Berberine Supplements: One of the Best Ways to Burn Fat!
Medically Reviewed by Dr. Nicole Avena

As we age, it’s normal for our metabolism to slow down.

A recent study published in Science found that there’s a gradual slowing of the metabolism after the age of 20. However, a significant decline in metabolism doesn’t occur until around the age of 60.

So, regardless of your age, how can you know if you have a slow metabolism?

Let’s find out!

Signs of a Slow Metabolism

Metabolism refers to a chain of complex physical processes. It occurs in all living things, transforming sustenance into the building blocks that allow functions like movement, growth, development, and reproduction. Metabolic function can be affected by numerous factors, including diet, exercise, and age.

So, what are the signs that your metabolism isn’t functioning at an optimal level?

You may:

  • feel sluggish, tired, or struggle with fatigue
  • experience weight gain or find it difficult to lose weight even if you eat healthy
  • have bloating, gas, or may frequently feel cold
  • deal with mood issues
  • maintain a poor diet
  • fail to get consistent exercise
  • have too much stress
  • get inadequate sleep

Other causes of a slow metabolism include genetics and certain medical conditions.

The good news is you can address these potential causes of low metabolism with healthier lifestyle choices.

An effective way to rev up your metabolism is with whole foods and high-quality dietary supplements. One supplement believed to assist with healthy weight management and metabolism is berberine.

What is Berberine?

Berberine is well known for its physiological effects on the body’s metabolism. Berberine is a benzylisoquinoline alkaloid found in medicinal plants and is considered one of the most promising natural ways to help metabolic challenges, including blood sugar, liver, and weight issues. Studies show that it can help regulate insulin sensitivity and improve the effectiveness of insulin secretion.

Berberine also may help support gut microbiota dysbiosis by allowing an increase in beneficial bacteria. A healthy gut microbiome may improve digestion and promote the breakdown of branch chain amino acids, which can help with insulin resistance.

With so many benefits, it’s clear why berberine is popular for maintaining a healthy weight and metabolism. That’s why BrainMD is proud to offer its new ultra-pure berberine supplement…

Smart Metabolic Burn 2

Smart Metabolic Burn: Premium Berberine Supplement!

Tired of trying every weight support program without seeing results? Wondering if there’s a breakthrough product or natural way to maintain a healthy appetite that can finally work for you?

Don’t waste your time on fads or gimmicks; support your health with a science-backed approach to metabolic wellness.

Burn Fat & Balance Glucose Levels

Smart Metabolic Burn is clinically formulated for sustainable, healthy weight management.* By targeting inflammation and decreasing oxidative stress, Smart Metabolic Burn addresses the root cause of weight-related challenges.*

Top Benefits of Smart Metabolic Burn

Taking Smart Metabolic Burn can help:

  • Improve metabolic health*
  • Reduce oxidative stress*
  • Promote healthy blood sugar levels and insulin sensitivity*
  • Decrease abdominal fat and waist to hip ratio*
  • Support metabolism of fat in the liver*
  • Maintain healthy cholesterol and triglyceride levels*
  • Support a healthy inflammatory response within the body*
  • Retain body composition when paired with diet and exercise*

Who Can Benefit from Smart Metabolic Burn?

This product is recommended for those seeking support for metabolic, cardiovascular, and GI health.* Individuals who struggle with cravings and overeating, or are trying to maintain healthy blood sugar levels, also may benefit from this formula.* Women experiencing menopausal symptoms may find support for healthy weight management by taking this product.*

Smart Metabolic Burn Ingredients


Oleoylethanolamide (OEA) is a novel substance in the field of weight management medicine. The compound works with the existing OEA synthesized in the intestine to reduce overall food intake and stimulate lipolysis, the breakdown of triacylglycerols into free fatty acids and glycerol. OEAs role in weight loss is based on the activation of peroxisome proliferator-activated receptor-α, which reduces blood lipid levels and enhances peripheral fatty acid breakdown.

Berberine Blend

Berberine is renowned for its physiological impact on the body’s metabolism and has been used for years in traditional Ayurvedic and Chinese medicine. Derived from benzylisoquinoline alkaloids found in medicinal plants, it stands out as a highly promising natural aid for metabolic issues.

Dihydroberberine is a bioactive form of berberine recognized for its superior bioavailability. Its unique structure facilitates rapid absorption in the intestines, maximizing its effectiveness and ensuring the body can harness its metabolic benefits.

Smart Metabolic Burn FAQ

How do I take Smart Metabolic Burn?

It’s recommended for adults to take one capsule twice per day, approximately 30 minutes before a meal.

How does this supplement support my insulin regulation?

Berberine has been shown to improve the uptake of glucose in the blood into the cells by improving reactions of insulin-like growth factor-1 (IGF-1), which helps increase overall insulin production throughout the body. This can be beneficial for maintaining healthy insulin levels.

Can this supplement make me dependent on it, or addicted?

Since this supplement is created from herbal blends, it doesn’t cause dependence.

Does this product have any side effects?

Berberine may cause diarrhea, upset stomach, or constipation. Oleoylethanolamide should only be taken under medical supervision if you have pre-existing liver issues.

Is this product safe to take during pregnancy?

This product isn’t recommended for use in women who are pregnant or nursing. If you’re trying to get pregnant, check with a medical professional prior to starting any dietary supplement.

What other BrainMD supplements work well with Smart Metabolic Burn?

Pairing this supplement with BrainMD’s Craving Control can help support metabolism and weight management.* The anti-inflammatory and insulin regulating effects of Smart Metabolic Burn, when taken with the mood balancers and recovery components of l-glutamine in Craving Control, make this a formidable weight support duo!*

Does this product contain any allergens?

No. It’s free of added sugar, nuts, gluten, corn, soy, eggs, or yeast, and has no artificial colorings or flavorings.

Feel the Burn

Smart Metabolic Burn had been clinically studied for healthy weight management.* By targeting inflammation and decreasing oxidative stress, Smart Metabolic Burn addresses the root cause of weight-related challenges.

Formulated with 99.5 mg of a proprietary berberine blend and 125 mg of oleoylethanolamide, Smart Metabolic Burn goes far beyond ordinary metabolic wellness supplements. Just two capsules a day can help kickstart your metabolism and promote healthy weight management.*

Try Smart Metabolic Burn today!


Note: It’s recommended to consult with a medical provider before taking a new supplement.


At BrainMD, we’re dedicated to providing the highest purity nutrients to improve your physical health and overall well-being. For more information about Smart Metabolic Burn and our full list of brain healthy supplements, please visit us at BrainMD.

*These statements have not been evaluated by the FDA. This content is for informational purposes only. It is not meant to substitute for medical or healthcare advice from a physician, nor is it intended to diagnose, treat, cure, or prevent any disease. Consult your healthcare provider before beginning a new health regimen.

Keith Rowe
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Jacqueline Volkmann

I would like to purchase this product but don’t see how to do that.

BrainMD Team

Thanks for reaching out, you can shop our newest product Smart Metabolic Burn here: