or our full catalog of brain healthy supplements, visit the online store at BrainMD.

Keith Rowe
5 1 vote
Article Rating
Notify of
Newest Most Voted
Inline Feedbacks
View all comments
Richard Tanner

I can find all the information I want on how to improve my brain health but no information on how to improve or repair my brain while taking medications for depression, anxiety, bipolar disorder, etc. I can change my diet and take some of the supplements suggested but not all of them. I need information on how I can slowly integrate them into my system while slowly cutting back on my medications. Any answers on where I can get that information.

Debra forsythe

What can give a 10 yr old boy


Thanks for this insightful article. Phosphatidylserine has helped with my sleep too!